Futher Novel Forms Of Interfering Rna Molecules - EP2258847

The patent EP2258847 was granted to Silence Therapeutics on Jul 1, 2020. The application was originally filed on Aug 5, 2003 under application number EP10012263A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2258847

SILENCE THERAPEUTICS
Application Number
EP10012263A
Filing Date
Aug 5, 2003
Status
Patent Maintained As Amended
May 29, 2020
Grant Date
Jul 1, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (3)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

SANOFIDec 15, 2017RAIWITHDRAWN
THE MEDICINES UKDec 14, 2017MACDONALDWITHDRAWN
ALNYLAM PHARMACEUTICALSOct 19, 2017POTTER CLARKSONWITHDRAWN

Patent Citations (27) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0586520
DESCRIPTIONEP0618925
DESCRIPTIONWO0044895
DESCRIPTIONWO0175164
DESCRIPTIONWO9932619
OPPOSITIONEP1144623
OPPOSITIONUS6107094
OPPOSITIONUS6239272
OPPOSITIONWO0044895
OPPOSITIONWO02055693
OPPOSITIONWO02097114
OPPOSITIONWO0216620
OPPOSITIONWO0244321
OPPOSITIONWO03064621
OPPOSITIONWO03070895
OPPOSITIONWO03070918
OPPOSITIONWO9207065
OPPOSITIONWO9401550
OPPOSITIONWO9618376
OPPOSITIONWO9746570
OPPOSITIONWO9955857
SEARCHWO0044895
SEARCHWO02055693
SEARCHWO0244321
SEARCHWO03070912
SEARCHWO9513834
SEARCHWO9741141

Non-Patent Literature (NPL) Citations (53) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BARSTEAD, CURR OPIN CHEM BIOL, (2001), vol. 5, pages 63 - 6-
DESCRIPTION- BAULCOMBE, CURR OPIN PLANT BIOL, (1999), vol. 2, pages 109 - 13-
DESCRIPTION- BERNSTEIN ET AL., NATURE, (2001), vol. 409, pages 363 - 6-
DESCRIPTION- BILLY ET AL., PROC NATL ACAD SCI U S A, (2001), vol. 98, pages 14428 - 33-
DESCRIPTION- CAZENAVE ET AL., NUCLEIC ACIDS RES, (1987), vol. 15, pages 10507 - 21-
DESCRIPTION- ELAYADI; COREY, CURR OPIN INVESTIG DRUGS, (2001), vol. 2, no. 4, pages 558 - 61-
DESCRIPTION- ELBASHIR ET AL., NATURE, (2001), vol. 411, pages 494 - 8-
DESCRIPTION- FIRE, TRENDS GENET, (1999), vol. 15, pages 358 - 63-
DESCRIPTION- GOOD ET AL., GENE THER, (1997), vol. 4, pages 45 - 54-
DESCRIPTION- GUAN K. L.; DIXON J. E., ANAL BIOCHEM., (1991), vol. 192, page 262-
DESCRIPTION- KENNERDELL ET AL., CELL, (1998), vol. 95, pages 1017 - 26-
DESCRIPTION- KENNERDELL ET AL., NATBIOTECHNOL, (2000), vol. 18, pages 896 - 8-
DESCRIPTION- KIM, CURR BIOL, (2001), vol. 11, pages R85 - 7-
DESCRIPTION- KLIPPEL, A.; ESCOBEDO, J. A.; HIRANO, M.; WILLIAMS, L. T., MOL CELL BIOL, (1994), vol. 14, pages 2675 - 2685-
DESCRIPTION- MAEDA ET AL., CURR BIOL, (2001), vol. 11, pages 171 - 6-
DESCRIPTION- MONTGOMERY ET AL., PROC NATL ACAD SCI U S A, (1998), vol. 95, pages 15502 - 7-
DESCRIPTION- NYKANEN, CELL, (2001), vol. 107, pages 309 - 21-
DESCRIPTION- ORUM; WENGEL, CURR OPIN MOL THER., (2001), vol. 3, no. 3, pages 239 - 43-
DESCRIPTION- SHARP, GENES DEV, (2001), vol. 15, pages 485 - 90-
DESCRIPTION- TUSCHL ET AL., GENES DEV, (1999), vol. 13, pages 3191 - 7-
DESCRIPTION- WATERHOUSE ET AL., NATURE, (2001), vol. 411, pages 834 - 42-
DESCRIPTION- WIANNY ET AL., NAT CELL BIOL, (2000), vol. 2, pages 70 - 5-
DESCRIPTION- WICKSTROM, J BIOCHEM BIOPHYS METHODS, (1986), vol. 13, pages 97 - 102-
OPPOSITION- INOUE H. et al., "SNTHESIS AND HYBRIDIZATION STUDIES ON TWO COMPLEMENTARY NONA(2'-O-METHYL)RIBONUCLEOTIDES", Nucleic Acids Res, (19870811), vol. 15, no. 15, pages 6131 - 6148, XP000570336-
OPPOSITION- MANOHARAN M., "2'-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation", Biochimica et Biopohysica Acta, (19990000), vol. 1489, pages 117 - 130, XP000979474-
OPPOSITION- "Muster (Struktur)", Wikipedia, (20080924), pages 1 - 2, URL: https://de.wikipedia.org/wiki/Muster_%28Struktur%29, XP055444070-
OPPOSITION- "pattern", Julius Grant, Hackh's Chemical Dictionary. 4th ed., McGraw Hill, (19690000), page 492, XP055444083-
OPPOSITION- "pattern", Oxford English Dictionary. 5th ed., Oxford University, (19330000), page 2123, XP055444074-
OPPOSITION- "pattern", Sybil P. Parker, Dictionary of Scientific and Technical Terms. 5th ed., McGraw-Hill, (19940000), page 1457, XP055444088-
OPPOSITION- "Sequence motif", Wikipedia, the free encyclopedia, (20090227), pages 1 - 6, URL: https://en.wikipedia.org/wiki/Sequence_motif, XP055444076-
OPPOSITION- "Sequenzanalyse", Fiedrich Lottspeich/Haralabos Zorbas, Bioanalytik, Spektrum Akademischer Verlag, (19980000), page 785, XP055444098-
OPPOSITION- CHOUNG et al., "Chemical modification of siRNAs to improve serum stability without loss of efficacy", Biochem Biophys Res Comm, (20060414), vol. 342, no. 3, pages 919 - 927, XP005312605
OPPOSITION- MARTINEZ J et al., "Single-stranded antisense siRNAs guide target RNA cleavage RNAi", Cell, (20020906), vol. 110, no. 5, pages 563 - 574, XP002257819
OPPOSITION- PARRISH S. et al., "Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference", MOLECULAR CELL, (20001100), vol. 6, no. 5, pages 1077 - 1087, XP002226298
OPPOSITION- PARRISH S. et al., "Functional Anatomy of a dsRNA Trigger: Differential Requirement for the Two Trigger Strands in RNA Interference", MOLECULAR CELL, (20001100), vol. 6, no. 5, pages 1077 - 1087, XP002328495
OPPOSITION- SCHWARZ, DS et al., "Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways", Mol Cell, (20020900), vol. 10, no. 3, pages 537 - 548, XP009019083
OPPOSITION- YA-LIN CHIU et al., "RNAi in Human Cells: Basic Structural and Functional Features of Small Interfering RNA", Molecular Cell, (20020900), vol. 10, no. 3, pages 549 - 561, XP002978510
OPPOSITION- BEVILACQUA P.C. et al., "Minor groove recognition of double stranded RNA by the double stranded RNA binding domain from the RNA activated protein kinase PKR", BIOCHEMISTRY, (19960000), vol. 35, pages 9983 - 9994, XP002091877
OPPOSITION- BUTORA et al., "Nucleoside Optimization for RNAi: A High-Throughput Platform", J. Am. Chem. Soc., (20111026), vol. 133, no. 42, pages 16766 - 16769, XP055057703
OPPOSITION- FIRE A. et al., "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans", Nature, (19980219), vol. 391, pages 806 - 811, XP002095876
OPPOSITION- WU H. et al., "Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19980000), vol. 273, no. 5, pages 2532 - 2542, XP002234692
OPPOSITION- HARBORTH, J et al., "Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing", Antisense Nucleic Acid Drug Dev, (20030400), vol. 13, no. 2, pages 83 - 105, XP002284355
OPPOSITION- CONKLIN et al., "Association of nucleotide patterns with gene function classes: application to human 3' untranslated sequences", Bioinformatics, (20020000), vol. 18, no. 1, pages 182 - 189, XP055444079
OPPOSITION- ELBASHIR S.M. et al., "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO JOURNAL, (20011203), vol. 20, no. 23, pages 6877 - 6888, XP002225998
OPPOSITION- AMARZGUIOUI, M. et al., "Tolerance for mutations and chemical modifications in a siRNA", Nucleic Acids Res, (20030115), vol. 31, no. 2, pages 589 - 595, XP002270887
OPPOSITION- AMARZGUIOUI, M et al., "Tolerance for mutations and chemical modifications in a siRNA", Nucleic Acids Res, (20030100), vol. 31, no. 2, pages 589 - 595, XP002607733
OPPOSITION- CZAUDERNA F. et al., "Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells", Nucleic Acids Res, (20030000), vol. 31, pages 2705 - 2716, XP002270732
OPPOSITION- KOLLER et al., "Competition for RISC binding predicts in vitro potency of siRNA", Nucl Acid Res, (20060831), vol. 34, no. 16, pages 4467 - 4476, XP002412029
OPPOSITION- COOK P.D., ANTISENSE DRUG TECHNOLOGY: Principles Strategies and Applications, New York, Marcel Dekker, (20010000), pages 29 - 56, XP002994162
OPPOSITION- CAPODICI et al., "Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference", The Journal of Immunology, (20021101), vol. 169, pages 5196 - 5201, XP002988100
SEARCH- PARRISH S ET AL, "Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference", MOLECULAR CELL, (200011), vol. 6, no. 5, ISSN 1097-2765, pages 1077 - 1087, XP002226298 [X] 1-4,12,15 * page 1081, column R; figure 5 * * page 1084, column L, paragraph 2 * [Y] 1-15
SEARCH- STERNBERGER M ET AL, "GeneBlocs are powerful tools to study and delineate signal transduction processes that regulate cell growth and transformation", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, (200206), vol. 12, no. 3, ISSN 1087-2906, pages 131 - 143, XP002226299 [AD] 1-15 * the whole document *
SEARCH- CZAUDERNA FRANK ET AL, "Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells.", NUCLEIC ACIDS RESEARCH, (20030601), vol. 31, no. 11, ISSN 0305-1048, pages 2705 - 2716, XP002270732 [XP] 1-7,12,14,15 * the whole document *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents