IP Verse

Medicaments For Increasing Endogenous Erythropoietine (Epo) - EP2289531

The patent EP2289531 was granted to Fibrogen on Jul 4, 2018. The application was originally filed on Dec 6, 2002 under application number EP10181768A. The patent is currently recorded with a legal status of "Revoked".

EP2289531

FIBROGEN
Application Number
EP10181768A
Filing Date
Dec 6, 2002
Status
Revoked
May 16, 2025
Grant Date
Jul 4, 2018
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

GLAXOSMITHKLINEFeb 19, 2020GODDARDINTERVENTION WITHDRAWN
AKEBIA THERAPEUTICSApr 3, 2019JONES DAYADMISSIBLE

Patent Citations (29) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0650960
DESCRIPTIONEP0650961
DESCRIPTIONUS4558006
DESCRIPTIONUS4667016
DESCRIPTIONUS5474796
DESCRIPTIONUS5605662
DESCRIPTIONUS5607954
DESCRIPTIONUS5610172
DESCRIPTIONUS5620995
DESCRIPTIONUS5620996
DESCRIPTIONUS5658933
DESCRIPTIONUS5719164
DESCRIPTIONUS5726305
DESCRIPTIONUS5916898
DESCRIPTIONUS6020350
DESCRIPTIONUS6093730
DESCRIPTIONUS6200974
DESCRIPTIONWO0050390
DESCRIPTIONWO9525116
DESCRIPTIONWO9535505
DESCRIPTIONWO9921860
EXAMINATIONDE10010423
EXAMINATIONEP0765871
EXAMINATIONEP0911340
EXAMINATIONEP1463823
EXAMINATIONWO9741103
OTHEREP1463823
OTHEREP1633333
SEARCHDE10010430

Non-Patent Literature (NPL) Citations (59) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ARAVIND; KOONIN, GENOME BIOL, (2001), page 2-
DESCRIPTION- BICKEL ET AL., HEPATOLOGY, (1998), vol. 28, pages 404 - 411-
DESCRIPTION- BIOCHEM J, (1985), vol. 229, pages 127 - 133-
DESCRIPTION- BRINES ET AL., PROC NATL ACAD SCI USA, (2000), vol. 97, pages 10526 - 10531-
DESCRIPTION- BRUICK; MCKNIGHT, SCIENCE, (2001), vol. 294, pages 1337 - 1340-
DESCRIPTION- CALAPAI ET AL., EUR J PHARMACOL, (2000), vol. 401, pages 349 - 356-
DESCRIPTION- CELIK ET AL., PROC NATL ACAD SCI USA, (2002), vol. 99, pages 2258 - 2263-
DESCRIPTION- COLOWICK, S. ET AL., Methods In Enzymology, ACADEMIC PRESS, INC.-
DESCRIPTION- CRISWELL ET AL., J APPL TOXICOL, (2000), vol. 20, pages 25 - 34-
DESCRIPTION- CROSBY, AMER J THERAP, (2002), vol. 9, pages 371 - 376-
DESCRIPTION- CUNLIFFE ET AL., BIOCHEM J, (1986), vol. 240, pages 617 - 619-
DESCRIPTION- DUPUY ET AL., GENOMICS, (2000), vol. 69, pages 348 - 54-
DESCRIPTION- EPSTEIN ET AL., CELL, (2001), vol. 107, pages 43 - 54-
DESCRIPTION- FRANKLIN ET AL., BIOCHEM J, (2001), vol. 353, pages 333 - 338-
DESCRIPTION- FRIEDMAN ET AL., PROC NATL ACAD SCI USA, (2000), vol. 97, pages 4736 - 4741-
DESCRIPTION- Handbook of Experimental Immunology, BLACKWELL SCIENTIFIC PUBLICATIONS, (1986), vol. I-IV-
DESCRIPTION- IVAN; KAELIN, SCIENCE, (2001), vol. 292, pages 464 - 468-
DESCRIPTION- JACKSON; HUNT, METHODS ENZYMOL, (1983), vol. 96, pages 50 - 74-
DESCRIPTION- JACOBSON ET AL., NATURE, (1957), vol. 179, pages 633 - 634-
DESCRIPTION- JIA ET AL., PROC NATL ACAD SCI USA, (1994), vol. 91, pages 7227 - 7231-
DESCRIPTION- JIANG ET AL., J BIOL CHEM, (1997), vol. 272, pages 19253 - 19260-
DESCRIPTION- KAULE; GUNZLER, ANAL BIOCHEM, (1990), vol. 184, pages 291 - 297-
DESCRIPTION- KIVIRIKKO; MYLLYHARJU, MATRIX BIOL, (1998), vol. 16, pages 357 - 368-
DESCRIPTION- LANDO ET AL., GENES DEV, (2002), vol. 16, pages 1466 - 1471-
DESCRIPTION- LANDO ET AL., SCIENCE, (2002), vol. 295, pages 858 - 861-
DESCRIPTION- LIN ET AL., PROC NATL ACAD SCI USA, (1985), vol. 82, pages 7580 - 7584-
DESCRIPTION- MAHON ET AL., GENES DEV, (2001), vol. 15, pages 2675 - 2686-
DESCRIPTION- MAJAMAA ET AL., BIOCHEM J, (1985), vol. 229, pages 127 - 133-
DESCRIPTION- MAJAMAA ET AL., EUR J BIOCHEM, (1984), vol. 138, pages 239 - 245-
DESCRIPTION- MAJAMAA ET AL., EUR J BIOCHEM, (1984), vol. 138, pages 239 - 45-
DESCRIPTION- Molecular Cloning: A Laboratory Manual, 2nd edition,, COLD SPRING HARBOR LABORATORY PRESS, (1989), vol. I-III-
DESCRIPTION- MYLLYHARJU; KIVIRIKKO, EMBO J, (1997), vol. 16, pages 1173 - 1180-
DESCRIPTION- NEMOTO ET AL., KIDNEY INT, (2001), vol. 59, pages 246 - 51-
DESCRIPTION- PALMERINI ET AL., J CHROMATOGR, (1985), vol. 339, pages 285 - 292-
DESCRIPTION- PELHAM; JACKSON, EUR J BIOCHEM, (1976), vol. 67, pages 247 - 256-
DESCRIPTION- PRIYADARSHI ET AL., KIDNEY INT, (2002), vol. 61, pages 542 - 546-
DESCRIPTION- RENCRICCA ET AL., BLOOD, (1970), vol. 36, pages 764 - 71-
DESCRIPTION- SAKANAKA, PROC NATL ACAD SCI U S A, (1998), vol. 95, pages 4635 - 4640-
DESCRIPTION- SEKI ET AL., CHEM ABSTRACTS, (1974), vol. 81, no. 21, page 424-
DESCRIPTION- SIREN ET AL., PROC NATL ACAD SCI USA, (2001), vol. 98, pages 4044 - 404-
DESCRIPTION- SRINIVAS, BIOCHEM BIOPHYS RES COMMUN, (1999), vol. 260, pages 557 - 561-
DESCRIPTION- TAN ET AL., KIDNEY INT, (1996), vol. 50, pages 1958 - 64-
DESCRIPTION- TAYLOR, GENE, (2001), vol. 275, pages 125 - 132-
DESCRIPTION- VAZIRI ET AL., AM J PHYSIOL, (1994), vol. 266, pages F360 - 6-
EXAMINATION- WARSHAKOON N C ET AL, "Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 16, no. 21, ISSN 0960-894X, (20061101), pages 5616 - 5620, (20061101), XP027966145-
EXAMINATION- HOFER T ET AL, "Oxygen sensing, HIF-1[alpha] stabilization and potential therapeutic strategies", PFLUEGERS ARCHIV: EUROPEAN JOURNAL OF PHYSIOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 443, no. 4, doi:10.1007/S00424-001-0759-8, ISSN 0031-6768, (20140430), pages 503 - 507, (20140430), XP036392387
OTHER- WARSHAKOON et al., "Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors", Bioorg. & Med. Chem. Letters, (20061101), vol. 16, no. 21, pages 5616 - 5620, XP027966145-
OTHER- IVAN et al., "Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible facto", Proc Natl Acad Sci USA, (20021015), vol. 99, no. 21, pages 13459 - 13464, XP002232952
SEARCH[ ] - ANNALS OF ANATOMY = ANATOMISCHER ANZEIGER : OFFICIAL ORGAN OF THE ANATOMISCHE GESELLSCHAFT OCT 1996 LNKD- PUBMED:8931850, (199610), vol. 178, no. 5, ISSN 0940-9602, pages 391 - 403-
SEARCH[ ] - BIOLOGICAL CHEMISTRY JUL 1997 LNKD- PUBMED:9278140, (199707), vol. 378, no. 7, ISSN 1431-6730, pages 609 - 616-
SEARCH- WENGER R H ET AL, "Oxygen(es) and the hypoxia-inducible factor-1.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (199707), Database accession no. NLM9278140, XP002684806 [Y] 1-9,11-15 * abstract *-
SEARCH- EPSTEIN A C R ET AL, "C. ELEGANS EGL-9 AND MAMMALIAN HOMOLOGS DEFINE A FAMILY OF DIOXYGENASES THAT REGULATE HIF BY PROLYL HYDROXYLATION", CELL, CELL PRESS, US, (20011005), vol. 107, no. 1, doi:10.1016/S0092-8674(01)00507-4, ISSN 0092-8674, pages 43 - 54, XP008046407 [Y] 1-9,11-15 * abstract * * page 43 - page 44, column l, paragraph 1 * * page 47, column l, paragraph 2 - page 48, column l, paragraph 1 * * paragraph 1 of "discussion"; page 51, column l * * page 52, column r, paragraph 2 - paragraph 3 *
SEARCH- JELKMANN W ET AL, "Erythropoietin in the control of red cell production.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (199610), Database accession no. NLM8931850, XP002684805 [Y] 1-9,11-15 * abstract *
SEARCH- S. SALCEDA, "Hypoxia-inducible Factor 1alpha (HIF-1alpha ) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions. ITS STABILIZATION BY HYPOXIA DEPENDS ON REDOX-INDUCED CHANGES", JOURNAL OF BIOLOGICAL CHEMISTRY, (19970905), vol. 272, no. 36, doi:10.1074/jbc.272.36.22642, ISSN 0021-9258, pages 22642 - 22647, XP055040278 [A] 1 * abstract * * page 22642 *
SEARCH- KALLIO PEKKA J ET AL, "Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, (19990305), vol. 274, no. 10, doi:10.1074/JBC.274.10.6519, ISSN 0021-9258, pages 6519 - 6525, XP002146028 [A] 1 * abstract * * page 6524, column l, paragraph 2 - paragraph 3 *
SEARCH- MASSON N ET AL, "Independent function of two destruction domains in hypoxia-inducible factor-alfa chains activated by prolyl hydroxylaTIOn", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, (20010101), vol. 20, no. 18, doi:10.1093/EMBOJ/20.18.5197, ISSN 0261-4189, pages 5197 - 5206, XP002253782 [A] 1 * abstract * * page 5201, column r, paragraph 2 - paragraph 3 *
SEARCH- P. JAAKKOLA ET AL, "Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation", SCIENCE, (20010420), vol. 292, no. 5516, doi:10.1126/science.1059796, ISSN 0036-8075, pages 468 - 472, XP055040289 [Y] 1-9,11-15 * abstract * * page 470, column 1, paragraph 3 - paragraph 4 * * page 471, column 1, paragraph 1 - column 2, paragraph 1 * * page 471, column 3, paragraph 3 *
SEARCH- IVAN MIRCEA ET AL, "HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, (20010420), vol. 292, no. 5516, doi:10.1126/SCIENCE.1059817, ISSN 0036-8075, pages 464 - 468, XP002207795 [Y] 1-9,11-15 * abstract * * page 467, column l, paragraph 2 - column r, paragraph 4 *
SEARCH- BRUICK RICHARD K ET AL, "A conserved family of prolyl-4-hydroxylases that modify HIF", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, (20011109), vol. 294, no. 5545, doi:10.1126/SCIENCE.1066373, ISSN 0036-8075, pages 1337 - 1340, XP002433273 [Y] 1-9,11-15 * abstract * * page 1337 * * page 1339, column 3, paragraph 3 - paragraph 4 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents