IP Verse

Stable And Soluble Antibodies Inhibiting Tnf - EP2307457

The patent EP2307457 was granted to Esbatech on Jun 22, 2022. The application was originally filed on Jun 25, 2009 under application number EP09768692A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2307457

ESBATECH
Application Number
EP09768692A
Filing Date
Jun 25, 2009
Status
Patent Maintained As Amended
May 20, 2022
Grant Date
Jun 22, 2022
External Links
Slate, Register, Google Patents

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STRAWMANMar 12, 2019GREAVES BREWSTERADMISSIBLE

Patent Citations (13) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTUS2004086979
INTERNATIONAL-SEARCH-REPORTUS2006099204
INTERNATIONAL-SEARCH-REPORTUS2006216293
INTERNATIONAL-SEARCH-REPORTWO0148017
INTERNATIONAL-SEARCH-REPORTWO03097697
INTERNATIONAL-SEARCH-REPORTWO2006131013
INTERNATIONAL-SEARCH-REPORTWO2008006235
OPPOSITIONEP2947095
OPPOSITIONEP3093026
OPPOSITIONUS2006216293
OPPOSITIONWO03097697
OPPOSITIONWO2008004834
OPPOSITIONWO2008006235

Non-Patent Literature (NPL) Citations (22) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
OPPOSITION- Aho numbering alignment of SEQ ID NOs: 1 & 2.
OPPOSITION- Borras et al, J. of Biological Chemistry, (20100000), vol. 285, no. 12, pages 9054 - 9066
OPPOSITION- CHEN et al., "Generation and Analysis of Random Point Mutations in an Antibody CDR2 Sequence: Many Mutated Antibodies Lose Their Ability to Bind Antigen", J. Exp. Med., (19920000), vol. 176, pages 855 - 866
OPPOSITION- KNAPPIK et al., "FULLY SYNTHESIS HUMAN COMBINATORIAL ANTIBODY LIBRARIES (HUCAL) BASED ON MODULAR CONSENSUS FRAMEWORKS AND CDRS RANDOMIZED WITH TRINUCLEOTIDES", J. Mol. Bio., (20000000), vol. 296, pages 57 - 86
OPPOSITION- KOENIG et al., "Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding", PNAS, (20170000), vol. 114, no. 4, pages E486 - E495
OPPOSITION- Proprietor response dated 08 March 2011
OPPOSITION- Proprietor response dated 16 May 2017 for EP3093026
OPPOSITION- Proprietor response dated 2 Nov 2018 for EP2947095
OPPOSITION- RUDIKOFF et al., "Single amino acid substitution altering antigen-binding specificity", Proc. Natl Acad. Sci. USA, (19820000), vol. 79, pages 1979 - 1983
OPPOSITION- Sequence alignment D3-D5 light chains vc SEQ ID No. 1
OPPOSITION- Sequence alignment D3-D5 light chains vs SEQ ID NO 1
OPPOSITION- Sequence alignment D3-D5 light chains vs SEQ ID NO 1.
OPPOSITION- Sequence alignment D3 vs SEQ ID NOs 1 & 2
OPPOSITION- Sequence alignment D4 framework + D1 CDRs vs SEQ ID Nos: 51-54
OPPOSITION- Sequence alignment D4 vs SEQ ID NOs 1 & 2
OPPOSITION- Sequence alignment D5 vs SEQ ID NOs 1 & 2
OPPOSITION- KNAPPIK et al., "FULLY SYNTHESIS HUMAN COMBINATORIAL ANTIBODY LIBRARIES (HUCAL) BASED ON MODULAR CONSENSUS FRAMEWORKS AND CDRS RANDOMIZED WITH TRINUCLEOTIDES", J. Mol. Bio., (20000000), vol. 296, pages 57 - 86, XP000939143
OPPOSITION- Presta, L.G., "Selection, design, and engineering of therapeutic antibodies", Journal of Allergy and Clinical Immunology, AMSTERDAM, NL, (20051001), vol. 116, no. 4, doi:10.1016/j.jaci.2005.08.003, ISSN 0091-6749, pages 731 - 736, XP005094459
OPPOSITION- Ewert, S. Honegger, A. Pluckthun, A., "Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering", Methods, NL, (20041001), vol. 34, no. 2, doi:10.1016/j.ymeth.2004.04.007, ISSN 1046-2023, pages 184 - 199, XP004526805
OPPOSITION- KOENIG et al., "Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding", PNAS, (20170000), vol. 114, no. 4, pages E486 - E495, XP055578865
OPPOSITION- RUDIKOFF et al., "Single amino acid substitution altering antigen-binding specificity", Proc. Natl Acad. Sci. USA, (19820000), vol. 79, pages 1979 - 1983, XP002683593
OPPOSITION- CHEN et al., "Generation and Analysis of Random Point Mutations in an Antibody CDR2 Sequence: Many Mutated Antibodies Lose Their Ability to Bind Antigen", J. Exp. Med., (19920000), vol. 176, pages 855 - 866, XP002517166

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