Pathways To Generate Hair Cells - EP2381936

The patent EP2381936 was granted to Massachusetts EYE & EAR Infirmary on Feb 12, 2020. The application was originally filed on Nov 24, 2009 under application number EP09828380A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2381936

MASSACHUSETTS EYE & EAR INFIRMARY
Application Number
EP09828380A
Filing Date
Nov 24, 2009
Status
Patent Maintained As Amended
Jan 10, 2020
Grant Date
Feb 12, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

JAMES POOLEJan 2, 2018GOODFELLOWWITHDRAWN

Patent Citations (17) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS19980027032
DESCRIPTIONUS20070953797
DESCRIPTIONWO2007US84654
DESCRIPTIONUS2005287127
DESCRIPTIONUS2006030837
DESCRIPTIONUS2007093878
DESCRIPTIONUS7206639
OPPOSITIONUS2005287127
OPPOSITIONWO0053632
OPPOSITIONWO0059939
OPPOSITIONWO2007075911
OPPOSITIONWO2008076556
SEARCHUS2005287127
SEARCHWO0053632
SEARCHWO0059939
SEARCHWO2007075911
SEARCHWO2008076556

Non-Patent Literature (NPL) Citations (41) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- AKAZAWA ET AL., J. BIOL. CHEM, (1995), vol. 270, pages 8730 - 8738
DESCRIPTION- BEN-ARIE ET AL., DEVELOPMENT, (2000), vol. 127, pages 1039 - 1048
DESCRIPTION- BEN-ARIE ET AL., HUM. MOL. GENE, (1996), vol. 5, pages 1207 - 1216
DESCRIPTION- BERMINGHAM ET AL., SCIENCE, (1999), vol. 284, pages 1837 - 1841
DESCRIPTION- BRORS ET AL., J. COMP. NEUROL., (2003), vol. 462, pages 90 - 100
DESCRIPTION- GILLESPIE ET AL., NEUROREPORT, (2001), vol. 12, pages 275 - 279
DESCRIPTION- HELMS ET AL., DEVELOPMENT, (1998), vol. 125, pages 919 - 928
DESCRIPTION- HELMS ET AL., DEVELOPMENT, (2000), vol. 121, pages 1185 - 1196
DESCRIPTION- ISAKA ET AL., EUR. J. NEUROSCI., (1999), vol. 11, pages 2582 - 2588
DESCRIPTION- JARMAN ET AL., CELL, (1993), vol. 73, pages 1307 - 1321
DESCRIPTION- KAWAMOTO ET AL., THE JOURNAL OF NEUROSCIENCE, (2003), vol. 23, pages 4395 - 4400
DESCRIPTION- LI ET AL., NAT MED., (2003), vol. 9, pages 1293 - 1299
DESCRIPTION- LI ET AL., NATURE MEDICINE, (2003), vol. 9, pages 1293 - 1299
DESCRIPTION- LI ET AL., TRENDS MOL MOD., (2004), vol. 1Q, pages 309 - 315
DESCRIPTION- RASK-ANDERSEN ET AL., HEAR. RES., (2005), vol. 203, pages 180 - 191
DESCRIPTION- SCIENCE, (1999), vol. 284, pages 1837 - 1841
DESCRIPTION- TSUCHIYA ET AL., GASTROENTEROLOGY, (2007), vol. 132, pages 208 - 220
OPPOSITION- "Chapter 1", BARKER N., Wnt Signaling, Humana Press, (20081101), vol. 1, pages 5 - 15, XP055449814
OPPOSITION- DABDOUB et al., "443 Wnt/B-Catenin Signaling in the Developing Mammalian Cochlea", ARO 31st Midwinter meeting, Phoenix, Arizona, USA, (20080216), vol. 31, page 153, XP055449758
OPPOSITION- DABDOUB et al., "8 Wnt Signaling in the Developing Mammalian Cochlea", ARO 30th Midwinter meeting, (20070210), vol. 30, page 2, XP055449830
OPPOSITION- LU et al., "774 The influence of glycogen synthase kinase 3 on cell proliferation in the murine vestibular sensory epithelium", ARO 31st Midwinter meeting, (20080216), vol. 31, page 263, XP055449780
OPPOSITION- SHI et al., "732 Interaction of 8-Catenin with an Atoh1 3' Enhancer Upregulates Atoh1 Expression and Increases Differentiation of Progenitors to Hair Cells", ARO 32nd Midwinter meeting, (20090214), vol. 32, XP055449821
OPPOSITION- LU et al., "The influence of glycogen synthase kinase 3 in limiting cell addition in the mammalian ear", Dev. Neurobiol., (20080700), vol. 68, no. 8, pages 1059 - 1075, XP055449769
OPPOSITION- SWAN et al., "Inner ear drug delivery for auditory applications", Adv. Drug Deliv. Rev., (20080921), vol. 60, no. 15, pages 1583 - 1599, XP025656954
OPPOSITION- CLEVERS, "Wnt/[beta]-Catenin Signaling in Development and Disease", Cell, (20061103), vol. 127, no. 3, pages 469 - 480, XP055120494
OPPOSITION- Edge A et al, "Hair cell regeneration", CURRENT OPINION IN NEUROBIOLOGY, (20080801), vol. 18, no. 4, pages 377 - 382, XP025632345
OPPOSITION- EDGE et al., "Hair cell regeneration", Curr. Opin. Neurobiol., (20080800), vol. 18, no. 4, pages 377 - 382, XP025632345
OPPOSITION- BEUREL et al., "Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases", Pharmacol. Ther., (20150709), vol. 148, pages 114 - 131, XP029199331
OPPOSITION- STEVENS et al., "Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear", Dev. Biol., (20030901), vol. 261, no. 1, pages 149 - 164, XP055449787
OPPOSITION- STAMBOLIC et al., "Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells", Current Biology, (19961200), vol. 6, no. 12, pages 1664 - 1668, XP055449796
OPPOSITION- IZUMIKAWA et al., "Auditory hair cell replacement and hearing improvement by Atohl gene therapy in deaf mammals", Nat. Med., (20050300), vol. 11, no. 3, pages 271 - 276, XP008109775
OPPOSITION- MOON et al., "WNT and .beta.-catenin signalling: diseases and therapies", Nat. Rev. Genet., (20040900), vol. 5, no. 9, pages 691 - 701, XP002545330
OPPOSITION- RENA et al., "D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a", EMBO Reports, (20041212), vol. 5, no. 1, pages 60 - 65, XP002498307
OPPOSITION- LI et al., "Generation of hair cells by stepwise differentiation of embryonic stem cells", Proc. Natl. Acad. Sci. USA, (20031030), vol. 100, no. 23, pages 13495 - 13500, XP007915572
OPPOSITION- BECVAROVSKI et al., "Round Window Gentamicin Absorption: An In Vivo Human Model", Laryngoscope, (20020900), vol. 112, no. 9, pages 1610 - 1613, XP055449798
OPPOSITION- PRICE, "CKI, there’s more than one: casein kinase I family members in Wnt and Hedgehog signaling", Genes Dev., (20060215), vol. 20, no. 4, pages 399 - 410, XP055449806
OPPOSITION- OKUBO et al., "Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm", J. Biol., (20040608), vol. 3, no. 3, page 11, XP021013065
OPPOSITION- OKUBO, T. ET AL, "Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm", JOURNAL OF BIOLOGY, (20040608), vol. 3, no. 3, page 11, XP021013065
OPPOSITION- STAHLE et al., "Long-term Progression of Meniere's Disease", Acta Otolaryngol. (Stockh), (19910000), vol. 111, no. sup485, pages 75 - 83, XP055449826
OPPOSITION- NADOL et al., "Degenerative Changes in the Organ of Corti and .Lateral Cochlear Wall inExperimental Endolymphatic Hydrops and Human Meniere's Disease", Acta Otolaryngol. Suppl., (19950000), vol. 115, no. sup519, pages 47 - 59, XP055449828
SEARCH- HUAWEI LI ET AL, "Generation of hair cells by stepwise differentiation of embryonic stem cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 100, no. 23, doi:10.10737PNAS.2334503100, ISSN 0027-8424, (20031111), pages 13495 - 13500, (20031030), XP007915572 [Y] 1-15 * page 13496; figure 1 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents