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Composition For Delivery Of Genetic Material - EP2419144

The patent EP2419144 was granted to Isis Innovation on Aug 7, 2019. The application was originally filed on Apr 15, 2010 under application number EP10714058A. The patent is currently recorded with a legal status of "Revoked".

EP2419144

ISIS INNOVATION
Application Number
EP10714058A
Filing Date
Apr 15, 2010
Status
Revoked
May 14, 2025
Grant Date
Aug 7, 2019
External Links
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STRAWMANMay 7, 2020ADMISSIBLE
TRUSCOTTMay 6, 2020ADMISSIBLE

Patent Citations (9) New

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Citation PhasePublication NumberPublication Link
EXAMINATIONWO03016522
INTERNATIONAL-SEARCH-REPORTWO0136601
INTERNATIONAL-SEARCH-REPORTWO2007126386
OPPOSITIONAU2004203482
OPPOSITIONUS2004028692
OPPOSITIONUS2004197314
OPPOSITIONWO0136601
OPPOSITIONWO03016522
OPPOSITIONWO2007126386

Non-Patent Literature (NPL) Citations (66) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALEXANDER IE; CUNNINGHAM SC; LOGAN GJ; CHRISTODOULOU J, "Potential of AAV vectors in the treatment of metabolic disease", GENE THER., (2008), vol. 15, no. 11, pages 831 - 9, XP008110672-
DESCRIPTION- ALTSCHUL, S, F ET AL., J MOL BIOL, (1990), vol. 215, pages 403 - 10-
DESCRIPTION- ALTSCHUL S. F., J MOL EVOL, (1993), vol. 36, pages 290 - 300-
DESCRIPTION- DANIEL R; SMITH JA, "Integration site selection by retroviral vectors: molecular mechanism and clinical consequences", HUM GENE THER, (2008), vol. 19, no. 6, pages 557 - 68-
DESCRIPTION- DEVEREUX ET AL., NUCLEIC ACIDS RESEARCH, (1984), vol. 12, pages 387 - 395-
DESCRIPTION- FLINT PW; LI ZB; LEHAR M; SAITO K; PAI SI, "Laryngeal muscle surface receptors identified using random phage library", LARYNGOSCOPE, (2005), vol. 115, no. 11, pages 1930 - 7-
DESCRIPTION- F. M. LAIRD; H. CAI; A.V. SAVONENKO; A. V. M.H. FARAH; K. HE ET AL., "BACEI, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions", J. NEUROSCI., (2005), vol. 25, no. 50, pages 11693 - 11709-
DESCRIPTION- HASBROUCK NC; HIGH KA, "AAV-mediated gene transfer for the treatment of hemophilia B: problems and prospects", GENE THER, (2008), vol. 15, no. 11, pages 870 - 5-
DESCRIPTION- HENIKOFF; HENIKOFF, PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 10915 - 10919-
DESCRIPTION- ISHIDA T; MASUDA K; ICHIKAWA T; ICHIHARA M; IRIMURA K; KIWADA H, "Accelerated clearance of a second injection ofPEGylated liposomes in mice", INT J PHARM, (2005), vol. 255, pages 167 - 74-
DESCRIPTION- JOOSS K; YANG Y; FISHER KJ; WILSON JM, "Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers", J VIROL, (1998), vol. 72, no. 5, pages 4212 - 23-
DESCRIPTION- KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 5873 - 5787-
DESCRIPTION- KAWABATA K; TAKAKURA Y; HASHIDA M, "The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake", PHARM RES, (1995), vol. 12, no. 6, pages 825 - 30-
DESCRIPTION- LOWENSTEIN PR; MANDEL RJ; XIONG WD; KROEGER K; CASTRO MG, "Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions", CURR GENE THER, (2007), vol. 7, no. 5, pages 347 - 60-
DESCRIPTION- MCKAY T; REYNOLDS P; JEZZARD S; CURIEL D; COUTELLE C, "Secretin-mediated gene delivery, a specific targeting mechanism with potential for treatment of biliary and pancreatic disease in cystic fibrosis", MOL THER, (2002), vol. 5, pages 447 - 454-
DESCRIPTION- REIS E SOUSA C, "Dendritic cells in a mature age", NAT REV IMMUNOL, (2006), vol. 6, no. 6, pages 476 - 83-
DESCRIPTION- RIPPE K; MüCKE N; LANGOWSKI J, "Superhelix dimensions of a 1868 base pair plasmid determined by scanning force microscopy in air and in aqueous solution", NUCLEIC ACIDS RES, (1997), vol. 25, no. 9, pages 1736 - 44-
DESCRIPTION- S.C. GONZALEZ; M.M. MCMENAMIN; H.M. CHARLTON; J. GOODMAN; T. LANTOS, "Readministration of adenoviral gene delivery to dopamine neurons", NEUROREPORT, (2007), vol. 18, no. 15, pages 1609 - 14-
DESCRIPTION- SMITH AJ; SCHLICHTENBREDE FC; TSCHERNUTTER M; BAINBRIDGE JW; THRASHER AJ; ALI RR, "AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa", MOL THER, (2003), vol. 8, no. 2, pages 188 - 95-
DESCRIPTION- TAKAKURA Y; NISHIKAWA M; YAMASHITA F; HASHIDA M, "Development of gene drug delivery systems based on pharmacokinetic studies", EUR J PHARM SCI, (2001), vol. 13, no. 1, pages 71 - 76-
DESCRIPTION- TAYLOR N; URIBE L; SMITH S; JAHN T; KOHN DB; WEINBERG K, "Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene", BLOOD, (1996), vol. 87, no. 8, pages 3103 - 7-
DESCRIPTION- THéRY C; ZITVOGEL L; AMIGORENA S, "Exosomes: composition, biogenesis and function", NAT REV IMMUNOL, (2002), vol. 2, no. 8, pages 569 - 79, XP001127450-
DESCRIPTION- VALADI H; EKSTROM K; BOSSIOS A; SJOSTRAND M; LEE JJ; LOTVALL JO, "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", NAT CELL BIOL, (2007), vol. 9, no. 6, pages 654 - 9-
DESCRIPTION- VIJAYANATHAN V; THOMAS T; SHIRAHATA A; THOMAS TJ, "DNA condensation by polyamines: a laser light scattering study of structural effects", BIOCHEMISTRY, (2001), vol. 40, no. 45, pages 13644 - 51-
DESCRIPTION- V.R. SIMHADRI; K.S. REINERS; H.P. HANSEN; D. TOPOLAR; V.L. SIMHADRI ET AL., "Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function", PLOS ONE., (2008), vol. 3, no. 10, page E3377-
DESCRIPTION- WANG Z; KUHR CS; ALLEN JM; BLANKINSHIP M; GREGOREVIC P; CHAMBERLAIN JS ET AL., "Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression", MOL THER, (2007), vol. 15, no. 6, pages 1160 - 6-
DESCRIPTION- WHITE MD; FARMER M; MIRABILE I; BRANDNER S; COLLINGE J; MALLUCCI GR, "Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease", PROC NATL ACAD SCI USA, (2008), vol. 105, no. 29, pages 10238 - 43-
DESCRIPTION- WILLIAMS DA, "RAC reviews serious adverse event associated with AAV therapy trial", MOL THER, (2007), vol. 15, no. 12, pages 2053 - 4-
DESCRIPTION- Y.C. WANG; X.B. HU; F. HE; F. FENG; L. WANG ET AL., "Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4", J BIOL CHEM., (2009), vol. 284, no. 23, pages 15993 - 6003-
DESCRIPTION- ZAISS AK; MURUVE DA, "Immune responses to adeno-associated viral vectors", CURR GENE THER, (2005), vol. 5, no. 3, pages 323 - 31-
DESCRIPTION- ZENG J; TOO HP; MA Y; LUO ESE; WANG S, "A synthetic peptide containing loop 4 of nerve growth factor for targeted gene delivery", J GENE MED., (2004), vol. 6, pages 1247 - 1256-
DESCRIPTION- ZHANG JS; LIU F; HUANG L, "Implications of pharmacokinetic behavior oflipoplex for its inflammatory toxicity", ADV DRUG DELIV REV, (2005), vol. 57, no. 5, pages 689 - 98-
DESCRIPTION- LENTZ, T. L., "Rabies virus binding to an acetylcholine receptor alpha-subunit peptide", J. MOL. RECOGNIT, (1990), vol. 3, doi:doi:10.1002/jmr.300030205, pages 82 - 88, XP055041338
DESCRIPTION- QUAH BJ; O'NEILL HC, "The immunogenicity of dendritic cell-derived exosomes", BLOOD CELLS MOL DIS, (2005), vol. 35, doi:doi:10.1016/j.bcmd.2005.05.002, pages 94 - 110, XP005074514
DESCRIPTION- ISHIDA T; ICHIHARA M; WANG X; YAMAMOTO K; KIMURA J; MAJIMA E; KIWADA H, "Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes", J CONTROL RELEASE, (2006), vol. 112, doi:doi:10.1016/j.jconrel.2006.01.005, pages 15 - 25, XP024957476
DESCRIPTION- S.D. LARSON; L.N. JACKSON; L.A. CHEN; P.G. RYCHAHOU; B.M. EVERS, "Effectiveness of siRNA uptake in target tissues by various delivery methods", SURGERY, (2007), vol. 142, no. 2, doi:doi:10.1016/j.surg.2007.03.011, pages 262 - 9, XP022203372
DESCRIPTION- OH YK; SOHN T; PARK JS; KANG MJ; CHOI HG; KIM JA ET AL., "Enhanced mucosal and systemic immunogenicity of human papillomavirus-like particles encapsidating interleukin-2 gene adjuvant", VIROLOGY, (2004), vol. 328, no. 2, doi:doi:10.1016/j.virol.2004.06.047, pages 266 - 73, XP004581379
DESCRIPTION- ELY A; NAIDOO T; MUFAMADI S; CROWTHER C; ARBUTHNOT P, "Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo", MOL THER, (2008), vol. 16, no. 6, doi:doi:10.1038/mt.2008.82, pages 1105 - 12, XP008102612
DESCRIPTION- KUMAR P; WU H; MCBRIDE JL; JUNG KE; KIM MH; DAVIDSON BL; LEE SK; SHANKAR P; MANJUNATH N, "Transvascular delivery of small interfering RNA to the central nervous system", NATURE, (2007), vol. 448, no. 7149, doi:doi:10.1038/nature05901, pages 39 - 43, XP002499820
DESCRIPTION- REYNOLDS A; LEAKE D; BOESE Q; SCARINGE S; MARSHALL WS; KHVOROVA A, "Rational siRNA design for RNA interference", NAT BIOTECHNOL, (2004), vol. 22, no. 3, doi:doi:10.1038/nbt936, pages 326 - 30, XP002311429
DESCRIPTION- SKOG J; WURDINGER T; VAN RIJN S; MEIJER DH; GAINCHE L; SENA-ESTEVES M; CURRY WT JR; CARTER BS; KRICHEVSKY AM; BREAKEFIELD XO, "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers", NAT CELL BIOL, (2008), vol. 10, no. 12, doi:doi:10.1038/ncb1800, pages 1470 - 6, XP002633335
DESCRIPTION- ZITVOGEL L; REGNAULT A; LOZIER A; WOLFERS J; FLAMENT C; TENZA D; RICCIARDI-CASTAGNOLI P; RAPOSO G; AMIGORENA S, "Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes", NAT MED, (1998), vol. 4, doi:doi:10.1038/nm0598-594, pages 594 - 600, XP002085387
DESCRIPTION- O. SINGER; R.A. MARR; E. ROCKENSTEIN; L. CREWS; N.G. COUFAL ET AL., "Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model", NAT. NEUROSCI., (2005), vol. 8, no. 10, doi:doi:10.1038/NN1531, pages 1343 - 1349, XP002537622
DESCRIPTION- LI JZ; LI H; HANKINS GR; DUNFORD B; HELM GA, "Local immunomodulation with CD4 and CD8 antibodies, but not cyclosporine A, improves osteogenesis induced by ADhBMP9 gene therapy", GENE THER, (2005), vol. 12, no. 16, doi:doi:10.1038/sj.gt.3302502, pages 1235 - 41, XP055468305
DESCRIPTION- RAPOSO G; NIJMAN HW; STOORVOGEL W; LIEJENDEKKER R; HARDING CV; MELIEF DJ; GEUZE HJ, "B lymphocytes secrete antigen-presenting vesicles", JEXP MED, (1996), vol. 183, doi:doi:10.1084/jem.183.3.1161, pages 1161 - 1172, XP002060486
DESCRIPTION- F.A. NUNES; E.E. FURTH; J.M. WILSON; S.E. RAPER, "Gene transfer into the liver of nonhuman primates with El-deleted recombinant adenoviral vectors: safety of readministration", HUM GENE THER., (1999), vol. 10, no. 15, doi:doi:10.1089/10430349950016852, pages 2515 - 26, XP002357351
DESCRIPTION- HAO S; MOYANA T; XIANG J, "Review: cancer immunotherapy by exosome-based vaccines", CANCER BIOTHER RADIOPHARM, (2007), vol. 22, doi:doi:10.1089/cbr.2007.368-R, pages 692 - 703, XP055508075
DESCRIPTION- H. YIN; H.M. MOULTON; C. BETTS; Y. SEOW; J. BOUTILIER ET AL., "A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice", HUM MOL GENET., (2009), vol. 18, no. 22, doi:doi:10.1093/HMG/DDP395, pages 4405 - 14, XP002627589
DESCRIPTION- K. NISHITOMI; G. SAKAGUCHI; Y. HORIKOSHI; A.J. GRAY; M. MAEDA ET AL., "BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice", J. NEUROCHEM., (2006), vol. 99, no. 6, doi:doi:10.1111/j.1471-4159.2006.04178.x, pages 1555 - 63, XP002411184
DESCRIPTION- JIANG H; COUTO LB; PATARROYO-WHITE S; LIU T; NAGY D; VARGAS JA ET AL., "Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy", BLOOD, (2006), vol. 108, no. 10, doi:doi:10.1182/blood-2006-04-017913, pages 3321 - 8, XP055175201
EXAMINATION- IK SANG CHO ET AL, "Improved serum stability and biophysical properties of siRNAs following chemical modifications", BIOTECHNOLOGY LETTERS, SPRINGER NETHERLANDS, DORDRECHT, (20080625), vol. 30, no. 11, doi:10.1007/S10529-008-9776-4, ISSN 1573-6776, pages 1901 - 1908, XP019639461
EXAMINATION- TEMCHURA V V ET AL, "Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus", VACCINE, ELSEVIER LTD, GB, vol. 26, no. 29-30, doi:10.1016/J.VACCINE.2008.04.069, ISSN 0264-410X, (20080704), pages 3662 - 3672, (20080617), XP022735985
INTERNATIONAL-SEARCH-REPORT- VALADI H ET AL, "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", NATURE CELL BIOLOGY, NATURE PUBLISHING GROUP, GB LNKD- DOI:10.1038/NCB1596, (20070606), vol. 9, no. 6, ISSN 1465-7392, pages 654 - 659, XP003016816 [XD] 1 * abstract * * page 656 * [I] 2-17
INTERNATIONAL-SEARCH-REPORT- SKOG JOHAN ET AL, "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers", NATURE CELL BIOLOGY, NATURE PUBLISHING GROUP, GB LNKD- DOI:10.1038/NCB1800, vol. 10, no. 12, ISSN 1465-7392, (20081201), pages 1470 - 1476, (20081116), XP002526160 [XD] 1 * abstract * * page 1475, column r, paragraph 5 * [I] 2-17
OPPOSITION- Y Seow, Et Al, "Targeted Delivery of Plasmid DNA and siRNA with Modified Dendritic Cell -Derived Exosomes", Molecular Therapy, (20090501), page S7, Molecular Therapy, (20200929), XP055734653-
OPPOSITION- CHO et al., "Improved serum stability and biophysical properties of siRNAs following chemical modifications", Biotechnol. Lett., (20080000), vol. 30, doi:10.1007/s10529-008-9776-4, pages 1901 - 1908, XP019639461
OPPOSITION- KOOIJMANS et al., "Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles", Journal of Controlled Release, (20130829), vol. 172, no. 1, doi:10.1016/j.jconrel.2013.08.014, pages 229 - 238, XP028772923
OPPOSITION- TEMCHURA et al., "Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus", Vaccine, (20080000), vol. 26, doi:10.1016/j.vaccine.2008.04.069, pages 3662 - 3672, XP022735985
OPPOSITION- Y T Ko, Et Al, "Gene delivery into ischemic myocardium by double-targeted lipoplexes with anti- myosin antibody and TAT peptide", Gene Therapy, (20090101), vol. 16, pages 52 - 59, XP055738422
OPPOSITION- ALVAREZ-ERVITI et al., "Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes", Nature Biotechnology, (20110320), vol. 29, no. 4, doi:10.1038/nbt.1807, pages 341 - 345, XP055554900
OPPOSITION- VALADI et al., "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", Nature Cell Biology, (20070606), vol. 8, no. 6, pages 654 - 659, XP003016816
OPPOSITION- SKOG et al., "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers", Nature Cell Biology, (20081201), vol. 10, no. 12, doi:10.1038/ncb1800, pages 1470 - 1476, XP002633335
OPPOSITION- FORSTER et al., "CCR7 and its ligands: balancing immunity and tolerance", Nature Reviews Immunology, (20080401), vol. 8, doi:10.1038/nri2297, pages 362 - 371, XP055096902
OPPOSITION- RATAJCZAK J ET AL, "Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery", Blood Cancer Journal, London, (20060501), vol. 20, no. 5, doi:10.1038/sj.leu.2404132, ISSN 0887-6924, pages 847 - 856, XP002456317
OPPOSITION- PONSAERTS P , BERNEMAN Z N, "Modulation of cellular behavior by exogenous messenger RNA.", Blood Cancer Journal, London, (20060501), vol. 20, no. 5, doi:10.1038/sj.leu.2404219, ISSN 0887-6924, pages 767 - 769, XP002544196
OPPOSITION- HUNG et al., "Stabilization of Exosome-targeting Peptides via Engineered Glycosylation", Journal of Biological Chemistry, (20150205), vol. 290, no. 13, doi:10.1074/jbc.M114.621383, pages 8166 - 8172, XP055547031

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