| DESCRIPTION | - AGATA ET AL., INT. IMMUNOL, (1996), vol. 8, pages 765 - 72 | - |
| DESCRIPTION | - ALLEN, T.M., NAT. REV. CANCER, (2002), vol. 2, pages 750 - 763 | - |
| DESCRIPTION | - ALTSCHUL. ET AL., J. MOL. BIOL.., (1990), vol. 215, pages 403 - 10 | - |
| DESCRIPTION | - ALTSCHUL ET AL., NUCLEIC ACIDS RES., (1997), vol. 25, no. 17, pages 3389 - 3402 | - |
| DESCRIPTION | - "Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy", Monoclonal Antibodies For Cancer Detection And Therapy, ACADEMIC PRESS, (1985), pages 303 - 16 | - |
| DESCRIPTION | - "Antibodies For Drug Delivery", HELLSTROM ET AL., Controlled Drug Delivery, MARCEL DEKKER, INC., (1987), pages 623 - 53 | - |
| DESCRIPTION | - "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review", THORPE, Monoclonal Antibodies '84: Biological And Clinical Applications, (1985), pages 475 - 506 | - |
| DESCRIPTION | - BALZANO, INT. J CANCER SUPPL., (1992), vol. 7, pages 28 - 32 | - |
| DESCRIPTION | - BENNETT ET AL., IMMUNOL, (2003), vol. 170, pages 711 - 8 | - |
| DESCRIPTION | - BENNETT ET AL., J LMMUNOL, (2003), vol. 170, pages 711 - 8 | - |
| DESCRIPTION | - BERGE, S.M., J PHARM. SCI., (1977), vol. 66, pages 1 - 19 | - |
| DESCRIPTION | - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426 | - |
| DESCRIPTION | - BLANK, CANCER IMMUNOL IMMUNOFHER., (2005), vol. 54, pages 307 - 314 | - |
| DESCRIPTION | - BLANK ET AL., CANCER IMMUNOL. IMMUNOTHER, (2005), vol. 54, pages 307 - 314 | - |
| DESCRIPTION | - BOSS, M. A., WOOD, C. R, IMMUNOLOGY TODAY, (1985), vol. 6, pages 12 - 13 | - |
| DESCRIPTION | - BRENNAN ET AL., SCIENCE, (1985), vol. 229, pages 81 - 83 | - |
| DESCRIPTION | - BRISCOE ET AL., AM. J PHYSIOL., (1995), vol. 1233, page 134 | - |
| DESCRIPTION | - BROWN ET AL., J IMMUNOL., (2003), vol. 170 | - |
| DESCRIPTION | - BROWN ET AL., J. IMMUNOL., (2003), vol. 170, pages 1257 - 66 | - |
| DESCRIPTION | - CAMACHO ET AL., J CLIN. ONCOLOGY, (2004), vol. 22, no. 145 | - |
| DESCRIPTION | - "Cancer Vaccines", RESTIFO, N., SZNOL, M. ET AL., Cancer: Principles and Practice of Oncology, (1997), pages 3023 - 3043 | - |
| DESCRIPTION | - "Cancer Vaccines", RESTIFO, SZNOL ET AL., Cancer: Principles and Practice of Oncology, (1997), pages 3023 - 3043 | - |
| DESCRIPTION | - CARTER ET AL., EUR JIMMUNOL, (2002), vol. 32, pages 634 - 43 | - |
| DESCRIPTION | - CHEN ET AL., EMBO J., (1993), vol. 12, pages 811 - 820 | - |
| DESCRIPTION | - CHEN, J. ET AL., EMBOJ., (1993), vol. 12, pages 821 - 830 | - |
| DESCRIPTION | - CHEN, J. ET AL., INTERNATIONAL IMMUNOLOGY, (1993), vol. 2, pages 647 - 656 | - |
| DESCRIPTION | - CHOI, NATURE GENETICS, (1993), vol. 4, pages 117 - 123 | - |
| DESCRIPTION | - DONG ET AL., J. MOL. MED., (2003), vol. 81, pages 281 - 7 | - |
| DESCRIPTION | - DONG ET AL., NAT MED, (2002), vol. 8, pages 787 - 9 | - |
| DESCRIPTION | - DONG ET AL., NAT. MED, (2002), vol. 8, pages 787 - 9 | - |
| DESCRIPTION | - DONG, J MOL MED, (2003), vol. 81, pages 281 - 7 | - |
| DESCRIPTION | - DRANOFF ET AL., PROC. NAFL. ACAD SCI US.A., (1993), vol. 90, pages 3539 - 43 | - |
| DESCRIPTION | - DRANOFF ET AL., PROC. NATL. ACAD. SCI U.S.A., (1993), vol. 90, pages 3539 - 43 | - |
| DESCRIPTION | - E. MEYERS, W. MILLER, COMPUT APPL. BIOSCI., (1988), vol. 4, pages 11 - 17 | - |
| DESCRIPTION | - FISHWILD, D. ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851 | - |
| DESCRIPTION | - FISHWILD ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851 | - |
| DESCRIPTION | - FOON, K., ASCO, EDUCATIONAL BOOK SPRING, (2000), pages 730 - 738 | - |
| DESCRIPTION | - FREEMAN ET AL., JEXP MED, (2000), vol. 192, pages 1027 - 34 | - |
| DESCRIPTION | - GLENNIE ET AL., J. 1MMUNOL, (1987), vol. 139, pages 2367 - 2375 | - |
| DESCRIPTION | - GOEDDEL, Gene Expression Technology. Methods in Enzymology, ACADEMIC PRESS, (1990), vol. 185 | - |
| DESCRIPTION | - GRAZIANO, R.F. ET AL., J IMMUNOL, (1995), vol. 155, no. 10, pages 4996 - 5002 | - |
| DESCRIPTION | - GREENBERG, R., RIDDELL, S., SCIENCE, (1999), vol. 285, pages 546 - 51 | - |
| DESCRIPTION | - HAHNE, M. ET AL., SCIENCE, (1996), vol. 274, pages 1363 - 1365 | - |
| DESCRIPTION | - HANSEN ET AL., IMMUNOGENICS, (1980), vol. 10, pages 247 - 260 | - |
| DESCRIPTION | - HARDING, F., LONBERG, N., ANN. N.Y. ACAD. SCI., (1995), vol. 764, pages 536 - 546 | - |
| DESCRIPTION | - HE ET AL., J IMMUNOL., (2004), vol. 173, pages 4919 - 28 | - |
| DESCRIPTION | - HE, J. IMMUNOL., (2004), vol. 173, pages 4919 - 28 | - |
| DESCRIPTION | - HOLLIGER, PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448 | - |
| DESCRIPTION | - HOWARD, M, O'GARRA, A, IMMUNOLOGY TODAY, (1992), vol. 13, pages 198 - 200 | - |
| DESCRIPTION | - HOWARD, M., O'GARRA, A., IMMUNOLOGY TODAY, (1992), vol. 13, pages 198 - 200 | - |
| DESCRIPTION | - HURWITZ ET AL., PROC. NATL. ACAD SCI. USA, (1998), vol. 95, no. 17, pages 10067 - 10071 | - |
| DESCRIPTION | - HUSTON ET AL., PROC. NATL. ACAD SCI. USA, (1988), vol. 85, pages 5879 - 5883 | - |
| DESCRIPTION | - HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883 | - |
| DESCRIPTION | - HUTLOFF, A. ET AL., NATURE, (1999), vol. 397, pages 262 - 266 | - |
| DESCRIPTION | - HUTLOFF ET AL., NATURE, (1999), vol. 397, pages 263 - 266 | - |
| DESCRIPTION | - ISHIDA ET AL., EMBO J, (1992), vol. 11, pages 3887 - 95 | - |
| DESCRIPTION | - ITO, N. ET AL., IMMUNOBIOLOGY, (2000), vol. 201, no. 5, pages 527 - 40 | - |
| DESCRIPTION | - IWAI ET AL., INT. IMMUNOL., (2005), vol. 17, pages 133 - 144 | - |
| DESCRIPTION | - IWAI ET AL., PNAS, (2002), vol. 99, pages 12293 - 7 | - |
| DESCRIPTION | - IWAI ET AL., PROC. NAT.'L. ACAD SCI. USA, (2002), vol. 99, pages 1.2293 - 7 | - |
| DESCRIPTION | - J.J. KILLION, I.J. FIDLER, IMMUNOMETHODS, (1994), vol. 4, page 273 | - |
| DESCRIPTION | - JONES, P. ET AL., NATURE, (1986), vol. 321, pages 522 - 525 | - |
| DESCRIPTION | - KARPOVSKY ET AL., J. EXP. MED., (1984), vol. 160, page 1686 | - |
| DESCRIPTION | - KEHRL, J. ET AL., 1. EXP. MED., (1986), vol. 163, pages 1037 - 1050 | - |
| DESCRIPTION | - KEHRL, J., J EXP. MED., (1986), vol. 163, pages 1037 - 1050 | - |
| DESCRIPTION | - KHAYAT, D., ASCO, EDUCATIONAL BOOK SPRING, (2000), pages 414 - 428 | - |
| DESCRIPTION | - KIM ET AL., SCIENCE, (1994), vol. 266, pages 2011 - 2013 | - |
| DESCRIPTION | - KIM, N ET AL., SCIENCE, (1994), vol. 266, pages 2011 - 2013 | - |
| DESCRIPTION | - K. KEINANEN, M.L. LAUKKANEN, FEBS LETT.., (1994), vol. 346, page 123 | - |
| DESCRIPTION | - KOHLER, MILSTEIN, NATURE, (1975), vol. 256, page 495 | - |
| DESCRIPTION | - KONISHI ET AL., CLIN. CANCER RES., (2004), vol. 10, pages 5094 - 100 | - |
| DESCRIPTION | - KUGLER, A., NATURE MEDICINE, (2000), vol. 6, pages 332 - 336 | - |
| DESCRIPTION | - KUGLER ET AL., NATURE MEDICINE, (2000), vol. 6, pages 332 - 336 | - |
| DESCRIPTION | - KUROIWA ET AL., NATURE BIOTECHNOLOGY, (2002), vol. 20, pages 889 - 894 | - |
| DESCRIPTION | - LATCHMAN ET AL., NAT IMMUNOL, (2001), vol. 2, pages 261 - 8 | - |
| DESCRIPTION | - LEACH ET AL., SCIENCE, (1996), vol. 271, pages 1734 - 1736 | - |
| DESCRIPTION | - LIU, MA ET AL., PROC. NATL. ACAD SCI. USA, (1985), vol. 82, page 8648 | - |
| DESCRIPTION | - LOGOTHETIS, C., ASCO, EDUCATIONAL BOOK SPRING, (2000), pages 300 - 302 | - |
| DESCRIPTION | - LONBERG ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859 | - |
| DESCRIPTION | - LONBERG, N. ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859 | - |
| DESCRIPTION | - LONBERG, N., Handbook ofExperimental Pharmacology, (1994), vol. 113, pages 49 - 101 | - |
| DESCRIPTION | - LONBERG, N., HUSZAR, D., INTERN. REV. IMMUNOL., (1995), vol. 13, pages 65 - 93 | - |
| DESCRIPTION | - MCCAFFERTY ET AL., NATURE, (1990), vol. 348, pages 552 - 554 | - |
| DESCRIPTION | - MELERO, I. ET AL., NATURE MEDICINE, (1997), vol. 3, pages 682 - 685 | - |
| DESCRIPTION | - MOKYR ET AL., CANCER RES., (1998), vol. 58, pages 5301 - 5304 | - |
| DESCRIPTION | - MOKYR ET AL., CANCER RESEARCH, (1998), vol. 58, pages 5301 - 5304 | - |
| DESCRIPTION | - MOKYR, M. ET AL., CANCER RESEARCH, (1998), vol. 58, pages 5301 - 5304 | - |
| DESCRIPTION | - "Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy", ARNON ET AL., Monoclonal Antibodies And Cancer Therapy, ALAN R. LISS, INC., (1985), pages 243 - 56 | - |
| DESCRIPTION | - MONTEIRO, R.C., J. IMMUNOL.., (1992), vol. 148, page 1764 | - |
| DESCRIPTION | - MORRISON, S., SCIENCE, (1985), vol. 229, page 1202 | - |
| DESCRIPTION | - MORTON, H.C. ET AL., CRITICAL REVIEWS IN IMMUNOLOGY, (1996), vol. 16, pages 423 - 440 | - |
| DESCRIPTION | - M. OWAIS ET AL., ANTIMICROB AGENTS CHEMOTHER., (1995), vol. 39, page 180 | - |
| DESCRIPTION | - MURATA, AM. J. PATHOL., (1999), vol. 155, pages 453 - 460 | - |
| DESCRIPTION | - MURPHY, HRUSHESKY, J: NAT'L. CANCER RES., (1973), vol. 50, pages 1013 - 1025 | - |
| DESCRIPTION | - NEEDLEMAN, WUNSCH, J. MOL. BIOL., (1970), vol. 48, pages 444 - 453 | - |
| DESCRIPTION | - NESTLE, F. ET AL., NATURE MEDICINE, (1998), vol. 4, pages 328 - 332 | - |
| DESCRIPTION | - NESTLE, NATURE MEDICINE, (1998), vol. 4, pages 328 - 332 | - |
| DESCRIPTION | - NIELSEN ET AL., LUPUS, (2004), vol. 13, page 10 | - |
| DESCRIPTION | - NISHIMURA ET AL., IMMUNITY, (1999), vol. 11, pages 141 - 51 | - |
| DESCRIPTION | - NISHIMURA ET AL., SCIENCE, (2001), vol. 291, pages 319 - 22 | - |
| DESCRIPTION | - OKAZAKI ET AL., CURR OPIN IMMUNOL, (2002), vol. 14, pages 391779 - 82 | - |
| DESCRIPTION | - OKAZAKI ET AL., CURR. OPIN. IMMUNOL., (2002), vol. 14, pages 391779 - 82 | - |
| DESCRIPTION | - OKAZAKI, PNAS, (2001), vol. 98, pages 13866 - 71 | - |
| DESCRIPTION | - OVERWIJK, W. ET AL., PROC. NATL. ACAD SCI. U.S.A., (1999), vol. 96, pages 2982 - 2987 | - |
| DESCRIPTION | - PASTAN, I., KREITMAN, R. J., CURR. OPIN. INVESTIG. DRUGS, (2002), vol. 3, pages 1089 - 1091 | - |
| DESCRIPTION | - PAULUS, BEHRING INS. MITT., (1985), pages 118 - 132 | - |
| DESCRIPTION | - PAYNE, G., CANCER CELL, (2003), vol. 3, pages 207 - 212 | - |
| DESCRIPTION | - P.G. BLOEMAN ET AL., FEBS LETT., (1995), vol. 357, page 140 | - |
| DESCRIPTION | - POLJAK, STRUCTURE, (1994), vol. 2, pages 1121 - 1123 | - |
| DESCRIPTION | - PROKUNINA, ALARCON-RIQUELME, HUM MOL GENET, (2004), vol. 13, page R143 | - |
| DESCRIPTION | - QUEEN, C. ET AL., PROC. NATL. ACAD SEE. USA, (1989), vol. 86, pages 10029 - 10033 | - |
| DESCRIPTION | - RIDGE, J. ET AL., NATURE, (1998), vol. 393, pages 474 - 478 | - |
| DESCRIPTION | - RIECHMANN, L. ET AL., NATURE, (1998), vol. 332, pages 323 - 327 | - |
| DESCRIPTION | - R. J. KAUFMAN, P. A. SHARP, MOL. BIOL., (1982), vol. 159, pages 601 - 621 | - |
| DESCRIPTION | - ROSENBERG, IMMUNITY, (1999), vol. 10, pages 281 - 7 | - |
| DESCRIPTION | - ROSENBERG, SA, IMMUNITY, (1999), vol. 10, pages 281 - 7 | - |
| DESCRIPTION | - ROSENBERG, S., Development of Cancer Vaccines, ASCO EDUCATIONAL BOOK SPRING, (2000), pages 60 - 62 | - |
| DESCRIPTION | - ROSENBERG, S., Development of Cancer Vaccines, ASCO, EDUCATIONAL BOOK SPRING, (2000), pages 60 - 62 | - |
| DESCRIPTION | - SAITO, G., ADV. DRUG DELIV. REV., (2003), vol. 55, pages 199 - 215 | - |
| DESCRIPTION | - SALAMA, JEXP MED, (2003), vol. 198, pages 71 - 78 | - |
| DESCRIPTION | - SCHENK, NATURE, (1999), vol. 400, pages 173 - 177 | - |
| DESCRIPTION | - SCHREIER ET AL., J BIOL. CHEM., (1994), vol. 269, page 9090 | - |
| DESCRIPTION | - SENTER, P.D., SPRINGER, C.J., ADV. DRUGDELIV. REV., (2001), vol. 53, pages 247 - 264 | - |
| DESCRIPTION | - SHIELDS, R.L. ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 6591 - 6604 | - |
| DESCRIPTION | - SHIELDS, R.L. ET AL., J BIOL. CHEM., (2002), vol. 277, pages 26733 - 26740 | - |
| DESCRIPTION | - SUOT, R, SRIVASTAVA, P, SCIENCE, (1995), vol. 269, pages 1585 - 1588 | - |
| DESCRIPTION | - SUOT, SRIVASTAVA, SCIENCE, (1995), vol. 269, pages 1585 - 1588 | - |
| DESCRIPTION | - TAKEBE, Y., MOL. CELL. BIOL., (1988), vol. 8, pages 466 - 472 | - |
| DESCRIPTION | - TAMURA ET AL., SCIENCE, (1997), vol. 278, pages 117 - 120 | - |
| DESCRIPTION | - TAMURA, Y. ET AL., SCIENCE, (1997), vol. 278, pages 117 - 120 | - |
| DESCRIPTION | - TARENTINO, A.L., BIOCHEM., (1975), vol. 14, pages 5516 - 23 | - |
| DESCRIPTION | - TAYLOR, L. ET AL., INTERNATIONAL IMMUNOLOGY, (1994), vol. 6, pages 579 - 591 | - |
| DESCRIPTION | - TAYLOR, L. ET AL., NUCLEIC ACIDS RESEARCH, (1992), vol. 20, pages 6287 - 6295 | - |
| DESCRIPTION | - THOMAS, M.L., J EXP MED, (1995), vol. 181, pages 1953 - 6 | - |
| DESCRIPTION | - TOMIZUKA ET AL., PROC. NATL. ACAD SCI. USA, (2000), vol. 97, pages 722 - 727 | - |
| DESCRIPTION | - TRAIL, P.A. ET AL., CANCER IMMUNOL. IMMUNOTHER., (2003), vol. 52, pages 328 - 337 | - |
| DESCRIPTION | - TUAILLON ET AL., J IMMUNOL., (1994), vol. 152, pages 2912 - 2920 | - |
| DESCRIPTION | - TUAILLON ET AL., PROC. NATL. ACAD SCI. USA, (1993), vol. 90, pages 3720 - 3724 | - |
| DESCRIPTION | - UMANA ET AL., NAT. BIOTECH., (1999), vol. 17, pages 176 - 180 | - |
| DESCRIPTION | - UMEZAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1988), vol. 153, page 1038 | - |
| DESCRIPTION | - URLAUB, CHASIN, PROC. NATL. ACAD SCI. USA, (1980), vol. 77, pages 4216 - 4220 | - |
| DESCRIPTION | - VIVIER, E, DAERON, M, IMMUNOL TODAY, (1997), vol. 18, pages 286 - 91 | - |
| DESCRIPTION | - V.V. RANADE, J CLIN. PHARMACOL., (1989), vol. 29, page 685 | - |
| DESCRIPTION | - WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546 | - |
| DESCRIPTION | - WEINBERG, A. ET AL., IMMUNOL, (2000), vol. 164, pages 2160 - 2169 | - |
| DESCRIPTION | - WEINBERG, A., IMMUNOL, (2000), vol. 164, pages 2160 - 2169 | - |
| DESCRIPTION | - YAMANE-OHNUKI ET AL., BIOTECHNOL BIOENG, (2004), vol. 87, pages 614 - 22 | - |
| DESCRIPTION | - COX, J. P. L. ET AL., "A Directory of Human Germ-line VH Segments Reveals a Strong Bias in their Usage", EUR. J. IMMUNOL., (1994), vol. 24, doi:doi:10.1002/eji.1830240409, pages 827 - 836, XP003004702 | |
| DESCRIPTION | - TOMLINSON, I. M, "The Repertoire of Human Germline VH Sequences Reveals about Fifty Groups of VH Segments with Different Hypervariable Loops", J. MOL. BIOL., (1992), vol. 227, doi:doi:10.1016/0022-2836(92)90223-7, pages 776 - 798, XP024020607 | |
| DESCRIPTION | - THORPE, "The Preparation And Cytotoxic Properties Of Antibody-Toxin Conjugates", IMMUNOL. REV., (1982), vol. 62, doi:doi:10.1111/j.1600-065X.1982.tb00392.x, pages 119 - 58, XP001179872 | |
| OPPOSITION | - BROWN et al., "Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production", J Immunol, (20030000), vol. 170, pages 1257 - 66, XP002973918 | - |
| OPPOSITION | - SANDNER et al., "Functions of the regulatory T cell costimulatory pathways CTLA-4 and PD-1 in alloreactive CD 4+ T cell responses in vivo", American transplant congress 2003 abstracts, page 152, XP055661617 | - |
| OPPOSITION | - VAUGHAN et al., "Huinan Antibodies with Sub-nanon1olar Affinities Isolated fron1 a Large Non-in1n1unized Phage Display Library", Nature Biotechnology, (19960000), vol. 14, pages 309 - 314, XP055661624 | - |
| OPPOSITION | - YANG X et al., "Eradication of Established Tumors by a Fully Human Monoclonal Antibody to the Epidermal Growth Factor Receptor without Concomitant Chemotherapy", Cancer Research, (19990000), vol. 59, pages 1236 - 1243, XP008154927 | - |
| OPPOSITION | - DONG et al., "B7-H1 pathway and its role in the evasion of tumor immunity", Journal of Molecular Medicine, (20030000), vol. 81, no. 5, pages 281 - 287, XP002520498 | |
| OPPOSITION | - BLANK et al., "Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy", Cancer Immunol Immunother, (20050000), vol. 54, pages 307 - 314, XP019333106 | |
| OPPOSITION | - LITTLE et al., "Of mice and men: hybridoma and recombinant antibodies", Immunology Today, (20000000), vol. 21, no. 8, pages 364 - 370, XP004215163 | |
| OPPOSITION | - LONBERG et al., "Antigen-specific human antibodies from mice comprising four distinct genetic modifications", Nature, (19940000), vol. 368, pages 856 - 859, XP002626115 | |
| OPPOSITION | - LATCHMAN et al., "PD-L2 is a second ligand for PD-1 and inhibits T cell activation", Nature immunology, (20010300), vol. 2, no. 3, pages 261 - 268, XP001064842 | |
| OPPOSITION | - ADAMS et al., "Monoclonal antibody therapy of cancer", Nature Biotech, (20050000), vol. 23, doi:10.1038/nbt1137, pages 1147 - 1157, XP002456710 | |
| OPPOSITION | - ABBAS et al., "Dendritic cells giveth and taketh away", Nature Immunology, (20050300), vol. 6, no. 3, pages 227 - 228, XP055661613 | |
| OPPOSITION | - EGEN et al., "CTLA-4 new insights into its biological function and use in tumor immunotherapy", Nature Immunology, (20020700), vol. 3, no. 7, pages 611 - 618, XP055661586 | |
| OPPOSITION | - PROBST et al., "Resting dendritic cells induce peripheral CD 8+ T cell tolerance through PD-1 and CTLA-4", Nature Immunology, (20050300), vol. 6, no. 3, pages 280 - 286, XP055661612 | |
| OPPOSITION | - FREEMAN et al., "Protect the killer: CTLs need defenses against the tumor", Nature Medicine, (20020800), vol. 8, no. 8, pages 787 - 789, XP055661595 | |
| OPPOSITION | - CHEN, "Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity", Nat Rev Immunology, (20040000), vol. 4, pages 336 - 347, XP055141186 | |
| OPPOSITION | - SHARPE et al., "The B7- CD 28 Superfamily", Nature Reviews Immunology, (20020000), vol. 2, no. 2, doi:10.1038/nri727, pages 116 - 126, XP008018232 | |
| OPPOSITION | - PHAN et al., "Cancer regression and autoimmunity induced by cytotoxic T lymphocyte- associated antigen 4 blockade in patients with metastatic melanoma", PNAS, (20030708), vol. 100, no. 14, doi:10.1073/pnas.1533209100, pages 8372 - 8377, XP002555771 | |
| OPPOSITION | - EVANS et al., "Boosting T Cell Costimulation in Cancer: The Possibilities Seem Endless", International Reviews of Immunology, (20030000), vol. 22, no. 2, pages 173 - 194, XP055661598 | |
| OPPOSITION | - ANSARI et al., "The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice", J. Exp. Med., (20030000), vol. 198, pages 63 - 69, XP055188563 | |
| OPPOSITION | - LEACH et al., "Enhancement of Antitumor Immunity by CTLA-4 Blockade", Science, (19960000), vol. 271, pages 1734 - 1736, XP000986211 | |
| OPPOSITION | - PARRY et al., "CTLA-4 and PD-1 Receptors Inhibit T- Cell Activation by Distinct Mechanisms", Molecular and Cellular Biology, vol. 25, no. 21, doi:10.1128/MCB.25.21.9543-9553.2005, (20051000), pages 9543 - 9553, XP003026807 | |
| OPPOSITION | - CARRENO et al., "The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses", Annu. Rev. Immunol., (20020000), vol. 20, pages 29 - 53, XP009004805 | |
| OPPOSITION | - CHEMNITZ et al., "CTLA-4 and PD-1 Receptors Inhibit T- Cell Activation by Distinct Mechanisms", Blood, (20040000), vol. 104, no. 11, page 2657, XP055661603 | |
| OPPOSITION | - CARTER et al., "Cytotoxic T-Lymphocyte Antigen-4 and Programmed Death-1 Function as Negative Regulators of Lymphocyte Activation", Immunologic Research, (20030000), vol. 28, no. 1, doi:10.1385/IR:28:1:49, pages 49 - 59, XP009057800 | |
| OPPOSITION | - SCHULTES et al., "Using antibodies in tumour immunotherapy", Expert Opinion on Biological Theory, (20040000), vol. 4, no. 8, doi:10.1517/14712598.4.8.1265, pages 1265 - 1284, XP008078858 | |
| OPPOSITION | - BENNETT et al., "Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses", J Immunol, (20030000), vol. 170, pages 711 - 718, XP055048008 | |
| OPPOSITION | - BLAZAR et al., "Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent Mechanism", J Immunol, (20030000), vol. 171, pages 1272 - 1277, XP055661609 | |
| OPPOSITION | - ITO et al., "Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo", J Immunol, (20050000), vol. 174, pages 6648 - 6656, XP055661611 | |
| OTHER | - IWAI Y; ET AL, "MICROANATOMICAL LOCALIZATION OF PD-1 IN HUMAN TONSILS", IMMUNOLOGY LETTERS, (200201), vol. 83, no. 3, pages 215 - 220, XP003007112 | |
| SEARCH | - BROWN JULIA A ET AL, "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, (20030201), vol. 170, no. 3, ISSN 0022-1767, pages 1257 - 1266, XP002973918 [Y] 1,2,4,5,7-15 * the whole document * | - |
| SEARCH | - HIRANO FUMIYA ET AL, "Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20050201), vol. 65, no. 3, ISSN 0008-5472, pages 1089 - 1096, XP002419626 [Y] 1,2,4,5,7-15 * page 72, column r, line 27 - page 72, column r, line 30 * | - |
| SEARCH | - LONBERG N ET AL, "ANTIGEN-SPECIFIC HUMAN ANTIBODIES FROM MICE COMPRISING FOUR DISTINCT GENETIC MODIFICATIONS", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, (19940428), vol. 368, no. 6474, ISSN 0028-0836, pages 856 - 859, XP000941636 [Y] 1,2,4,5,7-15 * the whole document * | |
