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Pegylated L-Asparaginase - EP2451486

The patent EP2451486 was granted to Alize Pharma II on Jan 18, 2023. The application was originally filed on Jul 6, 2010 under application number EP10730170A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2451486

ALIZE PHARMA II
Application Number
EP10730170A
Filing Date
Jul 6, 2010
Status
Patent Maintained As Amended
Dec 16, 2022
Grant Date
Jan 18, 2023
External Links
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MATHYS & SQUIREFeb 2, 2018TITMUSADMISSIBLE

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2002065397
DESCRIPTIONUS2003114647
DESCRIPTIONUS2009054590
DESCRIPTIONUS4179337
DESCRIPTIONUS4670417
DESCRIPTIONUS5252714
DESCRIPTIONUS5672662
DESCRIPTIONUS5766897
DESCRIPTIONUS6113906
DESCRIPTIONUS7419600
DESCRIPTIONWO2004083258
DESCRIPTIONWO2007103290
EXAMINATIONUS5672662
INTERNATIONAL-SEARCH-REPORTWO03018742

Non-Patent Literature (NPL) Citations (43) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- DAVID FILPULA ET AL, "Sequence of L-asparaginase gene from Erwinia chrysanthemi NCPPB 1125", NUCLEIC ACIDS RESEARCH,, (19881111), vol. 16, no. 21, page 10385, XP001317910-
EXAMINATION- Declaration Dr. David Beer-
EXAMINATION- Declaration Dr. Micheal Scawen-
EXAMINATION- "EPPO quarantine pest Data Sheets on Quarantine Pests: Erwinia chrysanthemi", (20040507), URL: http://www.eppo.int/QUARANTINE/bacteria/Erwinia_chrysanthemi/ERWICH_ds.pdf, (20150818), XP055208233-
EXAMINATION- LUCIANA SARTORE ET AL, "Accurate evaluation method of the polymer content in Monomethoxy(polyethylene glycol) modified proteins based on Amino acid analysis", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY ; PART A: ENZYME ENGINEERING AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, (19911201), vol. 31, no. 3, doi:10.1007/BF02921748, ISSN 1559-0291, pages 213 - 222, XP035175870
EXAMINATION- VERONESE F M ET AL, "Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol)", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (19960701), vol. 40, no. 3, doi:10.1016/0168-3659(95)00185-9, ISSN 0168-3659, pages 199 - 209, XP004037365
EXAMINATION- MINTON N P ET AL, "Nucleotide sequence of the Erwinia chrysanthemi NCPPB 1066 l-asparaginase gene", GENE, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 1, doi:10.1016/0378-1119(86)90163-0, ISSN 0378-1119, (19860101), pages 25 - 35, (19860101), XP025904632
EXAMINATION- CAMMACK K A ET AL, "PHYSICAL PROPERTIES AND SUBUNIT STRUCTURE OF L-ASPARAGINASE ISOLATED FROM ERWINIA CAROTOVORA", BIOCHEMICAL JOURNAL, PORTLAND PRESS LTD, GB, (19720101), vol. 126, ISSN 0264-6021, pages 361 - 379, XP003035934
OPPOSITION- "An effective treatment for leukaemia", CAMR, (19970000), pages 15 - 17-
OPPOSITION- Anonymous, "Erwinia chrysanthemi", Data Sheets on Quarantine Pests-
OPPOSITION- Anonymous, "Pegcrisantaspase", Adis Insight - Drug Profile, (20171226), URL: https://adisinsight.springer.com/drugs/800029657, XP055624487-
OPPOSITION- BUCK, P.W. et al., "The Batch production of L-asparaginase from Erwinia carotovora", Journal of General Microbiology, The Society for General Microbiology Sixtieth General Meeting, Microbiological Research Establishment, (19710000), vol. 65, XP055462210-
OPPOSITION- ClinicalTrials.gov record for trial NCT0T551524-
OPPOSITION- Cossar et al., Biosensors & Bioelectronics 5 (1990) 273-289-
OPPOSITION- EGLER, R. et al., "L-asparaginase in the treatment of patients with acute lymphoblastic leukemia", Journal of Pharmacology and Pharmacotherapeutics, (20160000), vol. 7, pages 62 - 71, XP055462282-
OPPOSITION- FILPULA, D. et al., "Sequence of L-asparaginase gene from Erwinia chrysanthemi NCPPB 1125", Nucleic Acids Research, (19880000), vol. 16, no. 21, page 10385, XP001317910-
OPPOSITION- FILPULA, D. et al., "Sequence of L-asparaginase gene from Erwinia chrysanthemi NCPPB 1125", Nucleic Acids Research, (19880000), vol. 16, page 10385, XP001317910-
OPPOSITION- James Everitt et al, "Centre for Applied Microbiology & Research - Annual Review 1994/95", Centre for Applied Microbiology & Research (CAMR), (19940000), pages FP, 1 - 15, XP055624493-
OPPOSITION- Jazz Pharmaceuticals, "A Dose Confirmation and Pharmacokinetic Study of Pegcrisantaspase Administered as Intravenous (IV) Infusion in Children and Young Adults With Acute Lymphoblastic Leukemia (ALL) /Lymphoblastic Lymphoma (LBL). Following Hypersensitivity to Pegaspargase (Oncaspar)", Clinical Trials NCT02257684, (20141006), URL: https://clinicaltrials.gov/ct2/show/NCT02257684, XP055624482-
OPPOSITION- MÃœLLER H.J. et al., "Use of L-asparaginase in childhood ALL", Critical Reviews in Oncology/Hematology, (19980000), vol. 28, pages 97 - 113-
OPPOSITION- MULLER H.J. et al., "Use of L-asparaginase in childhood ALL", Critical Reviews in Oncology/Hematology, (19980000), vol. 2B, pages 97 - 113, XP055462234-
OPPOSITION- WADA, H. et al., "Antitumor Enzyme: Polyethylene Glycol-modified Asparaginase", Annals New York Academy of Sciences, (19901200), vol. 613, pages 95 - 108, XP055462315-
OPPOSITION- WADE, H.E. et al., "A new L- asparaginase with antitumor activity", The Lancet (Letters to the Editor), (19681005), pages 776 - 777, XP055462205-
OPPOSITION- RAU E. R. et al., "Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group", Pediatric Blood Cancer, (20180300), vol. 65, no. 3, page e26873, XP055624110
OPPOSITION- SARTORE, L. et al., "Accurate Evaluation Method of the Polymer Content in Monomethoxy(Polyethylene Glycol) Modified Proteins Based on Amino Acid Analysis", Applied Biochemistry and Biotechnology, (19910000), vol. 31, doi:10.1007/BF02921748, pages 213 - 222, XP035175870
OPPOSITION- SARTORE, L. et al., "Accurate Evaluation Method of the Polymer Content in Monomethoxy(Polyethylene Glycol) Modified Proteins Based on Amino Acid Analysis", Applied Biochemistry and Biotechnology, (19910000), vol. 31, pages 213 - 222, XP035175870
OPPOSITION- YONG, W. et al., "L-Asparaginase- Based Regimen in the Treatment of Refractory Midline Nasal/Nasal-Type T/NK- Cell Lymphoma", International Journal of Hematology, (20030000), vol. 78, no. 2, pages 163 - 167, XP036411366
OPPOSITION- VERONESE, F.M. et al., "Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol", Journal of Controlled Release, (19960000), vol. 40, doi:10.1016/0168-3659(95)00185-9, pages 199 - 209, XP004037365
OPPOSITION- VERONESE, F.M. et al., "Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol", Journal of Controlled Release, (19960700), vol. 40, no. 3, pages 199 - 209, XP004037365
OPPOSITION- MINTON N.P. et al., "Nucleotide sequence of the Erwinia chrysanthemi NCPPB 1066 L-asparaginase gene", Gene, (19860000), vol. 46, no. 1, pages 25 - 35, XP025904632
OPPOSITION- ROBERTS, M.J. et al., "Chemistry for peptide and protein PEGylation", Advanced Drug Delivery Reviews, (20020617), vol. 54, no. 4, pages 459 - 476, XP002354432
OPPOSITION- CAMMACK, K.A. et al., "Physical properties and subunit structure of L-asparaginase isolated from Erwinia carotovora", Biochem. J., (19720000), vol. 126, pages 361 - 379, XP003035934
OPPOSITION- PAPAGEORGIOU, A.C. et al., "Structural and functional insights into Erwinia carotovora L- asparaginase", FEBS Journal, (20080000), vol. 275, pages 4306 - 4316, XP055462308
OPPOSITION- SALZER, W. L. et al., "Development of asparaginase Erwinia chrysanthemi for the treatment of acute lymphoblastic leukemia", Ann. N.Y. Acad. Sci., (20140805), vol. 1329, pages 81 - 92, XP055462212
OPPOSITION- VERONESE, F.M. et al., "Branched and Linear Poly(Ethylene Glycol): Influence of the Polymer Structure on Enzymological, Pharmacokinetic, and Immunological Properties of Protein Conjugates", Journal of Bioactive and Compatible Polymers, (19970000), vol. 12, pages 196 - 207, XP008038816
OPPOSITION- JACCARD, A. et al., "Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study", Blood, (20110000), vol. 117, pages 1834 - 1839, XP055462313
OPPOSITION- AVRAMIS, V.I. et al., "Pharmacokinetic/Pharmacodynamic Relationships of Asparaginase Formulations - The Past, the Present and Recommendations for the Future", Clin. Pharmacokinet, (20050000), vol. 44, no. 4, pages 367 - 393, XP008105154
OPPOSITION- VERONESE, F.M. et al., "The Impact of PEGylation on Biological Therapies", Biodrugs, (20080000), vol. 22, no. 5, pages 315 - 329, XP009116032
OTHER- FILPULA D. ET AL, "SEQUENCE OF L-ASPARAGINASE GENE FROM ERWINIA CHRYSANTHEMI NCPPB 1125", NUCLEIC ACIDS RESEARCH, (19881111), vol. 16, no. 21, page 10385, XP001317910-
OTHER- LUCIANA SARTORE ET AL, "ACCURATE EVALUATION METHOD OF THE POLYMER CONTENT IN MONOMETHOXY(POLYETHYLENE GLYCOL) MODIFIED PROTEINS BASED ON AMINO ACID ANALYSIS", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY ; PART A: ENZYME ENGINEERING AND BIOTECHNOLOGY, (199112), vol. 31, no. 3, doi:10.1007/BF02921748, pages 213 - 222, XP035175870
OTHER- VERONESE F.M., "IMPROVEMENT OF PHARMACOKINETIC, IMMUNOLOGICAL AND STABILITY PROPERTIES OF ASPARAGINASE BY CONJUGATION TO LINEAR AND BRANCHED MONOMETHOXY POLY(ETHYLENE GLYCOL)", JOURNAL OF CONTROLLED RELEASE, (199201), vol. 40, no. 1, pages 199 - 209, XP004037365
OTHER- MINTON N.P. ET AL, "NUCLEOTIDE SEQUENCE OF THE ERWINIA CHRYSANTHEMI NCPPB 1066 L-ASPARAGINASE GENE", GENE, (19860101), vol. 45, no. 1, pages 25 - 35, XP025904632
OTHER- CAMMACK K.A ET AL, "PHYSICAL PROPERTIES AND SUBUNIT STRUCTURE OF L-ASPARAGINASE ISOLATED FROM ERWINIA CAROTOVORA", BIOCHEM J., (197201), vol. 126, pages 361 - 379, XP003035934

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