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Methods Of Preventing And Removing Trisulfide Bonds - EP2483289

The patent EP2483289 was granted to Biogen Idec MA on Mar 26, 2025. The application was originally filed on Oct 1, 2010 under application number EP10763112A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2483289

BIOGEN IDEC MA
Application Number
EP10763112A
Filing Date
Oct 1, 2010
Status
Patent Maintained As Amended
Feb 21, 2025
Publication Date
Mar 26, 2025
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (3)

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ARNOLD & SIEDSMADec 20, 2019PRINSADMISSIBLE
HOFFMANN EITLEDec 20, 2019HOFFMANN EITLEADMISSIBLE
PATENTANWALTE ISENBRUCK BOSL HORSCHLER PARTG MBBDec 18, 2019SIMMONS & SIMMONS MUNICHADMISSIBLE

Patent Citations (47) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2002155537
DESCRIPTIONUS2003020734
DESCRIPTIONUS2009003999
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DESCRIPTIONUS5821333
DESCRIPTIONUS5892019
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OPPOSITIONUS2004038331
OPPOSITIONUS2006194280
OPPOSITIONUS7157557
OPPOSITIONUS7232894
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OPPOSITIONWO2006060083
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Non-Patent Literature (NPL) Citations (17) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
OPPOSITION- AONO et al., "Efficient on-column conversion of IgG"1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography", Journal of Chromatography A, (20100000), vol. 1217, pages 5225 - 5232, XP027142425
OPPOSITION- Aono, H. ; Wen, D. ; Zang, L. ; Houde, D. ; Pepinsky, R.B. ; Evans, D.R.H., "Efficient on-column conversion of IgG"1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography", Journal of Chromatography A, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20100806), vol. 1217, no. 32, ISSN 0021-9673, pages 5225 - 5232, XP027142425
OPPOSITION- PRISTATSKY et al., "Evidence for trisulfide bonds in a recombinant variant of a human IgG2 monoclonal antibody", Anal Chem, (20090000), vol. 81, pages 6148 - 6155, XP002608219
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OPPOSITION- Gu, S. ; Wen, D. ; Weinreb, P.H. ; Sun, Y. ; Zhang, L. ; Foley, S.F. ; Kshirsagar, R. ; Evans, D. ; Mi, S. ; Meier, W. ; Pepinsky, R.B., "Characterization of trisulfide modification in antibodies", Analytical Biochemistry, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20100501), vol. 400, no. 1, doi:10.1016/j.ab.2010.01.019, ISSN 0003-2697, pages 89 - 98, XP026940233
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OPPOSITION- HOUEN, G. et al., "Preparation of Bioconjugates by Solid-Phase Conjugation to Ion Exchange Matrix-Adsorbed Carrier Proteins", Bioconjugate Chemistry, (20030000), vol. 14, pages 75 - 79, XP055273119
OPPOSITION- WYPYCH, J. et al., "Human IgG2 antibodies display disulfide-mediated structural isoforms", J. Biol. Chem., (20080000), vol. 283, pages 16194 - 16205, XP002512404
OPPOSITION- DILLON, T.M. et al., "Structural and functional characterization of disulfide isoforms of the human IgG2 subclass", J. Biol. Chem., (20080000), vol. 283, pages 16206 - 16215, XP002512405
OPPOSITION- JESPERSEN A M,ET AL, "Characterisation of a trisulphide derivative of biosynthetic human growth hormone produced in Escherichia coli", European Journal of Biochemistry, Wiley-Blackwell Publishing Ltd., GB, GB, (19940101), vol. 219, no. 1-2, doi:10.1111/j.1432-1033.1994.tb19948.x, ISSN 0014-2956, pages 365 - 373, XP002372773
OPPOSITION- LIU et al., "Disulfide bond structures of IgG molecules: Structural variations, chemical modifications and possible impacts to stability and biological function", mAbs, (20120000), vol. 4, no. 1, pages 17 - 23, XP055134217

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