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Production Of Glycoproteins With Low N-Glycolylneuraminic Acid (Neu5Gc) Content - EP2501799

The patent EP2501799 was granted to LEK Pharmaceuticals DD on Jan 24, 2018. The application was originally filed on Nov 19, 2010 under application number EP10781888A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2501799

LEK PHARMACEUTICALS DD
Application Number
EP10781888A
Filing Date
Nov 19, 2010
Status
Granted And Under Opposition
Dec 22, 2017
Grant Date
Jan 24, 2018
External Links
Slate, Register, Google Patents

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MAIWALDOct 24, 2018MAIWALDADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0092037
DESCRIPTIONEP0543106
DESCRIPTIONUS2007161084
DESCRIPTIONUS5459031
INTERNATIONAL-SEARCH-REPORTUS2007161084
INTERNATIONAL-SEARCH-REPORTWO2008128227
OPPOSITIONUS2007161084
OPPOSITIONWO2004008100
OPPOSITIONWO2008128227

Non-Patent Literature (NPL) Citations (15) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- CORFIELD A. P.; SCHAUER R., CELL BIOLOGY MONOGRAPHS, (1982), vol. 10, pages 5 - 55-
DESCRIPTION- WERNER RG; KOPP K; SCHLUETER M., "Glycosylation of therapeutic proteins in different production systems", ACTA PæDIATRICA, (2007), vol. 96, pages 17 - 22, XP008080645-
DESCRIPTION- YAMAGUCHI; SHINYA; OHNISHI; JUN; MARU; ISAFUMI; OHTA; YASUHIRO, "Simple and Large-Scale Production of N-Acetylneuraminic Acid and N-Acetyl-D-Mannosamine", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, (2006), vol. 18, pages 245 - 252-
DESCRIPTION- GU X; WANG DIC, "Chinese Hamster Ovary Cell Culture by Feeding of N-Acetylmannosamine", BIOTECHNOLOGY AND BIOENGINEERING, (1998), vol. 58, no. 6, doi:doi:10.1002/(SICI)1097-0290(19980620)58:6<642::AID-BIT10>3.0.CO;2-9, pages 642 - 648, XP002331389
DESCRIPTION- TRAVING C; SCHAUER R., "Structure, function and metabolism of sialic acids Cell", MOL. LIFE SCI., (1998), vol. 54, doi:doi:10.1007/s000180050258, pages 1330 - 1349, XP002539709
DESCRIPTION- SCHAUER R., "Achievements and challenges of sialic acid research", GLYCOCONJUGATE JOURNAL, (2000), vol. 17, doi:doi:10.1023/A:1011062223612, pages 485 - 499, XP019206916
EXAMINATION- LLOP E ET AL, "Structural analysis of the glycosylation of gene-activated erythropoietin (epoetin delta, Dynepo)", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 383, no. 2, doi:10.1016/J.AB.2008.08.027, ISSN 0003-2697, (20081215), pages 243 - 254, (20080903), XP025585790
INTERNATIONAL-SEARCH-REPORT- FIBACH E ET AL, "Changes in cellular ferritin content during myeloid differentiation of human leukemic cell lines.", AMERICAN JOURNAL OF HEMATOLOGY FEB 1985 LNKD- PUBMED:3970011, (198502), vol. 18, no. 2, ISSN 0361-8609, pages 143 - 151, XP002615794 [X] 1,5 * abstract * * figure 3 * * page 144 * * page 148 * [I] 6
INTERNATIONAL-SEARCH-REPORT- BORK KAYA ET AL, "Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway.", JOURNAL OF PHARMACEUTICAL SCIENCES OCT 2009, (200910), vol. 98, no. 10, ISSN 1520-6017, pages 3499 - 3508, XP002572996 [A] 1-14 * the whole document *
INTERNATIONAL-SEARCH-REPORT- CHENU S ET AL, "Reduction of CMP-N-acetylneuraminic acid hydroxylase activity in engineered Chinese hamster ovary cells using an antisense-RNA strategy", BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, (20030723), vol. 1622, no. 2, ISSN 0304-4165, pages 133 - 144, XP004441035 [A] 7-14 * abstract * * pages 133-134 *
INTERNATIONAL-SEARCH-REPORT- RODRIGUEZ J ET AL, "Enhanced production of monomeric interferon-[beta] by CHO cells through the control of culture conditions", BIOTECHNOLOGY PROGRESS JANUARY/FEBRUARY 2005 AMERICAN CHEMICAL SOCIETY US, (200501), vol. 21, no. 1, pages 22 - 30, XP002572995 [X] 1,5,7-14 * abstract * * table 1 * * page 23 * * page 25 *
OPPOSITION- HILLS et al., "METABOLIC CONTROL OF RECOMBINANT MONOCLONAL ANTIBODY N-GLYCOSYLATION IN GS-NS0 CELLS", Biotechnol. Bioeng., (20010000), vol. 75, no. 2, pages 239 - 251, XP001206784
OPPOSITION- BAKER et al., "Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells", Biotechnol. Bioeng., (20010000), vol. 73, no. 3, pages 188 - 202, XP002524941
OPPOSITION- RODRIGUEZ et al., "Enhanced production of monomeric interferon-[beta] by CHO cells through the control of culture conditions", Biotechnol. Prog., (20050000), vol. 21, no. 1, pages 22 - 30, XP002572995
OPPOSITION- SCHAUER et al., "Traumatic events, PTSD, and psychiatric comorbidity in forensic patients - assessed by questionnaires and diagnostic interview", Biochemistry and role of sialic acids. In: Biology of Sialic Acids, New York, (19950000), vol. 2, pages 7 - 67, XP021019885

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