The patent EP2512491 was granted to Glaxo Group on Oct 11, 2017. The application was originally filed on Oct 15, 2010 under application number EP10824199A. The patent is currently recorded with a legal status of "Revoked".

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| INTERNATIONAL-SEARCH-REPORT | US2003148985 |
| INTERNATIONAL-SEARCH-REPORT | US2005014712 |
| INTERNATIONAL-SEARCH-REPORT | US2006128646 |
| OPPOSITION | US2003068301 |
| OPPOSITION | US2003139363 |
| OPPOSITION | US2003206887 |
| OPPOSITION | US2004054156 |
| OPPOSITION | US2007032441 |
| OPPOSITION | US2009137500 |
| OPPOSITION | WO0116312 |
| OPPOSITION | WO2012024170 |
| OPPOSITION | WO2012145674 |
| OPPOSITION | WO2015173208 |
| OPPOSITION | WO9639502 |
| OPPOSITION | WO9703211 |
| SEARCH | US2003206887 |
| SEARCH | US5985662 |
| SEARCH | WO2004078181 |
NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.
| Citation Phase | Reference Text |
|---|---|
| OPPOSITION | - "Chapter 19", CROOKE STANLEY T, Antisense Drug Technology, 2nd Ed., CRC PRESS, (20080000), pages 519 - 564, XP003036103 |
| OPPOSITION | - "Chapter 6", CROOKE, Antisense Drug Technology, 2nd Ed., CRC Press, pages 143 - 182, XP055461203 |
| OPPOSITION | - "Chapters 1 and 2", CROOKE Stanley T., Antisense Drug Technology, 2nd Ed., CRC Press, (20080000), pages 3 - 74, XP055501551 |
| OPPOSITION | - GRUNWELLER et al., "Locked Nucleic Acid Oligonucleotides", Biodrugs, (20070700), vol. 21, no. 4, pages 235 - 243, XP009125276 |
| OPPOSITION | - KOCH et al., "Quantum Mechanical Studies of DNA and LNA", Nucleic Acid Therapeutics, (20140100), vol. 24, no. 2, pages 139 - 148, XP055366884 |
| OPPOSITION | - REINIS et al., "INHIBITION OF HEPATITIS -B VIRUS SURFACE GENE EXPRESSION BY ANTISENSE OLIGODEOXYNUCLEOTIDES IN A HUMAN HEPATOMA CELL LIN.E ( hepatitis B virus/ PLC/PRF/5 cell line/ antisense oligonucleotides)", Folia Biologica, (19930512), vol. 39, no. 5, pages 262 - 269, XP000603123 |
| OPPOSITION | - S-H OH et al., "INHIBITION OF HEPATITIS B VIRUS EXPRESSION BY ANTISENSE OLIGODEOXYRIBONUCLEOTIDES", Korean Journal of Biochemistry, (19931200), vol. 25, no. 2, pages 113 - 118, XP000603311 |
| OPPOSITION | - HAGEDORN et al., "Locked nucleic acid: modality, diversity, and drug discovery", Drug Discovery Today, (20180100), vol. 23, no. 1, pages 101 - 114, XP055461215 |
| OPPOSITION | - VICKERS et al., "Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents: A comparative analysis", J. Biol. Chem., (20030228), vol. 278, no. 9, pages 7108 - 7118, XP002281434 |
| OPPOSITION | - SWAYZE et al., "Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals", Nucleic Acid Res, (20070000), vol. 35, no. 2, pages 687 - 700, XP002539513 |
Get a free citation report including examiner, opposition, and international search citations.
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Oct 19, 2017
Sep 14, 2017
Decision to grant a European patent
Search/Exam
Aug 29, 2017
(Electronic) Receipt
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Aug 29, 2017
Filing of the translations of the claims
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Aug 29, 2017
French translation of claims
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Aug 29, 2017
German translation of the claims
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Aug 29, 2017
Letter accompanying subsequently filed items
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Jun 20, 2017
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Intention to grant (signatures)
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Jun 20, 2017
Text intended for grant (clean copy)
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Jun 20, 2017
Text intended for grant (sequence listing)
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Jun 20, 2017
May 17, 2017
(Electronic) Receipt
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May 17, 2017
Amended claims with annotations
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May 17, 2017
Claims
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May 17, 2017
Letter accompanying subsequently filed items
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(Electronic) Receipt
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Mar 16, 2017
Nov 23, 2016
Annex to the communication
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Nov 23, 2016
Communication from the Examining Division
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Jun 24, 2016
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(Electronic) Receipt
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Dec 8, 2015
Amended claims with annotations
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Dec 8, 2015
Claims
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Dec 8, 2015
Letter accompanying subsequently filed items
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Dec 8, 2015
Sep 29, 2015
Sep 24, 2015
(Electronic) Receipt
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Sep 24, 2015
Letter accompanying subsequently filed items
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Sep 24, 2015
Jun 1, 2015
Annex to the communication
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Jun 1, 2015
Communication from the Examining Division
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May 21, 2015
Examination started
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Feb 7, 2014
Decision to allow further processing
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Jan 29, 2014
(Electronic) Receipt
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Jan 29, 2014
Jan 29, 2014
Amended claims with annotations
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Jan 29, 2014
Amendments received before examination
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Jan 29, 2014
Letter accompanying subsequently filed items
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Nov 26, 2013
Oct 14, 2013
(Electronic) Receipt
Search/Exam
Oct 14, 2013
Letter accompanying subsequently filed items
Search/Exam
Oct 14, 2013
Matter concerning the application
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Apr 12, 2013
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Mar 27, 2013
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European search opinion
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Mar 27, 2013
Supplementary European search report
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Mar 22, 2013
Sep 26, 2012
Aug 16, 2012
(Electronic) Receipt
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Aug 16, 2012
Drawings
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Aug 16, 2012
Letter accompanying subsequently filed items
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Aug 16, 2012
Matter concerning the application
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(Electronic) Receipt
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Amended claims with annotations
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May 16, 2012
Amendments received before examination
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May 16, 2012
Converted Sequence Listing
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May 16, 2012
Request for entry into the European phase
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May 11, 2012
Feb 24, 2012
Information on entry into European phase
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May 11, 2011
Apr 21, 2011
Converted Sequence Listing
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Apr 21, 2011
Copy of the international search report
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Apr 21, 2011
Published international application - A1
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