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Biological Inhibitors Of Ror1 Capable Of Inducing Cell Death - EP2513146

The patent EP2513146 was granted to Bioinvent on May 3, 2017. The application was originally filed on Dec 10, 2010 under application number EP10798728A. The patent is currently recorded with a legal status of "Revoked".

EP2513146

BIOINVENT
Application Number
EP10798728A
Filing Date
Dec 10, 2010
Status
Revoked
Feb 21, 2020
Publication Date
May 3, 2017
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (2)

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BISCHOFFeb 5, 2018-ADMISSIBLE
TAYLORFeb 5, 2018LEWIS SILKINADMISSIBLE

Patent Citations (21) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS4440859
DESCRIPTIONUS4530901
DESCRIPTIONUS4582800
DESCRIPTIONUS4677063
DESCRIPTIONUS4678751
DESCRIPTIONUS4704362
DESCRIPTIONUS4710463
DESCRIPTIONUS4757006
DESCRIPTIONUS4766075
DESCRIPTIONUS4810648
DESCRIPTIONWO9816643
INTERNATIONAL-SEARCH-REPORTWO2005100605
INTERNATIONAL-SEARCH-REPORTWO2007146957
INTERNATIONAL-SEARCH-REPORTWO2008076868
INTERNATIONAL-SEARCH-REPORTWO2010124188
OPPOSITIONUS2013273073
OPPOSITIONWO2005100605
OPPOSITIONWO2007051077
OPPOSITIONWO2008076868
OPPOSITIONWO2008103849
OPPOSITIONWO2010124188

Non-Patent Literature (NPL) Citations (47) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BETTER ET AL., SCIENCE, (1988), vol. 240, page 1041
DESCRIPTION- BIRD ET AL., SCIENCE, (1988), vol. 242, page 423
DESCRIPTION- CHESON B ET AL., BLOOD, (1996), vol. 87, pages 4990 - 4997
DESCRIPTION- CHIORAZZI N ET AL., N ENGL J MED, (2005), vol. 352, pages 804 - 15
DESCRIPTION- DAMLE RN ET AL., BLOOD, (1999), vol. 94, pages 1840 - 7
DESCRIPTION- DEROSSI ET AL., TRENDS CELL BIOL., (1998), vol. 8, pages 84 - 87
DESCRIPTION- D. WILKINSON, The Scientist, THE SCIENTIST, INC., (20000417), vol. 14, pages 25 - 28
DESCRIPTION- GLASS DJ ET AL., CELL, (1996), vol. 85, pages 513 - 23
DESCRIPTION- HAMBLIN TJ ET AL., BLOOD, (1999), vol. 94, pages 1848 - 54
DESCRIPTION- HARRIS NL ET AL., HISTOPATHOLOGY, (2000), vol. 36, pages 69 - 86
DESCRIPTION- HAY H, J CLIN LAB IMMUNOL, (1989), vol. 29, pages 151 - 5
DESCRIPTION- HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, page 5879
DESCRIPTION- KLEIN U ET AL., J EXP MED, (2001), vol. 194, pages 1625 - 38
DESCRIPTION- KOHLERMILSTEIN C, NATURE, (1975), vol. 256, pages 495 - 7
DESCRIPTION- KOKHAEI ET AL., EXP HEMATOL, (2007), vol. 35, page 297
DESCRIPTION- KOKHAEI P ET AL., EXP HEMATOL, (2007), vol. 35, pages 297 - 304
DESCRIPTION- MASIAKOWSKI P ET AL., BIOL CHEM, (1992), vol. 267, pages 26181 - 90
DESCRIPTION- MASIAKOWSKI P ET AL., J BIOL CHEM, (1992), vol. 267, pages 26181 - 90
DESCRIPTION- MCCAFFREYA. P., MEUSEL., PHAMT. T., CONKLIND. S., HANNON, G. J.KAY, M. A., "RNA interference in adult mice", NATURE, (2002), vol. 418, pages 38 - 39
DESCRIPTION- MIKAELSSON E ET AL., BLOOD, (2005), vol. 105, pages 4828 - 35
DESCRIPTION- MIKAELSSON ET AL., BLOOD, (2005), vol. 105, page 4828
DESCRIPTION- MORRISON ET AL., PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, pages 6851 - 6855
DESCRIPTION- REDDY UR ET AL., ONCOGENE, (1996), vol. 13, pages 1555 - 9
DESCRIPTION- REZVANY MR ET AL., BR J HAEMATOL, (2000), vol. 111, pages 608 - 17
DESCRIPTION- REZVANY MR ET AL., BR J HAEMATOL, (2001), vol. 115, pages 263 - 71
DESCRIPTION- ROSENWALD A ET AL., J EXP MED, (2001), vol. 194, pages 1639 - 47
DESCRIPTION- SAIKI ET AL., SCIENCE, (1988), vol. 239, pages 487 - 491
DESCRIPTION- SKERRA ET AL., SCIENCE, (1988), vol. 240, page 1038
DESCRIPTION- SONGE., LEES. K., WANQ, J. ET AL., NAT. MED., (2003), vol. 9, pages 347 - 351
DESCRIPTION- VALENZUELA DM ET AL., NEURON, (1995), vol. 15, pages 573 - 84
DESCRIPTION- WARD ET AL., NATURE, (1989), vol. 341, page 544
DESCRIPTION- WILLEMS P ET AL., "Belgium-Dutch Hematology-Oncology Group", BLOOD, (2000), vol. 96, pages 63 - 70
DESCRIPTION- WINTER ET AL., NATURE, (1991), vol. 349, pages 293 - 299
DESCRIPTION- YODA A ET AL., J RECEPT SIGNAL TRANSDUCT RES, (2003), vol. 23, pages 1 - 15
EXAMINATION- DANESHMANESH A H ET AL, Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells., LEUKEMIA JUN 2012, VOL. 26, NR. 6, PAGE(S) 1348 - 1355, (201206), ISSN 1476-5551
INTERNATIONAL-SEARCH-REPORT- HEANEY D L ET AL, "SOLUBLE RECEPTORS IN HUMAN DISEASE", JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, (19980801), vol. 64, no. 2, ISSN 0741-5400, pages 135 - 146, XP008005930 [A] 1-31 * the whole document *
INTERNATIONAL-SEARCH-REPORT- TAKAYAMA K ET AL, "Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER REREARCH, US, (20000415), vol. 60, no. 8, ISSN 0008-5472, pages 2169 - 2177, XP002312417 [A] 1-31 * the whole document *
INTERNATIONAL-SEARCH-REPORT- AMIR H DANESHMANESH ET AL, "Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, UNITED STATES, SWITZERLAND, GERMANY, vol. 123, no. 5, doi:DOI:10.1002/IJC.23587, ISSN 0020-7136, (20080901), pages 1190 - 1195, (20080610), XP002622341 [X] 1-7,27 * the whole document * [A] 8-26,28-31
INTERNATIONAL-SEARCH-REPORT- MACKEIGAN JEFFREY P ET AL, "Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance", NATURE CELL BIOLOGY, NATURE PUBLISHING GROUP, GB, (20050601), vol. 7, no. 6, doi:DOI:10.1038/NCB1258, ISSN 1465-7392, pages 591 - 600, XP002425115 [X] 1-31 * the whole document *
INTERNATIONAL-SEARCH-REPORT- FUKUDA TETSUYA ET AL, "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal,antigen and receptor for Wnt5a", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US, vol. 105, no. 8, doi:DOI:10.1073/PNAS.0712148105, ISSN 0027-8424, (20080226), pages 3047 - 3052, (20080219), XP009135222 [A] 1-31 * the whole document *
INTERNATIONAL-SEARCH-REPORT- J. W. TYNER ET AL, "RNAi screen for rapid therapeutic target identification in leukemia patients", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20090526), vol. 106, no. 21, doi:10.1073/pnas.0903233106, ISSN 0027-8424, pages 8695 - 8700, XP055003694 [X] 1-31 * the whole document * * including supporting information *
INTERNATIONAL-SEARCH-REPORT- ANIRUDDHA CHOUDHURY ET AL, "Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells", BRITISH JOURNAL OF HAEMATOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 151, no. 4, doi:DOI:10.1111/J.1365-2141.2010.08362.X, ISSN 0007-1048, (20100831), pages 327 - 335, (20100831), XP002622344 [XP] 1-31 * the whole document *
INTERNATIONAL-SEARCH-REPORT- BASKAR SIVASUBRAMANIAN ET AL, "Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20080115), vol. 14, no. 2, doi:DOI:10.1158/1078-0432.CCR-07-1823, ISSN 1078-0432, pages 396 - 404, XP009135221 [I] 1-31 * the whole document *
INTERNATIONAL-SEARCH-REPORT- LAPALOMBELLA ROSA ET AL, "Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 115, no. 13, doi:DOI:10.1182/BLOOD-2009-09-242438, ISSN 0006-4971, (20091124), pages 2619 - 2629, (20091124), XP009146859 [A] 1-31 * the whole document *
OPPOSITION- UniProtKB, (20171220), Database accession no. Q01973, XP055468014
OPPOSITION- FUKODA et al., "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal,antigen and receptor for Wnt5a", PNAS, (20080226), vol. 105, no. 8, pages 3047 - 3052, XP009135222
OPPOSITION- BASKAR et al., "Targeting malignant B cells with an immunotoxin against ROR1", mAbs, (20120500), vol. 4, no. 3, pages 349 - 361, XP002710758

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