Widespread Gene Delivery To Motor Neurons Using Peripheral Injection Of Aav Vectors - EP2527457

The patent EP2527457 was granted to Centre National DE LA Recherche Scientifique on Feb 20, 2019. The application was originally filed on Oct 3, 2008 under application number EP12180951A. The patent is currently recorded with a legal status of "Revoked".

EP2527457

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Application Number
EP12180951A
Filing Date
Oct 3, 2008
Status
Revoked
Mar 25, 2022
Grant Date
Feb 20, 2019
External Links
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Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO0028004
DESCRIPTIONWO0073316
DESCRIPTIONWO0123001
DESCRIPTIONWO0191803
DESCRIPTIONWO2004112727
DESCRIPTIONWO2005005610
DESCRIPTIONWO2005072364
DESCRIPTIONWO9640954
DESCRIPTIONWO9822607
DESCRIPTIONWO9906562
OPPOSITIONUS2007196338
OPPOSITIONWO0192551
OPPOSITIONWO03055983
OPPOSITIONWO2009013290
SEARCHWO03055983

Non-Patent Literature (NPL) Citations (38) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AZZOUZ, M.; A. HOTTINGER ET AL., "Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2", HUM MOL GENET, (2000), vol. 9, no. 5, pages 803 - 11-
DESCRIPTION- BOILLEE, S.; K. YAMANAKA ET AL., "Onset and progression in inherited ALS determined by motor neurons and microglia", SCIENCE, (2006), vol. 312, no. 5778, pages 1389 - 92-
DESCRIPTION- DALY, T. M.; C. VOGLER ET AL., "Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease", PROC NATL ACAD SCI USA, (1999), vol. 96, no. 5, pages 2296 - 300-
DESCRIPTION- FYFE, J. C.; M. MENOTTI-RAYMOND ET AL., "An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival", GENOME RES, (2006), vol. 16, no. 9, pages 1084 - 90-
DESCRIPTION- INOUE ET AL., J. VIROL., (1998), vol. 72, page 7024-
DESCRIPTION- MONANI, U. R., "Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease", NEURON, (2005), vol. 48, no. 6, pages 885 - 96-
DESCRIPTION- PASINELLI, P.; R. H. BROWN, "Molecular biology of amyotrophic lateral sclerosis: insights from genetics", NAT REV NEUROSCI, (2006), vol. 7, no. 9, pages 710 - 23-
DESCRIPTION- PASSINI, M. A.; J. H. WOLFE, "Widespread gene delivery and structure- specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector.", J VIROL, (2001), vol. 75, no. 24, pages 12382 - 92, XP003002613-
DESCRIPTION- SAMULSKI ET AL., J. VIROLOGY, (1989), vol. 63, page 3822-
DESCRIPTION- SCHERRMANN, J. M., "Drug delivery to brain via the blood-brain barrier", VASCUL PHARMACOL., (2002), vol. 38, pages 349 - 54-
DESCRIPTION- XIAO ET AL., J. VIROLOGY, (1998), vol. 72, page 2224-
DESCRIPTION- XIAO, X.; J. LI ET AL., "Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus", J VIROL, (1998), vol. 72, no. 3, pages 2224 - 32-
DESCRIPTION- MACLEAN, H. E.; G. L. WARNE ET AL., "Spinal and bulbar muscular atrophy: androgen receptor dysfunction caused by a trinucleotide repeat expansion", J NEUROL SCI, (1996), vol. 135, no. 2, doi:doi:10.1016/0022-510X(95)00284-9, pages 149 - 57, XP055267617
DESCRIPTION- FU, H.; J. MUENZER ET AL., "Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV- mediated transgene expression in mouse brain", MOL THER, (2003), vol. 8, no. 6, doi:doi:10.1016/j.ymthe.2003.08.021, pages 911 - 7, XP002350611
DESCRIPTION- CEARLEY, C. N.; J. H. WOLFE, "Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain", MOL THER, (2006), vol. 13, no. 3, doi:doi:10.1016/j.ymthe.2005.11.015, pages 528 - 37, XP055448080
DESCRIPTION- INAGAKI, K.; S. FUESS ET AL., "Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAVB", MOL THER, (2006), vol. 14, no. 1, doi:doi:10.1016/j.ymthe.2006.03.014, pages 45 - 53, XP005524560
DESCRIPTION- MCCARTY, D. M.; H. FU ET AL., "Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate- limiting step to transduction in vivo", GENE THER, (2003), vol. 10, no. 26, doi:doi:10.1038/sj.gt.3302134, pages 2112 - 8, XP002367806
DESCRIPTION- KASPAR, BK ET AL., "Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.", SCIENCE, (2003), vol. 301, doi:doi:10.1126/science.1086137, pages 839 - 42, XP002347775
DESCRIPTION- AZZOUZ, M ET AL., "Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy", J CLIN INVEST., (2004), vol. 114, no. 12, doi:doi:10.1172/JCI200422922, pages 1726 - 31, XP055040224
EXAMINATION- A M CLEMENT ET AL, "Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice", SCIENCE, (20031003), vol. 302, pages 113 - 117, XP055497320-
EXAMINATION- BOILLEE, S.; K. YAMANAKA ET AL., "Onset and progression in inherited ALS determined by motor neurons and microglia", SCIENCE, (2006), vol. 312, no. 5778, pages 1389 - 92-
EXAMINATION- LEFEBVRE S ET AL, "IDENTIFICATION AND CHARACTERIZATION OF AN SPINAL MUSCULAR ATROPHY-DETERMINING GENE", CELL, CELL PRESS, AMSTERDAM, NL, (19950113), vol. 80, doi:10.1016/0092-8674(95)90460-3, ISSN 0092-8674, pages 155 - 165, XP002022190
EXAMINATION- DAVID W. MILLER ET AL, "Glial cell inclusions and the pathogenesis of neurodegenerative diseases", NEURON GLIA BIOLOGY, Cambridge, (20040201), vol. 1, no. 01, doi:10.1017/S1740925X04000043, ISSN 1740-925X, XP055497324
OPPOSITION- CHAO et al., Mol Therapy, (20000000), vol. 2, no. 6, pages 619 - 623, XP055659166
OPPOSITION- FU et al., Mol Therapy, (20030000), vol. 8, no. 6, pages 911 - 917, XP002350611
OPPOSITION- CEARLEY et al., Mol Therapy, (20060000), vol. 13, no. 3, pages 528 - 536, XP005300360
OPPOSITION- INAGAKI et al., Mol Therapy, (20060000), vol. 14, no. 1, pages 45 - 53, XP005502560
OPPOSITION- LEFEBVRE et al., Nature Genetics, (19970000), vol. 16, pages 265 - 269, XP055659165
OPPOSITION- KASPER et al., Science, (20030000), vol. 301, pages 839 - 842, XP002347775
OPPOSITION- AKACHE et al., J Virol, (20061000), pages 9831 - 9836, XP055583003
OPPOSITION- GAO et al., J Virol, (20040000), vol. 78, no. 12, pages 6381 - 6388, XP002321999
OPPOSITION- NAKAI et al., J Virol, (20050100), pages 214 - 224, XP055174034
SEARCH- INAGAKI ET AL, "Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8", MOLECULAR THERAPY, (200607), vol. 14, no. 1, ISSN 1525-0016, pages 45 - 53, XP005560370 [A] 1-11 * page 49, column L, paragraph L * * figure 4; table 3 *-
SEARCH- BOULIS NICHOLAS M ET AL, "Adeno-associated viral vector gene expression in the adult rat spinal cord following remote vector delivery.", NEUROBIOLOGY OF DISEASE DEC 2003, (200312), vol. 14, no. 3, ISSN 0969-9961, pages 535 - 541, XP002474413 [A] 1-11 * abstract * * figures 1-3 * * page 539, column R, paragraph L - page 541, column L, paragraph 1 *
SEARCH- MORI S ET AL, "Two novel adeno-associated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein", VIROLOGY, (20041220), vol. 330, no. 2, doi:10.1016/J.VIROL.2004.10.012, ISSN 0042-6822, pages 375 - 383, XP004676906 [A] 1-11 * the whole document *
SEARCH- FU H ET AL, "Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain", MOLECULAR THERAPY, (200312), vol. 8, no. 6, ISSN 1525-0016, pages 911 - 917, XP002350611 [A] 1-11 * abstract * * page 912, column L, paragraph 5 - column R, paragraph 3 * * page 915, column R, paragraph 2 *
SEARCH- CEARLEY ET AL, "Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain", MOLECULAR THERAPY, (20060301), vol. 13, no. 3, doi:10.1016/J.YMTHE.2005.11.015, ISSN 1525-0016, pages 528 - 537, XP005326765 [AD] 1-11 * the whole document *
SEARCH- KASPAR B K ET AL, "Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model", SCIENCE, (20030808), vol. 301, no. 5634, ISSN 0036-8075, pages 839 - 842, XP002347775 [A] 1-11 * the whole document *

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