IP Verse

Klotho-Beta For Use In Treating Cancer, Liver Disorders, Gallstones, Wasting Syndrome And Obesity-Related Diseases - EP2550972

The patent EP2550972 was granted to Genentech on Feb 21, 2018. The application was originally filed on Apr 1, 2008 under application number EP12179244A. The patent is currently recorded with a legal status of "Revoked".

EP2550972

GENENTECH
Application Number
EP12179244A
Filing Date
Apr 1, 2008
Status
Revoked
Jul 10, 2020
Grant Date
Feb 21, 2018
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MATHYS & SQUIRENov 21, 2018WILDING -
NGM BIOPHARMACEUTICALSNov 20, 2018JONES DAY -

Patent Citations (6) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONJP2006158339
OPPOSITIONUS2005026243
OPPOSITIONWO0120031
SEARCHJP2001072607
SEARCHJP2003334088
SEARCHJP2006158339

Non-Patent Literature (NPL) Citations (22) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- GOETZ et al., "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members", Mol Cell Biol, (20070000), vol. 27, no. 9, pages 3417 - 3428, XP002596984-
OPPOSITION- GOETZ et al., "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members", Molecular and Cellular Biology, (20070000), vol. 27, no. 9, pages 3417 - 3428, XP002596984-
OPPOSITION- "Monoclonal antibody", Wikipedia, (20070328), XP055534496-
OPPOSITION- LI et al., "Transgenic Expression of Cholesterol 7a-Hydroxylase in the Liver Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice", NIH Public Access Author Manuscript, (20100000), vol. 52, no. 2, pages 1 - 22, XP055534488
OPPOSITION- HARMER et al., "The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinit", Biochemistry, (20040000), vol. 43, no. 3, pages 629 - 640, XP002596986
OPPOSITION- LEE et al., "Structures of beta -klotho reveal a 'zip code' -like mechanism for endocrine FGF signalling", Nature, (20180000), vol. 553, pages 501 - 505, XP055534031
OPPOSITION- GUNAWARDANE et al., "Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransfera se Modulate High Density Lipoprotein Metabolism", J Biol Chem, (20160000), vol. 291, no. 6, pages 2799 - 2811, XP055534022
OPPOSITION- LIN et al., "Liver-specific activities of FGF19 require klotho beta", J Biol Chem, (20070000), vol. 282, no. 37, pages 27277 - 27284, XP002542531
OPPOSITION- LIN et al., "Liver-specific activities of FGF19 require klotho beta", The Journal of Biological Chemistry, (20070000), vol. 282, no. 37, pages 27277 - 27284, XP002542531
OPPOSITION- KIM et al., "Tethered-variable CL bispecific lgG: an antibody platform for rapid bispecific antibody screening", Protein Eng Des Sel, (20170000), vol. 30, no. 9, pages 627 - 637, XP055534477
OPPOSITION- FOLTZ et al., "Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the [beta] Klotho/FGFR1c Receptor Complex", Sci Transl Med, (20120000), vol. 4, no. 162, pages 1 - 10, XP009166047
OPPOSITION- ITO et al., "Impaired negative feedback suppression of bile acid synthesis in mice lacking .beta.Klotho", J Clin Invest, (20050000), vol. 115, no. 8, pages 2202 - 2208, XP002542526
OPPOSITION- FU et al., "Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes", Endocrinology, (20040000), vol. 145, no. 6, pages 2594 - 2603, XP055534486
OPPOSITION- TOMLINSON et al., "Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity", Endocrinology, (20020000), vol. 143, no. 5, pages 1741 - 1747, XP055534633
OPPOSITION- FRENCH et al., "Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models", PLoS ONE, (20120000), vol. 7, no. 5, pages 1 - 12, XP055028245
SEARCH- DATABASE WPI, 0, Derwent World Patents Index, (20010321), vol. 2001, no. 32, Database accession no. 2001-304533, XP002689430 & JP2001072607 A 20010321 (KYOWA HAKKO KOGYO KK) [A] 1-15 * abstract *-
SEARCH- DATABASE WPI, 0, Derwent World Patents Index, (20031125), vol. 2004, no. 02, Database accession no. 2004-015995, XP002689431 & JP2003334088 A 20031125 (FARUMA DESIGN KK) [A] 1-15 * abstract *-
SEARCH- DATABASE WPI, 0, Derwent World Patents Index, (20060622), vol. 2006, no. 45, Database accession no. 2006-437636, XP002689429 & JP2006158339 A 20060622 (UNIV KYOTO) [X] 1,2,6,7,12-15 * abstract * [I] 1-15-
SEARCH- ARRESE M ET AL, "Beta.Klotho: a new kid on the bile acid biosynthesis block", HEPATOLOGY, WILEY, USA, (20060101), vol. 43, no. 1, doi:10.1002/HEP.21022, ISSN 0270-9139, pages 191 - 193, XP002542529 [A] 1-15 * abstract *
SEARCH- YUICHIRO SAITO ET AL, "In Vivo klotho Gene Delivery Protects against Endothelial Dysfunction in Multiple Risk Factor Syndrome", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (20000901), vol. 276, no. 2, doi:10.1006/bbrc.2000.3470, ISSN 0006-291X, pages 767 - 772, XP055047794 [A] 1-15 * abstract *
SEARCH- ITO SHINJI ET AL, "Impaired negative feedback suppression of bile acid synthesis in mice lacking beta Klotho", JOURNAL OF CLINICAL INVESTIGATION, (200508), vol. 115, no. 8, ISSN 0021-9738, pages 2202 - 2208, XP002542526 [X] 1,2,6,12-14 * abstract fig. 1-4 page 2206 righth column paragraph 7 - page 2207 paragraph 1 Methods *
SEARCH- MOSCHETTA ANTONIO ET AL, "Weaving beta Klotho into bile acid metabolism", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, (20050801), vol. 115, no. 8, doi:10.1172/JCI26046, ISSN 0021-9738, pages 2075 - 2077, XP002542528 [A] 1-15 * abstract *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents