IP Verse

Improved Cell Culture Medium - EP2563903

The patent EP2563903 was granted to Novartis on Aug 21, 2019. The application was originally filed on Apr 25, 2011 under application number EP11716890A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2563903

NOVARTIS
Application Number
EP11716890A
Filing Date
Apr 25, 2011
Status
Granted And Under Opposition
Jul 19, 2019
Grant Date
Aug 21, 2019
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (5)

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LASARMay 21, 2020MAIWALDADMISSIBLE
BUHLERMay 20, 2020MAIWALDADMISSIBLE
HOFFMANN EITLEMay 20, 2020HOFFMANN EITLEADMISSIBLE
MAIWALDMay 20, 2020MAIWALDADMISSIBLE
WEICKMANN & WEICKMANNMay 20, 2020-ADMISSIBLE

Patent Citations (56) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

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DESCRIPTIONUS5122469
DESCRIPTIONUS6048728
DESCRIPTIONUS6180401
DESCRIPTIONWO02101019
EXAMINATIONWO2007003640
EXAMINATIONWO9808934
INTERNATIONAL-SEARCH-REPORTUS2006160180
INTERNATIONAL-SEARCH-REPORTUS2006194323
INTERNATIONAL-SEARCH-REPORTUS2009061516
INTERNATIONAL-SEARCH-REPORTUS2011111495
INTERNATIONAL-SEARCH-REPORTUS5122469
INTERNATIONAL-SEARCH-REPORTUS6048728
INTERNATIONAL-SEARCH-REPORTWO02101019
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INTERNATIONAL-SEARCH-REPORTWO2008141207
INTERNATIONAL-SEARCH-REPORTWO2009127098
INTERNATIONAL-SEARCH-REPORTWO2010036767
INTERNATIONAL-SEARCH-REPORTWO9215670
INTERNATIONAL-SEARCH-REPORTWO9512664
OPPOSITIONEP1482031
OPPOSITIONEP1686173
OPPOSITIONEP2345713
OPPOSITIONUS2003087372
OPPOSITIONUS2003096414
OPPOSITIONUS2006094113
OPPOSITIONUS2006160180
OPPOSITIONUS2006216790
OPPOSITIONUS2007231895
OPPOSITIONUS2009061516
OPPOSITIONUS2009124006
OPPOSITIONUS4767704
OPPOSITIONUS6048728
OPPOSITIONUS6180401
OPPOSITIONWO0116294
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OPPOSITIONWO9815614
OTHERUS8986957
OTHERWO2007003640
OTHERWO9512664
OTHERWO9808934

Non-Patent Literature (NPL) Citations (34) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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OPPOSITION- Hatton Taylor, Barnett Shaun, Rashid Kamal, Voll Kevin, "CHO Cell Culture with Single-Use New Brunswick ™ CelliGen ® BLU Packed-Bed Fibra-Cel ® Basket", Eppendorf - APPLICATION NOTE No. 254, (20120701), pages 1 - 3, Eppendorf - APPLICATION NOTE No. 254, URL: https://www.eppendorf.com/product-media/doc/en/41047/New-Brunswick_Fermentors-Bioreactors_Application-Note_254_CelliGen-BLU_Fibra-Cel_CHO-Cell-Culture-Single-New-Brunswick-CelliGen-BLU-Packed-Bed-Fibra-Cel-Basket.pdf, (20240327), XP093146293-
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OPPOSITION- Liangzhi Xie, Weichang Zhou, "Fed-Batch Cultivation of Mammalian Cells for the Production of Recombinant Proteins", Cell Culture Technology For Pharmaceutical And Cell -Based Therapies, CRC Press, (20051010), pages 349 - 386, XP055519908-
OPPOSITION- Sung Hyun Kim, Gyun Min Lee, "Differences in Optimal pH and Temperature for Cell Growth and Antibody Production Between Two Chinese Hamster Ovary Clones Derived from the Same Parental Clone", J. Microbiol. Biotechnol., (20070101), vol. 17, no. 5, pages 712 - 720, XP055414758-
OPPOSITION- David Reinhart et al, "Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis", BIOTECHNOLOGY JOURNAL, WILEY-VCH VERLAG, WEINHEIM, DE, DE, (20190301), vol. 14, no. 3, doi:10.1002/biot.201700686, ISSN 1860-6768, page 1700686, XP055740516
OPPOSITION- Efren Pacis, Marcella Yu, Jennifer Autsen, Robert Bayer, Feng Li, "Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform", Biotechnology and Bioengineering, Wiley ¬etc.|, (20111001), vol. 108, no. 10, doi:10.1002/bit.23200, ISSN 00063592, pages 2348 - 2358, XP055080567
OPPOSITION- Patrick H. C. Van Berkel, Jolanda Gerritsen, Gerrard Perdok, Jesper Valbjørn, Tom Vink, Jan G. J. Van De Winkel, Paul W. H. I. Parren, "N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG", Biotechnology Progress, American Chemical Society, (20090101), vol. 25, no. 1, doi:10.1002/btpr.92, ISSN 87567938, pages 244 - 251, XP055043452
OPPOSITION- CHONG et al., "Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture Rapid Commun", Rapid Communications in Mass Spectrometry, (20091109), vol. 23, doi:10.1002/rcm.4328, pages 3763 - 3771, XP055720886
OPPOSITION- KEEN M J, HALE C, "THE USE OF SERUM-FREE MEDIUM FOR THE PRODUCTION OF FUNCTIONALLY ACTIVE HUMANISED MONOCLONAL ANTIBODY FROM NS0 MOUSE MYELOMA CELLS ENGINEERED USING GLUTAMINE SYNTHETASE AS A SELECTABLE MARKER", CYTOTECHNOLOGY., KLUWER ACADEMIC PUBLISHERS, DORDRECHT., NL, NL, (19960101), vol. 18, doi:10.1007/BF00767768, ISSN 0920-9069, pages 207 - 217, XP009037180
OPPOSITION- Reinhart David, Sommeregger Wolfgang, Debreczeny Monika, Gludovacz Elisabeth, Kunert Renate, "In search of expression bottlenecks in recombinant CHO cell lines—a case study", Applied Microbiology and Biotechnology, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20140701), vol. 98, no. 13, doi:10.1007/s00253-014-5584-z, ISSN 0175-7598, pages 5959 - 5965, XP093144168
OPPOSITION- Reinhart David; Damjanovic Lukas; Kaisermayer Christian; Kunert Renate, "Benchmarking of commercially available CHO cell culture media for antibody production", Applied Microbiology and Biotechnology, Springer Berlin Heidelberg, Berlin/Heidelberg, Berlin/Heidelberg, (20150407), vol. 99, no. 11, doi:10.1007/s00253-015-6514-4, ISSN 0175-7598, pages 4645 - 4657, XP035502970
OPPOSITION- Victor V. T. Wong ; Kah Wye Ho ; Miranda G. S. Yap, "Evaluation of insulin-mimetic trace metals as insulin replacements in mammalian cell cultures", Cytotechnology, Kluwer Academic Publishers, Do, Do , (20040701), vol. 45, no. 3, doi:10.1007/s10616-004-6173-2, ISSN 1573-0778, pages 107 - 115, XP019236841
OPPOSITION- Do Yun Kim ; Joon Chul Lee ; Ho Nam Chang ; Duk Jae Oh, "Effects of Supplementation of Various Medium Components on Chinese Hamster Ovary Cell Cultures Producing Recombinant Antibody", Cytotechnology, Kluwer Academic Publishers, Do, Do, (20050101), vol. 47, no. 1-3, doi:10.1007/s10616-005-3775-2, ISSN 1573-0778, pages 37 - 49, XP019236882
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OPPOSITION- Pan Xiao; Streefland Mathieu; Dalm Ciska; Wijffels René H.; Martens Dirk E., "Selection of chemically defined media for CHO cell fed-batch culture processes", Cytotechnology, Springer Netherlands, Dordrecht, Dordrecht, (20161129), vol. 69, no. 1, doi:10.1007/s10616-016-0036-5, ISSN 0920-9069, pages 39 - 56, XP036144121
OPPOSITION- KANDA YUTAKA ET AL, "Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types.", GLYCOBIOLOGY, Oxford University Press, US, US , (20060929), vol. 17, no. 1, doi:10.1093/glycob/cwl057, ISSN 0959-6658, pages 104 - 118, XP002443679
OPPOSITION- P. Hossler, S. F Khattak, Z. J. Li, "Optimal and consistent protein glycosylation in mammalian cell culture", Glycobiology, Oxford University Press, (20090901), vol. 19, no. 9, doi:10.1093/glycob/cwp079, ISSN 09596658, pages 936 - 949, XP055112498
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OPPOSITION- David Reinhart, Lukas Damjanovic, Wolfgang Sommeregger, Andreas Gili, Stanislaus Schafellner, Andreas Castan, Christian Kaisermayer, Renate Kunert, "Influence of cell culture media and feed supplements on cell metabolism and quality of IgG produced in CHO-K1, CHO-S, and CHO-DG44", BMC Proceedings, 24th European Society for Animal Cell Technology (ESACT) Meeting: C2P2: Cells, Culture, Patients, Products, (20151214), vol. 9, no. Suppl. 9, doi:10.1186/1753-6561-9-S9-P36, XP002799514
OPPOSITION- Li-Xiang Zhang, Wei-Yan Zhang, Chen Wang, Jin-Tao Liu, Xian-Cun Deng, Xu-Ping Liu, Li Fan, Wen-Song Tan, "Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism", Bioresources and Bioprocessing, (20161201), vol. 3, no. 1, doi:10.1186/s40643-015-0072-6, XP055715739
OPPOSITION- Li Zheng-Mei, Fan Zhen-Lin, Wang Xiao-Yin, Wang Tian-Yun, "Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells", Frontiers in Bioengineering and Biotechnology, Frontiers Research Foundation, CH, CH , (20220704), vol. 10, doi:10.3389/fbioe.2022.880155, ISSN 2296-4185, page 880155, XP093146294

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