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Molecules And Methods For Modulating Low-Density-Lipoprotein Receptor-Related Protein 6 (Lrp6) - EP2567709

The patent EP2567709 was granted to Novartis on Dec 27, 2017. The application was originally filed on Oct 31, 2008 under application number EP12188230A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2567709

NOVARTIS
Application Number
EP12188230A
Filing Date
Oct 31, 2008
Status
Granted And Under Opposition
Nov 24, 2017
Grant Date
Dec 27, 2017
External Links
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Patent Summary

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Patent Family

Patent Oppositions (2)

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MERCK PATENTSep 27, 2018-ADMISSIBLE
BOEHRINGER INGELHEIM RCV BOEHRINGER INGELHEIMSep 25, 2018D YOUNGWITHDRAWN

Patent Citations (131) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP0154316
DESCRIPTIONEP0338841
DESCRIPTIONEP0401384
DESCRIPTIONEP1176195
DESCRIPTIONEP1517921
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DESCRIPTIONUS2003175921
DESCRIPTIONUS2004161738
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DESCRIPTIONUS4447233
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DESCRIPTIONUS5877397
DESCRIPTIONUS5885793
DESCRIPTIONUS5939598
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DESCRIPTIONUS6005079
DESCRIPTIONUS6075181
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DESCRIPTIONUS6121022
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DESCRIPTIONWO0042072
DESCRIPTIONWO0109187
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Non-Patent Literature (NPL) Citations (112) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BERGE, S.M. ET AL., J. PHARM. SCI., (1977), vol. 66, pages 1 - 19-
DESCRIPTION- BHANOT ET AL., NATURE, (1996), vol. 382, pages 225 - 230-
DESCRIPTION- BIENZ ET AL., CELL, (2000), vol. 103, pages 311 - 320-
DESCRIPTION- BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426-
DESCRIPTION- BOSS; WOOD, IMMUNOLOGY TODAY, (1985), vol. 6, pages 12 - 13-
DESCRIPTION- BRENNAN ET AL., SCIENCE, (1985), vol. 229, pages 81 - 83-
DESCRIPTION- BRISCOE ET AL., AM. J. PHYSI01., (1995), vol. L233, page L34-
DESCRIPTION- CADIGAN ET AL., GENES & DEVELOPMENT, (1997), vol. 11, pages 3286 - 3305-
DESCRIPTION- CHEN ET AL., EMBO J., (1993), vol. 12, pages 811 - 820-
DESCRIPTION- CHEN, J. ET AL., EMBO J., (1993), vol. 12, pages 821 - 830-
DESCRIPTION- CHEN, J., INTERNATIONAL IMMUNOLOGY, (1993), vol. 5, pages 647 - 656-
DESCRIPTION- CHOI ET AL., NATURE GENETICS, (1993), vol. 4, pages 117 - 123-
DESCRIPTION- CONG ET AL., DEVELOPMENT, (2004), vol. 131, no. 20, page 5103-
DESCRIPTION- CORTEZ-RETAMOZO ET AL., INT. J. CANCER, (2002), vol. 89, pages 456 - 62-
DESCRIPTION- COX ET AL., EUR. J. IMMUNOL., (1994), vol. 24, pages 827 - 836-
DESCRIPTION- DEITERS ET AL., J AM CHEM SOC, (2003), vol. 125, pages 11782 - 11783-
DESCRIPTION- DUMOULIN ET AL., NATURE, (2003), vol. 424, pages 783 - 788-
DESCRIPTION- EASTMAN ET AL., CURR OPIN CELL BIOL, (1999), vol. 11, pages 233 - 240-
DESCRIPTION- E. MEYERS; W. MILLER, COMPUT. APPL. BIOSCI., (1988), vol. 4, pages 11 - 17-
DESCRIPTION- FISHWILD, D. ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851-
DESCRIPTION- FISHWILD ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851-
DESCRIPTION- FUJINO ET AL., PNAS, (2003), vol. 100, page 229-
DESCRIPTION- "Gene Expression Technology", GOEDDEL, Methods in Enzymology, ACADEMIC PRESS, (1990), vol. 185-
DESCRIPTION- GENOME BIOLOGY, (2001), vol. 3, no. 1, pages 1 - 15-
DESCRIPTION- GLENNIE ET AL., J. IMMUNOL., (1987), vol. 139, pages 2367 - 2375-
DESCRIPTION- GUMBINER, CURR. BIOL., (1997), vol. 7, pages R443 - 436-
DESCRIPTION- HARDING, F.; LONBERG, N., ANN. N. Y. ACAD. SCI., (1995), vol. 764, pages 536 - 546-
DESCRIPTION- HE ET AL., SCIENCE, (1998), vol. 281, pages 1509 - 3512-
DESCRIPTION- HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448-
DESCRIPTION- HOLLIGER; WINTER, CANCER IMMUNOL. IMMUNOTHER., (1997), vol. 45, no. 3-4, pages 128 - 30-
DESCRIPTION- HOLLIGER; WINTER, CANCER IMMUNOL. IMMUNOTHER., (1997), vol. 45, no. 34, pages 128 - 30-
DESCRIPTION- HOLLINGER; HUDSON, NATURE BIOTECHNOLOGY, (2005), vol. 23, no. 9, pages 1126 - 1136-
DESCRIPTION- HUSTON ET AL., PROC. NATL. ACAD. SCI., (1988), vol. 85, pages 5879 - 5883-
DESCRIPTION- HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883-
DESCRIPTION- J.J. KILLION; I.J. FIDLER, IMMUNOMETHODS, (1994), vol. 4, page 273-
DESCRIPTION- JONES ET AL., NATURE, (1986), vol. 321, pages 522 - 525-
DESCRIPTION- KARPOVSKY ET AL., J. EXP. MED., (1984), vol. 160, page 1686-
DESCRIPTION- KAUFMAN; SHARP, MOL. BIOL., (1982), vol. 159, pages 601 - 621-
DESCRIPTION- K. KEINANEN; M.L. LAUKKANEN, FEBSLETT., (1994), vol. 346, page 123-
DESCRIPTION- KOHLER; MILSTEIN, NATURE, (1975), vol. 256, page 495-
DESCRIPTION- KUROIWA ET AL., NATURE BIOTECHNOLOGY, (2002), vol. 20, pages 889 - 894-
DESCRIPTION- LAGACE ET AL., J. CLIN. INV., (2006), vol. 116, no. 11, pages 2995 - 3005-
DESCRIPTION- LAUWEREYS. ET AL., EMBO J., (1998), vol. 17, pages 3512 - 3520-
DESCRIPTION- LIU ET AL., PROC. NATL. ACAD. SCI. USA, (1985), vol. 82, page 8648-
DESCRIPTION- LONBERG ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859-
DESCRIPTION- LONBERG, N. ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859-
DESCRIPTION- LONBERG, N., Handbook of Experimental Pharmacology, (1994), vol. 113, pages 49 - 101-
DESCRIPTION- LONBERG, N.; HUSZAR, D., INTERN. REV. IMMUNOL., (1995), vol. 13, pages 65 - 93-
DESCRIPTION- LU ET AL., J. BIOL. CHEM., (2004), vol. 279, no. 4, pages 2856 - 65-
DESCRIPTION- MCCAFFERTY ET AL., NATURE, (1990), vol. 348, pages 552 - 554-
DESCRIPTION- MILLER, J.R., GENOME BIOLOGY, (2001), vol. 3, no. 1, pages 1 - 15-
DESCRIPTION- MORRISON, SCIENCE, (1985), vol. 229, page 1202-
DESCRIPTION- M. OWAIS ET AL., ANTIMICROB. AGENTS CHERNOTHER., (1995), vol. 39, page 180-
DESCRIPTION- NAT. STRUCT. BIOL., (2001), vol. 22, page 1172-
DESCRIPTION- NYGREN; UHLEN, CURRENT OPINION IN STRUCTURAL BIOLOGY, (1997), vol. 7, pages 463 - 469-
DESCRIPTION- PARR ET AL., CURR. OPINION GENETICS & DEVEL., (1994), vol. 4, pages 523 - 528-
DESCRIPTION- PAULUS, BEHRING INS. MITT., (1985), pages 118 - 132-
DESCRIPTION- PEIFER ET AL., SCIENCE, (2000), vol. 287, pages 1606 - 1609-
DESCRIPTION- PERRIMON, CELL, (1994), vol. 76, pages 781 - 784-
DESCRIPTION- P.G. BLOEMAN ET AL., FEBS LETT., (1995), vol. 357, page 140-
DESCRIPTION- PLESCHBERGER ET AL., BIOCONJUGATE CHEM., (2003), vol. 14, pages 440 - 448-
DESCRIPTION- PLUCKTHUN; PACK, IMMUNOTECHNOLOGY, (1997), vol. 3, no. 2, pages 83 - 105-
DESCRIPTION- POLAKIS ET AL., GENES DEV, (2000), vol. 14, pages 1837 - 1851-
DESCRIPTION- POLJAK ET AL., STRUCTURE, (1994), vol. 2, pages 1121 - 1123-
DESCRIPTION- QUEEN ET AL., PROC. NATL. ACAD. SEE. U.S.A., (1989), vol. 86, pages 10029 - 10033-
DESCRIPTION- RIDGWAY ET AL., PROTEIN ENG., (1996), vol. 9, no. 7, pages 617 - 21-
DESCRIPTION- RIECHMANN ET AL., NATURE, (1998), vol. 332, pages 323 - 327-
DESCRIPTION- ROBERTS; SZOSTAK, PROC. NATL. ACAD. SCI USA, (1997), vol. 94, page 12297-
DESCRIPTION- SCHREIER ET AL., J. BIOL. CHEM., (1994), vol. 269, page 9090-
DESCRIPTION- SCHWEIZER ET AL., BMC CELL BIOL., (2003), vol. 4, page 4-
DESCRIPTION- SHIELDS, R.L. ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 6591 - 6604-
DESCRIPTION- SHIELDS, R.L. ET AL., J. BIOL. CHEM., (2002), vol. 277, pages 26733 - 26740-
DESCRIPTION- SPRINGER, J. MOL. BIOL., (1998), vol. 283, page 837-
DESCRIPTION- STIJLEMANS ET AL., J. BIOL. CHEM., (2004), vol. 279, pages 1256 - 1261-
DESCRIPTION- TAKEBE ET AL., MOL. CELL. BIOL., (1988), vol. 8, pages 466 - 472-
DESCRIPTION- TAMAI ET AL., NATURE, (2004), vol. 407, page 530-
DESCRIPTION- TAYLOR, L. ET AL., INTERNATIONAL IMMUNOLOGY, (1994), pages 579 - 591-
DESCRIPTION- TAYLOR, L. ET AL., NUCLEIC ACIDS RESEARCH, (1992), vol. 20, pages 6287 - 6295-
DESCRIPTION- TOMIZUKA ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 722 - 727-
DESCRIPTION- TOMLINSON ET AL., J. MOL. BIOL., (1992), vol. 227, pages 776 - 798-
DESCRIPTION- TUAILLON ET AL., J. IMMUNOL., (1994), vol. 152, pages 2912 - 2920-
DESCRIPTION- TUAILLON ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 94, pages 3720 - 3724-
DESCRIPTION- UMANA ET AL., NAT. BIOTECH., (1999), vol. 17, pages 176 - 180-
DESCRIPTION- UMEZAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1988), vol. 153, page 1038-
DESCRIPTION- URLAUB; CHASIN, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, pages 4216 - 4220-
DESCRIPTION- V.V. RANADE, J. CLINE PHARMACOL., (1989), vol. 29, page 685-
DESCRIPTION- WANG ET AL., SCIENCE, (2001), vol. 292, pages 498 - 500-
DESCRIPTION- WANG; SCHULTZ, SCIENCE, (2003), vol. 301, pages 964 - 967-
DESCRIPTION- WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546-
DESCRIPTION- WU ET AL., IMMUNOTECHNOLOGY, (1996), vol. 2, no. 1, pages 21 - 36-
DESCRIPTION- ZAPATA ET AL., PROTEIN ENG., (1995), vol. 8, no. 10, pages 1057 - 1062-
DESCRIPTION- ZHANG ET AL., SCIENCE, (2004), vol. 303, pages 371 - 373-
EXAMINATION- VICTORIA E. AHN ET AL, "Supplemental Information Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6", (20111013), URL: http://www.sciencedirect.com/science/MiamiMultiMediaURL/1-s2.0-S1534580711004011/1-s2.0-S1534580711004011-mmc1.pdf/272236/html/S1534580711004011/173cac1f2c16524af2183bf8cb3d8344/mmc1.pdf, (20150929), XP055216866-
EXAMINATION- VICTORIAE E. AHN ET AL, "Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6", DEVELOPMENTAL CELL, CELL PRESS, US, vol. 21, no. 5, doi:10.1016/J.DEVCEL.2011.09.003, ISSN 1534-5807, (20110912), pages 862 - 873, (20110915), XP028108381
OPPOSITION- HUNG-PIN PENG et al., "Origins of specificity and affinity in antibody-protein interactions", PNAS, (20140617), vol. 111, no. 26, pages E2656 - E2665, XP055303914-
OPPOSITION- James W Stave Et Al.,, "Antibody and Antigen Contact Residues Define Epitope and Paratope size and Structure", J Immunol, (20130000), vol. 191, pages 1428 - 1435, XP055303910-
OPPOSITION- MAO, B et al., "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins", Nature, (20010101), vol. 411, no. 6835, pages 321 - 325, XP002249369
OPPOSITION- MAO, B et al., "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling", Nature, (20020606), vol. 417, no. 6889, pages 664 - 667, XP002211812
OPPOSITION- ETTENBERG, SA et al., "Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies", Proc Natl Acad Sci, (20100831), vol. 107, no. 35, pages 15473 - 15478, XP055002447
OPPOSITION- LI, L et al., "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled", J Biol Chem, (20020222), vol. 277, no. 8, pages 5977 - 5981, XP002538337
OPPOSITION- CHEN, L et al., "Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk", J Biol Chem, (20080000), vol. 283, no. 34, pages 23364 - 23370, XP055016199
OPPOSITION- KHAN, Z et al., "Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor", Cell Biol, (20071000), vol. 27, no. 20, pages 7291 - 7301, XP002538338
OPPOSITION- ZHANG, Y et al., "The LRP5 High-Bone Mass G17V Mutation Disrupts LEP5 Interaction with Mesd", Mol Cell Biol, (20040000), vol. 24, no. 11, pages 4677 - 4684, XP008116199
OPPOSITION- AI, M et al., "Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling", Mol Cell Biol, (20050615), vol. 25, no. 12, pages 4946 - 4955, XP055034028
OPPOSITION- HE, X et al., "LDL receptor-related proteins 5 and 6 in Wnt/p-catenin signaling:Arrows point the way", Development, (20040415), vol. 131, no. 8, pages 1663 - 1677, XP055298787
OPPOSITION- GONG, Y et al., "Wnt lsoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies", PLoS One, (20100913), vol. 5, no. 9, page e12682, XP055288481
OPPOSITION- LI, Y et al., "LRP5/6 in Wnt signaling and tumorigenesis", Future Oncol., (20051000), vol. 1, no. 5, pages 673 - 681, XP055298775
SEARCH- MAO BINGYU ET AL, "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, (20010101), vol. 411, no. 6835, ISSN 0028-0836, pages 321 - 325, XP002249369 [X] 29,31 * figures 1-5 * [I] 1-28,30,32-33
SEARCH- MAO BINGYU ET AL, "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, (20020606), vol. 417, no. 6889, doi:10.1038/NATURE756, ISSN 0028-0836, pages 664 - 667, XP002211812 [X] 29,31 * figures 1-5 * [I] 1-28,30,32-33
SEARCH[ ] - S. A. ETTENBERG ET AL, "Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20100831), vol. 107, no. 35, doi:10.1073/pnas.1007428107, ISSN 0027-8424, pages 15473 - 15478, XP055002447 [ ] * the whole document *
SEARCH[ ] - ERIC BOURHIS ET AL, "Reconstitution of a Frizzled8.Wnt3a.LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 285, no. 12, doi:10.1074/JBC.M109.092130, ISSN 0021-9258, (20100319), pages 9172 - 9179, (20100121), XP002646368 [ ] * the whole document *
SEARCH- LI LIN ET AL, "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 22 FEB 2002, (20020222), vol. 277, no. 8, ISSN 0021-9258, pages 5977 - 5981, XP002538337 [I] 1-3,9-28 * page 5978, column L, paragraph 4 * * page 5979, column L, paragraph 4 - column R, paragraph 1 * * figure 4 *

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