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Non-Diffusive Botulinum Toxin Causing Local Muscle Paralysis, And Purification Method Thereof - EP2578228

The patent EP2578228 was granted to Medexgen on Nov 15, 2017. The application was originally filed on May 13, 2011 under application number EP11789976A. The patent is currently recorded with a legal status of "Revoked".

EP2578228

MEDEXGEN
Application Number
EP11789976A
Filing Date
May 13, 2011
Status
Revoked
May 13, 2022
Grant Date
Nov 15, 2017
External Links
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WACHTERSHAUSER & HARTZ PATENTANWALTSPARTNERSCHAFT MBB BLODIGAug 14, 2018SCHIENER -

Patent Citations (11) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONKR20020000685
DESCRIPTIONKR20080016800
DESCRIPTIONUS7354740
DESCRIPTIONUS7452697
EXAMINATIONUS2005238664
INTERNATIONAL-SEARCH-REPORTKR20030060150
INTERNATIONAL-SEARCH-REPORTKR20050074806
INTERNATIONAL-SEARCH-REPORTKR20090091501
OPPOSITIONKR20050074806
OPPOSITIONWO2011152618
OTHERUS2005238664

Non-Patent Literature (NPL) Citations (31) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- H Sugiyama ET AL, "Improved procedure for crystallization of Clostridium botulinum type A toxic complexes", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (19770401), vol. 33, no. 4, ISSN 0099-2240, pages 963 - 966, XP055243277-
EXAMINATION- SCHANTZ E J ET AL, "PROPERTIES AND USE OF BOTULINUM TOXIN AND OTHER MICROBIAL NEUROTOXINS IN MEDICINE", MICROBIOLOGICAL REVIEWS, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, (19920301), vol. 56, no. 1, ISSN 0146-0749, pages 80 - 99, XP000569909-
EXAMINATION- WALKER T J ET AL, "Comparison and overview of currently available neurotoxins.", THE JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY, USA, (20140201), vol. 7, no. 2, ISSN 1941-2789, pages 31 - 39, XP055243263-
EXAMINATION- D Ranoux ET AL, "Respective potencies of Botox and Dysport: a double blind, randomised, crossover study in cervical dystonia", JOURNAL OF NEUROLOGY NEUROSURGERY & PSYCHIATRY., GB, (20020401), vol. 72, no. 4, doi:10.1136/jnnp.72.4.459, ISSN 0022-3050, pages 459 - 462, XP055243273
INTERNATIONAL-SEARCH-REPORT- CARL, J. ET AL., "Purification of Clostridium botulinum Type A Neurotoxin", METHODS IN MOLECULAR BIOLOGY: BACTERIAL TOXINS:METHODS AND PROTOCOLS, (2000), vol. 145, pages 27 - 39-
INTERNATIONAL-SEARCH-REPORT- GESSLER, F. ET AL., "Production and purification of Clostridium botulinum type C and D neurotoxin", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, (1999), vol. 24, pages 361 - 367, XP002343948-
OPPOSITION- DASGUPTA et al., "Purification of Clostridium Botulinum Type A Toxin", Biochim. Biophys. Acta, (19700000), vol. 214, pages 343 - 349, XP055516320-
OPPOSITION- DUFF et al., "Studies on Immunity to Toxins of Clostridium Botulinum. I. A simplified procedure for isolation of type A toxin", J. Bacteriol., (19570000), pages 42 - 47, XP055516306-
OPPOSITION- Experimental Report;-
OPPOSITION- GEHLING et al., "Evaluation of Volume of Intramuscular Injection into the Caudal Thigh Muscles of Female and Male BALB/c Mice (Mus musculus", Journal of the American Association for Laboratory Animal Science, (20180000), vol. 57, no. 1, pages 35 - 43, XP055516348-
OPPOSITION- "Ion Exchange Chromatography & Chromatofocussing - Principles and Methods", Amersham Biosciences 11-0004-21-
OPPOSITION- MALIZIO et al., "Methods in Molecular Biology", Bacterial Toxins: Methods and Protocols, Totowa NJ, (20000000), vol. 145, pages 27 - 39, XP000942377-
OPPOSITION- SCHANTZ et al., "Properties and Use of Botulinum Toxin and Other Microbial Neurotoxins in Medicine", Microbiological Reviews, (19920000), vol. 56, no. 1, pages 80 - 99, XP000569909-
OPPOSITION- "Sugii and Sakaguchi, Molecular Construction of Clostridium botulinum Type A Toxins", Infection and Immunit y, (19750000), vol. 12, no. 6, pages 1262 - 1270, XP055516352-
OPPOSITION- SUGIYAMA et al., "Improved Procedure for Crystallization of Clostridium botulinum Type A Toxic Complexes", Applied and Environmental Microbiology, (19770400), vol. 33, no. 4, pages 963 - 966, XP055243277-
OPPOSITION- EISELE et al., "Studies on the dissociation of botulinum neurotoxin type A complexes", Toxicon, (20110000), vol. 57, pages 555 - 565, XP028175511
OPPOSITION- STONE et al., "Characterization of diffusion and duration of action of a new botulinum toxin type A formulation", Toxicon, (20110000), vol. 58, pages 159 - 167, XP028239023
OPPOSITION- RANOUX et al., "Respective potencies of Botox and Dysport: a double blind, randomised, crossover study in cervical dystonia", J. Neurol. Neurosurg Psychiatry, (20020000), vol. 72, pages 459 - 462, XP055243273
OPPOSITION- FERNANDEZ-SALAS et al., "Botulinum neurotoxin serotype A specific cell - based potency assay replace the mouse bioassay", PLOS ONE, (20120000), vol. 7, no. 11, page e49516, XP055070996
OTHER- SCHANTZ, EDWARD J.; ERIC A. JOHNSON, "Properties and use of botulinum toxin and other microbial neurotoxins in medicine", Microbiological reviews, (19920000), vol. 56.1, pages 80 - 99, XP000569909-
OTHER- SUGIYAMA, H.; L. J. MOBERG; S. L. MESSER, "Improved procedure for crystallization of Clostridium botulinum type A toxic complexes", Applied and environmental microbiology, (19770000), vol. 33.4, pages 963 - 966, XP055243277-
OTHER- WALKER, T. J.; DAYAN, S. H., "Comparison and overview of currently available neurotoxins", The Journal of clinical and aesthetic dermatology, (20140000), vol. 7, no. 2, page 31, XP055243263-
OTHER- Ranoux D; Et Al, "Respective potencies of Botox and Dysport: a double blind, randomised, crossover study in cervical dystonia", Journal of Neurology, Neurosurgery & Psychiatry, vol. 72, no. 4, pages 459 - 462, XP055243273
SEARCH- ASHRAF AHMED S ET AL, "Factors Affecting Autocatalysis of Botulinum A Neurotoxin Light Chain*", JOURNAL OF PROTEIN CHEMISTRY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, (20041001), vol. 23, no. 7, ISSN 1573-4943, pages 445 - 451, XP019284362 [A] 1-3 * abstract *-
SEARCH- BRODSKY MATTHEW A ET AL, "Diffusion of botulinum toxins.", TREMOR AND OTHER HYPERKINETIC MOVEMENTS (NEW YORK, N.Y.) 2012, (2012), vol. 2, ISSN 2160-8288, XP002711135 [T] 1-3 * the whole document *-
SEARCH- JUAN RAMIREZ-CASTANEDA ET AL, "Diffusion, spread, and migration of botulinum toxin", MOVEMENT DISORDERS, (20130618), doi:10.1002/mds.25582, ISSN 0885-3185, pages n/a - n/a, XP055074742 [T] 1-3 * the whole document *
SEARCH- LI L ET AL, "High-Level Expression, Purification, and Characterization of Recombinant Type A Botulinum Neurotoxin Light Chain", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, (19991201), vol. 17, no. 3, doi:10.1006/PREP.1999.1138, ISSN 1046-5928, pages 339 - 344, XP004441580 [A] 1-3 * abstract * * page 340, column r, paragraph 2 *
SEARCH- MARTINA KERSCHER ET AL, "Comparison of the spread of three botulinum toxin type A preparations", ARCHIVES OF DERMATOLOGICAL RESEARCH ; FOUNDED IN 1869 AS ARCHIV FÜR DERMATOLOGIE UND SYPHILIS, SPRINGER, BERLIN, DE, (20111015), vol. 304, no. 2, doi:10.1007/S00403-011-1179-Z, ISSN 1432-069X, pages 155 - 161, XP035019369 [T] 1-3 * the whole document *
SEARCH- GILSDORF J ET AL, "Expression, purification, and characterization of Clostridium botulinum type B light chain", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 46, no. 2, doi:10.1016/J.PEP.2005.09.024, ISSN 1046-5928, (20060401), pages 256 - 267, (20060401), XP024908673 [A] 1-3 * abstract * * page 258, column l, paragraph 2 *
SEARCH- PICKETT ET AL, "Dysport<(>R): Pharmacological properties and factors that influence toxin action", TOXICON, ELMSFORD, NY, US, vol. 54, no. 5, doi:10.1016/J.TOXICON.2009.03.020, ISSN 0041-0101, (20091001), pages 683 - 689, (20090328), XP026498233 [A] 1-3 * abstract * * page 683, column l, paragraph last - page 686, column r; table 1 *
SEARCH- CLIFF SANDEEP H ET AL, "Different formulations of botulinum toxin type A have different migration characteristics: a double-blind, randomized study.", JOURNAL OF COSMETIC DERMATOLOGY MAR 2008, (200803), vol. 7, no. 1, ISSN 1473-2165, pages 50 - 54, XP002711134 [A] 1-3 * abstract * * page 51, column l, paragraph 1 - paragraph 2 *

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