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Non-Coding Immunomodulatory Dna Construct - EP2655623

The patent EP2655623 was granted to Gilead Sciences on Aug 30, 2023. The application was originally filed on Dec 23, 2011 under application number EP11805869A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2655623

GILEAD SCIENCES
Application Number
EP11805869A
Filing Date
Dec 23, 2011
Status
Patent Maintained As Amended
Jul 28, 2023
Grant Date
Aug 30, 2023
External Links
Slate, Register, Google Patents

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APTARION BIOTECHNov 22, 2017BOHMANNADMISSIBLE

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTDE10211558
INTERNATIONAL-SEARCH-REPORTEP2246433
INTERNATIONAL-SEARCH-REPORTEP2333091
INTERNATIONAL-SEARCH-REPORTUS2002095033
INTERNATIONAL-SEARCH-REPORTUS2008260820
OPPOSITIONDE10211558
OPPOSITIONEP1196178
OPPOSITIONEP2197488
OPPOSITIONUS2009169472
OPPOSITIONUS6251666
OPPOSITIONUS7879992
OPPOSITIONWO0226757
OPPOSITIONWO03057822
OPPOSITIONWO2006002038
OPPOSITIONWO2007047396
OPPOSITIONWO2012085291

Non-Patent Literature (NPL) Citations (51) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- A. D. MCNAUGHT et al., "Configuration (stereo chemical)", IUPAC. Compendium of Chemical Terminology Gold Book, Oxford, ISBN 0-9678550-9-8, (19970000), URL: http://goldbook.iupac.org-
OPPOSITION- A. D. MCNAUGHT et al., "Configuration (stereo chemical)", IUPAC. Compendium of Chemical Terminology Gold Book, Oxford, ISBN 0-9678550-9-8, (19970000), URL: http://goldbook.iupac.org, XP055440377-
OPPOSITION- A. D. MCNAUGHT et al., "Definition of ''Conformation'' in IUPAC . Compendium of Chemical Terminology", Gold Book, Oxford, ISBN 0-9678550-9-8, (19970000), URL: http://goldbook.iupac.org-
OPPOSITION- A. D. MCNAUGHT et al., "Definition of ''Conformation'' in IUPAC . Compendium of Chemical Terminology", Gold Book, Oxford, ISBN 0-9678550-9-8, (19970000), URL: http://goldbook.iupac.org, XP055440373-
OPPOSITION- Axel Vater et al"Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics", Drug Discovery Today, 2015,Volume 20, Number 1, pages 147-155-
OPPOSITION- Communication under R. 71(3) EPC of November 21,2016, together with the printing copy (“Druckexemplar") of the Opposed Patent-
OPPOSITION- Description of the Opposed Patent as originally filed-
OPPOSITION- DOI et al., "Structural characteristics of enantiomorphic DNA: crystal analysis of racemates of the d(CGCGCG) duplex", J. Am. Chem. Soc., (19931100), vol. 115, pages 10432 - 10433-
OPPOSITION- Experimental report-
OPPOSITION- GARBESI et al., "L-DNAs as potential antimessenger oligonucleotides: a reassessment", Nucleic Acids Res., (19930911), vol. 21, no. 18, pages 4159 - 4165-
OPPOSITION- GARBESI et al., "L-DNAs as potential antimessenger oligonucleotides: a reassessment", Nucleic Acids Res., (19930911), vol. 21, no. 18, pages 4159 - 4165, XP055440399-
OPPOSITION- GOODCHILD J, "Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties", Bioconjugate Chemistry, (19900000), vol. 1, no. 3, pages 165 - 187-
OPPOSITION- HAUSER et al., "Utilising the left-helical conformation of L-DNA for analysing different marker types on a single universal microarray platform", Nucleic Acids Res., (20060000), vol. 34, no. 18, pages 5101 - 5111-
OPPOSITION- HAYASHI et al., "Application of L-DNA as a molecular tag", Nucleic Acids Symp. Series., (20050000), vol. 49, pages 261 - 262-
OPPOSITION- HAYASHI et al., "Detection ofL-DNA-Tagged PCR Products by Surface Plasmon Resonance Imaging", ChemBioChem., (20070122), vol. 8, no. 2, pages 169 - 171-
OPPOSITION- HAYASHI et al., "Genotyping by allele-specific l-DNA-tagged PCR", J. Biotechnol., (20080601), vol. 135, no. 2, pages 157 - 160-
OPPOSITION- KIM et al., "Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem", Nucleic Acid Res., (20070000), vol. 35, no. 21, pages 7279 - 7287-
OPPOSITION- KRIEG et al., "CpG MOTIFS IN BACTERIAL DNA TRIGGER DIRECT B-CELL ACTIVATION", Nature, (19950406), vol. 374, pages 546 - 549-
OPPOSITION- KRIEG et al., "Development of TLR9 agonists for cancer therapy", J. Clin. Invest, (20070000), vol. 117, no. 5, pages 1184 - 1194-
OPPOSITION- KRIEG et al., "Therapeutic potential of Toll-like receptor 9 activation", Nat. Rev. Drug Discov, (20060000), vol. 5, pages 471 - 484-
OPPOSITION- KRISHNAMACHARI Y et al., "Innovative strategies for co-delivering antigens and CpG oligonucleotides", Advanced Drug Delivery Reviews, (20090328), vol. 61, no. 3, pages 205 - 217-
OPPOSITION- LEVA et al., "GnRH binding RNA and DNA Spiegelmers: A novel approach toward GnRH antagonism", Chemistry & Biology, (20020300), vol. 9, pages 351 - 359-
OPPOSITION- M. J. J. Blommers et al. "Effects of the Introduction of L-Nucleotides into DNA. Solution Structure of the Heterochiral Duplex d(G-C-G-(L)T-G-C-G)-d(C-G-C A-C-G-C) Studied by NMR Spectroscopy",Biochemistry, 1994, 33, pages 7886 - 7896-
OPPOSITION- PURSCHKE et al., "A DNA Spiegelmer to staphylococcal enterotoxin B", Nucleic Acids Res., (20030615), vol. 31, no. 12, pages 3027 - 3032-
OPPOSITION- SING Y et al., "Recent developments in oligonucleotide conjugation", Chem Soc. Rev., (20100000), vol. 39, no. 6, pages 2054 - 2070-
OPPOSITION- SOSUNOV et al., "Stereochemical control of DNA biosynthesis", Nucleic Acids Res., (20000301), vol. 28, no. 5, pages 1170 - 117-
OPPOSITION- SOSUNOV et al., "Stereochemical control of DNA biosynthesis", Nucleic Acids Res., (20000301), vol. 28, no. 5, pages 1170 - 117, XP055440405-
OPPOSITION- TONDELLI et al., "Terminally L- modified oligonucleotides: pairing, stability and biological properties", Anti-Cancer Drugs, (19960200), vol. 7, pages 189 - 194-
OPPOSITION- TONDELLI et al., "Terminally L- modified oligonucleotides: pairing, stability and biological properties", Anti-Cancer Drugs, (19960200), vol. 7, pages 189 - 194, XP055440379-
OPPOSITION- URATA et al., "NMR study of a heterochiral DNA: stable Watson-Crick-type base-pairing between the enantiomeric residues", J. Am. Chem. Soc., (19930000), vol. 115, pages 9852 - 9853-
OPPOSITION- Urata et al., ..Synthesis and properties of mirror-image DNA“, 1992,Nucleic Acids Research. Vol. 20. No. 13. po. 3325 - 3332-
OPPOSITION- Wikibooks entry "Structural Biochemistry / Organic Chemistry, Carbohydrates; obtained on April 30, 2018 (https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Carbohydrates)-
OPPOSITION- WILLIAMS et al., "Bioactive and nuclease-resistant L-DNA ligand of vasopressin", PNAS, (19970000), vol. 94, no. 21, pages 11285 - 11290-
OPPOSITION- WLOTZKA et al., "In vivo Properties of an Anti-GnRH Spiegelmer: An Example of an Oligonucleotide-Based Therapeutic Substance Class", PNAS, (20020625), vol. 99, no. 13, pages 8898 - 8902-
OPPOSITION- HAYASHI et al., "Detection ofL-DNA-Tagged PCR Products by Surface Plasmon Resonance Imaging", ChemBioChem., (20070122), vol. 8, no. 2, pages 169 - 171, XP055016726
OPPOSITION- KRISHNAMACHARI Y et al., "Innovative strategies for co-delivering antigens and CpG oligonucleotides", Advanced Drug Delivery Reviews, (20090328), vol. 61, no. 3, pages 205 - 217, XP025972625
OPPOSITION- HAYASHI et al., "Genotyping by allele-specific l-DNA-tagged PCR", J. Biotechnol., (20080601), vol. 135, no. 2, pages 157 - 160, XP022678777
OPPOSITION- LEVA et al., "GnRH binding RNA and DNA Spiegelmers: A novel approach toward GnRH antagonism", Chemistry & Biology, (20020300), vol. 9, pages 351 - 359, XP002221140
OPPOSITION- GOODCHILD J, "Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties", Bioconjugate Chemistry, (19900000), vol. 1, no. 3, pages 165 - 187, XP000174627
OPPOSITION- URATA et al., "NMR study of a heterochiral DNA: stable Watson-Crick-type base-pairing between the enantiomeric residues", J. Am. Chem. Soc., (19930000), vol. 115, pages 9852 - 9853, XP002052970
OPPOSITION- DOI et al., "Structural characteristics of enantiomorphic DNA: crystal analysis of racemates of the d(CGCGCG) duplex", J. Am. Chem. Soc., (19931100), vol. 115, pages 10432 - 10433, XP055440417
OPPOSITION- KRIEG et al., "CpG MOTIFS IN BACTERIAL DNA TRIGGER DIRECT B-CELL ACTIVATION", Nature, (19950406), vol. 374, pages 546 - 549, XP000197060
OPPOSITION- KRIEG et al., "Therapeutic potential of Toll-like receptor 9 activation", Nat. Rev. Drug Discov, (20060000), vol. 5, pages 471 - 484, XP008109144
OPPOSITION- SING Y et al., "Recent developments in oligonucleotide conjugation", Chem Soc. Rev., (20100000), vol. 39, no. 6, pages 2054 - 2070, XP055155493
OPPOSITION- WLOTZKA et al., "In vivo Properties of an Anti-GnRH Spiegelmer: An Example of an Oligonucleotide-Based Therapeutic Substance Class", PNAS, (20020625), vol. 99, no. 13, pages 8898 - 8902, XP055188935
OPPOSITION- WILLIAMS et al., "Bioactive and nuclease-resistant L-DNA ligand of vasopressin", PNAS, (19970000), vol. 94, no. 21, pages 11285 - 11290, XP002185340
OPPOSITION- PURSCHKE et al., "A DNA Spiegelmer to staphylococcal enterotoxin B", Nucleic Acids Res., (20030615), vol. 31, no. 12, pages 3027 - 3032, XP055030769
OPPOSITION- HAUSER et al., "Utilising the left-helical conformation of L-DNA for analysing different marker types on a single universal microarray platform", Nucleic Acids Res., (20060000), vol. 34, no. 18, pages 5101 - 5111, XP002667723
OPPOSITION- KIM et al., "Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem", Nucleic Acid Res., (20070000), vol. 35, no. 21, pages 7279 - 7287, XP007920248
OPPOSITION- HAYASHI et al., "Application of L-DNA as a molecular tag", Nucleic Acids Symp. Series., (20050000), vol. 49, pages 261 - 262, XP002667724
OPPOSITION- KRIEG et al., "Development of TLR9 agonists for cancer therapy", J. Clin. Invest, (20070000), vol. 117, no. 5, pages 1184 - 1194, XP009155276

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