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The patent EP2687223 was granted to Mayo Foundation FOR Medical Education And Research on Nov 20, 2024. The application was filed on May 30, 2007 under application number EP13174869A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".
Methods and materials for detecting and treating frontotemporal dementia (FTD) through progranulin (PGRN) gene analysis and therapy. The methods involve identifying mutations in the PGRN gene that are associated with FTD, and using nucleic acid encoding a PGRN polypeptide to treat the disease. The therapy can involve administering a PGRN polypeptide or nucleic acid to increase PGRN levels in the brain, thereby slowing or halting disease progression.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| JAMES POOLE | Apr 12, 2018 | CARPMAELS & RANSFORD | ADMISSIBLE |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | US5508167 |
| DESCRIPTION | US5877399 |
| DESCRIPTION | US5976872 |
| DESCRIPTION | US6066726 |
| DESCRIPTION | WO2004047871 |
| DESCRIPTION | WO9957318 |
| OTHER | EP3009143 |
| OTHER | WO2008019187 |
| SEARCH | US2002001586 |
| SEARCH | US2004131618 |
| SEARCH | US2005069881 |
| SEARCH | US2005071088 |
| SEARCH | US2005074497 |
| SEARCH | US2005123962 |
| SEARCH | WO2004078782 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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