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Combinations Comprising Brexpiprazole Or A Salt Thereof And A Second Drug For Use In The Treatment Of A Cns Disorder - EP2694043

The patent EP2694043 was granted to Otsuka Pharmaceutical on Nov 1, 2017. The application was originally filed on Apr 4, 2012 under application number EP12719460A. The patent is currently recorded with a legal status of "Revoked".

EP2694043

OTSUKA PHARMACEUTICAL
Application Number
EP12719460A
Filing Date
Apr 4, 2012
Status
Revoked
Feb 21, 2020
Grant Date
Nov 1, 2017
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Oppositions (2)

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GENERICS UKAug 1, 2018ELKINGTON AND FIFEADMISSIBLE
ALFRED E TIEFENBACHERJul 31, 2018HAMM & WITTKOPPADMISSIBLE

Patent Citations (13) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONJP2008115172
DESCRIPTIONUS5178878
DESCRIPTIONUS6221392
DESCRIPTIONWO2006112464
INTERNATIONAL-SEARCH-REPORTJP2008115172
INTERNATIONAL-SEARCH-REPORTWO2004060374
INTERNATIONAL-SEARCH-REPORTWO2006112464
INTERNATIONAL-SEARCH-REPORTWO2009128537
OPPOSITIONEP1575590
OPPOSITIONJP2008115172
OPPOSITIONWO2004060374
OPPOSITIONWO2006112464
OPPOSITIONWO2009128537

Non-Patent Literature (NPL) Citations (20) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- FREY, B.N. ET AL., LIFE SCI., (2006), vol. 79, pages 281 - 286
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DESCRIPTION- JUN ISHIGOOKA; KEN INADA, JAPANESE JOURNAL OF CLINICAL PSYCOPHARMACOLOGY, (2001), vol. 4, pages 1653 - 1664
DESCRIPTION- MASAHARU KUBOTA ET AL., JAPANESE JOURNAL OF CLINICAL PSYCHIATRY, (2000), vol. 29, pages 891 - 899
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DESCRIPTION- MITSUKUNI MURASAKI, JAPANESE JOURNAL OF CLINICAL PSYCOPHARMACOLOGY, (1998), vol. 1, pages 5 - 22
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DESCRIPTION- SVENSSON, T. H., PROG. NEURO-PSYCHOPHARMACOL. BIOL. PSYCHIATRY, (2003), vol. 27, pages 1145 - 1158
DESCRIPTION- TETSURO KIKUCHI; TSUYOSHI HIROSE, BRAIN SCIENCE, (2004), vol. 25, pages 579 - 583
DESCRIPTION- WONG ET AL., NEUROPSYCHOPHARMACOLOGY, (1993), vol. 8, pages 337 - 344
DESCRIPTION- YAMANAKA K, "Effect of repeated dosing of sertraline on marble-burying behavior in mice", JPN J NEUROPSYCHOPHARMACOL., (1997), vol. 19, no. 6, pages 387 - 393
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EXAMINATION- C. A. OOSTERHOF ET AL, "Acute Effects of Brexpiprazole on Serotonin, Dopamine, and Norepinephrine Systems: An In Vivo Electrophysiologic Characterization", PHARMACOLOGICAL REVIEWS, US, (20141023), vol. 351, no. 3, doi:10.1124/jpet.114.218578, ISSN 0031-6997, pages 585 - 595, XP055247302
OPPOSITION- "Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder", Clinicaltrials.gov NCT00797966, (20110715), URL: https://clinicaltrials.gov/ct2/history/NCT00797966?V_4=View#StudyPageTop, (20180730), XP055509788
OPPOSITION- MAEDA et al., "Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin- dopamine activity modulator", J Pharmacol Exp Ther., (20140619), vol. 350, no. 3, pages 589 - 604, XP055217100

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