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The patent EP2694049 was granted to Grnenthal on Oct 31, 2018. The application was filed on Apr 3, 2012 under application number EP12718064A. The patent is currently recorded with a legal status of "Revoked".
Using tapentadol, a centrally acting analgesic with a dual mode of action consisting of µ-opioid receptor (MOR) agonism and norepinephrine (NE) reuptake inhibition, to prevent pain chronification. Tapentadol can be administered during the acute pain phase following an injury or surgery to prevent the conversion of acute pain into chronic pain. The mechanism involves reversal of nerve injury-induced hyperalgesia and allodynia in both cephalic and extracephalic territories. Tapentadol can also be used to treat pain in subjects suffering from chronification of pain.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| DEVELCO PHARMA | Jan 13, 2021 | GREINER | WITHDRAWN |
| GENERICS UK | Jul 31, 2019 | ELKINGTON AND FIFE | ADMISSIBLE |
| HEXAL | Jul 29, 2019 | KRAUS & LEDERER PARTGMBB | WITHDRAWN |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | EP0693475 |
| DESCRIPTION | EP1985292 |
| DESCRIPTION | US2005058706 |
| DESCRIPTION | US4612008 |
| DESCRIPTION | US4765989 |
| DESCRIPTION | US4783337 |
| INTERNATIONAL-SEARCH-REPORT | EP1985292 |
| INTERNATIONAL-SEARCH-REPORT | WO2007128412 |
| INTERNATIONAL-SEARCH-REPORT | WO2009067703 |
| OPPOSITION | EP1985292 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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CDS Clean up - amended applicant details
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Letter accompanying subsequently filed items
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Refund of fees
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Priority search results copy provided by EPO
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Priority search results copy provided by EPO
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Communication to designated inventor
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Request for entry into the European phase
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Written opinion
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Copy of the international search report
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Oct 11, 2012
Published international application - A1
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Abstract
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Apr 24, 2012
Claims
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Apr 24, 2012
Description
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