IP Verse

Methods Of Preventing And Removing Trisulfide Bonds - EP2707383

The patent EP2707383 was granted to Biogen Idec MA on Apr 18, 2018. The application was originally filed on May 11, 2012 under application number EP12723781A. The patent is currently recorded with a legal status of "Revoked".

EP2707383

BIOGEN IDEC MA
Application Number
EP12723781A
Filing Date
May 11, 2012
Status
Revoked
Mar 26, 2025
Grant Date
Apr 18, 2018
External Links
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Patent Summary

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Patent Family

Patent Oppositions (2)

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MAIWALDJan 18, 2019MAIWALDADMISSIBLE
F HOFFMANN LA ROCHEJan 4, 2019MEWBURN ELLISADMISSIBLE

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTWO0118175
INTERNATIONAL-SEARCH-REPORTWO2008141207
INTERNATIONAL-SEARCH-REPORTWO2011041721
OPPOSITIONUS7232894
OPPOSITIONWO0118175
OPPOSITIONWO02066603
OPPOSITIONWO2004031213
OPPOSITIONWO2006069940
OPPOSITIONWO2008141207
OPPOSITIONWO2011041721
OPPOSITIONWO2012040216
OPPOSITIONWO2012158551
OPPOSITIONWO9424157
OPPOSITIONWO9602570

Non-Patent Literature (NPL) Citations (19) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
INTERNATIONAL-SEARCH-REPORT- GU S ET AL, "Characterization of trisulfide modification in antibodies", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 400, no. 1, doi:10.1016/J.AB.2010.01.019, ISSN 0003-2697, (20100501), pages 89 - 98, (20100118), XP026940233 [X] 1-6,8-31 * the whole document * * page 97, paragraph 2 - paragraph 3 *
OPPOSITION- AONO et al., "Efficient on-column conversion of IgG"1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography", Journal of Chromatography A, (20100000), vol. 1217, no. 32, pages 5225 - 5232, XP027142425
OPPOSITION- "Methylglyoxal", Wikipedia, (20181027), XP055559358
OPPOSITION- PRISTATSKY et al., "Evidence for trisulfide bonds in a recombinant variant of a human IgG2 monoclonal antibody", Anal. Chem., (20090000), vol. 81, pages 6148 - 6155, XP002608219
OPPOSITION- KSHIRSAGAR et al., "Controlling trisulfide modification in recombinant monoclonal antibody produced in fed‐batch cell culture", Biotechnology and Bioengineering, vol. 109, no. 10, (20121000), pages 2523 - 2532, (20120409), XP055559320
OPPOSITION- BANKS et al., "Removal of cysteinylation from an unpaired sulfhydryl in the variable region of a recombinant monoclonal IgG1 antibody improves homogeneity, stability, and biological activity", JOURNAL OF PHARMACEUTICAL SCIENCES, (20080202), vol. 97, no. 2, pages 764 - 779, XP002545264
OPPOSITION- GU et al., "Characterization of trisulfide modification in antibodies", ANALYTICAL BIOCHEMISTRY, NEW YORK, (20100501), vol. 400, no. 1, pages 89 - 98, XP026940233
OPPOSITION- SINGH et al., "Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H 2 S Biogenesis via Alternative Trans-sulfuration Reactions", THE JOURNAL OF BIOLOGICAL CHEMISTRYVOL, (20090814), vol. 284, no. 33, pages 22457 - 22466, XP055559308
OPPOSITION- CHIKU et al., "H2S Biogenesis by Human Cystathionine y-Lyase Leads to the Novel Sulfur Metabolites anthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (20090424), vol. 284, no. 17, pages 11601 - 11612, XP055559301
OPPOSITION- ZHAO et al., "The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener", Embo J., (20010000), vol. 20, no. 21, pages 6008 - 6016, XP003005347
OPPOSITION- JESPERSEN et al., "Characterisation of a trisulphide derivative of biosynthetic human growth hormone produced in Escherichia coli", Eur. J. Biochem., (19940000), vol. 219, no. 1-2, pages 365 - 373, XP002372773
OPPOSITION- LIU et al., "Disulfide bond structures of IgG molecules", mAbs, vol. 4, no. 1, (20120000), pages 17 - 23, (20120101), XP055559327
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OTHER- NISHIUCH, YASU, "Cytotoxicity of cysteine in culture media.", In vitro, (19760901), vol. 12, no. 9, pages 635 - 638, XP055453044
OTHER- BABICH, H., "Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals", In Vitro Cell. Dev. Biol.- Animal, (20090130), vol. 45, no. 5-6, pages 226 - 233, XP055741183
OTHER- BELLO ROSARIO I., "NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells", BELLO ROSARIO I., Rosario I Bello et al, Isotope Labeling of Biomolecules - Applications, Elsevier, (20040101), vol. 382, pages 234 - 243, XP55741188
OTHER- O'DONNELL-TORMEY, JILL, "Secretion of pyruvate. An antioxidant defense of mammalian cells", The Journal of Experimental Medicine, (19870201), vol. 165, no. 2, doi:10.1084/jem.165.2.500, pages 500 - 514, XP002309326
OTHER- RASMUS WEDEL Nielsen et al, "Trisulfides in proteins", Antioxidants & Redox Signaling, (20110413), vol. 15, no. 1, doi:10.1089/ars.2010.3677, pages 67 - 75, XP002772577
OTHER- HALLIWELL, BARRY, "Cell culture, oxidative stress, and antioxidants: avoiding pitfalls.", Biomedical Journal, (20140500), vol. 37, no. 3, pages 99 - 105, XP055741191

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