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Adam6 Mice - EP2738258

The patent EP2738258 was granted to Regeneron Pharmaceuticals on Feb 1, 2023. The application was originally filed on Feb 24, 2012 under application number EP14154918A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2738258

REGENERON PHARMACEUTICALS
Application Number
EP14154918A
Filing Date
Feb 24, 2012
Status
Patent Maintained As Amended
Dec 30, 2022
Grant Date
Feb 1, 2023
External Links
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KYMABJun 25, 2020CMS CAMERON MCKENNA NABARRO OLSWANG -

Patent Citations (19) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2007280945
DESCRIPTIONUS6586251
DESCRIPTIONUS6596541
DESCRIPTIONUS7105348
DESCRIPTIONUS7294754
DESCRIPTIONUS7473557
DESCRIPTIONUS7576259
DESCRIPTIONUS7659442
EXAMINATIONWO2013061098
EXAMINATIONWO2013079953
OPPOSITIONWO02066630
OPPOSITIONWO2011004192
OPPOSITIONWO2011158009
OPPOSITIONWO2013079953
OTHEREP2793567
OTHERWO02066630
SEARCHUS2004018626
SEARCHWO2011004192
SEARCHWO2011158009

Non-Patent Literature (NPL) Citations (75) New

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OPPOSITION- L. E. Macdonald et al, "Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes", Proceedings of the National Academy of Sciences, (20140408), vol. 111, no. 14, doi:10.1073/pnas.1323896111, ISSN 00278424, pages 5147 - 5152-
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OPPOSITION- VORONINA et al., "Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct", Biology of Reproduction, (20190000), vol. 100, no. 3, doi:10.1093/biolre/ioy210, pages 686 - 696-
OPPOSITION- Hirohata, S. Seldin, M.F. Apte, S.S., "Chromosomal Assignment of Two ADAM Genes, TACE (ADAM17) and MLTNB (ADAM19), to Human Chromosomes 2 and 5, Respectively, and ofMltnbto Mouse Chromosome 11", GENOMICS, ACADEMIC PRESS, SAN DIEGO., US, US, (19981115), vol. 54, no. 1, doi:10.1006/geno.1998.5544, ISSN 0888-7543, pages 178 - 179, XP004448970
OPPOSITION- Keisuke Hoiruchi, Carl P. Blobel, "Studies from ADAM Knockout Mice", The ADAM Family of Proteases, Berlin/Heidelberg, Springer-Verlag, (20050101), vol. 4, pages 29 - 64, doi:10.1007/0-387-25151-0_2, ISBN 978-0-387-25149-3, XP055302416
OPPOSITION- Edwards, D.R. ; Handsley, M.M. ; Pennington, C.J., "The ADAM metalloproteinases", MOLECULAR ASPECTS OF MEDICINE., PERGAMON PRESS, OXFORD., GB, GB, (20091001), vol. 29, no. 5, doi:10.1016/j.mam.2008.08.001, ISSN 0098-2997, pages 258 - 289, XP025473840
OPPOSITION- Choi, I. Oh, J. Cho, B.-N. Ahnn, J. Jung, Y.-K. Han Kim, D. Cho, C., "Characterization and comparative genomic analysis of intronless Adams with testicular gene expression", GENOMICS, ACADEMIC PRESS, SAN DIEGO., US, US, (20040401), vol. 83, no. 4, doi:10.1016/j.ygeno.2003.10.001, ISSN 0888-7543, pages 636 - 646, XP004495995
OPPOSITION- Lee E-Chiang; Liang Qi; Ali Hanif; Bayliss Luke; Beasley Alastair; Bloomfield-Gerdes Tara; Bonoli Laura; Brown Richard; Campbell Jamie; Carpenter Adam; Chalk Sara; Davis Alison; England Nick; Fane-Dremucheva Alla; Franz Bettina; Germaschewski Volker; Holmes Helen; Holmes Steve; Kirby Ian; Kosmac Miha; Legent Anais; Lui Hui; Manin Anais; O'Leary Siobhan; Paterson Jemima; Sciarrillo Rocco; Speak Anneliese; Spensberger Dominik; Tuffery Laura; Waddell Nikole; Wang Wei; Wells Sophie; Wong Vivian; Wood Andrew; Owen Michael J; Friedrich Glenn A; Bradley Allan, "Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery", Nature Biotechnology, Gale Group Inc., New York, us, us, (20140316), vol. 32, no. 4, doi:10.1038/nbt.2825, ISSN 1087-0156, pages 356 - 363, XP037135270
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OPPOSITION- L. E. Macdonald et al, "Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20140408), vol. 111, no. 14, doi:10.1073/pnas.1323896111, ISSN 00278424, pages 5147 - 5152, XP055126064
OPPOSITION- Karen Featherstone, Andrew L. Wood, Adam J. Bowen and Anne E. Corcoran, "The Mouse Immunoglobulin Heavy Chain V-D Intergenic Sequence Contains Insulators That May Regulate Ordered V(D)J Recombination", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, (20100326), vol. 285, no. 13, doi:10.1074/JBC.M109.098251, ISSN 0021-9258, pages 9327 - 9338, XP002677428
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OPPOSITION- Cecil Han et al, "Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.", Biology of Reproduction, New York, NY [u.a.] : Academ. Press, US, US, (20090501), vol. 80, no. 5, doi:10.1095/BIOLREPROD.108.073700, ISSN 0006-3363, pages 1001 - 1008, XP002677427
OPPOSITION- Andrew Murphy, "VelocImmune: Immunoglobulin Variable Region Humanized Mice", Recombinant Antibodies for Immunotherapy, GB, Cambridge University Press, (20090101), pages 100 - 107, doi:http://dx.doi.org/10.1017/CBO9780511596773.011, ISBN 978-0-521-88732-8, XP008160379
SEARCH- EDWARDS D R ET AL, "The ADAM metalloproteinases", MOLECULAR ASPECTS OF MEDICINE, PERGAMON PRESS, OXFORD, GB, vol. 29, no. 5, doi:10.1016/J.MAM.2008.08.001, ISSN 0098-2997, (20091001), pages 258 - 289, (20080815), XP025473840 [A] 1-19 * the whole document *
SEARCH- CHOI I ET AL, "Characterization and comparative genomic analysis of intronless Adams with testicular gene expression", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, (20040401), vol. 83, no. 4, doi:10.1016/J.YGENO.2003.10.001, ISSN 0888-7543, pages 636 - 646, XP004495995 [A] 1-19 * the whole document *
SEARCH- LONBERG NILS, "Human antibodies from transgenic animals", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20050901), vol. 23, no. 9, doi:10.1038/NBT1135, ISSN 1087-0156, pages 1117 - 1125, XP002442149 [AD] 1-19 * figure 3 * * page 1119 - page 1120 *
SEARCH- FEATHERSTONE KAREN ET AL, "The Mouse Immunoglobulin Heavy Chain V-D Intergenic Sequence Contains Insulators That May Regulate Ordered V(D)J Recombination", JOURNAL OF BIOLOGICAL CHEMISTRY, (201003), vol. 285, no. 13, ISSN 0021-9258, pages 9327 - 9338, XP002677428 [A] 1-19 * page 9331 * * page 9332 * * page 9336 *
SEARCH- HAN CECIL ET AL, "Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.", BIOLOGY OF REPRODUCTION MAY 2009 LNKD- PUBMED:19129510, (200905), vol. 80, no. 5, ISSN 0006-3363, pages 1001 - 1008, XP002677427 [A] 1-19 * the whole document *

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