Method To Diagnose Pancreatic Cancer - EP2770328

The patent EP2770328 was granted to MED Life Discoveries LP on Dec 27, 2017. The application was originally filed on Oct 1, 2010 under application number EP14164872A. The patent is currently recorded with a legal status of "Revoked".

EP2770328

MED LIFE DISCOVERIES LP
Application Number
EP14164872A
Filing Date
Oct 1, 2010
Status
Revoked
Jul 10, 2020
Grant Date
Dec 27, 2017
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

METANOMICS HEALTHSep 27, 2018ALTMANN STOSSEL DICK PATENTANWALTE PARTG MBBWITHDRAWN

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONWO0157518
OPPOSITIONWO2009151967
OTHEREP2483697
OTHERWO2009061404
SEARCHWO2007062142

Non-Patent Literature (NPL) Citations (43) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BERNSTEIN, H.; C. BERNSTEIN; C. M. PAYNE; K. DVORAK, "Bile acids as endogenous etiologic agents in gastrointestinal cancer", WORLD J GASTROENTEROL, (2009), vol. 15, pages 3329 - 3340
DESCRIPTION- BILLICH, A.; T. BAUMRUKER, "Sphingolipid metabolizing enzymes as novel therapeutic targets", SUBCELL BIOCHEM, (2008), vol. 49, pages 487 - 522
DESCRIPTION- BOYLE, P.; J. FERLAY., "Cancer incidence and mortality in Europe", ANN ONCOL, (2004), vol. 16, pages 481 - 488
DESCRIPTION- CLARIA, J., "Regulation of cell proliferation and apoptosis by bioactive lipid mediators", RECENT PAT ANTICANCER DRUG DISCOV., (2006), vol. 1, pages 369 - 382
DESCRIPTION- DÄBRITZ, J.; R. PRESTON; J. HÄNFLER; H. OETTLE, "Follow-up study of K-ras mutations in the plasma of patients with pancreatic cancer: correlation with clinical features and carbohydrate antigen 19-9", PANCREAS, (2009), vol. 38, pages 534 - 541
DESCRIPTION- DYATLOVITSKAYA, E. V.; A. G. KANDYBA, "Role of biologically active sphingolipids in tumor growth", BIOCHEMISTRY (MOSC)., (2006), vol. 71, pages 10 - 17, XP019294685
DESCRIPTION- GEMMEL, C.; A. EICKHOFF; L. HELMSTÄDTER; J. F. RIEMANN, "Pancreatic cancer screening: state of the art", EXPERT REV GASTROENTEROL HEPATOL., (2009), vol. 3, pages 89 - 96
DESCRIPTION- KHAN, S. A.; I. J. COX; A. V. THILLAINAYAGAM; D. S. BANSI; H. C. THOMAS; S. D. TAYLOR-ROBINSON, "Proton and phosphorus-31 nuclear magnetic resonance spectroscopy of human bile in hepatopancreaticobiliary cancer", EUR J GASTROENTEROL HEPATOL, (2005), vol. 17, pages 733 - 738
DESCRIPTION- KLAPMAN, J.; M. P. MALAFA, "Early detection of pancreatic cancer: why, who, and how to screen", CANCER CONTROL., (2008), vol. 15, pages 280 - 287
DESCRIPTION- KOLB, A.; S. RIEDER; D. BORN; N. A. GIESE; T. GIESE; G. RUDOFSKY; J. WERNER; M. W. BIICHLER; H. FRIESS; I. ESPOSITO, "Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus", CANCER BIOL THER, (2009), vol. 8
DESCRIPTION- KOOPMANN, J.; C. N. WHITE ROSENZWEIG; Z. ZHANG; M. I. CANTO; D. A. BROWN; M. HUNTER; C. YEO; D. W. CHAN; S. N. BREIT; M. GOGGINS, "Serum Markers in Patients with Resectable Pancreatic Adenocarcinoma: Macrophage Inhibitory Cytokine 1 versus CA19-9", CLINICAL CANCER RESEARCH, (2006), vol. 12, pages 442 - 446
DESCRIPTION- MODRAK, D. E.; E. LEON; D. M. GOLDENBERG; D. V. GOLD, "Ceramide regulates gemcitabine-induced senescence and apoptosis in human pancreatic cancer cell lines", MOL CANCER RES, (2009), vol. 7, pages 890 - 896
DESCRIPTION- PERACAULA, R.; S. BARRABES; A. SARRATS; P. M. RUDD; R. DE LLORENS, "Altered glycosylation in tumours focused to cancer diagnosis", DIS MARKERS, (2008), vol. 25, pages 207 - 218
DESCRIPTION- ROSTY, C.; L. CHRISTA; S. KUZDZAL; B. W.M., M. L. ZAHURAK; F. CARNOT; D. W. CHAN; M. CANTO; K. D. LILLEMOE; J. L. CAMERON; C. J. Y, "Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology", CANCER RESEARCH, (2002), vol. 62, pages 1868 - 1875, XP001179968
DESCRIPTION- SZAFRANSKA, A. E.; T. S. DAVISON; J. JOHN; T. CANNON; B. SIPOS; A. MAGHNOUJ; E. LABOURIER; S. A. HAHN, "MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma", ONCOGENE, (2007), vol. 26, pages 4442 - 4452
DESCRIPTION- WARDEN, C. H.; A. DALUISKI; X. BU; D. A. PURCELL-HUYNH; C. DE MEESTER; B. H. SHIEH; D. L. PUPPIONE; R. M. GRAY; G. M. REAVEN; Y. D, "Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1993), vol. 90, pages 10886 - 10890
DESCRIPTION- ZUIJDGEEST-VAN LEEUWEN, S. D.; M. S. VAN DER HEIJDEN; T. RIETVELD; J. W. VAN DEN BERG; H. W. TILANUS; J. A. BURGERS; J. H. WILSON;, "Fatty acid composition of plasma lipids in patients with pancreatic, lung and oesophageal cancer in comparison with healthy subjects", CLINICAL NUTRITION, (2002), vol. 21, pages 225 - 230
DESCRIPTION- BLOOMSTON, M.; W. L. FRANKEL; F. PETROCCA; S. VOLINIA; H. ALDER; J. P. HAGAN; C. G. LIU; D. BHATT; C. TACCIOLI; C. M. CROCE, "MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis", JAMA, (2007), vol. 297, doi:doi:10.1001/jama.297.17.1901, pages 1901 - 1908, XP055048225
DESCRIPTION- LEE, E. J.; Y. GUSEV; J. JIANG; G. J. NUOVO; M. R. LERNER; W. L. FRANKEL; D. L. MORGAN; R. G. POSTIER; D. J. BRACKETT; T. D. SCHMI, "Expression profiling identifies microRNA signature in pancreatic cancer", INT J CANCER, (2007), vol. 120, doi:doi:10.1002/IJC.22394, pages 1046 - 1054, XP002569593
DESCRIPTION- HELMSTAEDTER, L.; J. F. RIEMANN, "Pancreatic cancer--EUS and early diagnosis", LANGENBECKS ARCH SURG, (2008), vol. 393, doi:doi:10.1007/s00423-007-0275-1, pages 923 - 927, XP019657904
DESCRIPTION- RAMIREZ DE MOLINA, A.; D. GALLEGO-ORTEGA; J. SARMENTERO-ESTRADA; D. LAGARES; T. GOMEZ DEL PULGAR; E. BANDRÉS; J. GARCIA-FONCILLAS, "Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, (2008), vol. 40, doi:doi:10.1016/j.biocel.2008.01.013, pages 1753 - 1763, XP022734731
DESCRIPTION- GARCEA, G.; C. P. NEAL; C. J. PATTENDEN; W. P. STEWARD; D. P. BERRY, "Molecular prognostic markers in pancreatic cancer: a systematic review", EUR J CANCER, (2005), vol. 41, doi:doi:10.1016/j.ejca.2005.04.044, pages 2213 - 2236, XP025298123
DESCRIPTION- TROUGAKOS, I. P.; E. S. GONOS, "Clusterin/apolipoprotein J in human aging and cancer", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, (2002), vol. 34, doi:doi:10.1016/S1357-2725(02)00041-9, pages 1430 - 1448, XP002348133
DESCRIPTION- AHARONI, A.; C. H. RIC DE VOS; H. A. VERHOEVEN; C. A. MALIEPAARD; G. KRUPPA; R. BINO; D. B. GOODENOWE, "Nontargeted metabolome analysis by use of Fourier Transform Ion Cyclotron Mass Spectrometry", OMICS, (2002), vol. 6, doi:doi:10.1089/15362310260256882, pages 217 - 234, XP009037503
DESCRIPTION- BARRABÉS, S.; L. PAGES-PENS; C. M. RADCLIFFE; G. TABARÉS; E. FORT; L. ROYLE; D. J. HARVEY; M. MOENNER; R. A. DWEK; P. M. RUDD, "Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer", GLYCOBIOLOGY, (2008), vol. 17, doi:doi:10.1093/GLYCOB/CWM002, pages 388 - 400, XP002638711
DESCRIPTION- EHMANN, M.; K. FELIX; D. HARTMANN; M. SCHNOLZER; M. NEES; S. VORDERWÜLBECKE; R. BOGUMIL; M. W. BÜCHLER; H. FRIESS, "Identification of potential markers for the detection of pancreatic cancer through comparative serum protein expression profiling", PANCREAS, (2007), vol. 34, doi:doi:10.1097/01.mpa.0000250128.57026.b2, pages 205 - 214, XP008183746
DESCRIPTION- GRAY, G. R.; D. HEATH, "A global reorganization of the metabolome in Arabidopsis during cold acclimation is revealed by metabolic fingerprinting", PHYSIOLOGIA PLANTARUM, (2005), vol. 124, doi:doi:10.1111/j.1399-3054.2005.00507.x, pages 236 - 248, XP002475400
DESCRIPTION- MODRAK, D. E.; D. V. GOLD; D. M. GOLDENBERG, "Sphingolipid targets in cancer therapy", MOL CANCER THER, (2006), vol. 5, doi:doi:10.1158/1535-7163.MCT-05-0420, pages 200 - 208, XP002378561
DESCRIPTION- TIAN, M.; Y. Z. CUI; G. H. SONG; M. J. ZONG; X. Y. ZHOU; Y. R. CHEN; J. X. HAN, "Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients", BMC CANCER, (2008), vol. 8, doi:doi:10.1186/1471-2407-8-241, page 241, XP021042880
DESCRIPTION- GOODENOWE, D. B.; L. L. COOK; J. LIU; Y. LU; D, A. JAYASINGHE; P. W. AHIAHONU; D. HEATH; Y. YAMAZAKI; J. FLAX; K. F. KRENITSKY, "Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia", JOURNAL OF LIPID RESEARCH, (2007), vol. 48, doi:doi:10.1194/JLR.P700023-JLR200, pages 2485 - 2498, XP008122068
DESCRIPTION- JANARDHAN, S.; P. SRIVANI; G. N. SASTRY, "Choline kinase: an important target for cancer", CURR MED CHEM, (2006), vol. 13, doi:doi:10.2174/092986706776360923, pages 1169 - 1186, XP002517956
OPPOSITION- anonymous, "List of Isobaric and Isomeric Lipid Species", BIOCRATES life Sciences AG, Innsbruck, (20170206), pages 1 - 27, URL: https://www.biocrates.com/images/List-of-Isobaric-and-Isomeric-Lipid-Species.pdf, XP055523596
OPPOSITION- "Chapter 4", BERNARD ROSNER, Fundamentals of Biostatistics. 7th Ed, Duxbury Press Hardcover, (20180819), pages 83 - 87, ISBN 978-0-538-73349-6, XP055523664
OPPOSITION- "Chapter 7.7", BERNARD ROSNER, Fundamentals of Biostatistics. 7th Ed, Duxbury Press Hardcover, (20100819), page 235, XP055523667
OPPOSITION- "Chapter 7", BERNARD ROSNER, Fundamentals of Biostatistics. 7th Ed, Duxbury Press Hardcover, (20100819), pages 207 - 215, ISBN 9780538733496, XP055523604
OPPOSITION- QUEHENBERGER et al., "Lipidomics reveals a remarkable diversity of lipids in human plasma", J Lipid Res., (20101100), vol. 51, no. 11, pages 3299 - 305, XP055068776
OPPOSITION- DI GANGI et al., "Metabolomic profile in pancreatic cancer patients: a con- sensus-based approach to identify highly discriminating metabolites", Oncotarget, (20160202), vol. 7, no. 5, pages 5815 - 5829, XP055523431
SEARCH- D.E. MISEK ET AL., "Early Detection and Biomarkers in Pancreatic cancer", JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, (2007), vol. 5, no. 10, pages 1034 - 1041, XP055053031 [A] 1 * page 1034, column 1, line 1 - page 1035, column 1, line 10 * * page 1037, column 1, paragraph 4 - page 1040, column 1, paragraph 1 *
SEARCH- HSU F F ET AL, "Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of glycerophospholipids: Mechanisms of fragmentation and structural characterization", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, (20090915), vol. 877, no. 26, pages 2673 - 2695, XP026422743 [A] 1 * page 2678, second column, point 4.2.1.2. *
SEARCH- M SUGIMOTO ET AL, "Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles", METABOLOMICS, (20090910), vol. 6, no. 1, pages 78 - 95, XP019796459 [A] 1 * table 2 *
SEARCH- SHIRO URAYAMA ET AL, "Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, (20100315), vol. 24, no. 5, pages 613 - 620, XP055008619 [XP] 1,4,6-11 * table 2 *
SEARCH- RICHARD D BEGER ET AL, "Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma", METABOLOMICS, (2006), vol. 2, no. 3, pages 125 - 134, XP019438369 [A] 1,4-11 * paragraph [02.5]; figures 3,4 *
SEARCH- FANG FANG ET AL, "Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high-resolution magic angle spinning 1 H nuclear magnetic resonance and principal components analysis", CANCER SCIENCE, (2007), vol. 98, no. 11, pages 1678 - 1682, XP055153245 [A] 1 * the whole document *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents