A Method Of Producing An Antibody Comprising A Human Variable Region And A Rodent Constant Region. - EP2786657

The patent EP2786657 was granted to Regeneron Pharmaceuticals on Feb 7, 2018. The application was originally filed on Feb 15, 2002 under application number EP14172437A. The patent is currently recorded with a legal status of "Revoked".

EP2786657

REGENERON PHARMACEUTICALS
Application Number
EP14172437A
Filing Date
Feb 15, 2002
Status
Revoked
Nov 10, 2023
Grant Date
Feb 7, 2018
External Links
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Patent Summary

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Patent Oppositions (6)

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ICELYNov 7, 2018APPLEYARD LEESADMISSIBLE
MERUSNov 7, 2018LAHRTZWITHDRAWN
NOVO NORDISKNov 6, 2018POTTER CLARKSONWITHDRAWN
JAMES POOLEOct 31, 2018CARPMAELS & RANSFORDADMISSIBLE
LIGAND PHARMACEUTICALS INCORPORATEDOct 31, 2018D YOUNGADMISSIBLE
KYMABMar 21, 2018CMS CAMERON MCKENNA NABARRO OLSWANGWITHDRAWN

Patent Citations (25) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS5350689
DESCRIPTIONUS5436149
DESCRIPTIONUS5508189
DESCRIPTIONUS5770429
DESCRIPTIONUS5789215
OPPOSITIONEP1360287
OPPOSITIONEP2262163
OPPOSITIONEP2263163
OPPOSITIONEP2264163
OPPOSITIONEP2787075
OPPOSITIONUS5939598
OPPOSITIONUS6114598
OPPOSITIONWO02066630
OPPOSITIONWO9100906
OPPOSITIONWO9312227
OPPOSITIONWO9824893
OPPOSITIONWO9945962
OTHEREP1360287
OTHEREP2517556
OTHEREP3085780
OTHERWO02066630
OTHERWO9945962
SEARCHUS5770429
SEARCHUS5939598
SEARCHWO9713852

Non-Patent Literature (NPL) Citations (124) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ABREMSKI; HOESS, J BIOL CHEM, (1984), vol. 259, pages 1509 - 14-
DESCRIPTION- ADRA ET AL., GENE, (1987), vol. 60, pages 65 - 74-
DESCRIPTION- ANAL BIOCHEM, (20010315), vol. 290, no. 2, pages 260 - 71-
DESCRIPTION- ANDREWS ET AL., CELL, (1985), vol. 40, pages 795 - 803-
DESCRIPTION- ANGRAND ET AL., NUCLEIC ACIDS RES, (1999), vol. 27, page E16-
DESCRIPTION- AUSUBEL ET AL.,, Current Protocols in Molecular Biology, GREENE PUBL. ASSOC., WILEY INTERSCIENCE-
DESCRIPTION- BAGUISI ET AL., NAT BIOTECHNOL, (1999), vol. 17, pages 456 - 61-
DESCRIPTION- BECKER; GOLD, PROC NATL ACAD SCI USA, (1978), vol. 75, pages 4199 - 203-
DESCRIPTION- BECK ET AL., GENE, (1982), vol. 19, pages 327 - 36-
DESCRIPTION- BERNARD ET AL., EXP CELL RES, (1985), vol. 158, pages 237 - 43-
DESCRIPTION- BETHKE,B.; SAUER,B., NUCLEIC ACIDS RES., (1997), vol. 25, pages 2828 - 2834-
DESCRIPTION- BOER ET AL., BIOCHEM GENET, (1990), vol. 28, pages 299 - 308-
DESCRIPTION- CAMPBELL ET AL., NATURE, (1996), vol. 380, pages 64 - 6-
DESCRIPTION- CANTOR ET AL., ANNU REV BIOPHYS BIOPHYS CHEM, (1988), vol. 17, pages 287 - 304-
DESCRIPTION- CHENG ET AL., NATURE, (1994), vol. 369, pages 684 - 5-
DESCRIPTION- CLARK ET AL., COLD SPRING HARB SYMP QUANT BIOL, (1984), vol. 49, pages 453 - 62-
DESCRIPTION- COX, PROC NATL ACAD SCI USA, (1983), vol. 80, pages 4223 - 7-
DESCRIPTION- DECHIARA ET AL., NATURE, (1990), vol. 345, pages 78 - 80-
DESCRIPTION- DENG; CAPECCHI, MOL CELL BIOL, (1992), vol. 12, pages 3365 - 71-
DESCRIPTION- DHAR ET AL., PROC NATL ACAD SCI U S A, (1974), vol. 71, pages 371 - 5-
DESCRIPTION- DHAR ET AL., PROC NATL ACAD SCI USA, (1974), vol. 71, pages 371 - 5-
DESCRIPTION- DOETSCHMAN ET AL., NATURE, (1987), vol. 330, pages 576 - 578-
DESCRIPTION- FOORD; ROSE, PCR METHODS APPL, (1994), vol. 3, pages 149 - 61-
DESCRIPTION- FOROZAN ET AL., TRENDS GENET, (1997), vol. 13, pages 405 - 9-
DESCRIPTION- FUJIEDA, S.; LIN, Y. Q.; SAXON, A.; ZHANG, K., J IMMUNOL, (1996), vol. 157, pages 3450 - 3459-
DESCRIPTION- GIORDANO; MCALLISTER, GENE, (1990), vol. 88, pages 285 - 8-
DESCRIPTION- H6RAULTY.; RASSOULZADEGAN, M.; CUZIN, F.; DUBOULE, D., NATURE GENETICS, (1998), vol. 20, pages 381 - 384-
DESCRIPTION- HAINES, B. B.; BRODEUR, P. H., EUR J IMMUNOL, (1998), vol. 28, pages 4228 - 4235-
DESCRIPTION- HALL ET AL., J BACTERIOL, (1993), vol. 175, pages 277 - 87-
DESCRIPTION- HALL; KOLODNER, PROC NATL ACAD SCI USA, (1994), vol. 91, pages 3205 - 9-
DESCRIPTION- HILL ET AL., GENOMICS, (2000), vol. 64, pages 111 - 3-
DESCRIPTION- HOESS, R.H.; WIERZBICKI,A.; ABREMSKI,K., NUCLEIC ACIDS RES., (1986), vol. 14, pages 2287 - 2300-
DESCRIPTION- HOULDSWORTH; CHAGANTI, AM J PATHOL, (1994), vol. 145, pages 1253 - 60-
DESCRIPTION- IZUMI ET AL., EXP CELL RES, (1991), vol. 197, pages 29 - 3-
DESCRIPTION- JOYNER, THE PRACTICAL APPROACH SERIES, (1999), vol. 293-
DESCRIPTION- KAFATOS FC; JONES CW; EFSTRATIADIS A, NUCLEIC ACIDS RES, (1979), vol. 7, no. 6, pages 1541 - 52-
DESCRIPTION- KOHLER; MILSTEIN, EUR. J. IMMUNOL., (1976), vol. 6, pages 511 - 519-
DESCRIPTION- KOLLER ET AL., PROC NATL ACAD SCI USA, (1989), vol. 86, pages 8927 - 8931-
DESCRIPTION- KOLODNER ET AL., MOL MICROBIOL, (1994), vol. 11, pages 23 - 30-
DESCRIPTION- KOVALL; MATTHEWS, SCIENCE, (1997), vol. 277, pages 1824 - 7-
DESCRIPTION- KU M ET AL., SCIENCE, (1991), vol. 254, pages 07 - 10-
DESCRIPTION- KUROIWA ET AL., NAT BIOTECHNOL, (2000), vol. 18, pages 1086 - 1090-
DESCRIPTION- KUSANO ET AL., GENE, (1994), vol. 138, pages 17 - 25-
DESCRIPTION- LAAN ET AL., HUM GENET, (1995), vol. 96, pages 275 - 80-
DESCRIPTION- LIE; PETROPOULOS, CURR OPIN BIOTECHNOL, (1998), vol. 9, pages 43 - 8-
DESCRIPTION- LIZARDI ET AL., NAT GENET, (1998), vol. 19, pages 225 - 32-
DESCRIPTION- MEYER-LEON ET AL., COLD SPRING HARB SYMP QUANT BIOL, (1984), vol. 49, pages 797 - 804-
DESCRIPTION- MURPHY, J BACTERIOL, (1991), vol. 173, pages 5808 - 21-
DESCRIPTION- MUYRERS ET AL., NUCLEIC ACIDS RES, (1999), vol. 27, pages 1555 - 7-
DESCRIPTION- MYERS; STAHL, ANNU REV GENET, (1994), vol. 28, pages 49 - 70-
DESCRIPTION- NARAYANAN ET AL., GENE THER, (1999), vol. 6, pages 442 - 7-
DESCRIPTION- NOIROT; KOLODNER, J BIOL CHEM, (1998), vol. 273, pages 12274 - 80-
DESCRIPTION- ONG, J.; STEVENS, S.; ROEDER, R. G.; ECKHARDT, L. A., J IMMUNOL, (1998), vol. 160, pages 4896 - 4903-
DESCRIPTION- PAIN ET AL., DEVELOPMENT, (1996), vol. 122, pages 2339 - 48-
DESCRIPTION- PAN, Q.; PETIT-FRERE, C.; STAVNEZER, J.; HAMMARSTROM, L., EUR J IMMUNOL, (2000), vol. 30, pages 1019 - 1029-
DESCRIPTION- PONCE; MICOL, NUCLEIC ACIDS RES, (1992), vol. 20, page 623-
DESCRIPTION- POTEETE ET AL., J BACTERIOL, (1988), vol. 170, pages 2012 - 21-
DESCRIPTION- RACKWITZ ET AL., GENE, (1985), vol. 40, pages 259 - 66-
DESCRIPTION- REDDY ET AL., SCIENCE, (1978), vol. 200, pages 494 - 502-
DESCRIPTION- RIDEOUT ET AL., NAT GENET, (2000), vol. 24, pages 109 - 10-
DESCRIPTION- ROBERTSON, PRACTICAL APPROACH SERIES, (1987), vol. 254-
DESCRIPTION- RONAI, D.; BERRU, M.; SHULMAN, M., J. MOL CELL BIOL, (1999), vol. 19, pages 7031 - 7040-
DESCRIPTION- SAMBROOK, J.; E. F. FRITSCH; T. MANIATIS ET AL., Molecular Cloning: A Laboratory Manual, Second Edition,, (1989), vol. 1, 2, 3-
DESCRIPTION- SAMBROOK, J.; E. F. FRITSCH; T. MANIATIS, Molecular Cloning: A Laboratory Manual, Second Edition,, (1989), vol. 1, 2, 3-
DESCRIPTION- SANTERRE ET AL., GENE, (1984), vol. 30, pages 147 - 56-
DESCRIPTION- SANTERRE ET AL., GENE, (1984), vol. 30, pages 47 - 6-
DESCRIPTION- SCHOONJANS ET AL., MOL REPROD DEV, (1996), vol. 45, pages 439 - 43-
DESCRIPTION- SCHWARTZBERG ET AL., SCIENCE, (1989), vol. 246, pages 799 - 803-
DESCRIPTION- SCHWARTZ; CANTOR, CELL, (1984), vol. 37, pages 67 - 75-
DESCRIPTION- SHIZUYA ET AL., PROC NATL ACAD SCI USA, (1992), vol. 89, pages 8794 - 7-
DESCRIPTION- SMITHIES ET AL., NATURE, (1985), vol. 317, pages 230 - 234-
DESCRIPTION- SOUTHERN, J. MOL. BIOL., (1975), vol. 98, page 503-
DESCRIPTION- SUBRAMANIAN ET AL., PROG NUCLEIC ACID RES MOL BIOL, (1976), vol. 19, pages 157 - 64-
DESCRIPTION- TAN ET AL., CHEMISTRY, (2000), vol. 6, pages 1107 - 11-
DESCRIPTION- THIMMAPPAYA ET AL., J BIOL CHEM, (1978), vol. 253, pages 1613 - 8-
DESCRIPTION- THOMAS ET AL., CELL, (1987), vol. 51, pages 503 - 512-
DESCRIPTION- THOMAS ET AL., NATURE, (1990), vol. 346, pages 847 - 850-
DESCRIPTION- THOMPSON; GRAY, J CELL BIOCHEM SUPPL, (1993), pages 139 - 43-
DESCRIPTION- THOMSON ET AL., CELL, (1989), vol. 5, pages 13 - 21-
DESCRIPTION- THRESHER ET AL., J MOL BIOL, (1995), vol. 254, pages 364 - 71-
DESCRIPTION- TILLETT; NEILAN, BIOTECHNIQUES, (1998), vol. 24, pages 568 - 70,572-
DESCRIPTION- TOMIZUKA, K.; SHINOHARA, T.; YOSHIDA, H.; UEJIMA, H.; OHGUMA, A.; TANAKA, S.; SATO, K; OSHIMURA, M.; ISHIDA, I., PROC NATL ACAD SCI (USA, (2000), vol. 97, pages 722 - 727-
DESCRIPTION- WAKAYAMA ET AL., NAT GENET, (2000), vol. 24, pages 108 - 9-
DESCRIPTION- WAKAYAMA ET AL., NATURE, (1998), vol. 394, pages 369 - 74-
DESCRIPTION- WAKAYAMA ET AL., PROC NATL ACAD SCI U S A, (1999), vol. 96, pages 14984 - 9-
DESCRIPTION- WANG ET AL., MECH DEV, (1997), vol. 62, pages 137 - 45-
DESCRIPTION- WILLERS, J.; KOLB, C.; WEILER, E., IRNMUNOBIOLOGY, (2000), vol. 200, pages 150 - 164-
DESCRIPTION- WILMUT ET AL., NATURE, (1997), vol. 385, pages 810 - 3-
DESCRIPTION- WILMUT ET AL., REPROD FERTIL DEV, (1998), vol. 10, pages 639 - 43-
DESCRIPTION- WOOD ET AL., NATURE, (1993), vol. 365, pages 87 - 9-
DESCRIPTION- W WURST; A. GOSSLER; JOYNER, "Gene trap strategies in ES cells", THE PRACTICAL APPROACH SERIES, (1999), vol. 293-
DESCRIPTION- YANG ET AL., NAT BIOTECHNO, (1997), vol. 15, pages 859 - 65-
DESCRIPTION- YANG ET AL., NAT BIOTECHNOL, (1997), vol. 15, pages 859 - 65-
DESCRIPTION- YU ET AL., PROC NATL ACAD SCI U S A, (2000), vol. 97, pages 5978 - 83-
DESCRIPTION- ZHANG ET AL., NAT GENET, (1998), vol. 20, page 23-
DESCRIPTION- ZHANG ET AL., NAT GENET, (1998), vol. 20, pages 123 - 8-
OPPOSITION- Anonymous, "Difference between Mice and Rat - Difference Between", Difference btw, (20150504), URL: https://www.differencebtw.com/difference-between-mice-and-rat/, XP055528846-
OPPOSITION- Anonymous, "Mouse vs Rat", Orkin, (20180000), URL: https://www.orkin.com/rodents/mouse-control/facts/differences-between-rats-and-mice/, XP055528864-
OPPOSITION- Chang Tong; Ping Li; Nancy L Wu; Youzhen Yan; Qi-Long Ying, "Production of p53 gene knockout rats by homologous recombination in embryonic stem cells", HHS Public Access Author manuscript, (20110309), pages 1 - 13, XP055528818-
OPPOSITION- Jacobus Hendricks; et al.,, "Organisations of the variable region of the immunoglobulin heavy-chain gene locus of the rat", Immunoqenetics, (20100505), vol. 62, no. 7, pages 479 - 486, XP019841464-
OPPOSITION- PAIN B; ET AL, "Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple morphogenetic potentialities", Development, (19960000), vol. 122, pages 2339 - 2348, XP002164729-
OPPOSITION- YANKEE T.M., Clark E.A., "Signaling through the B cell antigen receptor in developing B cells", Reviews in Immunogenetics, (20000200), vol. 2, pages 185 - 203, XP055528673-
OPPOSITION- HIRABAYASHI, M. et al., "Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency", Mol. Reprod. Dev., (20090000), vol. 77, no. 94, XP055459191
OPPOSITION- MUYLDERMANS S; LAUWEREYS M, "Unique single-domain antigen binding fragments derived from naturally occurring camel heavy-chain antibodies", JOURNAL OF MOLECULAR RECOGNITION,, (19990300), vol. 12, no. 2, pages 131 - 140, XP002374742
OPPOSITION- Meek Stephen; Mashimo Tomoji; Burdon Tom, "From engineering to editing the rat genome", MAMMALIAN GENOME, (20170727), vol. 28, no. 7, pages 302 - 314, XP036304559
OPPOSITION- Hurle M R; Gross M, "Protein engineering techniques for antibody humanization", Current Opinion in Biotechnology, (19940800), vol. 5, no. 4, pages 428 - 433, XP023601527
OPPOSITION- LI, P. et al., "Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts", Cell, (20081226), vol. 135, pages 1299 - 1310, XP008153339
OPPOSITION- BUEHR, M. et al., "Capture of authentic embryonic stem cells from rat blastocysts", Cell, (20081226), vol. 135, pages 1287 - 1298, XP002599001
OPPOSITION- LIAO, J. et al., "Generation of Induced Pluripotent Stem Cell Lines from Adult Rat Cells", Cell Stem Cell, (20090000), vol. 4, pages 11 - 15, XP055013361
OPPOSITION- CLARK M, "Antibody humanization: a case of the 'Emperor's new clothes'?", Immunology Today, (20000801), vol. 21, no. 8, pages 397 - 402, XP004215168
OPPOSITION- ZOU Y-R; ET AL, "CRE-LOXP-MEDIATED GENE REPLACEMENT: A MOUSE STRAIN PRODUCING HUMANIZED ANTIBODIES", Current Biology, (19940000), vol. 4, no. 12, pages 1099 - 1103, XP009034794
OPPOSITION- HAMERS-CASTERMAN et al., "NATURALLY OCCURRING ANTIBODIES DEVOID OF LIGHT CHAINS", Nature, (19930000), vol. 363, pages 446 - 448, XP002048619
OPPOSITION- Duanqing Pei, "2008: year of the rat for stem cell research", Cell Res, (20090000), vol. 19, pages 149 - 151, XP055528795
OPPOSITION- Rat Genome Sequencing Project Consortium, "Genome sequence of the Brown Norway rat yields insights into mammalian evolution", Nature, (20040401), vol. 428, pages 493 - 521, XP008120410
OPPOSITION- BAKER, M., "Authentic rat embryonic stem cells", Nature Reports Stem Cells, (20090000), URL: https://www.nature.com/stemcells/2009/0901/090108/full/stemcells.2009.11.html, XP055528805
OPPOSITION- JANSSENS RICK; ET AL, "Generation of heavy-chain-only antibodies in mice", PNAS, (20061010), vol. 103, no. 41, pages 15130 - 15135, XP002494537
OPPOSITION- Wojciech Makałowski, Mark S. Boguski, "Evolutionary parameters of the transcribed mammalian genome: An analysis of 2,820 orthologous rodent and human sequences", PNAS, (19980000), vol. 95, pages 9407 - 9412, XP055528878
OPPOSITION- QI ZHOU; ET AL, "Generation of Fertile Cloned Rats by Regulating Oocyte Activation", Science, (20031114), vol. 302, page 1179, XP002277914
OPPOSITION- GEURTS, A.M. et al., "Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases", Science, (20090724), vol. 325, page 433, XP002580718
OPPOSITION- Linda J Mullins, Mullins John J, "Insights from the rat genome sequence", Genome Biology, (20040430), vol. 5, no. 5, pages 221.1 - 221.3, XP055528872
OPPOSITION- Siim Pauklin, Roger A. Pedersen, Ludovic Vallier, "Mouse pluripotent stem cells at a glance", Journal of Cell Science, (20110000), vol. 124, no. 22, pages 3727 - 3732, XP055528904
OPPOSITION- Xiangang Zou; et al., "Expression of a dromedary heavy chain-only antibody and B cell development in the mouse (Supplementary Information enclosed)", Journal of immunology, (20050915), vol. 175, no. 6, pages 3769-3779, 1 - 8, XP055528895
SEARCH- HURLE M R ET AL, "Protein engineering techniques for antibody humanization", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 5, no. 4, doi:10.1016/0958-1669(94)90053-1, ISSN 0958-1669, (19940801), pages 428 - 433, (19940801), XP023601527 [A] 2-22 * the whole document *
SEARCH- CLARK M, "Antibody humanization: a case of the 'Emperor's new clothes'?", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, (20000801), vol. 21, no. 8, doi:10.1016/S0167-5699(00)01680-7, ISSN 0167-5699, pages 397 - 402, XP004215168 [A] 2-22 * page 400, column 2drt; table 1 *

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