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Porcine Circovirus Type-2 Subunit Vaccine - EP2789627

The patent EP2789627 was granted to SBC Virbac on Sep 27, 2017. The application was originally filed on Dec 5, 2012 under application number EP12855059A. The patent is currently recorded with a legal status of "Revoked".

EP2789627

SBC VIRBAC
Application Number
EP12855059A
Filing Date
Dec 5, 2012
Status
Revoked
Aug 28, 2020
Grant Date
Sep 27, 2017
External Links
Slate, Register, Google Patents

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BOEHRINGER INGELHEIM ANIMAL HEALTH USAJun 27, 2018D YOUNGADMISSIBLE

Patent Citations (13) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTCN101180406
INTERNATIONAL-SEARCH-REPORTCN101884787
INTERNATIONAL-SEARCH-REPORTCN101936993
INTERNATIONAL-SEARCH-REPORTCN102127533
OPPOSITIONGB2467722
OPPOSITIONUS2008206271
OPPOSITIONWO03049703
OPPOSITIONWO9929871
SEARCHGB2467722
SEARCHUS2008206271
SEARCHUS2009017064
SEARCHUS2012164170
SEARCHWO9929871

Non-Patent Literature (NPL) Citations (38) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
INTERNATIONAL-SEARCH-REPORT- GUO, LONGJUN ET AL., "Identification of Antigen Epitope Located at the N Terminal Nuclear Localization Signal Region in Capsid Protein of Porcine Circovirus Type 2 (PCV2)", SCIENTIA AGRICULTURA SINICA, (201007), vol. 43, no. 7, pages 1480 - 1486, XP055155802
OPPOSITION- CHEN et al., "Detoxified Pseudomonas Exotoxin A Enhanced the Immune Response of a Porcine Circovirus type 2 (PCV2) ORF2 Recombinant Protein", Taiwan Veterinary Journal, (20110000), vol. 37, pages 233 - 245, XP055504931
OPPOSITION- FRAILE et al., "Prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) in an integrated swine production system experiencing postweaning multisystemic wasting syndrome", Canadian Journal of Veterinary Research, (20090000), vol. 73, pages 308 - 312, XP055245083
OPPOSITION- MAHE et al., "Differential recognition of ORF2 protein from type 1 and type 2 porcine circoviruses and identification of immunorelevant epitopes", Journal of General Virology, (20000000), vol. 81, pages 1815 - 1824, XP002978779
OPPOSITION- Mierendorf et al., "Expression and Purification of Recombinant Proteins Using the pET system", Mierendorf et al., Ralph Ripley, The Nucleic Acid Protocols Handbook, pages 947,972 - 974, XP055505000
OPPOSITION- "SubName: Full=Capsid protein {ECO:0000313|EMBL:AAU81715.1}", UniProtKB, (20041123), Database accession no. Q5XVM5, URL: UniProt, XP055654250
OPPOSITION- "SubName: Full=Capsid protein {ECO:0000313|EMBL:ABP68638.1}", UniProtKB, (20070529), Database accession no. A5A446, URL: UniProt, XP055654247
OPPOSITION- "SubName: Full=Capsid protein {ECO:0000313|EMBL:ABX71779.1};", UniProtKB, (20080502), Database accession no. A9QMC6, URL: UniProt, XP055654246
OPPOSITION- "SubName: Full=Capsid protein {ECO:0000313|EMBL:AEG89583.1}; Flags: Fragment", UniProtKB, (20110921), Database accession no. F8V1X0, URL: UniProt, XP002745122
OPPOSITION- "SubName: Full=Capsid protein {ECO:0000313|EMBL:AEN03276.1}", UniProtKB, (200300601), Database accession no. Q80QW2, URL: UniProt, XP055654241
OPPOSITION- TRUNDOVA et al., "Expression of porcine circovirus 2 ORF2 gene requires codon optimized E. coli cells", Virus Genes, (20070000), vol. 34, no. 2, pages 199 - 204, XP019485101
OPPOSITION- YIN et al., "An ELISA based on a truncated soluble ORF2 protein for the detection of PCV2 antibodies in domestic pigs", Virologica Sinica, (20100000), vol. 25, pages 191 - 198, XP055504967
OPPOSITION- LOU et al., "Prokaryotic expression and potential application of the truncated PCV-2 capsid protein", Virologica Sinica, (20100000), vol. 25, pages 86 - 97, XP055215508
OPPOSITION- ZHANG et al., "Low-usage codons in Escherichia coli, yeast, fruit fly and primates", Gene, (19910000), vol. 105, pages 61 - 72, XP023541673
OPPOSITION- ZHOU et al., "In vitro expression, monoclonal antibody and bioactivity for capsid protein of porcine circovirus type II without nuclear localization signal", Journal of Biotechnology, (20050000), vol. 118, pages 201 - 211, XP004963578
OPPOSITION- WU et al., "Expression of the porcine circovirus type 2 capsid protein subunits and application to an indirect ELISA", Journal of Biotechnology, (20080000), vol. 133, pages 58 - 64, XP022347945
OPPOSITION- SHANG et al., "Fine mapping of antigenic epitopes on capsid proteins of porcine circovirus, and antigenic phenotype of porcine circovirus Type 2", Molecular Immunology, (20090000), vol. 46, no. 3, pages 327 - 334, XP025816733
OPPOSITION- JU et al., "Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2", Veterinary Microbiology, (20050000), vol. 109, pages 179 - 190, XP004996465
OPPOSITION- WANG et al., "Genetic variation analysis of Chinese strains of porcine circovirus type 2", Virus Research, (20090000), vol. 145, pages 151 - 156, XP055215765
OPPOSITION- BLANCHARD et al., "Protection of swine against post-weaning multisystemic wasting syndrome (PMWS) by porcine circovirus type 2 (PCV2) proteins", Vaccine, (20030000), vol. 21, no. 31, pages 4565 - 4575, XP004467337
OPPOSITION- TRIBLE et al., "Antibody Recognition of Porcine Circovirus Type 2 Capsid Protein Epitopes after Vaccination, Infection, and Disease", Clinical and Vaccine Immunology, (20110000), vol. 18, no. 5, pages 749 - 757, XP055307985
OPPOSITION- OPRIESSNIG et al., "A Live-Attenuated Chimeric Porcine Circovirus Type 2 (PCV2) Vaccine Is Transmitted to Contact Pigs but Is Not Upregulated by Concurrent Infection with Porcine Paivovirus (PPV) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Is Efficacious in a PCV2b-PRRSV-PPV Challenge Model", Clinical. and Vaccine Immunology, (20110000), vol. 18, pages 1261 - 1268, XP055505024
OPPOSITION- FENAUX et al., "Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weanling pigs", Journal of Virology, (20030000), vol. 77, no. 20, pages 11232 - 11243, XP002359218
OPPOSITION- LIU et al., "Characterization of a Previously Unidentified Viral Protein in Porcine Circovirus Type 2-Infected Cells and Its Role in Virus-Induced Apoptosis", Journal of Virology, (20050000), vol. 79, pages 8262 - 8274, XP003004485
SEARCH- Lorenzo Fraile ET AL, "Prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) in an integrated swine production system experiencing postweaning multisystemic wasting syndrome", Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire, Canada, (20091001), pages 308 - 312, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757713/pdf/cjvr_10_308.pdf, (20160127), XP055245083 [A] 1-17 * Introdution *
SEARCH[ ] - "Porcine circovirus 2 capsid mutant protein K99R.", Geneseq, (20090402), Database accession no. AWF75438, URL: EBI [ ] * 97% identical to SEQ. ID 2;; sequence . *
SEARCH[ ] - "Porcine circovirus 2 capsid protein SEQ ID 10.", Geneseq, (20100415), Database accession no. AWF75400, URL: EBI [ ] * 94,8% identical to SEQ. ID 53;; sequence . *
SEARCH[ ] - "Porcine circovirus 2 capsid protein SEQ ID 12.", Geneseq, (20090402), Database accession no. AWF75402, URL: EBI [ ] * 88% identical to SEQ ID 51; 98,7% to SEQ. ID 16;; sequence . *
SEARCH- "RecName: Full=Polymerase acidic protein {ECO:0000256|RuleBase:RU361280, ECO:0000256|SAAS:SAAS00262764};", UniProt, (20060418), Database accession no. Q20QW2, URL: EBI, XP002745121 [Y] 5-7,10,11,17 * 100% identical to SEQ. ID 2;; sequence . *
SEARCH- "SubName: Full=Capsid protein {ECO:0000313|EMBL:AAU81715.1};", UniProt, (20041123), Database accession no. Q5XVM5, URL: EBI, XP002745120 [X] 5-7,10,11,17 * 100% identical to SEQ. ID 16;; sequence . *
SEARCH[ ] - "SubName: Full=Capsid protein {ECO:0000313|EMBL:ABP68638.1};", UniProt, (20070529), Database accession no. A5A446, URL: EBI [ ] * 100% identical to SEQ. ID 53;; sequence . *
SEARCH[ ] - "SubName: Full=Capsid protein {ECO:0000313|EMBL:ABX71779.1};", UniProt, (20080205), Database accession no. A9QMC6, URL: EBI [ ] * 100% identical to SEQ. ID 51;; sequence . *
SEARCH- "SubName: Full=Capsid protein {ECO:0000313|EMBL:AEG89583.1}; Flags: Fragment;", UniProt, (20110921), Database accession no. F8V1X0, URL: EBI, XP002745122 [Y] 5-7,10,11,17 * 98,7% identical to SEQ. ID 20;; sequence . *
SEARCH- "SubName: Full=Capsid protein {ECO:0000313|EMBL:AEN03276.1}; SubName: Full=Putative capsid protein {ECO:0000313|EMBL:AAO23146.1};", UniProt, (20030601), Database accession no. Q80QW2, URL: EBI, XP002745119 [Y] 5-7,10,11,17 * 100% identical to SEQ ID 2;; sequence . *
SEARCH- ZHONG-ZI LOU ET AL, "Prokaryotic expression and potential application of the truncated PCV-2 capsid protein", VIROLOGICA SINICA, (20100401), vol. 25, no. 2, doi:10.1007/s12250-010-3111-7, ISSN 1674-0769, pages 86 - 97, XP055215508 [X] 1-4,8,9,13-16 * the whole document * [Y] 1-12,17
SEARCH- SHANG S B ET AL, "Fine mapping of antigenic epitopes on capsid proteins of porcine circovirus, and antigenic phenotype of porcine circovirus Type 2", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 46, no. 3, doi:10.1016/J.MOLIMM.2008.10.028, ISSN 0161-5890, (20090101), pages 327 - 334, (20081206), XP025816733 [X] 1-4,8,9,13-16 * abstract * [Y] 1-12,17
SEARCH- DUPONT ET AL, "Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case-control study supports a shift in genotypes with time", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, (20080206), vol. 128, no. 1-2, doi:10.1016/J.VETMIC.2007.09.016, ISSN 0378-1135, pages 56 - 64, XP022458461 [Y] 5-7,10,11,17 * Uniprot A9QMC6 is 100% identical to SEQ. ID N°51 *
SEARCH- FANG WANG ET AL, "Genetic variation analysis of Chinese strains of porcine circovirus type 2", VIRUS RESEARCH, (20091001), vol. 145, no. 1, doi:10.1016/j.virusres.2009.05.015, ISSN 0168-1702, pages 151 - 156, XP055215765 [Y] 5-7,10,11,17 * Uniprot:A5A446 *

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