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Animal Models And Therapeutic Molecules - EP2792236

The patent EP2792236 was granted to Kymab on Mar 22, 2023. The application was originally filed on Jul 7, 2010 under application number EP14176740A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2792236

KYMAB
Application Number
EP14176740A
Filing Date
Jul 7, 2010
Status
Patent Maintained As Amended
Feb 17, 2023
Grant Date
Mar 22, 2023
External Links
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REGENERON PHARMACEUTICALSAug 14, 2018J A KEMPADMISSIBLE

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
EXAMINATIONDE10251918
EXAMINATIONGB2403475
OPPOSITIONDE10251918
OPPOSITIONGB2403475
OPPOSITIONUS2009093059
OPPOSITIONUS7205148
OPPOSITIONWO02066630
OPPOSITIONWO2008081197
OPPOSITIONWO2009013620
OPPOSITIONWO2009076464
SEARCHWO02059263
SEARCHWO02066630
SEARCHWO03006639
SEARCHWO2005004592
SEARCHWO2009076464

Non-Patent Literature (NPL) Citations (71) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- A J Murphy et al, "Supporting Information to Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice", PNAS, (20140408), vol. 111, no. 14, doi:10.1073/pnas.1324022111, pages 1 - 6-
OPPOSITION- BRUGGEMANN, "58. The preparation of human antibodies from Mice Harbouring Human Immunoglobulin Loci", BRUGGEMANN, Houdebine, Transgenic animals, Amsterdam, pages 397 - 402, XP055303684-
OPPOSITION- BRUGGEMANN, "Human antibody expression in transgenic mice", Arch Immunol Ther Exp, (20010000), vol. 49, no. 3, pages 203 - 208, XP009039754-
OPPOSITION- FRASER et al., "Precise excision of TTAA-specific lepidopteran transposon piggyback (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines.. .", Insect Molecular Biology, (19960000), vol. 5, no. 2, pages 141 - 151, XP055513309-
OPPOSITION- HASTY et al., "Gene targeting, principles, and practice in mammalian cells", Gene Targeting, A Practical Approach, Oxford, University Press, Oxford, pages 2 - 35, 38-99,101-174, XP055500641-
OPPOSITION- KOTZAMANIS et al., "Construction of human artificial chromosome vectors by recombineering", Gene, (20050000), vol. 351, pages 29 - 38, XP027872271-
OPPOSITION- LONBERG, "Human antibodies from transgenic animals", Nature Biotechnology, (20050000), vol. 23, no. 9, pages 1117 - 1125, XP003025935-
OPPOSITION- NAGLE, "Regeneron helps make Sanofi Velocimmune to its 'weak' pipeline", Outsourcing - Pharma.com, (20071203), URL: http://www.outsourcing-pharma.com/content/view/print/325803, (20131110), XP055512949-
OPPOSITION- SOSIO et al., "Assembly of large genomic segments in artificial chromosomes by homologous recombination in Escherichia coli", Nucleic Acids Res., (20010000), vol. 29, no. 7, pages 1 - 7, XP002630416-
OPPOSITION- STEVENS, "Human Antibody Discovery", Pharma Focus Asia, (20080000), vol. 8, pages 72 - 74, XP003035947-
OPPOSITION- TORRES et al., "Flox-and-invert", Laboratory Protocols for Conditional Gene targeting, Oxford, pages 37 - 41, XP055500666-
OPPOSITION- WOLTIJEN et al., "piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells", Nature, (20090000), vol. 458, pages 766 - 770, XP009139776-
OPPOSITION- QU et al., "Gene targeting of ErbB using a Cre-mediated unidirectional DNA inversion strategy", Genesis, (20060000), vol. 44, pages 477 - 486, XP055500670
OPPOSITION- GUAN et al., "A Review of Current Large-Scale Mouse Knockout Efforts", Genesis, (20100000), vol. 48, pages 73 - 85, XP055046410
OPPOSITION- FENG et al., "Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange", J Mol Biol, (19990000), vol. 292, pages 779 - 785, XP004462572
OPPOSITION- LARGAESPADA, "Transposon mutagenesis in mice", NIH Public Access Author Manuscript, (20090000), vol. 530, pages 1 - 10, XP055304524
OPPOSITION- OUMARD et al., "Recommended Method for Chromosome Exploitation: RMCE-based Cassette-exchange Systems in Animal Cell Biotechnology", Cytotechnology, (20060000), vol. 50, no. 1-3, pages 93 - 108, XP019393904
OPPOSITION- WALLACE et al., "Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence", Cell, (20070000), vol. 128, no. 1, pages 197 - 209, XP002481713
OPPOSITION- S OPHER et al., "Efficient recombination-based methods for bacterial artificial chromosome fusion and mutagenesis", Gene, (20060000), vol. 371, pages 136 - 143, XP024934339
OPPOSITION- WOODWARD et al., "piggyBac-ing models and new therapeutic strategies", Trends in Biotechnology, (20150000), vol. 33, pages 525 - 533, XP055513326
OPPOSITION- PEREZ-LUZ et al., "Factor VIII mRNA expression from a BAC carrying the intact locus made by homologous recombination", Genomics, (20071100), vol. 90, no. 5, pages 610 - 619, XP022324400
OPPOSITION- HOHN et al., "Elimination of selection markers from transgenic plants", Curr Opin Biotechnol, (20010000), vol. 12, pages 139 - 143, XP002466486
OPPOSITION- BAER et al., "Coping with kinetic and thermodynamic barriers: RMCE, an efficient strategy for the targeted integration of transgenes", Curr Opin Biotechnol., (20010000), vol. 12, no. 5, pages 473 - 480, XP002209666
OPPOSITION- MUYRERS et al., "Techniques: Recombinogenic engineering - new options for cloning and manipulating DNA", TRENDS in Biochemical Sciences, (20010000), vol. 26, no. 5, pages 325 - 331, XP004241877
OPPOSITION- MURPHY, "Veloclmmune: Immunoglobulin Variable Region Humanised Mice", MURPHY, Little, Recombinant Antibodies for Immunotherapy, New York, Cambridge University Press, pages 100 - 107, XP055304492
OPPOSITION- GIRALDO et al., "Size matters: use of YACs, BACs and PACs in transgenic animals", Transgenic Research, (20010000), vol. 10, pages 83 - 103, XP055022741
OPPOSITION- YANCOPOULOS et al., "Preferential utilisation of the most JH-proximal VH gene segments in pre-B- cell lines", Nature, (19840000), vol. 311, pages 727 - 733, XP055304516
OPPOSITION- COPELAND et al., "Recombineering: a powerful new tool for mouse functional genomics", Nature Reviews Genetics, (20010000), vol. 2, pages 769 - 779, XP001097509
OPPOSITION- RAMIREZ-SOLIS et al., "Chromosome engineering in mice", Nature, (19950000), vol. 378, pages 720 - 724, XP001026456
OPPOSITION- MITRA et al., "Piggyback can bypass DNA synthesis during cut and paste transposition", EMBO J, (20080000), vol. 27, pages 1097 - 1109, XP055500675
OPPOSITION- KAJI et al., "Virus-free induction of pluripotent and subsequent excision of reprogramming factors", Nature, (20090000), vol. 458, pages 771 - 775, XP002568858
OPPOSITION- KLING, "Big Pharma vies for mice", Nature Biotechnology, (20070000), vol. 25, no. 6, pages 613 - 614, XP055304499
OPPOSITION- SCOTT, "Mice with a human touch", Nature Biotechnology, (20070000), vol. 25, no. 10, pages 1075 - 1077, XP055098497
OPPOSITION- SCHNUTGEN et al., "A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse", Nature Biotechnology, (20030000), vol. 21, pages 562 - 565, XP055108504
OPPOSITION- GLASER et al., "Current issues in mouse genome engineering", Nature Genetics, (20050000), vol. 37, no. 11, pages 1187 - 1193, XP055277100
OPPOSITION- KOKUBU et al., "A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice (includes Online Methods)", Nature Genetics, (20090000), vol. 41, no. 8, pages 946 - 952+2PP, XP055513298
OPPOSITION- RUSK, "Making mice at high speed", Nature Methods, (20070000), vol. 4, no. 3, pages 196 - 197, XP055208370
OPPOSITION- YUSA et al., "Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon", Nature Methods, (20090000), vol. 6, no. 5, pages 363 - 369, XP055040531
OPPOSITION- IVICS et al., "Transposon-mediated genome manipulation in vertebrates", Nature Methods, (20090528), vol. 6, no. 6, pages 415 - 422, XP055032021
OPPOSITION- SHARAN et al., "Recombineering: a homologous recombination-based method of genetic engineering", Nature Protocols, (20091000), vol. 2, pages 206 - 223, XP001525689
OPPOSITION- WILSON et al., "piggyBac transposon-mediated gene transfer in human cells", Mol Ther, (20070000), vol. 15, pages 139 - 145, XP055026848
OPPOSITION- SINZELLE et al., "Transposition of a reconstructed Harbinger element into human cells and functional homology with two transposon-derived cellular genes", PNAS, (20080000), vol. 105, pages 4715 - 4720, XP055513323
OPPOSITION- WANG et al., "Chromosomal transposition of PiggyBac in mouse embryonic stem cells", PNAS, (20080000), vol. 105, no. 27, pages 9290 - 9295, XP055026857
OPPOSITION- WU et al., "Double replacement: strategy for efficient introduction of subtle mutations into the murine Colla-1 gene by homologous recombination in embryonic stem cells", Proc Natl Acad Sci USA, (19940000), vol. 91, no. 7, pages 2819 - 23, XP002074111
OPPOSITION- LUO et al., "Chromosomal transposition of a Tcl/mariner-like element in mouse embryonic stem cells", PNAS, (19980000), vol. 95, pages 10769 - 10773, XP002946962
OPPOSITION- BATES et al., "Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination", JEM, (20070000), vol. 204, no. 13, pages 3247 - 3256, XP055304520
OPPOSITION- NI et al., "Transposon tools hopping in vertebrates", Briefings in Functional Genomics and Proteomics, (20080000), vol. 7, pages 444 - 453, XP002666602
OPPOSITION- CALL et al., "A Cre-lox recombination system for the targeted integration of circular yeast artificial chromosomes into embryonic stem cells", Human Molecular Genetics, (20000000), vol. 9, pages 1745 - 1751, XP002956896
OPPOSITION- XU et al., "Site-specific recombination in Schizosaccharomyces pombe and systematic assembly of a 400kb transgene array in mammalian cells using the integrase of Streptomyces phage phiBT1", Nucleic Acids Res., (20070000), vol. 36, no. 1, pages 1 - 9, XP055500662
OPPOSITION- ZHANG et al., "Combination of overlapping bacterial artificial chromosomes by a two-step recombinogenic engineering method", Nucleic Acids Research, (20030000), vol. 31, no. 15, pages 1 - 6, XP055320496
OPPOSITION- OBERDOERFFER et al., "Unidirectional cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71", Nucleic Acids Research, (20030000), vol. 31, no. 22, pages 1 - 7, XP002992914
OPPOSITION- DAFHNIS-CALAS et al., "Iterative in vivo assembly of large and complex transgenes by combining the activities of phiC31 integrase and Cre recombinase", Nucleic Acids Res, (20050000), vol. 33, no. 22, pages 1 - 14, XP002561513
OPPOSITION- GIBSON et al., "Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome", Science, (20080000), vol. 319, no. 5867, pages 1215 - 1220, XP009101716
OPPOSITION- ASKEW et al., "Site-Directed Point Mutations in Embryonic Stem Cells: a Gene -Targeting Tag-and-Exchange Strategy", Mol. Cell . Biol., (19930000), vol. 13, no. 7, pages 4115 - 4124, XP000568152
OPPOSITION- STACEY et al., "Use of double-replacement gene targeting to replace the murine a-lactalbumin gene with its human counterpart in embryonic stem cells and mice", Mol Cell Biol, (19940000), vol. 14, pages 1009 - 1016, XP000562809
OPPOSITION- ZHENG et al., "Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications", Mol Cell Biol, (20000000), vol. 20, no. 2, pages 648 - 655, XP001004605
OPPOSITION- STORB et al., "Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favours proximate target sequences", Mol. Cell . Biol., (19890000), vol. 9, no. 2, pages 711 - 718, XP055304521
OPPOSITION- ADAMS et al., "Contemporary approaches for modifying the mouse genome", Physiol. Genomics, (20080000), vol. 34, pages 225 - 238, XP055054853
OPPOSITION- MORTUZA et al., "Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukaemia reveals preferential usage of JH-proximal variable gene segments", Blood, (20010000), vol. 97, pages 2716 - 2726, XP055304512
OPPOSITION- KOTZAMANIS et al., "Recombining overlapping BACs into a single larger BAC", BMC Biotechnology, (20040000), vol. 4, pages 1 - 10, XP021005925
OPPOSITION- UNGRIN et al., "Strict control of telomerase activation using Cre- mediated inversion", BMC Biotechnology, (20060000), vol. 6, no. 10, pages 1 - 9, XP021017036
OPPOSITION- CLARK et al., "Pigs taking wing with transposon and recombinases", Genome Biology, (20070000), vol. 8, pages 1 - 16, XP002490458
OPPOSITION- BRAULT et al., "Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization", PLoS Genetics, (20060000), vol. 2, no. 7, pages 911 - 919, XP055255516
OPPOSITION- BODE et al., "The transgeneticist's toolbox: Novel methods for the targeted modification of eukaryotic genomes", Biological Chemistry, (20000000), vol. 381, no. 9-10, pages 801 - 813, XP001021315
OPPOSITION- MUÑOZ-LÓPEZ et al., "DNA transposons: nature and applications in genomics", Curr Genomics, (20100400), vol. 11, no. 2, pages 115 - 128, XP055109912
OPPOSITION- WILLIAMS et al., "Unequal VH gene rearrangement frequency within the large VH 7183 gene family is not due to recombination signal sequence variation...", J Immunol., (20010000), vol. 167, pages 257 - 263, XP055304513
OPPOSITION- GONDO et al., "Next-generation gene targeting in the mouse for functional genomics", BMB Reports, (20090600), vol. 42, no. 6, pages 315 - 323, XP055500658
OTHER- SOPHER B.L.; LA SPADA, "Efficient recombination-based methods for bacterial artificial chromosome fusion and mutagenesis", Gene, (20060000), vol. 371, no. 1, pages 136 - 143, XP024934339
OTHER- PEREZ-LUZ et al., "Factor VIII mRNA expression from a BAC carrying the intact locus made by homologous recombination", Genomics, (20071100), vol. 90, no. 5, pages 610 - 619, XP022324400
OTHER- ZHANG; HUANG, "Combination of overlapping bacterial artificial chromosomes by a two-step recombinogenic engineering method", Nucleic Acids Research, (20038000), vol. 31, no. 15, pages 1 - 6, XP055320496
OTHER- KOTZAMANIS; HUXLEY, "Recombining overlapping BACs into a single larger BAC", BMC Biotechnology, (20040601), vol. 4, no. 1, pages 1 - 10, XP021005925

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