IP Verse

Methods Of Treating Pain By Inhibition Of Vgf Activity - EP2807191

The patent EP2807191 was granted to Imperial College Innovations on Jan 15, 2025. The application was originally filed on Jan 25, 2013 under application number EP13702262A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2807191

IMPERIAL COLLEGE INNOVATIONS
Application Number
EP13702262A
Filing Date
Jan 25, 2013
Status
Patent Maintained As Amended
Dec 13, 2024
Grant Date
Jan 15, 2025
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

ZACCO DENMARKApr 8, 2020- -

Patent Citations (48) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2008050342
DESCRIPTIONUS2009264411
DESCRIPTIONUS2010179124
DESCRIPTIONUS2010197676
DESCRIPTIONUS4946778
DESCRIPTIONUS5223409
DESCRIPTIONUS5403484
DESCRIPTIONUS5427908
DESCRIPTIONUS5516637
DESCRIPTIONUS5571698
DESCRIPTIONUS5580717
DESCRIPTIONUS5585089
DESCRIPTIONUS5658727
DESCRIPTIONUS5698426
DESCRIPTIONUS5733743
DESCRIPTIONUS5750753
DESCRIPTIONUS5780225
DESCRIPTIONUS5821047
DESCRIPTIONUS5969108
DESCRIPTIONWO03077914
DESCRIPTIONWO2004051268
DESCRIPTIONWO2004106377
DESCRIPTIONWO2005003169
DESCRIPTIONWO2005003170
DESCRIPTIONWO2005003171
DESCRIPTIONWO2007044084
DESCRIPTIONWO2009093009
DESCRIPTIONWO2009093013
DESCRIPTIONWO2010121646
DESCRIPTIONWO2011156588
DESCRIPTIONWO9002809
DESCRIPTIONWO9109967
DESCRIPTIONWO9110737
DESCRIPTIONWO9111172
DESCRIPTIONWO9201047
DESCRIPTIONWO9202551
DESCRIPTIONWO9218619
DESCRIPTIONWO9222853
DESCRIPTIONWO9308829
DESCRIPTIONWO9311236
DESCRIPTIONWO9402518
DESCRIPTIONWO9515982
DESCRIPTIONWO9520401
DESCRIPTIONWO9855148
EXAMINATIONWO0107074
INTERNATIONAL-SEARCH-REPORTWO03016475
OPPOSITIONWO2008100328
OPPOSITIONWO2010111702

Non-Patent Literature (NPL) Citations (39) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Berhane Ghebrehiwet, Et Al, "Structure-function studies usning deletion mutants identify domains of gC1qR/p33 potential therapeutic targets for vascular permeability and inflammation", Frontiers in Immunology, (20110101), vol. 2, no. 58, pages 1 - 9, XP055724865-
OPPOSITION- Gao, Y.J. ; Ji, R.R., "Targeting Astrocyte Signaling for Chronic Pain", Neurotherapeutics, ELSEVIER INC., US, US, (20101001), vol. 7, no. 4, ISSN 1933-7213, pages 482 - 493, XP027350969-
OPPOSITION- Jörn Lötsch, Geisslinger, Gerd, "Pharmacogenetics of new analgesics", British Journal of Pharmacology, (20110101), vol. 163, pages 447 - 460, XP055724956-
OPPOSITION- Katrin Färber, Et Al, "C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation", (20090215), vol. 87, no. 3, pages 644 - 652, XP055724902-
OPPOSITION- MIKA JOANNA, "Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness", PHARMACOLOGICAL REPORTS, POLSKA AKADEMIA NAUK, INSTYTUT FARMAKOLOGII, KRAKOW, PL, PL, (20080501), vol. 60, no. 3, ISSN 1734-1140, pages 297 - 307, XP002576970-
OPPOSITION- TRANI et al., Journal of Neurochemistry, (20020000), vol. 81, pages 565 - 574-
OPPOSITION- White, F.A. ; Miller, R.J., "Insights into the regulation of chemokine receptors by molecular signaling pathways: Functional roles in neuropathic pain", BRAIN, BEHAVIOR AND IMMUNITY., ACADEMIC PRESS, SAN DIEGO, CA, US, US, (20100801), vol. 24, no. 6, ISSN 0889-1591, pages 859 - 865, XP027118300-
OPPOSITION- R. Possenti, Et Al, "A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway", The EMBO Journal, (19890101), vol. 8, no. 8, pages 2217 - 2223, XP055724954
OPPOSITION- Richard J. Miller, Et Al, "Cytokine and Chemokine Regulation of Sensory Neuron Function", Handb. Exp. Pharmacol, (20090101), doi:10.1007/978-3-540-79090-7_12, pages 417 - 449, XP055731978
OPPOSITION- A Bartolomucci, Et Al, "Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice", Genes Nutr4, (20090101), vol. 4, pages 49 - 57, XP055731915
OPPOSITION- Geber, C. ; Baumgartner, U. ; Schwab, R. ; Muller, H. ; Stoeter, P. ; Dieterich, M. ; Sommer, C. ; Birklein, F. ; Treede, R.D., "Revised Definition of Neuropathic Pain and Its Grading System: An Open Case Series Illustrating Its Use in Clinical Practice", AMERICAN JOURNAL OF MEDICINE., Excerpta Medica, Inc., United States, United States, (20091001), vol. 122, no. 10, doi:10.1016/j.amjmed.2009.04.005, ISSN 0002-9343, pages S3 - S12, XP026669923
OPPOSITION- Thakker-Varia, S. ; Alder, J., "Neuropeptides in depression: Role of VGF", BEHAVIOURAL BRAIN RESEARCH., ELSEVIER, AMSTERDAM., NL, NL, (20090211), vol. 197, no. 2, doi:10.1016/j.bbr.2008.10.006, ISSN 0166-4328, pages 262 - 278, XP025770968
OPPOSITION- Peerschke, E.I.B. Ghebrehiwet, B., "The contribution of gC1qR/p33 in infection and inflammation", IMMUNOBIOLOGY, Urban und Fischer Verlag, DE, DE, (20070531), vol. 212, no. 4-5, doi:10.1016/j.imbio.2006.11.011, ISSN 0171-2985, pages 333 - 342, XP022099022
OPPOSITION- Fleur Bossi; Ellinor I. Peerschke; Berhane Ghebrehiwet; Francesco Tedesco;, "Cross-talk between the complement and the kinin system in vascular permeability", IMMUNOLOGY LETTERS., Elsevier BV, NL, NL, (20110623), vol. 140, no. 1, doi:10.1016/j.imlet.2011.06.006, ISSN 0165-2478, pages 7 - 13, XP028268231
OPPOSITION- Zhang, R.X. ; Liu, B. ; Li, A. ; Wang, L. ; Ren, K. ; Qiao, J.T. ; Berman, B.M. ; Lao, L., "Interleukin 1@b facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation", NEUROSCIENCE, NEW YORK, NY, US, US, (20080717), vol. 154, no. 4, doi:10.1016/j.neuroscience.2008.04.072, ISSN 0306-4522, pages 1533 - 1538, XP022797087
OPPOSITION- Adriana del Rey; Hau-Jie Yau; Anke Randolf; Maria V. Centeno; Johannes Wildmann; Marco Martina; Hugo O. Besedovsky; A. Vania Apkarian;, "Chronic neuropathic pain-like behavior correlates with IL-1 expression and disrupts cytokine interactions in the hippocampus", PAIN, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, NL, (20110915), vol. 152, no. 12, doi:10.1016/j.pain.2011.09.013, ISSN 0304-3959, pages 2827 - 2835, XP028109061
OPPOSITION- Caio Marcio Barros De Oliveira, Et Al, "Cytokines and Pain", Rev Bras Anestesiol, (20110101), vol. 61, no. 2, pages 255 - 265, XP055724886
OPPOSITION- SWEITZER S, MARTIN D, DELEO J A, "INTRATHECAL INTERLEUKIN-1 RECEPTOR ANTAGONIST IN COMBINATION WITH SOLUBLE TUMOR NECROSIS RECEPTOR EXHIBITS AN ANTI-ALLODYNIC ACTION IN A RAT MODEL OF NEUROPATHIC PAIN", NEUROSCIENCE, NEW YORK, NY, US, US, (20010301), vol. 103, no. 02, doi:10.1016/S0306-4522(00)00574-1, ISSN 0306-4522, pages 529 - 539, XP001036875
OPPOSITION- Yeong Ray Wen, Et Al, "Role of microglia in neuropathic pain, postoperative pain, and morphine tolerance", J Formos Med Assoc, (20110801), vol. 110, no. 8, doi:10.1016/S0929-6646(11)60074-0, pages 487 - 494, XP055724882
OPPOSITION- Yasuhiko Kawasaki, Zhen-Zhong Xu, Xiaoying Wang, Jong Yeon Park, Zhi-Ye Zhuang, Ping-Heng Tan, Yong-Jing Gao, Kristine Roy, Gabriel Corfas, Eng H Lo, Ru-Rong Ji, "Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain", Nature Medicine, Nature Pub. Co., New York, New York, (20080301), vol. 14, no. 3, doi:10.1038/nm1723, ISSN 1078-8956, pages 331 - 336, XP055231613
OPPOSITION- Fletcher A. White, Et Al, "Chemokines: Integrators of Pain and Inflamation", Nat. Rev. Drug. Discov., (20051001), vol. 4, no. 10, doi:10.1038/nrd1852, pages 834 - 844, XP055731986
OPPOSITION- Alice Meunier, Joao Braz, Fran�ois Cesselin, Michel Hamon, Michel Pohl, "Inflammation et douleur : th�rapie g�nique exp�rimentale", m�decine/sciences, (20040301), vol. 20, no. 3, doi:10.1051/medsci/2004203325, ISSN 07670974, pages 325 - 330, XP055096298
OPPOSITION- BARTOLOMUCCI A, ET AL, "TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20060926), vol. 103, no. 39, doi:10.1073/PNAS.0606102103, ISSN 0027-8424, pages 14584 - 14589, XP002577374
OPPOSITION- Larry R Steranka, Et Al, "Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions", Proc.Natl.Acad.Sci., (19880501), vol. 85, pages 3245 - 3249, XP055724870
OPPOSITION- Ya Chun Chen, Et Al, "Identification of a Receptor for Neuropeptide VGF and its Role in Neuropathic Pain", Journal of Biological Chemistry, (20131129), vol. 288, no. 48, pages 34638 - 34646, XP055724906
OPPOSITION- YAMAGUCHI HIDEKI, ET AL, "Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and-2", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (20070901), vol. 282, no. 36, doi:10.1074/JBC.M701665200, ISSN 0021-9258, pages 26354 - 26360, XP002538510
OPPOSITION- Foo Wah Foong, Et Al, "The periaqueductal gray is the site of the antinociceptive action of carbamazepine as related to bradykinin-induced trigeminal pain", Br. J. Pharmac., (19840101), vol. 83, pages 493 - 497, XP055724874
OPPOSITION- Koji Toshinai, Et Al, "Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus", Am J Physiol Endocrinol Metab, (20100615), pages E394 - E401, XP055732040
OPPOSITION- Koji Toshinai, Et Al, "Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus", Am J Physiol Endocrinol Metab, (20100615), vol. 299, pages E394 - E401, XP055732049
OPPOSITION- M. M. Khan, Harlan N Bradford, Irma Isordia-Salas, Yuchuan Liu, Yi Wu, Ricardo G Espinola, Berhane Ghebrehiwet, Robert W Colman, "High-Molecular-Weight Kininogen Fragments Stimulate the Secretion of Cytokines and Chemokines Through uPAR, Mac-1, and gC1qR in Monocytes", Arteriosclerosis, thrombosis, and vascular biology, Lippincott, Williams & Wilkins, (20061001), vol. 26, no. 10, doi:10.1161/01.ATV.0000240290.70852.c0, ISSN 1079-5642, pages 2260 - 2266, XP055343572
OPPOSITION- Boyi Liu, Et Al, "The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated CI- channels", The Journal of Clinical Investigation, (20100401), vol. 120, no. 4, pages 1240 - 1252, XP055732048
OPPOSITION- Kinga K Hosszu, Et Al, "Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity", Innate Immun, (20100101), vol. 16, no. 2, pages 115 - 127, XP055732033
OPPOSITION- Leung Lawrence; Cahill Catherine M, "TNF-α and neuropathic pain - a review", JOURNAL OF NEUROINFLAMMATION, BIOMED CENTRAL LTD., LONDON, GB, GB, (20100416), vol. 7, no. 1, doi:10.1186/1742-2094-7-27, ISSN 1742-2094, page 27, XP021079504
OPPOSITION- Talbot Sébastien; Chahmi Emna; Dias Jenny Pena; Couture Réjean, "Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy", JOURNAL OF NEUROINFLAMMATION, BIOMED CENTRAL LTD., LONDON, GB, GB, (20100629), vol. 7, no. 1, doi:10.1186/1742-2094-7-36, ISSN 1742-2094, page 36, XP021079512
OPPOSITION- MOSS ET AL., MOLECULAR PAIN, vol. 4, 2008, pages 62, XP002695039
OPPOSITION- Maureen S Riedl, Et Al, "Proteomic Analysis Uncovers Novel Actions of the Neurosecretory Protein VGF in Nociceptive Processing", The Journal of Neuroscience, (20091021), pages 13377 - 13388, XP055732009
OPPOSITION- Janet Alder, Et Al, "Brain-derived Neurotrophic Factor-Induced Gene Expression Reveals Novel Actions of VGF in Hippocampal Synaptic Plasticity", The Journal of Neuroscience, (20031126), vol. 23, no. 34, pages 10800 - 10808, XP055732055
OPPOSITION- J. W. Bryant, Shariat Madar, "Human plasma kallikrein-kinin system: Physiological and biochemical parameters", Cardiovasc Hematol Agents Med Chem, (20160613), vol. 7, no. 3, pages 234 - 250, XP055724962
OPPOSITION- Jo Lewis, Brameld, John And Jethwa, Preeti, "Neuroendocrine role for VGF", Frontiers in Endocrinology, (20150202), vol. 6, no. 3, pages 1 - 8, XP055732046

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents