Modulation Of Rna By Repeat Targeting - EP2812342

The patent EP2812342 was granted to Ionis Pharmaceuticals on Nov 15, 2017. The application was originally filed on Feb 8, 2013 under application number EP13746752A. The patent is currently recorded with a legal status of "Revoked".

EP2812342

IONIS PHARMACEUTICALS
Application Number
EP13746752A
Filing Date
Feb 8, 2013
Status
Revoked
May 10, 2019
Grant Date
Nov 15, 2017
External Links
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Patent Citations (93) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS19990130377-
DESCRIPTIONUS20020399998-
DESCRIPTIONUS20020419532-
DESCRIPTIONUS20070989574-
DESCRIPTIONUS20080026995-
DESCRIPTIONUS20080026998-
DESCRIPTIONUS20080056564-
DESCRIPTIONUS20080086231-
DESCRIPTIONUS20080097787-
DESCRIPTIONUS20080099844-
DESCRIPTIONWO1998DK00393-
DESCRIPTIONWO2003US33466-
DESCRIPTIONWO2005US19219-
DESCRIPTIONUS2003109476
DESCRIPTIONUS2004171570
DESCRIPTIONUS2005130923
DESCRIPTIONUS2008039618
DESCRIPTIONUS2009012281
DESCRIPTIONUS2010184833
DESCRIPTIONUS4981957
DESCRIPTIONUS5034506
DESCRIPTIONUS5118800
DESCRIPTIONUS5166315
DESCRIPTIONUS5185444
DESCRIPTIONUS5319080
DESCRIPTIONUS5359044
DESCRIPTIONUS5393878
DESCRIPTIONUS5446137
DESCRIPTIONUS5466786
DESCRIPTIONUS5514785
DESCRIPTIONUS5519134
DESCRIPTIONUS5567811
DESCRIPTIONUS5576427
DESCRIPTIONUS5591722
DESCRIPTIONUS5597909
DESCRIPTIONUS5610300
DESCRIPTIONUS5627053
DESCRIPTIONUS5639873
DESCRIPTIONUS5646265
DESCRIPTIONUS5670633
DESCRIPTIONUS5698685
DESCRIPTIONUS5700920
DESCRIPTIONUS5792847
DESCRIPTIONUS6268490
DESCRIPTIONUS6525191
DESCRIPTIONUS6600032
DESCRIPTIONUS6670461
DESCRIPTIONUS6673661
DESCRIPTIONUS6770748
DESCRIPTIONUS6794499
DESCRIPTIONUS7034133
DESCRIPTIONUS7053207
DESCRIPTIONUS7399845
DESCRIPTIONUS7427672
DESCRIPTIONUS7547684
DESCRIPTIONUS7696345
DESCRIPTIONWO0063364
DESCRIPTIONWO0149687
DESCRIPTIONWO03004602
DESCRIPTIONWO2004106356
DESCRIPTIONWO2005021570
DESCRIPTIONWO2005121371
DESCRIPTIONWO2006047842
DESCRIPTIONWO2007134181
DESCRIPTIONWO2008101157
DESCRIPTIONWO2008150729
DESCRIPTIONWO2008154401
DESCRIPTIONWO2009006478
DESCRIPTIONWO2010036696
DESCRIPTIONWO2011097614
DESCRIPTIONWO2011097641
DESCRIPTIONWO2011139702
DESCRIPTIONWO9414226
DESCRIPTIONWO9839352
DESCRIPTIONWO9914226
INTERNATIONAL-SEARCH-REPORTUS2003109476
INTERNATIONAL-SEARCH-REPORTUS2010184833
OPPOSITIONUS5696248
OPPOSITIONUS7485421
OPPOSITIONWO0020645
OPPOSITIONWO02094250
OPPOSITIONWO2005012526
OPPOSITIONWO2007109797
OPPOSITIONWO2008018795
OPPOSITIONWO2009127680
OPPOSITIONWO2011097614
OPPOSITIONWO2011097641
OPPOSITIONWO2012110457
OPPOSITIONWO2012177639
OPPOSITIONWO2013043817
OPPOSITIONWO9419945
SEARCHWO2011097614
SEARCHWO2011097641

Non-Patent Literature (NPL) Citations (83) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALBAEK ET AL., J. ORG. CHEM., (2006), vol. 71, pages 7731 - 7740-
DESCRIPTION- ALLSHIRE, SCIENCE, (2002), vol. 297, pages 1818 - 1819-
DESCRIPTION- ALTMANN ET AL., BIOCHEM. SOC. TRANS., (1996), vol. 24, pages 630 - 637-
DESCRIPTION- ALTMANN ET AL., CHIMIA, (1996), vol. 50, pages 168 - 176-
DESCRIPTION- ALTMANN ET AL., NUCLEOSIDES NUCLEOTIDES, (1997), vol. 16, pages 917 - 926-
DESCRIPTION- ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, page 403 410-
DESCRIPTION- BAKER ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 11944 - 12000-
DESCRIPTION- BRAASCH ET AL., BIOCHEMISTRY, (2002), vol. 41, pages 4503 - 4510-
DESCRIPTION- BRAASCH ET AL., CHEM. BIOL., (2001), vol. 8, pages 1 - 7-
DESCRIPTION- CHATTOPADHYAYA ET AL., J. ORG. CHEM., (2009), vol. 74, pages 118 - 134-
DESCRIPTION- CROOKE ET AL., J. PHARMACOL. EXP. THER., (1996), vol. 277, pages 923 - 937-
DESCRIPTION- ELAYADI ET AL., CURR. OPINION INVEST. DRUGS, (2001), vol. 2, pages 558 - 561-
DESCRIPTION- FREIER ET AL., NUCLEIC ACIDS RESEARCH, (1997), vol. 25, no. 22, pages 4429 - 4443-
DESCRIPTION- FRIEDEN ET AL., NUCLEIC ACIDS RESEARCH, (2003), vol. 21, pages 6365 - 6372-
DESCRIPTION- GAUTSCHI ET AL., J. NATL. CANCER INST., (200103), vol. 93, pages 463 - 471-
DESCRIPTION- GU ET AL., NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, (2005), vol. 24, no. 5-7, pages 993 - 998-
DESCRIPTION- GU ET AL., OLIGONUCLEOTIDES, (2003), vol. 13, no. 6, pages 479 - 489-
DESCRIPTION- GU ET AL., TETRAHEDRON, (2004), vol. 60, no. 9, pages 2111 - 2123-
DESCRIPTION- HALL ET AL., SCIENCE, (2002), vol. 297, pages 2232 - 2237-
DESCRIPTION- HORVATH ET AL., TETRAHEDRON LETTERS, (2007), vol. 48, pages 3621 - 3623-
DESCRIPTION- JENUWEIN, SCIENCE, (2002), vol. 297, pages 2215 - 2218-
DESCRIPTION- JONES, L.J. ET AL., ANALYTICAL BIOCHEMISTRY, (1998), vol. 265, pages 368 - 374-
DESCRIPTION- KABANOV ET AL., FEBS LETT., (1990), vol. 259, pages 327 - 330-
DESCRIPTION- KOSHKIN ET AL., TETRAHEDRON, (1998), vol. 54, pages 3607 - 3630-
DESCRIPTION- KUMAR ET AL., BIOORG. MED. CHEM. LETT., (1998), vol. 8, pages 2219 - 2222-
DESCRIPTION- LETSINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 6553 - 6556-
DESCRIPTION- LEUMANN, BIOORG. MED. CHEM., (2002), vol. 10, pages 841 - 854-
DESCRIPTION- MAHER; DOLNICK, NUC. ACID. RES, (1988), vol. 16, pages 3341 - 3358-
DESCRIPTION- MANOHARAN ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 660, pages 306 - 309-
DESCRIPTION- MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1993), vol. 3, pages 2765 - 2770-
DESCRIPTION- MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1994), vol. 4, pages 1053 - 1060-
DESCRIPTION- MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, (1995), vol. 14, pages 969 - 973-
DESCRIPTION- MANOHARAN ET AL., TETRAHEDRON LETT., (1995), vol. 36, pages 3651 - 3654-
DESCRIPTION- MARTIN, HELV. CHIM. ACTA, (1995), vol. 78, pages 486 - 504-
DESCRIPTION- MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, (1995), vol. 1264, pages 229 - 237-
DESCRIPTION- NAUWELAERTS ET AL., J. AM. CHEM. SOC., (2007), vol. 129, no. 30, pages 9340 - 9348-
DESCRIPTION- NAUWELAERTS ET AL., NUCLEIC ACIDS RESEARCH, (2005), vol. 33, no. 8, pages 2452 - 2463-
DESCRIPTION- OBERHAUSER ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 533 - 538-
DESCRIPTION- ORUM ET AL., CURR. OPINION MOL. THER., (2001), vol. 3, pages 239 - 243-
DESCRIPTION- PAL-BHADRA ET AL., SCIENCE, (2004), vol. 303, pages 669 - 672-
DESCRIPTION- ROBEYNS ET AL., CTA CRYSTALLOGRAPHICA, SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, (2005), vol. F61, no. 6, pages 585 - 586-
DESCRIPTION- ROBEYNS ET AL., J. AM. CHEM. SOC., (2008), vol. 130, no. 6, pages 1979 - 1984-
DESCRIPTION- SAISON-BEHMOARAS ET AL., EMBO J., (1991), vol. 10, pages 1111 - 1118-
DESCRIPTION- SHEA ET AL., NUCL. ACIDS RES., (1990), vol. 18, pages 3777 - 3783-
DESCRIPTION- SINGH ET AL., CHEM. COMMUN., (1998), vol. 4, pages 455 - 456-
DESCRIPTION- SINGH ET AL., J. ORG. CHEM., (1998), vol. 63, pages 10035 - 10039-
DESCRIPTION- SMITH; WATERMAN, ADV. APPL. MATH., (1981), vol. 2, page 482 489-
DESCRIPTION- SRIVASTAVA ET AL., J. AM. CHEM. SOC., (2007), vol. 129, no. 26, pages 8362 - 8379-
DESCRIPTION- SVINARCHUK ET AL., BIOCHIMIE, (1993), vol. 75, pages 49 - 54-
DESCRIPTION- VERBEURE ET AL., NUCLEIC ACIDS RESEARCH, (2001), vol. 29, no. 24, pages 4941 - 4947-
DESCRIPTION- VERDEL ET AL., SCIENCE, (2004), vol. 303, pages 672 - 676-
DESCRIPTION- VOLPE ET AL., SCIENCE, (2002), vol. 297, pages 1833 - 1837-
DESCRIPTION- WAHLESTED ET AL., PROC. NATL. ACAD. SCI. U. S. A., (2000), vol. 97, pages 5633 - 5638-
DESCRIPTION- WANG ET AL., J. AM. CHEM., (2000), vol. 122, pages 8595 - 8602-
DESCRIPTION- WANG ET AL., J. ORG. CHEM., (2001), vol. 66, pages 8478 - 82-
DESCRIPTION- WANG ET AL., J. ORG. CHEM., (2003), vol. 68, pages 4499 - 4505-
DESCRIPTION- WANG ET AL., NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, (2001), vol. 20, no. 4-7, pages 785 - 788-
DESCRIPTION- WOOLF ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 7305 - 7309-
DESCRIPTION- ZHANG; MADDEN, GENOME RES., (1997), vol. 7, page 649 656-
OPPOSITION- "chapter 1,2 and 5", CROOKE, ST et al., Antisense Drug Technology: Principles, Strategies, and Applications, (20080000), pages 1-74,117 - 141, XP055517726-
OPPOSITION- "chapter 38 Approaches for Manipulation of Gene Expression", YUan , Y et al., Textbook of Pulmonary Vascular Disease, (20110000), pages 557 - 566, XP055517777-
OPPOSITION- HAGEDORN, PH et al., "SURVEY AND SUMMARY Managing the sequence-specificity of antisenseoligonucleotides in drug discovery", Nucleic Acid Res, (20170000), vol. 45, pages 2262 - 2282, XP055517757-
OPPOSITION- HERTEL, KJ et al., "Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements", RNA, (19960000), vol. 2, pages 969 - 981, XP055210095-
OPPOSITION- KNOWLING, S et al., "Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells", Molecular Therapy-Nucleic Acids, (20120000), vol. 1, pages 1 - 10, XP055517753-
OPPOSITION- LALIOTI, MD et al., "Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy", Nature, (19970424), vol. 386, pages 847 - 851, XP055517784-
OPPOSITION- "Proteins", ALBERTS, B et al., Molecular Biology of the Cell, (20020000), pages 162 - 163, XP055517788-
OPPOSITION- STEPHENSON, ML et al., "INHIBITION OF ROUS SARCOMA VIRAL RNA TRANSLATION BY A SPECIFIC OLIGODEOXYRIBONUCLEOTIDE", Proc Natl Acad Sci, (19780000), vol. 75, no. 1, pages 285 - 288, XP000575586-
OPPOSITION- LEAMAN, DW et al., "Targeted Therapy of Respiratory Syncytial Virus in African Green Monkeys by Intranasally Administered 2-5A Antisense", Virology, (20020000), vol. 292, pages 70 - 77, XP055210051
OPPOSITION- GAGNON, KT et al., "Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat", Biochemistry, (20100000), vol. 49, pages 10166 - 10178, XP055033274
OPPOSITION- NAKAMORI, M et al., "Stabilization of Expanded (CTG)center dot(CAG) Repeats by Antisense Oligonucleotides", Molecular Therapy, (20110000), vol. 19, pages 2222 - 2227, XP008153690
OPPOSITION- LINDHOLM, MW et al., "PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates", Molecular Therapy, (20120000), vol. 20, pages 376 - 381, XP055154163
OPPOSITION- SARMA, K et al., "- Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome", Proc Natl Acad Sci, (20100000), vol. 107, pages 22196 - 22201, XP055139924
OPPOSITION- WU, H et al., "Properties of cloned and expressed human RNase H1", J Biol Chem, (19990000), vol. 274, pages 28270 - 28278, XP002234691
OPPOSITION- VICKERS, TA et al., "Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents", J Biol Chem, (20030000), vol. 278, pages 7108 - 7118, XP002281434
OPPOSITION- GAUTSCHI, O et al., "ACTIVITY OF A NOVEL BCL-2/BCL-XL-BISPECIFIC ANTISENSE OLIGONUCLEOTIDE AGAINST TUMORS OF DIVERSE HISTOLOGIC ORIGINS", J Nat Cancer Inst, (20010000), vol. 93, pages 463 - 471, XP009003270
OPPOSITION- VICKERS, TA et al., "EFFECTS OF RNA SECONDARY STRUCTURE ON CELLULAR ANTISENSE ACTIVITY", Nucleic Acid Res, (20000000), vol. 28, pages 1340 - 1347, XP001084042
OPPOSITION- SILAHTAROGLU, A et al., "LNA-modified oligonucleotides are highly efficient as FISH probes", Cytogenet Genome Res, (20040000), vol. 107, pages 32 - 37, XP008144161
OPPOSITION- VICKERS, TA et al., "Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency", PLoS One, (20140000), vol. 9, no. 10, pages 1 - 27, XP055210012
SEARCH- HERTEL K J ET AL, "Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements", RNA 1996 US, (1996), vol. 2, no. 10, ISSN 1355-8382, pages 969 - 981, XP002743813 [X] 1,3,5-9 * page 976 - page 977 *-
SEARCH- DOUGLAS W. LEAMAN ET AL, "Targeted Therapy of Respiratory Syncytial Virus in African Green Monkeys by Intranasally Administered 2-5A Antisense", VIROLOGY, (20020101), vol. 292, no. 1, doi:10.1006/viro.2001.1213, ISSN 0042-6822, pages 70 - 77, XP055210054 [X] 1,3,5-8,10,11 * page 70 - page 71; table 1 *
SEARCH- KEITH T. GAGNON ET AL, "Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat", BIOCHEMISTRY, (20101130), vol. 49, no. 47, doi:10.1021/bi101208k, ISSN 0006-2960, pages 10166 - 10178, XP055033274 [X] 1,3,6,9,10 * figure 2A *
SEARCH- NAKAMORI MASAYUKI ET AL, "Stabilization of Expanded (CTG).(CAG) Repeats by Antisense Oligonucleotides", vol. 19, no. 12, doi:10.1038/MT.2011.191, ISSN 1525-0016, (20111201), pages 2222 - 2227, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, URL: http://www.nature.com/mt/index.html, (20111004), XP008153690 [X] 1,3,6,9-11 * figure 1 *
SEARCH- TIMOTHY A. VICKERS ET AL, "Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency", PLOS ONE, (20141015), vol. 9, no. 10, doi:10.1371/journal.pone.0110615, page e110615, XP055210012

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