| DESCRIPTION | - ALBAEK ET AL., J. ORG. CHEM., (2006), vol. 71, pages 7731 - 7740 | - |
| DESCRIPTION | - ALLSHIRE, SCIENCE, (2002), vol. 297, pages 1818 - 1819 | - |
| DESCRIPTION | - ALTMANN ET AL., BIOCHEM. SOC. TRANS., (1996), vol. 24, pages 630 - 637 | - |
| DESCRIPTION | - ALTMANN ET AL., CHIMIA, (1996), vol. 50, pages 168 - 176 | - |
| DESCRIPTION | - ALTMANN ET AL., NUCLEOSIDES NUCLEOTIDES, (1997), vol. 16, pages 917 - 926 | - |
| DESCRIPTION | - ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, page 403 410 | - |
| DESCRIPTION | - BAKER ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 11944 - 12000 | - |
| DESCRIPTION | - BRAASCH ET AL., BIOCHEMISTRY, (2002), vol. 41, pages 4503 - 4510 | - |
| DESCRIPTION | - BRAASCH ET AL., CHEM. BIOL., (2001), vol. 8, pages 1 - 7 | - |
| DESCRIPTION | - CHATTOPADHYAYA ET AL., J. ORG. CHEM., (2009), vol. 74, pages 118 - 134 | - |
| DESCRIPTION | - CROOKE ET AL., J. PHARMACOL. EXP. THER., (1996), vol. 277, pages 923 - 937 | - |
| DESCRIPTION | - ELAYADI ET AL., CURR. OPINION INVEST. DRUGS, (2001), vol. 2, pages 558 - 561 | - |
| DESCRIPTION | - FREIER ET AL., NUCLEIC ACIDS RESEARCH, (1997), vol. 25, no. 22, pages 4429 - 4443 | - |
| DESCRIPTION | - FRIEDEN ET AL., NUCLEIC ACIDS RESEARCH, (2003), vol. 21, pages 6365 - 6372 | - |
| DESCRIPTION | - GAUTSCHI ET AL., J. NATL. CANCER INST., (200103), vol. 93, pages 463 - 471 | - |
| DESCRIPTION | - GU ET AL., NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, (2005), vol. 24, no. 5-7, pages 993 - 998 | - |
| DESCRIPTION | - GU ET AL., OLIGONUCLEOTIDES, (2003), vol. 13, no. 6, pages 479 - 489 | - |
| DESCRIPTION | - GU ET AL., TETRAHEDRON, (2004), vol. 60, no. 9, pages 2111 - 2123 | - |
| DESCRIPTION | - HALL ET AL., SCIENCE, (2002), vol. 297, pages 2232 - 2237 | - |
| DESCRIPTION | - HORVATH ET AL., TETRAHEDRON LETTERS, (2007), vol. 48, pages 3621 - 3623 | - |
| DESCRIPTION | - JENUWEIN, SCIENCE, (2002), vol. 297, pages 2215 - 2218 | - |
| DESCRIPTION | - JONES, L.J. ET AL., ANALYTICAL BIOCHEMISTRY, (1998), vol. 265, pages 368 - 374 | - |
| DESCRIPTION | - KABANOV ET AL., FEBS LETT., (1990), vol. 259, pages 327 - 330 | - |
| DESCRIPTION | - KOSHKIN ET AL., TETRAHEDRON, (1998), vol. 54, pages 3607 - 3630 | - |
| DESCRIPTION | - KUMAR ET AL., BIOORG. MED. CHEM. LETT., (1998), vol. 8, pages 2219 - 2222 | - |
| DESCRIPTION | - LETSINGER ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 6553 - 6556 | - |
| DESCRIPTION | - LEUMANN, BIOORG. MED. CHEM., (2002), vol. 10, pages 841 - 854 | - |
| DESCRIPTION | - MAHER; DOLNICK, NUC. ACID. RES, (1988), vol. 16, pages 3341 - 3358 | - |
| DESCRIPTION | - MANOHARAN ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 660, pages 306 - 309 | - |
| DESCRIPTION | - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1993), vol. 3, pages 2765 - 2770 | - |
| DESCRIPTION | - MANOHARAN ET AL., BIOORG. MED. CHEM. LET., (1994), vol. 4, pages 1053 - 1060 | - |
| DESCRIPTION | - MANOHARAN ET AL., NUCLEOSIDES & NUCLEOTIDES, (1995), vol. 14, pages 969 - 973 | - |
| DESCRIPTION | - MANOHARAN ET AL., TETRAHEDRON LETT., (1995), vol. 36, pages 3651 - 3654 | - |
| DESCRIPTION | - MARTIN, HELV. CHIM. ACTA, (1995), vol. 78, pages 486 - 504 | - |
| DESCRIPTION | - MISHRA ET AL., BIOCHIM. BIOPHYS. ACTA, (1995), vol. 1264, pages 229 - 237 | - |
| DESCRIPTION | - NAUWELAERTS ET AL., J. AM. CHEM. SOC., (2007), vol. 129, no. 30, pages 9340 - 9348 | - |
| DESCRIPTION | - NAUWELAERTS ET AL., NUCLEIC ACIDS RESEARCH, (2005), vol. 33, no. 8, pages 2452 - 2463 | - |
| DESCRIPTION | - OBERHAUSER ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 533 - 538 | - |
| DESCRIPTION | - ORUM ET AL., CURR. OPINION MOL. THER., (2001), vol. 3, pages 239 - 243 | - |
| DESCRIPTION | - PAL-BHADRA ET AL., SCIENCE, (2004), vol. 303, pages 669 - 672 | - |
| DESCRIPTION | - ROBEYNS ET AL., CTA CRYSTALLOGRAPHICA, SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, (2005), vol. F61, no. 6, pages 585 - 586 | - |
| DESCRIPTION | - ROBEYNS ET AL., J. AM. CHEM. SOC., (2008), vol. 130, no. 6, pages 1979 - 1984 | - |
| DESCRIPTION | - SAISON-BEHMOARAS ET AL., EMBO J., (1991), vol. 10, pages 1111 - 1118 | - |
| DESCRIPTION | - SHEA ET AL., NUCL. ACIDS RES., (1990), vol. 18, pages 3777 - 3783 | - |
| DESCRIPTION | - SINGH ET AL., CHEM. COMMUN., (1998), vol. 4, pages 455 - 456 | - |
| DESCRIPTION | - SINGH ET AL., J. ORG. CHEM., (1998), vol. 63, pages 10035 - 10039 | - |
| DESCRIPTION | - SMITH; WATERMAN, ADV. APPL. MATH., (1981), vol. 2, page 482 489 | - |
| DESCRIPTION | - SRIVASTAVA ET AL., J. AM. CHEM. SOC., (2007), vol. 129, no. 26, pages 8362 - 8379 | - |
| DESCRIPTION | - SVINARCHUK ET AL., BIOCHIMIE, (1993), vol. 75, pages 49 - 54 | - |
| DESCRIPTION | - VERBEURE ET AL., NUCLEIC ACIDS RESEARCH, (2001), vol. 29, no. 24, pages 4941 - 4947 | - |
| DESCRIPTION | - VERDEL ET AL., SCIENCE, (2004), vol. 303, pages 672 - 676 | - |
| DESCRIPTION | - VOLPE ET AL., SCIENCE, (2002), vol. 297, pages 1833 - 1837 | - |
| DESCRIPTION | - WAHLESTED ET AL., PROC. NATL. ACAD. SCI. U. S. A., (2000), vol. 97, pages 5633 - 5638 | - |
| DESCRIPTION | - WANG ET AL., J. AM. CHEM., (2000), vol. 122, pages 8595 - 8602 | - |
| DESCRIPTION | - WANG ET AL., J. ORG. CHEM., (2001), vol. 66, pages 8478 - 82 | - |
| DESCRIPTION | - WANG ET AL., J. ORG. CHEM., (2003), vol. 68, pages 4499 - 4505 | - |
| DESCRIPTION | - WANG ET AL., NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, (2001), vol. 20, no. 4-7, pages 785 - 788 | - |
| DESCRIPTION | - WOOLF ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 7305 - 7309 | - |
| DESCRIPTION | - ZHANG; MADDEN, GENOME RES., (1997), vol. 7, page 649 656 | - |
| OPPOSITION | - "chapter 1,2 and 5", CROOKE, ST et al., Antisense Drug Technology: Principles, Strategies, and Applications, (20080000), pages 1-74,117 - 141, XP055517726 | - |
| OPPOSITION | - "chapter 38 Approaches for Manipulation of Gene Expression", YUan , Y et al., Textbook of Pulmonary Vascular Disease, (20110000), pages 557 - 566, XP055517777 | - |
| OPPOSITION | - HAGEDORN, PH et al., "SURVEY AND SUMMARY Managing the sequence-specificity of antisenseoligonucleotides in drug discovery", Nucleic Acid Res, (20170000), vol. 45, pages 2262 - 2282, XP055517757 | - |
| OPPOSITION | - HERTEL, KJ et al., "Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements", RNA, (19960000), vol. 2, pages 969 - 981, XP055210095 | - |
| OPPOSITION | - KNOWLING, S et al., "Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells", Molecular Therapy-Nucleic Acids, (20120000), vol. 1, pages 1 - 10, XP055517753 | - |
| OPPOSITION | - LALIOTI, MD et al., "Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy", Nature, (19970424), vol. 386, pages 847 - 851, XP055517784 | - |
| OPPOSITION | - "Proteins", ALBERTS, B et al., Molecular Biology of the Cell, (20020000), pages 162 - 163, XP055517788 | - |
| OPPOSITION | - STEPHENSON, ML et al., "INHIBITION OF ROUS SARCOMA VIRAL RNA TRANSLATION BY A SPECIFIC OLIGODEOXYRIBONUCLEOTIDE", Proc Natl Acad Sci, (19780000), vol. 75, no. 1, pages 285 - 288, XP000575586 | - |
| OPPOSITION | - LEAMAN, DW et al., "Targeted Therapy of Respiratory Syncytial Virus in African Green Monkeys by Intranasally Administered 2-5A Antisense", Virology, (20020000), vol. 292, pages 70 - 77, XP055210051 | |
| OPPOSITION | - GAGNON, KT et al., "Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat", Biochemistry, (20100000), vol. 49, pages 10166 - 10178, XP055033274 | |
| OPPOSITION | - NAKAMORI, M et al., "Stabilization of Expanded (CTG)center dot(CAG) Repeats by Antisense Oligonucleotides", Molecular Therapy, (20110000), vol. 19, pages 2222 - 2227, XP008153690 | |
| OPPOSITION | - LINDHOLM, MW et al., "PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates", Molecular Therapy, (20120000), vol. 20, pages 376 - 381, XP055154163 | |
| OPPOSITION | - SARMA, K et al., "- Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome", Proc Natl Acad Sci, (20100000), vol. 107, pages 22196 - 22201, XP055139924 | |
| OPPOSITION | - WU, H et al., "Properties of cloned and expressed human RNase H1", J Biol Chem, (19990000), vol. 274, pages 28270 - 28278, XP002234691 | |
| OPPOSITION | - VICKERS, TA et al., "Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents", J Biol Chem, (20030000), vol. 278, pages 7108 - 7118, XP002281434 | |
| OPPOSITION | - GAUTSCHI, O et al., "ACTIVITY OF A NOVEL BCL-2/BCL-XL-BISPECIFIC ANTISENSE OLIGONUCLEOTIDE AGAINST TUMORS OF DIVERSE HISTOLOGIC ORIGINS", J Nat Cancer Inst, (20010000), vol. 93, pages 463 - 471, XP009003270 | |
| OPPOSITION | - VICKERS, TA et al., "EFFECTS OF RNA SECONDARY STRUCTURE ON CELLULAR ANTISENSE ACTIVITY", Nucleic Acid Res, (20000000), vol. 28, pages 1340 - 1347, XP001084042 | |
| OPPOSITION | - SILAHTAROGLU, A et al., "LNA-modified oligonucleotides are highly efficient as FISH probes", Cytogenet Genome Res, (20040000), vol. 107, pages 32 - 37, XP008144161 | |
| OPPOSITION | - VICKERS, TA et al., "Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency", PLoS One, (20140000), vol. 9, no. 10, pages 1 - 27, XP055210012 | |
| SEARCH | - HERTEL K J ET AL, "Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements", RNA 1996 US, (1996), vol. 2, no. 10, ISSN 1355-8382, pages 969 - 981, XP002743813 [X] 1,3,5-9 * page 976 - page 977 * | - |
| SEARCH | - DOUGLAS W. LEAMAN ET AL, "Targeted Therapy of Respiratory Syncytial Virus in African Green Monkeys by Intranasally Administered 2-5A Antisense", VIROLOGY, (20020101), vol. 292, no. 1, doi:10.1006/viro.2001.1213, ISSN 0042-6822, pages 70 - 77, XP055210054 [X] 1,3,5-8,10,11 * page 70 - page 71; table 1 * | |
| SEARCH | - KEITH T. GAGNON ET AL, "Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat", BIOCHEMISTRY, (20101130), vol. 49, no. 47, doi:10.1021/bi101208k, ISSN 0006-2960, pages 10166 - 10178, XP055033274 [X] 1,3,6,9,10 * figure 2A * | |
| SEARCH | - NAKAMORI MASAYUKI ET AL, "Stabilization of Expanded (CTG).(CAG) Repeats by Antisense Oligonucleotides", vol. 19, no. 12, doi:10.1038/MT.2011.191, ISSN 1525-0016, (20111201), pages 2222 - 2227, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, URL: http://www.nature.com/mt/index.html, (20111004), XP008153690 [X] 1,3,6,9-11 * figure 1 * | |
| SEARCH | - TIMOTHY A. VICKERS ET AL, "Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency", PLOS ONE, (20141015), vol. 9, no. 10, doi:10.1371/journal.pone.0110615, page e110615, XP055210012 | |