IP Verse

Cancer Patient Selection For Administration Of Wnt Signaling Inhibitors Using Rnf43 Mutation Status - EP2820151

The patent EP2820151 was granted to IRM on Mar 25, 2020. The application was originally filed on Feb 22, 2013 under application number EP13707527A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2820151

IRM
Application Number
EP13707527A
Filing Date
Feb 22, 2013
Status
Granted And Under Opposition
Feb 21, 2020
Grant Date
Mar 25, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BOEHRINGER INGELHEIM RCV BOEHRINGER INGELHEIMDec 15, 2020D YOUNGWITHDRAWN

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONEP1487877
DESCRIPTIONUS7425612
DESCRIPTIONUS7718364
DESCRIPTIONUS8093011
DESCRIPTIONWO03024392
DESCRIPTIONWO2010101849
INTERNATIONAL-SEARCH-REPORTEP2275544
INTERNATIONAL-SEARCH-REPORTWO2004032838
INTERNATIONAL-SEARCH-REPORTWO2006017318
INTERNATIONAL-SEARCH-REPORTWO2011004379
OPPOSITIONEP2820151
OPPOSITIONWO2013011479
OPPOSITIONWO2013054307
OPPOSITIONWO2017093478

Non-Patent Literature (NPL) Citations (64) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BAKER ET AL., SCIENCE, (1989), vol. 244, pages 217 - 221-
DESCRIPTION- CALL ET AL., CELL, (1990), vol. 60, pages 509 - 520-
DESCRIPTION- CHEN B ET AL., NAT. CHEM. BIOL., (2009), vol. 5, no. 2, pages 100 - 7-
DESCRIPTION- CHEN B ET AL., NATURE CHEM. BIOL, (2009), vol. 5, pages 100 - 107-
DESCRIPTION- CLEVERS H, CELL, (2006), vol. 127, no. 3, pages 469 - 80-
DESCRIPTION- DEALMEIDA VI ET AL., CANCER RES., (2007), vol. 67, no. 11, pages 5371 - 9-
DESCRIPTION- ETTENBERG S ET AL., PROC. NATL. ACAD. SCI. USA, (2010), vol. 107, no. 35, pages 15473 - 8-
DESCRIPTION- FEARON ET AL., CELL, (1990), vol. 61, pages 759 - 767-
DESCRIPTION- FRIEND ET AL., NATURE, (1986), vol. 323, pages 643 - 646-
DESCRIPTION- FURUKAWA T ET AL., SCI. REP., (2011), vol. 1, page 161-
DESCRIPTION- GURNEY A ET AL., PROC. NATL. ACAD. SCI. USA, (2012), vol. 109, no. 29, pages 11717 - 22-
DESCRIPTION- HAO H-X ET AL., NATURE, (2012), vol. 485, no. 7397, pages 195 - 200-
DESCRIPTION- HAO HX ET AL., NATURE, (2012), vol. 485, no. 7397, pages 195 - 200-
DESCRIPTION- HEISER PW ET AL., DEVELOPMENT, (2006), vol. 133, no. 10, pages 2023 - 32-
DESCRIPTION- HEZEL AF, GENES DEV., (2006), vol. 20, no. 10-
DESCRIPTION- HUANG SM ET AL., NATURE, (2009), vol. 461, no. 7264, pages 614 - 20-
DESCRIPTION- KINZLER ET AL., SCIENCE, (1991), vol. 253, pages 661 - 665-
DESCRIPTION- KOO BK ET AL., NATURE, (2012), vol. 488, no. 7413, pages 665 - 9-
DESCRIPTION- KOO BK, NATURE, (2012), vol. 488, no. 7413, pages 665 - 9-
DESCRIPTION- LASKO ET AL., ANNU. REV. GENET., (1991), vol. 25, pages 281 - 314-
DESCRIPTION- LOGAN CY; NUSSE R, ANNU. REV. CELL. DEV. BIOL., (2004), vol. 20, pages 781 - 810-
DESCRIPTION- LUEBKE AM ET AL., PANCREATOLOGY, (2012), vol. 12, no. 1, pages 16 - 22-
DESCRIPTION- MACDONALD BT ET AL., DEV. CELL, (2009), vol. 17, no. 1, pages 9 - 26-
DESCRIPTION- MATTHAEI H ET AL., ANN. SURG. ONCOL., (2011), vol. 18, no. 12, pages 3493 - 9-
DESCRIPTION- MCDONALD BT ET AL., DEVELOPMENTAL CELL, (2009), vol. 17, no. 1, pages 9 - 26-
DESCRIPTION- MEINKOTH ET AL., ANAL. BIOCHEM., (1984), vol. 138, pages 267 - 284-
DESCRIPTION- MORRIS JP ET AL., NAT. REV. CANCER, (2010), vol. 10, no. 10, pages 683 - 95-
DESCRIPTION- NUSSE R, CELL RESEARCH, (2005), vol. 15, no. 1, pages 28 - 32-
DESCRIPTION- PASCA DI MAGLIANO M ET AL., PLOS ONE, (2007), vol. 2, no. 11, page E1155-
DESCRIPTION- ROGAN P ET AL., GENOME RES., (2001), vol. 11, no. 6, pages 1086 - 1094-
DESCRIPTION- SAMBROOK ET AL., Molecular Cloning: A Laboratory Manual, COLD SPRING HARBOR LABS PRESS, (1989), pages 9.31 - 9.62-
DESCRIPTION- SCHOLER-DAHIREL A ET AL., PROC. NATL. ACAD. SCI. USA, (2011), vol. 108, no. 41, pages 17135 - 40-
DESCRIPTION- SUGIURA T ET AL., EXP. CELL RES., (2008), vol. 314, no. 7, pages 1519 - 28-
DESCRIPTION- THERASSE P ET AL., J. NATL. CANCER INST., (2000), vol. 92, no. 3, pages 205 - 216-
DESCRIPTION- THERASSE P. ET AL., J. NATL. CANCER INST., (2000), vol. 92, no. 3, pages 205 - 216-
DESCRIPTION- VOGELSTEIN ET AL., NEW ENGL. J. MED., (1988), vol. 319, no. 9, pages 525 - 532-
DESCRIPTION- WANG L ET AL., CANCER SCI., (2009), vol. 101, no. 3, pages 700 - 6-
DESCRIPTION- WELLS JM, BMC DEV. BIOL., (2007), vol. 7, page 4-
DESCRIPTION- WU J ET AL., PROC. NATL. ACAD. SCI., (2011), vol. 108, page 2188-
DESCRIPTION- WU J ET AL., PROC. NATL. ACAD. SCI. USA, (2011), vol. 108, no. 52, pages 21188 - 93-
INTERNATIONAL-SEARCH-REPORT- HUAI-XIANG HAO ET AL, "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner", NATURE, (20120429), vol. 485, no. 7397, doi:10.1038/nature11019, ISSN 0028-0836, pages 195 - 200, XP055061275 [XP] 1-30 * the whole document *
INTERNATIONAL-SEARCH-REPORT- BON-KYOUNG KOO ET AL, "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors", NATURE, (20120815), vol. 488, no. 7413, doi:10.1038/nature11308, ISSN 0028-0836, pages 665 - 669, XP055061276 [XP] 1-30 * the whole document *
INTERNATIONAL-SEARCH-REPORT- J. LIU ET AL, "PD08-11: Targeting Porcupine, a Critical Node for Wnt Signalling in Cancer.", CANCER RESEARCH, (20111215), vol. 71, no. 24 Supplement, doi:10.1158/0008-5472.SABCS11-PD08-11, ISSN 0008-5472, pages PD08 - 11, XP055061279 [I] 26-30 * the whole document *
OPPOSITION- Akiko Mukai, Miki Yamamoto-Hino, Wakae Awano, Wakako Watanabe, Masayuki Komada, Satoshi Goto, "Balanced ubiquitylation and deubiquitylation of frizzled regulate cellular responsiveness to Wg/Wnt", The EMBO Journal, (20100000), vol. 29, no. 13, pages 2114 - 2125, XP055783291-
OPPOSITION- Anonymous, "A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands", ClinicalTrials.gov, (20110500), pages 1 - 9, XP002780915-
OPPOSITION- Anonymous, "Small molecules in Wnt signalling", the Wnt homepage, (20180123), page 1, URL: https://web.stanford.edu/group/nusselab/cgi/bin/wnt/smallmolecules, XP055783318-
OPPOSITION- Daniel Bottomly, Sydney L. Kyler, Shannon K. McWeeney, and Gregory S. Yochum, "Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq", Nucleic Acids Research, (20100000), vol. 38, no. 17, pages 5735 - 5745, XP055783300-
OPPOSITION- Dong Guo, Siu Yuen, Wai Tsui, Annie Chan, Tsun Chan and Suet Leung, "Expression of wnt signaling target genes in colorectal cancer progression", AACR annual meeting, (20070000), pages 1 - 3, XP055783273-
OPPOSITION- IVANOV et al., "Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells", Oncogene, (20070000), vol. 26, pages 2873 - 2884, XP055783277-
OPPOSITION- Jianghua Tu , Soohyun Park , Wangsheng Yu , Sheng Zhang , Ling Wu , Kendra Carmon , Qingyun J Liu, "The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis", Sci Rep, (20190000), vol. 9, no. 18557, pages 1 - 12, XP055783323-
OPPOSITION- Kyoung-Sub Song , Kaipeng Jing, Jong-Seok Kim, Eun-Jin Yun, Soyeon Shin, Kang-Sik Seo, Ji-Hoon Park, Jun-Young Heo, Jing X Kang, Kwang-Sun Suh, Tong Wu, Jong-Il Park, Gi-Ryang Kweon, Wan-Hee Yoon, Byung-Doo Hwang, Kyu Lim, "Omeda-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-Catenin Signaling", Pancreatology, (20110000), vol. 11, pages 574 - 584, XP055783337-
OPPOSITION- NUSSE R., "Wnt signaling in disease and in development", Cell Research, (20050000), vol. 15, no. 1, pages 28 - 32, XP055783283-
OPPOSITION- SATO et al., "MAINTENANCE OF PLURIPOTENCY IN HUMAN AND MOUSE EMBRYONIC STEM CELLS THROUGH ACTIVATION OF WNT SIGNALING BY A PHARMACOLOGICAL GSK-3-SPECIFIC INHIBITOR", Nature Medicine, (20040000), vol. 10, no. 1, pages 55 - 63, XP002380572-
OPPOSITION- CAIRO et al., "Hepatic Stem-like Phenotype and Interplay of Wnt/beta-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer", Cancer Cell, (20080000), vol. 14, pages 471 - 484, XP002508978
OPPOSITION- Huai-Xiang Hao; Yang Xie; Yue Zhang; Olga Charlat; Emma Oster; Monika Avello; Hong Lei; Craig Mickanin; Dong Liu; Heinz Ruffner; Xiaohong Mao; Qicheng Ma; Raffaella Zamponi; Tewis Bouwmeester; Peter M Finan; Marc W Kirschner; Jeffery A Porter; Fabrizio C Serluca; Feng Cong, "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner", Nature, (20120000), vol. 485, no. 7397, pages 195 - 200, XP002706010
OPPOSITION- Bon-Kyoung Koo; Maureen Spit; Ingrid Jordens; Teck Y Low; Daniel E Stange; Marc van de Wetering; Johan H van Es; Shabaz Mohammed; Albert J R Heck; Madelon M Maurice; Hans Clevers, "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors", Nature, (20120000), vol. 488, pages 665 - 669, XP002696011
OPPOSITION- Baozhi Chen; Michael E Dodge; Wei Tang; Jianming Lu; Zhiqiang Ma; Chih-Wei Fan; Shuguang Wei; Wayne Hao; Jessica Kilgore; Noelle S Williams; Michael G Roth; James F Amatruda; Chuo Chen; Lawrence Lum, "Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer", Nat Chem Biol, (20090000), vol. 5, no. 2, pages 100 - 107, XP055295218
OPPOSITION- Li Shan; Lavrijsen Marla; Bakker Aron; Magierowski Marcin; Magierowska Katarzyna; Liu Pengyu; Wang Wenhui; Peppelenbosch Maikel P; Smits Ron, "Commonly observedmutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers", Oncogene, (20200000), vol. 39, pages 3458 - 3472, XP037098180
OPPOSITION- Aguilera O; Fraga M F; Ballestar E; Paz M F; Herranz M; Espada J; García J M; Muñoz A; Esteller M; González-Sancho J M, "Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer", Oncogene, (20060000), vol. 25, no. 29, pages 4116 - 4121, XP002679453
OPPOSITION- Toru Furukawa; Yuko Kuboki; Etsuko Tanji; Shoko Yoshida; Takashi Hatori; Masakazu Yamamoto; Noriyuki Shibata; Kyoko Shimizu; Naoyuki Kamatani; and Keiko Shiratori, "Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas", Scientific Reports, (20110000), vol. 1, no. 161, pages 1 - 7, XP002733929
OPPOSITION- Wu J; Jiao Y; Dal Molin M; Maitra A; De Wilde R F; Wood L D; Eshleman J R; Goggins M G; Wolfgang C L; Canto M I; Schulick R D; Edil B H; Choti M A; Adsay V; Klimstra D S; Offerhaus G J A; Klein A P; Kopelovich L; Carter H; Karchin R; Allen P J; Schmidt C M; Naito Y; Diaz L A; Kinzler K W; Papadopoulos N; Hruban R H; Vogelstein B, "Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways", PNAS, (20110000), vol. 108, no. 52, pages 21188 - 21193, XP055069412
OPPOSITION- Jiang X; H-X Hao; Growney J D; Woolfenden S; Bottiglio C; Ng N; Lu B; Hsieh M H; Bagdasarian L; Meyer R; Smith T R; Avello M; Charlat O; Xie Y; Porter J A; Pan S; Liu J; Mclaughlin M E; Cong F, "Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma", PNAS, (20130000), vol. 110, no. 31, pages 12649 - 12654, XP055200712
OPPOSITION- Liu J; Pan S; Sun F; Kasibhatla S; Schuller A; Li A; Li C; Cui X; Wang T; Villarroel M; Mclaughlin M; Sellers W; Boral A; Harris J, "PD08-11: Targeting Porcupine, a Critical Node for Wnt Signalling in Cancer", Cancer Research, (20110000), vol. 71, no. 24, page PD08-11, XP055061279
OPPOSITION- RING et al., "Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo", Diabetes, (20030000), vol. 52, pages 588 - 595, XP002305100

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents