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Method Of Blocking Vascular Leakage Using An Anti-Ang2 Antibody - EP2835380

The patent EP2835380 was granted to Samsung Electronics on Apr 7, 2021. The application was originally filed on Jul 29, 2014 under application number EP14178843A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2835380

SAMSUNG ELECTRONICS
Application Number
EP14178843A
Filing Date
Jul 29, 2014
Status
Patent Maintained As Amended
Mar 5, 2021
Grant Date
Apr 7, 2021
External Links
Slate, Register, Google Patents

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ABLYNXJun 6, 2018SANOFIADMISSIBLE

Patent Citations (9) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
EXAMINATIONEP2848631
OPPOSITIONEP2848631
OPPOSITIONUS2015010572
OPPOSITIONUS2015037343
OPPOSITIONWO2006045049
OPPOSITIONWO2006068953
OPPOSITIONWO2008049227
SEARCHWO2006045049
SEARCHWO2006068953

Non-Patent Literature (NPL) Citations (42) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALMAGRO, J. C.; FRANSSON, J., "Humanization of antibodies", FRONTIERS IN BIOSCIENCE, (2008), vol. 13, pages 1619 - 1633-
DESCRIPTION- SCHWABER, J; COHEN, E. P., "Human x Mouse Somatic Cell Hybrid Clones Secreting Immunoglobulins of Both Parental Types", NATURE, (1973), vol. 244, pages 444 - 447-
OPPOSITION- abcam, "Anti-Angiopoietin 2 antibody ab845", abcam Online Catalogue, (20141113), URL: https://www.abcam.com/angiopoietin-2-antibody-ab8452.html-
OPPOSITION- abcam, "Anti-Angiopoietin 2 antibody ab845", abcam Online Catalogue, (20141113), URL: https://www.abcam.com/angiopoietin-2-antibody-ab8452.html, XP002732471-
OPPOSITION- Andrew V. Benest et al.,, "Angiopoietin-2 is critical for cytokine-induced vascular leakage", PLoS ONE, (20130801), vol. 8, no. 8, pages e70459-1 - e70459-9-
OPPOSITION- Andrew V. Benest et al.,, "Angiopoietin-2 is critical for cytokine-induced vascular leakage", PLoS ONE, (20130801), vol. 8, no. 8, pages e70459-1 - e70459-9, XP055520065-
OPPOSITION- Anonymous, "Recombinant mouse Angiopoietin-2", R&D systems leaflet catalog number: 7186-AN, (20180602), page 1-
OPPOSITION- Anonymous, "Recombinant mouse Angiopoietin-2", R&D systems leaflet catalog number: 7186-AN, (20180602), page 1, XP055520052-
OPPOSITION- BARTON WILLIAM A ET AL, "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex", NATURE STRUCTURAL & MOLECULAR BIOLOGY, (20060601), vol. 13, no. 6, pages 524 - 532-
OPPOSITION- DALY et al., "Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition", CANCER RESEARCH, (20121113), vol. 73, pages 108 - 118-
OPPOSITION- Gerald D; Chintharlapalli S; Augustin H G; Benjamin L E, "Angiopoietin-2 an attractive target for improved anti- angiogenic tumor therapy", Cancer Research, (20130315), vol. 73, no. 6, pages 1649 - 1657-
OPPOSITION- Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi, Samir M. Parikh, "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium", MOLECULAR AND CELLULAR BIOLOGY, (20090415), vol. 29, no. 8, pages 2011 - 2022-
OPPOSITION- HOLOPAINEN et al., "Effects of Angiopoietin-2-blocking antibody on endothelial cell - cell juntion and lung metastais", JOURNAL OF THE NATIONAL CANCER INSTITUTE, (20120321), vol. 104, pages 461 - 475-
OPPOSITION- KIM et al., "A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis", BIOCHIMICA ET BIOPHYSICA ACTA, (20090210), vol. 1793, no. 5, pages 772 - 780-
OPPOSITION- LANA KLIONSKY et al., "A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (20060000), vol. 319, no. 1, pages 192 - 198, XP055520075-
OPPOSITION- LANA KLIONSKY et al., "A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (2006), vol. 319, no. 1, pages 192 - 198-
OPPOSITION- MIJARES A. et al., "From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta2-adrenoceptor antibody behave as antagonists", Molecular Pharmacology, (20000000), vol. 58, pages 373 - 379, XP055520069-
OPPOSITION- MIJARES A. et al., "From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta2-adrenoceptor antibody behave as antagonists", Molecular Pharmacology, (2000), vol. 58, pages 373 - 379-
OPPOSITION- Philipp Kümpers et al., "The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis", Critical Care, (20111031), vol. 15, no. 5, page R261-
OPPOSITION- PIETILA R. et al., "Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses", Journal of Cell Science, (20120501), vol. 125, no. 9, pages 2212 - 2223-
OPPOSITION- Santa Cruz Biotechnology Inc.,, "Ang-2 (F-1): sc-74403", Santa Cruz Biotechnology Online Catalogue, (20130322), URL: http://datasheets.scbt.com/sc-74403.pdf-
OPPOSITION- Santa Cruz Biotechnology Inc.,, "Ang-2 (F-1): sc-74403", Santa Cruz Biotechnology Online Catalogue, (20130322), URL: http://datasheets.scbt.com/sc-74403.pdf, XP002732470-
OPPOSITION- SRIRAJASKANTHAN et al., "Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis", Endocrine - Related Cancer,, (20090605), vol. 16, no. 3, pages 967 - 976-
OPPOSITION- Tilman Ziegler et al., "Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis", JOURNAL OF CLINICAL INVESTIGATION,, (20130801), vol. 123, no. 8, pages 3436 - 3445-
OPPOSITION- YAO DACHUN ET AL, "High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A", Journal of Biological Chemistry,, (20070801), vol. 282, no. 42, pages 31038 - 31045-
OPPOSITION- KIM et al., "A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis", BIOCHIMICA ET BIOPHYSICA ACTA, (20090210), vol. 1793, no. 5, pages 772 - 780, XP026106489
OPPOSITION- YAO DACHUN ET AL, "High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A", Journal of Biological Chemistry,, (20070801), vol. 282, no. 42, pages 31038 - 31045, XP002732473
OPPOSITION- HOLOPAINEN et al., "Effects of Angiopoietin-2-blocking antibody on endothelial cell - cell juntion and lung metastais", JOURNAL OF THE NATIONAL CANCER INSTITUTE, (20120321), vol. 104, pages 461 - 475, XP055238810
OPPOSITION- BARTON WILLIAM A ET AL, "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex", NATURE STRUCTURAL & MOLECULAR BIOLOGY, (20060601), vol. 13, no. 6, pages 524 - 532, XP009140199
OPPOSITION- Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi, Samir M. Parikh, "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium", MOLECULAR AND CELLULAR BIOLOGY, (20090415), vol. 29, no. 8, pages 2011 - 2022, XP055520045
OPPOSITION- DALY et al., "Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition", CANCER RESEARCH, (20121113), vol. 73, pages 108 - 118, XP008161599
OPPOSITION- Gerald D; Chintharlapalli S; Augustin H G; Benjamin L E, "Angiopoietin-2 an attractive target for improved anti- angiogenic tumor therapy", Cancer Research, (20130315), vol. 73, no. 6, pages 1649 - 1657, XP055236902
OPPOSITION- Tilman Ziegler et al., "Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis", JOURNAL OF CLINICAL INVESTIGATION,, (20130801), vol. 123, no. 8, pages 3436 - 3445, XP002732474
OPPOSITION- Philipp Kümpers et al., "The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis", Critical Care, (20111031), vol. 15, no. 5, page R261, XP021112680
OPPOSITION- PIETILA R. et al., "Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses", Journal of Cell Science, (20120501), vol. 125, no. 9, pages 2212 - 2223, XP055520058
OPPOSITION- SRIRAJASKANTHAN et al., "Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis", Endocrine - Related Cancer,, (20090605), vol. 16, no. 3, pages 967 - 976, XP002732472
SEARCH- abcam, "Anti-Angiopoietin 2 antibody ab8452", (20141113), abcam Online Catalogue, URL: http://www.abcam.com/Angiopoietin-2-antibody-ab8452.pdf, (20141113), XP002732471 [AP] 1-11 * the whole document *-
SEARCH- Santa Cruz Biotechnology, inc., "Ang-2 (F-1): sc-74403", (20130322), Santa Cruz Biotechnology Online Catalogue, URL: http://datasheets.scbt.com/sc-74403.pdf, (20141113), XP002732470 [A] 1-11 * the whole document *-
SEARCH- YAO DACHUN ET AL, "High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 19 OCT 2007, (20071019), vol. 282, no. 42, ISSN 0021-9258, pages 31038 - 31045, XP002732473 [A] 1-11 * page 31039, column left *
SEARCH- BARTON WILLIAM A ET AL, "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex", NATURE STRUCTURAL & MOLECULAR BIOLOGY, NATURE PUBLISHING GROUP, US, (20060601), vol. 13, no. 6, doi:10.1097/ACO.0B013E328332A473, ISSN 1545-9985, pages 524 - 532, XP009140199 [T] * page 524, column right * * figure 1B *
SEARCH- ZIEGLER TILMAN ET AL, "Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis", JOURNAL OF CLINICAL INVESTIGATION, (20130801), vol. 123, no. 8, pages 3436 - 3445, XP002732474 [XP] 3 * page 34444, column right * [I] 11
SEARCH- SRIRAJASKANTHAN R ET AL, "Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis.", ENDOCRINE-RELATED CANCER SEP 2009, (200909), vol. 16, no. 3, ISSN 1479-6821, pages 967 - 976, XP002732472 [A] 1-11 * page 969, column right *

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