Hla Class Ii Deficient Cells, Hla Class I Deficient Cells Capable Of Expressing Hla Class Ii Proteins, And Uses Thereof - EP2838548

The patent EP2838548 was granted to University OF Washington Through ITS Center FOR Commercialization on Jul 19, 2023. The application was originally filed on Mar 15, 2013 under application number EP13714128A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2838548

UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
Application Number
EP13714128A
Filing Date
Mar 15, 2013
Status
Granted And Under Opposition
Jun 16, 2023
Grant Date
Jul 19, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateOpposition Status

Get instant alerts for new oppositions and patent status changes

PAGEApr 16, 2024ADMISSIBLE
JAMES POOLEAug 3, 2023ADMISSIBLE

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2008219956
DESCRIPTIONUS4892538
DESCRIPTIONUS5011472
DESCRIPTIONUS5837234
DESCRIPTIONWO9110425
DESCRIPTIONWO9110470
EXAMINATIONWO2012145384
EXAMINATIONWO9209688
EXAMINATIONWO9517911
OPPOSITIONUS2005196404
OPPOSITIONUS6514752
OPPOSITIONWO2007091078
OPPOSITIONWO2012145384
OPPOSITIONWO9209688
OPPOSITIONWO9517911

Non-Patent Literature (NPL) Citations (28) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- HILLYARD ET AL, "Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylation", ATHEROSCLEROSIS, ELSEVIER, AMSTERDAM, NL, (20070315), vol. 191, no. 2, doi:10.1016/J.ATHEROSCLEROSIS.2006.05.037, ISSN 0021-9150, pages 319 - 325, XP005925073
EXAMINATION- DULBERGER CHARLES L ET AL, "Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors", IMMUNITY, CELL PRESS, AMSTERDAM, NL, (20170620), vol. 46, no. 6, doi:10.1016/J.IMMUNI.2017.06.002, ISSN 1074-7613, page 1018, XP085094631
EXAMINATION- LAURA RIOLOBOS ET AL, "HLA Engineering of Human Pluripotent Stem Cells", MOLECULAR THERAPY, (20130601), vol. 21, no. 6, doi:10.1038/mt.2013.59, ISSN 1525-0016, pages 1232 - 1241, XP055145726
EXAMINATION- GERMÁN G GORNALUSSE ET AL, "HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells", NATURE BIOTECHNOLOGY, New York, (20170515), vol. 35, no. 8, doi:10.1038/nbt.3860, ISSN 1087-0156, pages 765 - 772, XP055640664
EXAMINATION- Beatriz Suárez-Álvarez ET AL, "Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells", PL o S One, US, (20100101), vol. 5, no. 4, doi:10.1371/journal.pone.0010192, ISSN 1932-6203, pages e10192 - e10192, XP055301715
OPPOSITION- Benjamin G Lilienfeld , Mark D Crew, Pietro Forte, Bettina C Baumann, Jörg D Seebach, "Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity", Xenotransplantation, (20070101), vol. 14, pages 126 - 134, XP055514962-
OPPOSITION- Villard Jean, Masternak Krzysztof, Lisowska-Grospierre Barbara, Fischer Alain, Reith Walter, " MHC Class II Deficiency A Disease of Gene Regulation", Medicine, (20011101), vol. 80, no. 6, pages 405 - 418, XP093187666-
OPPOSITION- Frederic Deschaseaux; Diego Delgado; Vito Pistoia; Massimo Giuliani; Fabio Morandi; Antoine Durrbach, "HLA-G in organ transplantation: towards clinical applications", Cellular and Molecular Life Sciences, Ba , (20101120), vol. 68, no. 3, doi:10.1007/s00018-010-0581-6, ISSN 1420-9071, pages 397 - 404, XP019873575
OPPOSITION- A. Peijnenburg, R. Van Den Berg, M.J.C.A. Van Eggermond, Ö. Sanal, J. M. J. J. Vossen, A. -M. Lennon, C. AlcaïDe-Loridan, P.J. Van Den Elsen, "Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene", Immunogenetics, (20000113), vol. 51, no. 1, doi:10.1007/s002510050007, ISSN 00937711, pages 42 - 49, XP055064848
OPPOSITION- Wei-Hua Yan, "Human leukocyte antigen-G in cancer: Are they clinically relevant?", Cancer letters, US , (20110714), vol. 311, no. 2, doi:10.1016/j.canlet.2011.07.019, ISSN 0304-3835, pages 123 - 130, XP028298361
OPPOSITION- Dulberger Charles L.; McMurtrey Curtis P.; Hölzemer Angelique; Neu Karlynn E.; Liu Victor; Steinbach Adriana M.; Garcia-Beltran Wilfredo F.; Sulak Michael; Jabri Bana; Lynch Vincent J.; Altfeld Marcus; Hildebrand William H.; Adams Erin J., "Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors", Immunity, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (20170620), vol. 46, no. 6, doi:10.1016/j.immuni.2017.06.002, ISSN 1074-7613, page 1018, XP085094631
OPPOSITION- van Eggermond, M.C.J.A. ; Tezcan, I. ; Heemskerk, M.H.M. ; van den Elsen, P.J., "Transcriptional silencing of RFXAP in MHC class II-deficiency", Molecular Immunology, PERGAMON, GB, GB , (20080501), vol. 45, no. 10, doi:10.1016/j.molimm.2008.01.026, ISSN 0161-5890, pages 2920 - 2928, XP022606011
OPPOSITION- Moscoso, J. ; Serrano-Vela, J.I. ; Pacheco, R. ; Arnaiz-Villena, A., "HLA-G, -E and -F: Allelism, function and evolution", Transplant Immunology, NL , (20061201), vol. 17, no. 1, doi:10.1016/j.trim.2006.09.010, ISSN 0966-3274, pages 61 - 64, XP025013487
OPPOSITION- Laura Riolobos, Roli K Hirata, Cameron J Turtle, Pei-Rong Wang, German G Gornalusse, Maja Zavajlevski, Stanley R Riddell, David W Russell, "HLA Engineering of Human Pluripotent Stem Cells", Molecular Therapy, No longer published by Elsevier, (20130601), vol. 21, no. 6, doi:10.1038/mt.2013.59, ISSN 15250016, pages 1232 - 1241, XP055145726
OPPOSITION- Germán G Gornalusse, Roli K Hirata, Sarah E Funk, Laura Riolobos, Vanda S Lopes, Gabriel Manske, Donna Prunkard, Aric G Colunga, Laïla-Aïcha Hanafi, Dennis O Clegg, Cameron Turtle, David W Russell, "HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20170801), vol. 35, no. 8, doi:10.1038/nbt.3860, ISSN 1087-0156, pages 765 - 772, XP055640664
OPPOSITION- Iram F Khan, Roli K Hirata, David W Russell, "AAV-mediated gene targeting methods for human cells", Nature Protocols, Nature Publishing Group, GB, GB , (20110301), vol. 6, no. 4, doi:10.1038/nprot.2011.301, ISSN 1754-2189, pages 482 - 501, XP055232661
OPPOSITION- BRADLEY J A, BOLTON E M, PEDERSEN R A, "Stem cell medicine encounters the immune system", Nature Reviews Immunology, Nature Publishing Group UK, London, London, (20021101), vol. 2, no. 11, doi:10.1038/nri934, ISSN 1474-1733, pages 859 - 871, XP002981993
OPPOSITION- Bonini Chiara, Bondanza Attilio, Perna Serena Kimi, Kaneko Shin, Traversari Catia, Ciceri Fabio, Bordignon Claudio, "The Suicide Gene Therapy Challenge: How to Improve a Successful Gene Therapy Approach", Molecular Therapy, US , (20070701), vol. 15, no. 7, doi:10.1038/sj.mt.6300190, ISSN 1525-0016, pages 1248 - 1252, XP093187673
OPPOSITION- Satoh Ayumi; Toyota Minoru; Ikeda Hideyuki; Morimoto Yoshikazu; Akino Kimishige; Mita Hiroaki; Suzuki Hiromu; Sasaki Yasushi; Kanaseki Takayuki; Takamura Yukio; Soejima Hidenobu; Urano Takeshi; Yanagihara Kazuyoshi; Endo Takao; Hinoda Yuji; Fujita Masahiro; Hosokawa Masao; Sato Noriyuki; Tokino Takashi; Imai Kohzoh, "Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-γ-induced HLA-DR expression in colorectal and gastric cancer cells", Oncogene, London , (20041004), vol. 23, no. 55, doi:10.1038/sj.onc.1208144, ISSN 0950-9232, pages 8876 - 8886, XP037737394
OPPOSITION- Tiberghien P, "Use of suicide gene-expressing donor T-cells to control alloreactivity after haematopoietic stem cell transplantation", Journal of internal medicine, GB , (20010101), vol. 249, doi:10.1046/j.1365-2796.2001.00809.x, ISSN 0954-6820, pages 369 - 377, XP002967331
OPPOSITION- K Toshitani , V Braud, M J Browning, N Murray, A J McMichael, W F Bodmer, "Expression of a single-chain HLA class I molecule in a human cell line: Presentation of exogenous peptide and processed antigen to cytotoxic T lymphocytes", Proceedings of the National Academy of Sciences, National Academy of Sciences, (19960109), vol. 93., no. 01., doi:10.1073/pnas.93.1.236, ISSN 0027-8424, pages 236 - 240., XP002051157
OPPOSITION- BORREGO, FRANCISCO ET AL, "Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94 /NKG2 confers protection from natural killer cell-mediated lysis.", Journal of Experimental Medicine, Rockefeller University Press, US, US , (19980302), vol. 187., no. 05., doi:10.1084/jem.187.5.813, ISSN 0022-1007, pages 813 - 818., XP002109019
OPPOSITION- Batten Puspa, Rosenthal Nadia A, Yacoub Magdi H, "Immune response to stem cells and strategies to induce tolerance", Philosophical transactions royal society of London B biological sciences, GB , (20070829), vol. 362, no. 1484, doi:10.1098/rstb.2007.2120, ISSN 0962-8436, pages 1343 - 1356, XP093187649
OPPOSITION- V Steimle, B Durand, E Barras, M Zufferey, M R Hadam, B Mach, W Reith, "A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).", Genes & Development, Cold Spring Harbor Laboratory Press, (19950501), vol. 9, no. 9, doi:10.1101/gad.9.9.1021, ISSN 08909369, pages 1021 - 1032, XP055064845
OPPOSITION- Arase Hisashi , Edward S. Mocarski, Ann E. Campbell, Ann B. Hill, Lewis L. Lanier, "Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors", Science, (20020517), vol. 296, doi:10.1126/science.1070884, pages 1323 - 1326, XP093187660
OPPOSITION- D. S. Kaufman, "Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells", Blood, US , (20091022), vol. 114, no. 17, doi:10.1182/blood-2009-03-191304, ISSN 0006-4971, pages 3513 - 3523, XP055506843
OPPOSITION- Beatriz Suárez-Álvarez, Ramón M. Rodriguez, Vincenzo Calvanese, Miguel A. Blanco-Gelaz, Steve T. Suhr, Francisco Ortega, Jesus Otero, Jose B. Cibelli, Harry Moore, Mario F. Fraga, Carlos López-Larrea, "Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells", PLOS ONE, US , (20100101), vol. 5, no. 4, doi:10.1371/journal.pone.0010192, ISSN 1932-6203, pages 1 - 12, XP055301715
OPPOSITION- Y. Matsunaga, D. Fukuma, S. Hirata, S. Fukushima, M. Haruta, T. Ikeda, I. Negishi, Y. Nishimura, S. Senju, "Activation of Antigen-Specific Cytotoxic T Lymphocytes by  2-Microglobulin or TAP1 Gene Disruption and the Introduction of Recipient-Matched MHC Class I Gene in Allogeneic Embryonic Stem Cell-Derived Dendritic Cells", The Journal of Immunology, American Association of Immunologists, (20081101), vol. 181, no. 9, doi:10.4049/jimmunol.181.9.6635, ISSN 00221767, pages 6635 - 6643, XP055145645

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents