Methods For Selecting Binders By Phage Display And Masked Selection - EP2855678

The patent EP2855678 was granted to Centre National DE LA Recherche Scientifique Cnrs on Aug 23, 2017. The application was originally filed on May 24, 2013 under application number EP13724608A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2855678

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Application Number
EP13724608A
Filing Date
May 24, 2013
Status
Granted And Under Opposition
Jul 21, 2017
Grant Date
Aug 23, 2017
External Links
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ABLYNXMay 23, 2018-WITHDRAWN

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS4861719
DESCRIPTIONUS4960716
DESCRIPTIONUS5278056
DESCRIPTIONUS5306811
DESCRIPTIONUS5324822
DESCRIPTIONUS5882877
DESCRIPTIONUS6013516
DESCRIPTIONWO9419478
DESCRIPTIONWO9514785
DESCRIPTIONWO9622378
INTERNATIONAL-SEARCH-REPORTUS2011076752
OPPOSITIONUS2011076752
OPPOSITIONUS2011091449
OPPOSITIONWO2006017174
OPPOSITIONWO2008071447
OPPOSITIONWO9621671

Non-Patent Literature (NPL) Citations (36) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ACRES ET AL., CURR OPIN MOL THER, (200402), vol. 6, pages 40 - 7-
DESCRIPTION- ALVAREZ-RUEDA N; BEHAR G; FERRE V; PUGNIERE M; ROQUET F; GASTINEL L; JACQUOT C; AUBRY J; BATY D; BARBET J, "Generation of llama single-domain antibodies against methotrexate, a prototypical hapten", MOL IMMUNOL, (2007), vol. 44, pages 1680 - 1690-
DESCRIPTION- BEHAR G; CHAMES P; TEULON I; CORNILLON A; ALSHOUKR F; ROQUET F; PUGNIERE M; TEILLAUD JL; GRUAZ-GUYON A; PELEGRIN A, "Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen", FEBS J, (2009), vol. 276, pages 3881 - 3893-
DESCRIPTION- BEIBOER SH; REURS A; ROOVERS RC; ARENDS JW; WHITELEGG NR; REES AR; HOOGENBOOM HR, "Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent", J MOL BIOL, (2000), vol. 296, pages 833 - 849-
DESCRIPTION- EMENS ET AL., CANCER BIOL THER., vol. 2, no. 4, pages 161 - 8-
DESCRIPTION- EVEN-DESRUMEAUX K; BATY D; CHAMES P, "Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost- effective antibody array generation", MOL BIOSYST, (2010), vol. 6, pages 2241 - 2248-
DESCRIPTION- FIGINI M; OBICI L; MEZZANZANICA D; GRIFFITHS A; COLNAGHI MI; WINTER G; CANEVARI S, "Panning phage antibody libraries on cells: isolation of human Fab fragments against ovarian carcinoma using guided selection", CANCER RES, (1998), vol. 58, pages 991 - 996-
DESCRIPTION- GEUIJEN CA; BIJL N; SMIT RC; COX F; THROSBY M; VISSER TJ; JONGENEELEN MA; BAKKER AB; KRUISBEEK AM; GOUDSMIT J, "A proteomic approach to tumour target identification using phage display, affinity purification and mass spectrometry", EUR J CANCER, (2005), vol. 41, pages 178 - 187-
DESCRIPTION- HOOGENBOOM HR, "Selecting and screening recombinant antibody libraries", NAT BIOTECHNO12005, vol. 23, pages 1105 - 1116-
DESCRIPTION- JENSEN KB; JENSEN ON; RAVN P; CLARK BF; KRISTENSEN P, "Identification of keratinocyte-specific markers using phage display and mass spectrometry", MOL CELL PROTEOMICS, (2003), vol. 2, pages 61 - 69-
DESCRIPTION- KOHLER G; MILSTEIN C, "Continuous cultures of fused cells secreting antibody of predefined specificity", NATURE, (1975), vol. 256, pages 495 - 497-
DESCRIPTION- LIEW PX; GE F; GULLO C; TEOH GK; HWANG WY, "Use of phage display to isolate specific human monoclonal antibody fragments against a potential target for multiple myeloma", ANN ACAD MED SINGAPORE, (2009), vol. 38, pages 621 - 629-
DESCRIPTION- MAZUET C; LEROUGE D; POUL MA; BLIN N, "Breast carcinoma specific antibody selection combining phage display and immunomagnetic cell sorting", BIOCHEM BIOPHYS RES COMMUN, (2006), vol. 348, pages 550 - 559-
DESCRIPTION- MCCAFFERTY J; GRIFFITHS AD; WINTER G; CHISWELL DJ, "Phage antibodies: filamentous phage displaying antibody variable domains", NATURE, (1990), vol. 348, pages 552 - 554-
DESCRIPTION- NGAI PK; ACKERMANN F; WENDT H; SAVOCA R; BOSSHARD HR, "Protein A antibody-capture ELISA (PACE): an ELISA format to avoid denaturation of surface-adsorbed antigens", J IMMUNOL METHODS, (1993), vol. 158, pages 267 - 276-
DESCRIPTION- NIELSEN UB; MARKS JD, "Internalizing antibodies and targeted cancer therapy: direct selection from phage display libraries", PHARM SCI TECHNOLO TODAY, (2000), vol. 3, pages 282 - 291-
DESCRIPTION- OHSHIMA ET AL., INT J CANCER, (20010701), vol. 93, no. 1, pages 91 - 6-
DESCRIPTION- OMIDFAR K; RASAEE MJ; MODJTAHEDI H; FOROUZANDEH M; TAGHIKHANI M; GOLMAKANI N, "Production of a novel camel single-domain antibody specific for the type III mutant EGFR", TUMOUR BIOL, (2004), vol. 25, pages 296 - 305-
DESCRIPTION- ROOVERS RC; VAN DER LINDEN E; DE BRUINE AP; ARENDS JW; HOOGENBOOM HR, "Identification of colon tumour-associated antigens by phage antibody selections on primary colorectal carcinoma", EUR J CANCER, (2001), vol. 37, pages 542 - 549-
DESCRIPTION- SIVA AC; KIRKLAND RE; LIN B; MARUYAMA T; MCWHIRTER J; YANTIRI-WERNIMONT F; BOWDISH KS; XIN H, "Selection of anti-cancer antibodies from combinatorial libraries by whole-cell panning and stringent subtraction with human blood cells", J IMMUNOL METHODS, (2008), vol. 330, pages 109 - 119-
DESCRIPTION- STEFAN N; MARTIN-KILLIAS P; WYSS-STOECKLE S; HONEGGER A; ZANGEMEISTER-WITTKE U; PLUCKTHUN A, "DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency", J MOL BIOL, (2011), vol. 413, pages 826 - 843-
DESCRIPTION- TAYLOR-PAPADIMITRIOU ET AL., BIOCHIM BIOPHYS ACTA, (19991008), vol. 1455, no. 2-3, pages 301 - 13-
DESCRIPTION- VEGGIANI G; OSSOLENGO G; ALIPRANDI M; CAVALLARO U; DE MARCO A, "Single-domain antibodies that compete with the natural ligand fibroblast growth factor block the internalization of the fibroblast growth factor receptor 1", BIOCHEM BIOPHYS RES COMMUN, (2011), vol. 408, pages 692 - 696-
DESCRIPTION- WEINER LM, "Fully human therapeutic monoclonal antibodies", J IMMUNOTHER, (2006), vol. 29, pages 1 - 9-
INTERNATIONAL-SEARCH-REPORT- ARBABI-GHAHROUDI MEHDI ET AL, "Selection of non-aggregating VH binders from synthetic VH phage-display libraries", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS INC, NJ, US, (20090101), vol. 525, doi:10.1007/978-1-59745-554-1_10, ISSN 1064-3745, pages 187 - 216, XP009171418 [Y] 1-5 * page 193, lines 27,28; figure 10.3 *
INTERNATIONAL-SEARCH-REPORT- ARBABI-GHAHROUDI MEHDI ET AL, Isolation of monoclonal antibody fragments from phage display libraries., METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 2009, VOL. 502, PAGE(S) 341 - 364, (2009), ISSN 1064-3745, XP009171725 [I] 1-5 * page 347, line 1 - page 349, line l * * page 350, line 26 - page 354, line 6; figures 20.2, 20.3 * * page 355, line 30 - page 356, line 15 *
INTERNATIONAL-SEARCH-REPORT- NIKOLAS STEFAN ET AL, "DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 413, no. 4, doi:10.1016/J.JMB.2011.09.016, ISSN 0022-2836, (20110908), pages 826 - 843, (20110921), XP028326151 [Y] 1-5 * page 828, column 1, paragraph 2 * * page 839, column 1, paragraphs 3,4 *
INTERNATIONAL-SEARCH-REPORT- EVEN-DESRUMEAUX KLERVI ET AL, "Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches", MOLECULAR BIOSYSTEMS, (20120706), vol. 8, no. 9, pages 2385 - 2394, XP002709707 [XP] 1-5 * the whole document *
INTERNATIONAL-SEARCH-REPORT- JÉRÔME BOUCHET ET AL, "Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ACS PUBLICATIONS, US, vol. 117, no. 13, doi:10.1182/BLOOD-2010-07-296749, ISSN 0002-7863, (20110331), pages 3559 - 3568, (20110203), XP002669440 [Y] 1-5 * page 3560, column 1, paragraphs 4,5 * * page 3561, column 1, paragraph l - page 3561, column 2, paragraph 3 *
OPPOSITION- DITZEL HJ et al., "Neutralizing Recombinant Human Antibodies to a Conformational V2- and CD 4-Binding Site-Sensitive Epitope of HIV-1 gp120 Isolated by Using an Epitope-Masking Procedure", The Journal of Immunology, (19950000), vol. 154, no. 2, pages 893 - 906, XP002302539-
OPPOSITION- ISHII K et al., "Isolation of pathogenic pemphigus foliaceus (PF) monoclonal antibodies (mAbs) using an innovative phage display approach , ''non- pathogenic epitope blocking", The Journal of Investigative Dermatology, (20070000), vol. 127, page S10, XP055496540-
OPPOSITION- O'BRIEN PM et al., "Antibody Phage Display - Methods and Protocols", Methods in Molecular Biology, (20020000), vol. 178, pages 1 - 401, XP055496528-
OPPOSITION- TSUI P et al., "Isolation of a Neutralizing Human RSV Antibody from a Dominant, Non-Neutralizing Immune Repertoire by Epitope-Blocked Panning", The Journal of Immunology, (19960000), vol. 157, no. 2, pages 772 - 780, XP002088282-
OPPOSITION- ARBABI-GHAHROUDI M et al., "Isolation of Monoclonal Antibody Fragments from Phage Display Libraries", Methods in Molecular Biology, (20090000), vol. 502, pages 341 - 364, XP009171725
OPPOSITION- STEINER D et al., "Efficient Selection of DARPins with Sub- nanomolar Affinities using SRP Phage Display", Journal of Molecular Biology, (20080000), vol. 382, no. 5, pages 1211 - 1227, XP025426617
OPPOSITION- STEFAN N et al., "DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency", Journal of Molecular Biology, (20110000), vol. 413, pages 826 - 843, XP028326151

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