Mammalian Cell Culture Processes For Protein Production - EP2906683

The patent EP2906683 was granted to Bristol Myers Squibb on May 31, 2017. The application was originally filed on Oct 14, 2013 under application number EP13824043A. The patent is currently recorded with a legal status of "Revoked".

EP2906683

BRISTOL MYERS SQUIBB
Application Number
EP13824043A
Filing Date
Oct 14, 2013
Status
Revoked
Jul 10, 2020
Grant Date
May 31, 2017
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (3)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

NEUEFEINDFeb 28, 2018NEUEFEINDADMISSIBLE
F HOFFMANN LA ROCHEFeb 27, 2018VOSSIUS & PARTNERADMISSIBLE
F HOFFMANN LA ROCHEFeb 27, 2018VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE

Patent Citations (39) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS20060086786
DESCRIPTIONUS4357422
DESCRIPTIONUS5705364
DESCRIPTIONUS5721121
DESCRIPTIONUS5844095
DESCRIPTIONUS5851800
DESCRIPTIONUS5976833
DESCRIPTIONUS7332303
DESCRIPTIONUS7541164
DESCRIPTIONWO0036092
DESCRIPTIONWO0065070
DESCRIPTIONWO8605807
DESCRIPTIONWO8704462
DESCRIPTIONWO8901036
DESCRIPTIONWO8910404
DESCRIPTIONWO9106657
DESCRIPTIONWO9961650
INTERNATIONAL-SEARCH-REPORTWO2008141207
INTERNATIONAL-SEARCH-REPORTWO2012023085
OPPOSITIONDE4313620
OPPOSITIONUS2011104758
OPPOSITIONUS5844095
OPPOSITIONUS7202210
OPPOSITIONUS7309489
OPPOSITIONUS7572599
OPPOSITIONWO0114529
OPPOSITIONWO03046162
OPPOSITIONWO2006030220
OPPOSITIONWO2006045438
OPPOSITIONWO2007077217
OPPOSITIONWO2009087087
OPPOSITIONWO2011014838
OPPOSITIONWO2011134919
OPPOSITIONWO2011134921
OPPOSITIONWO2012023085
OPPOSITIONWO2014062535
OPPOSITIONWO8502610
OPPOSITIONWO9425599
OPPOSITIONWO9808934

Non-Patent Literature (NPL) Citations (57) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ANDERSON, ANN. REV. BIOCHEM., vol. 62, 1993, pages 191 - 121
DESCRIPTION- AUSUBEL, F.M. ET AL.: "Current Protocols in Molecular Biology", 1989, JOHN WILEY & SONS
DESCRIPTION- BEBBINGTON, C.R. ET AL.: "DNA Cloning, Vol. 3: A Practical Approach", vol. 3, 1987, IRL PRESS LIMITED, PUBL., article "The use of vectors based on gene amplification for the expression of cloned genes in mammalian cells", pages: 163 - 188
DESCRIPTION- CHAKRAVARTHI ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 39872 - 39879
DESCRIPTION- CHASIN ET AL., SOM. CELL MOLEC. GENET., vol. 12, 1986, pages 555 - 556
DESCRIPTION- CHIRINO ET AL., NAT. BIOTECHNOL., vol. 22, 2004, pages 1383 - 1391
DESCRIPTION- CLINICAL PHARMACY, vol. 12, pages 488 - 505
DESCRIPTION- COLBERRE-GARAPIN ET AL., J. MOL. BIOL., vol. 150, 1981, pages 1
DESCRIPTION- CROMWELL ET AL., AAPS J., vol. 8, 2006, pages E572 - E579
DESCRIPTION- CROUSE ET AL., MOL. CELL. BIOL., vol. 3, 1983, pages 257
DESCRIPTION- CUOZZO ET AL., NAT. CELL BIOL., vol. 1, 1999, pages 130 - 135
DESCRIPTION- "Current Protocols in Human Genetics", 1994, JOHN WILEY & SONS
DESCRIPTION- "Current Protocols in Molecular Biology", 1993, JOHN WILEY & SONS
DESCRIPTION- FIERS ET AL., NATURE, vol. 273, 1973, pages 113
DESCRIPTION- GRAHAM ET AL., J. GEN. VIROL., vol. 36, 1977, pages 59
DESCRIPTION- KARIN ET AL., NATURE, vol. 299, 1982, pages 797 - 802
DESCRIPTION- KOLKEKAR ET AL., BIOCHEMISTRY, vol. 36, 1997, pages 10901 - 10909
DESCRIPTION- KRIEGLER: "Gene Transfer and Expression, A Laboratory Manual", 1990, STOCKTON PRESS
DESCRIPTION- LOWY ET AL., CELL, vol. 22, 1980, pages 817
DESCRIPTION- MATHER, ANN. NY ACAD. SCI., vol. 383, 1982, pages 44 - 68
DESCRIPTION- MATHER, BIOL. REPROD., vol. 23, 1980, pages 243 - 251
DESCRIPTION- MULLIGAN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 2072
DESCRIPTION- MULLIGAN, SCIENCE, vol. 260, 1993, pages 926 - 932
DESCRIPTION- O'HARE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 1527
DESCRIPTION- ROESSLER ET AL., ENZYME AND MICROBIAL TECHNOLOGY, vol. 18, 1996, pages 423 - 427
DESCRIPTION- SAMBROOK, J. ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
DESCRIPTION- SANTERRE ET AL., GENE, vol. 30, 1984, pages 147
DESCRIPTION- SWIFT, G. ET AL., CELL, vol. 38, 1984, pages 639 - 646
DESCRIPTION- SZYBALSKA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 48, 1992, pages 202
DESCRIPTION- THOMAS ET AL., EXP. GERONTOL., vol. 36, 2001, pages 1519 - 1526
DESCRIPTION- TIB TECH, vol. 11, no. 5, May 1993 (1993-05-01), pages 155 - 215
DESCRIPTION- TOLSTOSHEV, ANN. REV. PHARMACOL. TOXICOL., vol. 32, 1993, pages 573 - 596
DESCRIPTION- URLAUB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
DESCRIPTION- WIGLER ET AL., CELL, vol. 11, 1977, pages 223
DESCRIPTION- WIGLER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 357
DESCRIPTION- WU ET AL., BIOTHERAPY, vol. 3, 1991, pages 87 - 95
DESCRIPTION- ZHANGI ET AL., BIOTECHNOL. PROG., vol. 16, 2000, pages 319 - 325
EXAMINATION- NATALIA GOMEZ ET AL, "Culture temperature modulates aggregation of recombinant antibody in cho cells", BIOTECHNOLOGY AND BIOENGINEERING., US, (20120101), vol. 109, no. 1, doi:10.1002/bit.23288, ISSN 0006-3592, pages 125 - 136, XP055271209
INTERNATIONAL-SEARCH-REPORT- SUNLEY K ET AL, "Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest", BIOTECHNOLOGY ADVANCES, ELSEVIER PUBLISHING, BARKING, GB, vol. 28, no. 3, ISSN 0734-9750, (20100501), pages 385 - 394, (20100213), XP026983670 [A] 1-20 * the whole document *
INTERNATIONAL-SEARCH-REPORT- INN H. Y. YUK ET AL, "A GFP-based screen for growth-arrested, recombinant protein-producing cells", BIOTECHNOLOGY AND BIOENGINEERING, (20020705), vol. 79, no. 1, doi:10.1002/bit.10293, ISSN 0006-3592, pages 74 - 82, XP055105502 [X] 1,3,6,7,11-13,17-20 * the whole document * * "Selection strategy"; page 77, column L * * figure 2 *
INTERNATIONAL-SEARCH-REPORT- JONG KWANG HONG ET AL, "Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 155, no. 2, doi:10.1016/J.JBIOTEC.2011.06.020, ISSN 0168-1656, (20110617), pages 225 - 231, (20110623), XP028260117 [X] 17-20 * the whole document * * § 2.1-2.2; page 226 * * § 3.1; page 227 - page 228 *
INTERNATIONAL-SEARCH-REPORT- MORRIS A E ET AL, "EFFECTS OF INSULIN AND LONGR3 ON SERUM-FREE CHINESE HAMSER OVARY CELL CULTURES EXPRESSING TWO RECOMBINANT PROTEINS", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, (20000101), vol. 16, no. 5, doi:10.1021/BP0000914, ISSN 8756-7938, pages 693 - 697, XP000979091 [X] 1,3,6-13,17-20 * the whole document * * figures 1B, 2B * [Y] 2,4,5,14-16
INTERNATIONAL-SEARCH-REPORT- BRIAN RASMUSSEN ET AL, "Isolation, characterization and recombinant protein expression in Veggie-CHO: A serum-free CHO host cell line", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, (19980901), vol. 28, no. 1-3, doi:10.1023/A:1008052908496, ISSN 1573-0778, pages 31 - 42, XP019236568 [X] 17-20 * the whole document * * "Isolation of Veggie-CHO cells ..."; page 37 *
OPPOSITION- BURGENER et al., Cell Culture Technology for Pharmaceutical and Cell - Based Therapies, (20060000), pages 41 - 79, XP055468581
OPPOSITION- "Cell Culture Catalogue", Bioconcept AG, (20040000), XP055468535
OPPOSITION- Jun Tian, Et Al.,, "Exogenous growth factor signaling is not required for production of biotherapeutics in Chinese hamster ovary cells: Toward chemically defined cell cultures free of proteins and peptides", 245th ACS National Meeting and Exposition, Abstracts of Papers, New Orleans, LA, US, (20130410), XP055472149
OPPOSITION- "Lutrol® F68 NF", BASF PHARMA INGREDIENTS, (20010000), XP055468540
OPPOSITION- "Product leaflet Cascade Biologics", Product leaflet, (20090530), XP055468587
OPPOSITION- "The Merck Index", AN ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS, (20060000), pages 467 - 468, XP055468563
OPPOSITION- VOET et al., Biochemistry, (19950000), pages 56 - 57, XP055468569
OPPOSITION- GOMEZ et al., "Culture temperature modulates aggregation of recombinant antibody in cho cells", Biotechnology and Bioengineering, (20110930), vol. 109, no. 1, pages 125 - 136, XP055271201
OPPOSITION- RENNER et al., "Recombinant Cyclin E Expression Activates Proliferation and Obviates Surface Attachment of Chinese Hamster Ovary (CHO) Cells in Protein-Free Medium", Biotechnology and Bioengineering, (19950000), vol. 47, no. 4, pages 476 - 482, XP003014087
OPPOSITION- DESHPANDE et al., "Microplates with integrated oxygen sensing for medium optimization in animal cell culture", Cytotechnology, (20040000), vol. 46, no. 1, pages 1 - 8, XP019236847
OPPOSITION- KIM et al., "Development of serum-free media for a recombinant CHO cell line producing recombinant antibody", Enzyme and Microbial, (20060000), vol. 39, no. 3, pages 426 - 433, XP005459377
OPPOSITION- RODRIGUES et al., "Comparison of commercial serum-free media for CHO-K1 cell growth and monoclonal antibody production", International Journal of Pharmaceutics, (20120809), vol. 437, pages 303 - 315, XP055132241
OPPOSITION- SCHRODER et al., "Serum- and protein-free media formulations for the Chinese hamster ovary cell line DUKXB11", Journal of Biotechnology, (20040000), vol. 108, no. 3, pages 279 - 292, XP055073796
OPPOSITION- ZANG et al., "Production of Recombinant Proteins in Chinese Hamster Ovary Cells Using A Protein-Free Cell Culture Medium", Biotechnology, (19950000), vol. 13, no. 665, pages 389 - 392, XP001344740

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents