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The patent EP2914248 was granted to Vertex Pharmaceuticals Incorporated on Oct 18, 2023. The application was filed on Nov 1, 2013 under application number EP13792149A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".
Combination tablet therapy for treating cystic fibrosis using a specific ratio of two drugs, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) and N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2). The tablet contains 100-200 mg Compound 1 Form I and 125 mg amorphous Compound 2. This combination provides balanced CFTR potentiation and correction for improved CFTR function in cystic fibrosis patients.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| GENERICS UK | Jun 4, 2019 | TER MEER STEINMEISTER & PARTNER | - |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | US2003144257 |
| DESCRIPTION | US2004105820 |
| DESCRIPTION | US2005164973 |
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| DESCRIPTION | WO2004028480 |
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| DESCRIPTION | WO2009150137 |
| DESCRIPTION | WO2010019239 |
| DESCRIPTION | WO2011028740 |
| DESCRIPTION | WO2011079087 |
| DESCRIPTION | WO2011113894 |
| DESCRIPTION | WO2012035158 |
| INTERNATIONAL-SEARCH-REPORT | WO2009073757 |
| INTERNATIONAL-SEARCH-REPORT | WO2010019239 |
| INTERNATIONAL-SEARCH-REPORT | WO2013112804 |
| OPPOSITION | US2011256220 |
| OPPOSITION | WO2009073757 |
| OPPOSITION | WO2010019239 |
| OPPOSITION | WO2010037066 |
| OPPOSITION | WO2012147101 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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