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Pyrrolobenzodiazepines And Conjugates Thereof - EP2935268

The patent EP2935268 was granted to Medimmune on Feb 17, 2021. The application was originally filed on Dec 20, 2013 under application number EP13814939A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2935268

MEDIMMUNE
Application Number
EP13814939A
Filing Date
Dec 20, 2013
Status
Patent Maintained As Amended
Jan 15, 2021
Grant Date
Feb 17, 2021
External Links
Slate, Register, Google Patents

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JAMES POOLEAug 22, 2018WARNERADMISSIBLE

Patent Citations (6) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTWO2011130598
INTERNATIONAL-SEARCH-REPORTWO2013177481
OPPOSITIONUS6362331
OPPOSITIONUS6884799
OPPOSITIONWO2011130598
OPPOSITIONWO2012112708

Non-Patent Literature (NPL) Citations (10) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
OPPOSITION- Biospace press release, (20100915), URL: https://www.biospace.com/article/releases/celtic-therapeutics-and-b-spirogen- limited-b-release-commencement-of-a-phase-ii-clinical-trial-of-sg2000-in- ovarian-cancer
OPPOSITION- HOWARD et al., "Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate", Bioorg. Med. Chem. Lett., (20090000), vol. 19, no. 22, pages 6463 - 6466
OPPOSITION- KAMAL et al., "Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity", Bioorganic & Medicinal Chemistry, (20040000), vol. 12, pages 5427 - 5436
OPPOSITION- Kamal et al., "Design, Synthesis, and Evaluation of New Non-Crosslinking Pyrrolobenzodiazepine Dimers with Efficient DNA Binding Ability and Potent Antitumor Activity", J. Med. Chem., (20020000), vol. 45, pages 4679 - 4688
OPPOSITION- KAMAL et al., "Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity", Bioorganic & Medicinal Chemistry, (20040000), vol. 12, pages 5427 - 5436, XP004573363
OPPOSITION- Kamal et al., "Pyrrolo[2,1-c][1,4]benzodiazepine-@b-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies", Bioorg. Med. Chem. Lett., (20080000), vol. 18, pages 3769 - 3773, XP022716296
OPPOSITION- HOWARD et al., "Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate", Bioorg. Med. Chem. Lett., (20090000), vol. 19, no. 22, pages 6463 - 6466, XP026703829
OPPOSITION- GREGSON et al., "Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity", J. Med. Chem., (20010000), vol. 44, no. 5, pages 737 - 748, XP002272009
OPPOSITION- Kamal et al., "Design, Synthesis, and Evaluation of New Non-Crosslinking Pyrrolobenzodiazepine Dimers with Efficient DNA Binding Ability and Potent Antitumor Activity", J. Med. Chem., (20020000), vol. 45, pages 4679 - 4688, XP002249808
OPPOSITION- PUZANOV et al., "Phase I Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-linking Agent, in Advanced Solid Tumors", Clin. Cancer Res., (20110000), vol. 17, pages 3794 - 3802, XP055603138

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