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Method For Predicting The Off-Target Biding Of A Peptide Which Binds To A Target Peptide Presented By A Major Histocompatibility Complex - EP2936158

The patent EP2936158 was granted to Adaptimmune on Feb 13, 2019. The application was originally filed on Dec 17, 2013 under application number EP13811256A. The patent is currently recorded with a legal status of "Revoked".

EP2936158

ADAPTIMMUNE
Application Number
EP13811256A
Filing Date
Dec 17, 2013
Status
Revoked
Nov 5, 2021
Grant Date
Feb 13, 2019
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (3)

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SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBNov 13, 2019SCHIWECK WEINZIERL KOCH PATENTANWALTE PARTNERSCHAFT MBBADMISSIBLE
GRAF VON STOSCH PATENTANWALTSGESELLSCHAFTNov 12, 2019-ADMISSIBLE
MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBBFeb 15, 2019-ADMISSIBLE

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO1992US09965-
DESCRIPTIONEP0120694
DESCRIPTIONEP0125023
DESCRIPTIONEP0184187
DESCRIPTIONEP0239400
DESCRIPTIONGB2188638
DESCRIPTIONUS5225539
DESCRIPTIONWO03020763
DESCRIPTIONWO2004033685
DESCRIPTIONWO2010133828
DESCRIPTIONWO2012013913
DESCRIPTIONWO9413804
DESCRIPTIONWO9960120
INTERNATIONAL-SEARCH-REPORTWO2011161127
OPPOSITIONWO2014096803
OTHEREP2936158

Non-Patent Literature (NPL) Citations (39) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- BOYLE ALAN P ET AL, "High-resolution mapping studies of chromatin and gene regulatory elements.", EPIGENOMICS 01 DEC 2009, (20091201), vol. 1, no. 2, ISSN 1750-192X, pages 319 - 329-
EXAMINATION- BRAWLEY J V ET AL, "Systematic mutagenesis of TCR complementarity-determining region 3 residues: a single conservative substitution dramatically improves response to both multiple HLA-DR alleles and peptide variants.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 01 NOV 1999, (19991101), vol. 163, no. 9, ISSN 0022-1767, pages 4946 - 4952, XP055437646-
EXAMINATION- CAMERON BRIAN J ET AL, "Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells.", SCIENCE TRANSLATIONAL MEDICINE 07 AUG 2013, (20130807), vol. 5, no. 197, ISSN 1946-6242, page 197ra103-
EXAMINATION- HAUSMANN S ET AL, "Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAY 1999, (19990501), vol. 162, no. 9, ISSN 0022-1767, pages 5389 - 5397, XP002287146-
EXAMINATION- HUDSON ELTON P ET AL, "Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes.", SCIENTIFIC REPORTS 2012, (2012), vol. 2, ISSN 2045-2322, page 706-
EXAMINATION- KITA HIROTO ET AL, "Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis.", HEPATOLOGY (BALTIMORE, MD.) OCT 2002, (200210), vol. 36, no. 4 Pt 1, doi:doi:10.1053/jhep.2002.35616, ISSN 0270-9139, pages 918 - 926, XP055437640
EXAMINATION- WEISS G A ET AL, "Rapid mapping of protein functional epitopes by combinatorial alanine scanning.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 01 AUG 2000, (20000801), vol. 97, no. 16, doi:doi:10.1073/pnas.160252097, ISSN 0027-8424, pages 8950 - 8954, XP002161102
EXAMINATION- J. K. LEE, "T Cell Cross-Reactivity and Conformational Changes during TCR Engagement", JOURNAL OF EXPERIMENTAL MEDICINE, (20041206), vol. 200, no. 11, doi:10.1084/jem.20041251, ISSN 0022-1007, pages 1455 - 1466, XP055108653
OPPOSITION- Brawley et al., "Brawley and Concannon. Systematic Mutagenesis of TCR Complementarity-Deter- mining Region 3 Residues: A Single Conservative Substitution Dramatically Im- proves Response to Both Multiple HLA-DR Alleles and Peptide Variants", Journal of Immunology, (19990000), vol. 163, no. 9, pages 4946 - 4952, XP055437646-
OPPOSITION- GROGAN et al., "Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice", Journal of Immunology, vol. 163, pages 3764 - 3770, XP055654579-
OPPOSITION- HAUSMANN S et al., "Peptide recognition by two HLA-A2/Taxll-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures", J. Immunol., (19990501), vol. 162, no. 9, pages 5389 - 5397, XP002287146-
OPPOSITION- LEVITSKY et al., "The Clonal Composition of a Peptide-Specific Oligoclonal CTL Repertoire Selected in Response to Persistent EBV Infection Is Stable Over Time", J Immunol, (19980000), vol. 161, pages 594 - 601, XP055654572-
OPPOSITION- UDYAVAR ET et al., J Immunol., (20090401), vol. 182, no. 7, pages 4439 - 4447-
OPPOSITION- MAIER et al., "Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.", Eur. J. Immunol., (20000000), vol. 30, doi:10.1002/1521-4141(200002)30:2<448::AID-IMMU448>3.3.CO;2-0, pages 448 - 457, XP001033847
OPPOSITION- LINNEMANN et al., "Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries", Eur. J. Immunol., (20010000), vol. 31, pages 156 - 165, XP002241433
OPPOSITION- KINNUNEN et al., "The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells", Eur. J. Immunol., (20030000), vol. 33, pages 1717 - 1726, XP055654595
OPPOSITION- RAMMENSEE, H. et al., "SYFPEITHI: database for MHC ligands and peptide motifs", Immunogenetics, (19990000), vol. 50, pages 213 - 219, XP002183663
OPPOSITION- BIJEN et al., "Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs", Molecular Therapy, (20180000), vol. 26, no. 5, pages 1206 - 1214, XP055654816
OPPOSITION- BIJEN, H. M. et al., "Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs", Molecular Therapy, (20180000), vol. 26, no. 5, pages 1 - 9, XP055652004
OPPOSITION- HARD et al., "HDAC6 and Ubp-M BUZ Domains Recognize Specific C-Terminal Sequences of Proteins", NIH Public Access Author Manuscript, (20101221), vol. 49, no. 50, pages 10737 - 10746, XP055654582
OPPOSITION- Matthias Obenaus, Leit�o Catarina, Leisegang Matthias, Chen Xiaojing, Gavvovidis Ioannis, Van Der Bruggen Pierre, Uckert Wolfgang, Schendel Dolores J, Blankenstein Thomas, "Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice", Nature Biotechnology, Gale Group Inc., vol. 33, no. 4, doi:10.1038/nbt.3147, ISSN 10870156, pages 402 - 407, XP055212602
OPPOSITION- HUDSON et al., "Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes", Sci Rep., (20120000), vol. 2, pages 1 - 9, XP055438413
OPPOSITION- KITA et al., "Analysis of TCR antagonism and molecular mimicry of an HLA-A*0201-restricted CTL epitope in primary biliary cirrhosis", Hepatology, (20020000), vol. 36, pages 918 - 926, XP055437640
OPPOSITION- KITA et al., "Analysis of TCR antagonism and molecular mimicry of an HLA-A*0201-restricted CTL epitope in primary biliary cirrhosis", Hepatology, (20021000), vol. 36, no. 4, pages 918 - 926, XP055437640
OPPOSITION- WEISS et al., "Rapid mapping of protein functional epitopes by combinatorial alanine scanning", PNAS, (20000000), vol. 97, no. 16, XP002161102
OPPOSITION- WOOLDRIDGE L et al., "A single autoimmune T cell receptor recognizes more than a million different peptides", J Biol Chem., (20120106), vol. 287, no. 2, pages 1168 - 1177, XP055578540
OPPOSITION- LEE et al., "T Cell Cross-Reactivity and Conformational Changes during TCR Engagement", J Exp Med., (20041206), vol. 200, no. 11, pages 1455 - 1466, XP055108653
OPPOSITION- SETHI et al., "A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC", J Exp Med., (20110117), vol. 208, no. 1, pages 91 - 102, XP055654578
OPPOSITION- CAMERON BJ et al., "Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells", HHS Public Access Author Manuscript, (20130807), vol. 5, no. 197, pages 1 - 24, XP055578546
OPPOSITION- SIDNEY et al., "Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries", Immunome Research, (20080125), vol. 4, pages 1 - 14, XP021039204
OPPOSITION- FRANKILD et al., "Amino Acid Similarity Accounts for T Cell Cross-Reactivity and for Holes in the T Cell Repertoire", PLOSone, (20080000), vol. 3, pages 1 - 8, XP055107157
OPPOSITION- MACDONALD IK et al., "MHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell Receptors", PLoS Pathog, (20100000), vol. 6, no. 10, pages 1 - 11, XP055578560
OPPOSITION- PETROVA et al., "Cross-Reactivity of T Cells and Its Role in the Immune System Crit Rev Immunol.", NIH Public Access Author Manuscript, (20120000), vol. 32, no. 4, pages 1 - 26, XP055578532
OPPOSITION- PETROVA et al., "Cross-Reactivity of T Cells and Its Role in the Immune System", NIH Public Access Author Manuscript, (20120000), vol. 32, no. 4, pages 1 - 26, XP055578532
OPPOSITION- STONE et al., "Role of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies", Front. Immunol., (20130000), vol. 4, no. 244, pages 1 - 16, XP055217565
OPPOSITION- AUDEHM, S. et al., "Key Features relevant to select Antigens and TCR from the MHC-Mismatched Repertoire to treat Cancer", Frontiers in Immunology, (20190000), vol. 10, pages 1 - 27, XP055652001
OPPOSITION- CHINNASAMY et al., "A TCR Targeting the HLA-A*0201-Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer", J Immunol, (20110000), vol. 186, no. 2, pages 685 - 696, XP002712845
OPPOSITION- UEMURA et al., "Systematic Analysis of the Combinatorial Nature of Epitopes Rec- ognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid De- carboxylase 65-Specific TCRs", J Immunol, (20030115), vol. 170, no. 2, pages 947 - 960, XP055578553
OTHER- HAUSMANN S. ET AL, "PEPTIDE RECOGNITION BY TWO HLA-A2/TAX11-19-SPECIFIC T CELL CLONES IN RELATIONSHIP TO THEIR MHC/PEPTIDE/TCR CRYSTAL STRUCTURES", THE JOURNAL OF IMMUNOLOGY, (199905), vol. 162, no. 9, pages 5389 - 5397, XP002287146-

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