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Propane-I-Sulfonic Acid {3- [5- (4- Chloro-Phenyl) -1H-Pyrrolo [2, 3-B} Pyridine-3-Carbonyl] -2, 4-Difluoro-Phenyl} -Amide Compositions And Uses Thereof - EP2955180

The patent EP2955180 was granted to F Hoffmann LA Roche on Jan 10, 2018. The application was originally filed on Mar 31, 2010 under application number EP15171526A. The patent is currently recorded with a legal status of "Revoked".

EP2955180

F HOFFMANN LA ROCHE
Application Number
EP15171526A
Filing Date
Mar 31, 2010
Status
Revoked
Feb 6, 2024
Publication Date
Jan 10, 2018
External Links
Slate, Register, Google Patents

Patent Summary

Improving the solubility and bioavailability of the compound propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide (Compound I) by forming solid dispersions and molecular complexes with polymers. This involves microprecipitating Compound I with a polymer like hydroxypropyl methylcellulose acetate succinate (HPMC-AS) using methods like spray drying, lyophilization, solvent-controlled precipitation, pH-controlled precipitation, hot melt extrusion, and supercritical fluid technology. The resulting compositions have improved water solubility and bioavailability compared to the cryst

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GENERICS UKOct 5, 2018ELKINGTON AND FIFEADMISSIBLE

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2004077595
DESCRIPTIONUS6350786
DESCRIPTIONWO2007002325
OPPOSITIONWO2007002325
SEARCHWO2007002325

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