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Chemical Compounds - EP2955190

The patent EP2955190 was granted to Nucana on Mar 28, 2018. The application was originally filed on Jul 20, 2004 under application number EP15154759A. The patent is currently recorded with a legal status of "Revoked".

EP2955190

NUCANA
Application Number
EP15154759A
Filing Date
Jul 20, 2004
Status
Revoked
May 23, 2023
Grant Date
Mar 28, 2018
External Links
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GILEAD SCIENCESDec 17, 2018J A KEMP -

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONAU2451601
DESCRIPTIONCA2317505
DESCRIPTIONEP0116797
DESCRIPTIONEP1200455
DESCRIPTIONUS6339151
DESCRIPTIONWO0239952
OPPOSITIONEP1523489
OPPOSITIONEP2332952
OPPOSITIONUS2003109697
OPPOSITIONWO2005003147
OPPOSITIONWO9629336
SEARCHUS2003109697
SEARCHWO0107454
SEARCHWO9937753

Non-Patent Literature (NPL) Citations (36) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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DESCRIPTION- SIDDIQUI ET AL., J. MED. CHEM., (1999), vol. 42, pages 393 - 9-
EXAMINATION- MAGDALENA SLUSARCZYK ET AL, "Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development", JOURNAL OF MEDICINAL CHEMISTRY, (20140227), vol. 57, no. 4, doi:10.1021/jm401853a, ISSN 0022-2623, pages 1531 - 1542, XP055205033
OPPOSITION- CLARK et al., "Design Synthesis and Antiviral Activity of 2'-Deoxy-2'-f luoro-2'- C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication", J. Med. Chem., (20050000), vol. 48, pages 5504 - 5508, XP0002415215-
OPPOSITION- DR J-F GRIFFON et al., "A. Synthesis of the 2'-fluoro-2'-methyl-cytosine. Progress Report no. 24", Identix, (20021200), XP055541481-
OPPOSITION- Geert-Jan Boons, Et Al, "Functionalised Saccharides", Organic Synthesis with Carbohydrates, (20000101), pages 59 - 60, XP055761291-
OPPOSITION- SINGH et al., "Recent Advances in Nucleophilic Fluorination Reactions of Organic Compounds Using Deoxofluor and DAST", Synthesis, (20020000), vol. 17, pages 2561 - 2578, XP001143690-
OPPOSITION- CLARK et al., "Synthesis of 2-Deoxy-2-Fluoro-2-C-methyl-D-Ribofuranoses", J. Carbohydrate Chem., (20060000), vol. 25, pages 461 - 470, XP055541463
OPPOSITION- CLARK et al., "Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C- methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication", Bioorg. Med. Chem. Lett., (20060000), vol. 16, pages 1712 - 1715, XP028755023
OPPOSITION- Shaoman Zhou et al, "2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture", Journal of Medicinal Chemistry, American Chemical Society, (20170713), vol. 60, no. 13, doi:10.1021/acs.jmedchem.7b00067, ISSN 0022-2623, pages 5424 - 5437, XP055489870
OPPOSITION- LAL et al., "Electrophilic NF Fluorinating Agents", Chem. Rev., (19960000), vol. 96, pages 1737 - 1755, XP055277022
OPPOSITION- FENG J.Y. et al., "Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus", Antimicrobial Agents and Chemotherapy, (20160000), vol. 60, no. 2, pages 806 - 817, XP055314248
SEARCH- S.A. HARRIS ET AL., "Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine", ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, (2001), vol. 12, pages 293 - 300, XP008037325 [A] 1 * the whole document *-
SEARCH- LACKEY D B ET AL, "Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, (2001), vol. 61, ISSN 0006-2952, pages 179 - 189, XP002204184 [A] 1 * the whole document *
SEARCH- ABRAHAM T W ET AL, "Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (19960101), vol. 39, doi:10.1021/JM9603680, ISSN 0022-2623, pages 4569 - 4575, XP002147029 [A] 1 * the whole document *

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