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A Method For Producing A Product (E.G. Polypeptide) In A Continuous Cell Culture Fermentation Process. - EP2976418

The patent EP2976418 was granted to CMC Biologics on Sep 30, 2020. The application was originally filed on Mar 11, 2014 under application number EP14708915A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2976418

CMC BIOLOGICS
Application Number
EP14708915A
Filing Date
Mar 11, 2014
Status
Granted And Under Opposition
Aug 28, 2020
Grant Date
Sep 30, 2020
External Links
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WILKJun 30, 2021WILK -

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTEP0062026
INTERNATIONAL-SEARCH-REPORTEP0200032
INTERNATIONAL-SEARCH-REPORTEP0270905
INTERNATIONAL-SEARCH-REPORTEP1498475
INTERNATIONAL-SEARCH-REPORTEP2014760
INTERNATIONAL-SEARCH-REPORTUS2003166040
INTERNATIONAL-SEARCH-REPORTWO03040380
INTERNATIONAL-SEARCH-REPORTWO2005083052
INTERNATIONAL-SEARCH-REPORTWO2011012725
OPPOSITIONEP2014760
OPPOSITIONUS2009042253
OPPOSITIONWO2005095578
OPPOSITIONWO2008006494
OPPOSITIONWO2008152075
OPPOSITIONWO2009023562

Non-Patent Literature (NPL) Citations (9) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
INTERNATIONAL-SEARCH-REPORT- STARK D ET AL, "IN SITU PRODUCT REMOVAL (ISPR) IN WHOLE CELL BIOTECHNOLOGY DURING THE LAST TWENTY YEARS", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOLOGY, SPRINGER, BERLIN, DE, (20030131), vol. 80, ISSN 0724-6145, pages 149 - 175, XP009043803 [A] 1-13 * page 150, paragraph 3 * * page 163, paragraph 3 - page 164, paragraph 1 *-
OPPOSITION- Deschênes J-S, Et Al, "Use of cell bleed in a high cell density perfusion culture and multivariable control of biomass and metabolite concentrations", Asia-Pacific Journal of Chemical Engineering, (20060101), vol. 1, pages 82 - 91, XP055938731-
OPPOSITION- Henry Olivier, Et Al, "Simpler Noninstrumented Batch and Semicontinuous Cultures Provide Mammalian Cell Kinetic Data Comparable to Continuous and Perfusion Cultures", Biotechnol. Prog., (20080101), vol. 24, pages 921 - 931, XP055938739-
OPPOSITION- Matthews Guy, "Fermentation Equipment Selection: Laboratory Scale Bioreactor Design Considerations", Practical Fermentation Technology, (20080101), pages 1 - 70, XP093037232-
OPPOSITION- Strandberg Per Erik, "Examensarbete Mathematical models of bacteria population growth in bioreactors: formulation, phase space pictures, optimisation and control", Thesis Linköping University, (20040101), pages 1 - 52, XP055938724-
OPPOSITION- D. Voisard; F. Meuwly; PA. Ruffieux; G. Baer; A. Kadouri, "Potential of cell retention techniques for large scale high density perfusion culture of suspended mammalian cells", Biotechnology and Bioengineering, Hoboken, USA, (20030411), vol. 82, no. 7, doi:10.1002/bit.10629, ISSN 0006-3592, pages 751 - 765, XP071108522
OPPOSITION- Dalm Marcella C.F., Cuijten Suzanne M.R., Van Grunsven Wout M.J., Tramper Johannes, Martens Dirk E., "Effect of feed and bleed rate on hybridoma cells in an acoustic perfusion bioreactor: Part I. Cell density, viability, and cell-cycle distribution", Biotechnology and Bioengineering, Hoboken, USA, (20041205), vol. 88, no. 5, doi:10.1002/bit.20287, ISSN 0006-3592, pages 547 - 557, XP055798569
OPPOSITION- HILLER G W , CLARK D S, BLANCH H W, "Cell retention-chemostat studies of hybridoma cells: Analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium", Biotechnology and Bioengineering, Hoboken, USA, (19930101), vol. 42, no. 2, doi:10.1002/bit.260420206, ISSN 0006-3592, pages 185 - 195, XP002599810
OPPOSITION- Pohlscheidt Michael, Jacobs Melanie, Wolf Stefan, Thiele Joerg, Jockwer Alexander, Gabelsberger Josef, Jenzsch Marco, Tebbe Hermann, Burg Josef, "Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors", Biotechnology Progress, American Chemical Society, (20130101), vol. 29, no. 1, doi:10.1002/btpr.1672, ISSN 8756-7938, pages 222 - 229, XP055788645

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