Method For The Production Of Domain Antibodies - EP2982690

The patent EP2982690 was granted to Ablynx on Jan 27, 2021. The application was originally filed on Apr 30, 2010 under application number EP15174570A. The patent is currently recorded with a legal status of "Opposition Rejected".

EP2982690

ABLYNX
Application Number
EP15174570A
Filing Date
Apr 30, 2010
Status
Opposition Rejected
Jan 5, 2024
Grant Date
Jan 27, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

EIPJan 27, 2021RAI -

Patent Citations (53) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS20090181384-
DESCRIPTIONWO2010EP54747-
DESCRIPTIONWO2010EP54764-
DESCRIPTIONEP0368684
DESCRIPTIONEP1134231
DESCRIPTIONEP1433793
DESCRIPTIONUS4572798
DESCRIPTIONWO0040968
DESCRIPTIONWO0043507
DESCRIPTIONWO0065057
DESCRIPTIONWO0121817
DESCRIPTIONWO0140310
DESCRIPTIONWO0144301
DESCRIPTIONWO0190190
DESCRIPTIONWO0248193
DESCRIPTIONWO03025020
DESCRIPTIONWO03035694
DESCRIPTIONWO03050531
DESCRIPTIONWO03054016
DESCRIPTIONWO03055527
DESCRIPTIONWO2004041862
DESCRIPTIONWO2004041863
DESCRIPTIONWO2004041865
DESCRIPTIONWO2004041867
DESCRIPTIONWO2004062551
DESCRIPTIONWO2004068820
DESCRIPTIONWO2005018629
DESCRIPTIONWO2005044858
DESCRIPTIONWO2006003388
DESCRIPTIONWO2006030220
DESCRIPTIONWO2006040153
DESCRIPTIONWO2006079372
DESCRIPTIONWO2006122786
DESCRIPTIONWO2006122787
DESCRIPTIONWO2006122825
DESCRIPTIONWO2008020079
DESCRIPTIONWO2008101985
DESCRIPTIONWO2008142164
DESCRIPTIONWO2009068627
DESCRIPTIONWO9404678
DESCRIPTIONWO9425591
DESCRIPTIONWO9504079
DESCRIPTIONWO9634103
DESCRIPTIONWO9749805
DESCRIPTIONWO9923221
DESCRIPTIONWO9937681
EXAMINATIONWO2004041863
OPPOSITIONUS4572798
OPPOSITIONWO2007136463
OPPOSITIONWO2009009523
SEARCHWO2006047340
SEARCHWO2006138737
SEARCHWO2008142164

Non-Patent Literature (NPL) Citations (74) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BORTH ET AL., BIOTECHNOL. PROG, (2005), vol. 21, page 106-
DESCRIPTION- BORTH ET AL., BIOTECHNOL. PROG., (2005), vol. 21, page 106-
DESCRIPTION- CHADERJIAN ET AL., BIOTECHNOL., (2005), vol. 21, page 550-
DESCRIPTION- CLINE ET AL., ANALYTICAL BIOCHEMISTRY, (2004), vol. 335, pages 168 - 170-
DESCRIPTION- CONRATH ET AL., J. BIOL. CHEM., (2001), vol. 276, no. 10, pages 7346 - 7350-
DESCRIPTION- DAMASCENO ET AL., APPL. MICROBIOL. BIOTECHNOL., (2007), vol. 74, page 381-
DESCRIPTION- DAMASCENO ET AL., MICROBIAL. BIOTECHNOL., (2007), vol. 74, page 381-
DESCRIPTION- DAMASCENO ET AL., MICROBIOL. BIOTECHNOL, (2007), vol. 74, page 381-
DESCRIPTION- FREEDMAN ET AL., TRENDS BIOCHEM. SCI., (1994), vol. 19, page 331-
DESCRIPTION- GASSER ET AL., APPL. ENVIRON. MICROBIOL., (2007), vol. 73, page 6499-
DESCRIPTION- GASSER ET AL., APPL. ENVIRONM MICROBIOL., (2007), vol. 73, page 6499-
DESCRIPTION- GASSER ET AL., APPL. & ENV. MICROBIOL., (2007), vol. 73, page 6499-
DESCRIPTION- GASSER ET AL., BIOTECHNOL. BIOENG, (2006), vol. 94, page 353-
DESCRIPTION- GASSER ET AL., BIOTECHNOL. BIOENG., (2006), vol. 94, page 353-
DESCRIPTION- GASSER ET AL., BIOTECHNOL. BIOENG., (2006), vol. 94, page 535-
DESCRIPTION- GOLDSTEIN ET AL., FREE RADICAL BIOL MED, (1986), vol. 2, pages 3 - 11-
DESCRIPTION- GONZALES ET AL., TUMOUR BIOL., (2005), vol. 26, no. 1, pages 31 - 43-
DESCRIPTION- GONZALEZ ET AL., BIOTECHNCL. PROG., (2001), vol. 17, page 217-
DESCRIPTION- GONZALEZ ET AL., BIOTECHNOL. PROG., (2001), vol. 17, page 217-
DESCRIPTION- HOLT ET AL., TRENDS BIOTECHNOL., (2003), vol. 21, no. 11, pages 484 - 490-
DESCRIPTION- HSU ET AL., PROTEIN EXPR. PURIF, (1996), vol. 7, page 281-
DESCRIPTION- HSU ET AL., PROTEIN EXPR. PURIF., (1996), vol. 7, page 281-
DESCRIPTION- HSU ET AL., PROTEIN EXPR.& PURIF., (1996), vol. 7, page 281-
DESCRIPTION- HUMPHREYS ET AL., FEBS LETT., (1996), vol. 380, page 194-
DESCRIPTION- HUMPHREYS ET AL., FEBS LETTERS, (1996), vol. 380, page 194-
DESCRIPTION- IRVINQ ET AL., J. IMMUNOL. METHODS, (2001), vol. 248, no. 1-2, pages 31 - 45-
DESCRIPTION- KIMURA ET AL., J. BIOL. CHEM., (2005), vol. 280, page 31438-
DESCRIPTION- LEVIN; WEISS, MOL. BIOSYST., (2006), vol. 2, no. 1, pages 49 - 57-
DESCRIPTION- LILIE ET AL., J. BIOL. CHEM., (1994), vol. 269, page 14290-
DESCRIPTION- LITSKE; DORRINGTON, J. BIOL. CHERR., (1974), vol. 249, page 5633-
DESCRIPTION- MAYER ET AL., J. BIOL. CHEM., (2000), vol. 275, page 29421-
DESCRIPTION- MERK ET AL., BIOCHEM., (1999), vol. 125, page 328-
DESCRIPTION- MERK ET AL., J. BIOCHEM., (1999), vol. 125, page 328-
DESCRIPTION- Methods in Molecular Biology, HUMANA PRESS-
DESCRIPTION- MOHAN ET AL., BIOTECHNOL. & BIOENG, (2007), vol. 98, page 611-
DESCRIPTION- MOHAN ET AL., BIOTECHNOLOGY AND BIOENGINEERING, (2007), vol. 98, page 611-
DESCRIPTION- MUYLDERMANS, REVIEWS IN MOLECULAR BIOTECHNOLOGY, (2001), vol. 74, pages 277 - 302-
DESCRIPTION- NILSSON ET AL., IMMUNOL. LETT, (2004), vol. 94, page 83-
DESCRIPTION- NILSSON ET AL., IMMUNOL. LETT., (2004), vol. 94, page 83-
DESCRIPTION- PRESTA, ADV. DRUG DELIV. REV., (2006), vol. 58, no. 5-6, pages 640 - 56-
DESCRIPTION- RYABOVA ET AL., NALURE BIOTECHN, (1997), vol. 15, no. 79-
DESCRIPTION- RYABOVA ET AL., NATURE BIOTECHNOLOGY, (1997), vol. 15, page 79-
DESCRIPTION- SAMBROOK ET AL., Molecular Cloning: A Laboratory Manual, COLD SPRING HARBOR LABORATORY PRESS, (1989), vol. 1-3-
DESCRIPTION- SCLUNITZ E, PLACENTA, (2000), vol. 21, pages 8106 - 12-
DESCRIPTION- SHUSTA ET AL., NAT. BIOTECHNOL., (1998), vol. 16, page 773-
DESCRIPTION- SHUSTA ET AL., NATURE BIOTECH., (1998), vol. 16, page 773-
DESCRIPTION- VINCI ET AL., J. BIOL. CHEM., (2004), vol. 279, page 15059-
DESCRIPTION- WARD ET AL., NATURE, (19891012), vol. 341, no. 6242, pages 544 - 6-
DESCRIPTION- WHITELEY ET AL., J. BIOL. CHEM., (1997), vol. 272, page 22556-
DESCRIPTION- WILKINSON ET AL., J. BIOL. CHEM., (2005), vol. 280, page 11483-
DESCRIPTION- XU ET AL., METABOL. ENGINEER, (2005), vol. 7, page 269-
DESCRIPTION- XU ET AL., METABOL. ENGINEER., (2005), vol. 7, page 269-
DESCRIPTION- XU ET AL., METABOLIC ENGINEERING, (2005), vol. 7, page 269-
EXAMINATION- "Pichia Fermentation Process Guidelines", INVITROGEN, (2002), pages 1 - 11-
EXAMINATION- YVONNE E THOMASSENA ET AL, "Large-scale production of VHH antibody fragments by Saccharomyces cerevisiae", ENZYME AND MICROBIAL TECHNO, STONEHAM, MA, US, (20020101), vol. 30, ISSN 0141-0229, pages 273 - 278, XP007915755-
EXAMINATION- BIRCH ET AL, "Antibody production", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM, NL, (20060807), vol. 58, no. 5-6, doi:10.1016/J.ADDR.2005.12.006, ISSN 0169-409X, pages 671 - 685, XP005611421
EXAMINATION- FIRER M A, "Efficient elution of functional proteins in affinity chromatography", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, AMSTERDAM, NL, (20011030), vol. 49, no. 1-3, doi:10.1016/S0165-022X(01)00211-1, ISSN 0165-022X, pages 433 - 442, XP002497544
OPPOSITION- CHISTI Y., "Strategies in downstream processing", Bioseparation and Bioprocessing: A Handbook, (19980000), vol. 2, pages 3 - 30, XP055861423-
OPPOSITION- Humana Press INC, "Methods in Molecular Biology - Pichia Protocols Second Edition", Methods in Molecular Biology Second Edition, (20070000), vol. 389, pages 1 - 32, XP055861418-
OPPOSITION- PRICE et al., "Effect of divalent cations on the reduction and re-formation of the disulfide bonds of deoxyribonuclease", The Journal of Biological Chemistry, (19690000), vol. 244, no. 4, pages 929 - 932, XP055861419-
OPPOSITION- "Thioredoxin-1 (TRX1 _YEAST)", UNITPROTKB, (19910801), Database accession no. P22217, URL: UNITPROT, XP055861448-
OPPOSITION- THOMASSEN et al., "Large-scale production of VHH antibody fragments by Saccharomyces cerevisiae", Enzyme and Microbial Technology, (20020000), vol. 30, pages 273 - 278, XP007915755-
OPPOSITION- LITSKE PETERSEN et al., "An in vitro system for studying the kinetics of interchain disulfide bond formation in immunoglobulin G", The Journal of Biological Chemistry, (19740000), vol. 249, no. 17, pages 5633 - 5641, XP055690586
OPPOSITION- CHADERJIAN et al., "Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed", Biotechnol. Prog, (20050000), vol. 21, pages 550 - 553, XP002500111
OPPOSITION- HOLLIGER et al., "Engineered antibody fragments and the rise of single domains", Nature Biotechnology, (20050000), vol. 23, no. 9, doi:10.1038/nbt1142, pages 1126 - 1136, XP008076746
OTHER- FIRER et al., "Efficient elution of functional proteins in affinity chromatography", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, (20011030), vol. 49, no. 1-3, pages 433 - 442, XP002497544
OTHER- M.A. Firer, "Efficient elution of functional proteins in affinity chromatography", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, (2001), vol. 49, pages 433 - 442, XP002497544
SEARCH- BRIGITTE GASSER ET AL, "Antibody production with yeasts and filamentous fungi: on the road to large scale?", BIOTECHNOLOGY LETTERS, SPRINGER NETHERLANDS, DORDRECHT, (20061122), vol. 29, no. 2, ISSN 1573-6776, pages 201 - 212, XP019463949 [A] 1-21 * the whole document *-
SEARCH- TEUN VAN DE LAAR ET AL, "Increased Heterologous Protein Production by Saccharomyces cerevisiae Growing on Ethanol as Sole Carbon Source", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, vol. 96, no. 3, ISSN 0006-3592, (20070215), pages 483 - 494, (20060831), XP007914112 [X] 1,2,10,14-20,22 * abstract; pages 492-493 *-
SEARCH- GASSER BRIGITTE ET AL, "Engineering of Pichia pastoris for improved production of antibody fragments", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, (20060601), vol. 94, no. 2, doi:10.1002/BIT.20851, ISSN 0006-3592, pages 353 - 361, XP002499994 [AD] 1,2,6,19 * the whole document *
SEARCH- HARMSEN M M ET AL, "Properties, production, and applications of camelid single-domain antibody fragments", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, (20070818), vol. 77, no. 1, doi:10.1007/S00253-007-1142-2, ISSN 1432-0614, pages 13 - 22, XP019560673 [X] 22 * the whole document * [A] 1-21
SEARCH- BENJAMIN J HACKEL ET AL, "Production of Soluble and Active Transferrin Receptor-Targeting Single-Chain Antibody using Saccharomyces cerevisiae", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, (20060325), vol. 23, no. 4, doi:10.1007/S11095-006-9778-7, ISSN 1573-904X, pages 790 - 797, XP019405238 [A] 1,2,6,7,10,19,20 * abstract *
SEARCH- THOMASSEN Y E ET AL, "Specific production rate of VHH antibody fragments by Saccharomyces cerevisiae is correlated with growth rate, independent of nutrient limitation", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20050822), vol. 118, no. 3, doi:10.1016/J.JBIOTEC.2005.05.010, ISSN 0168-1656, pages 270 - 277, XP004987755 [X] 1-3,5,14-20,22 * abstract; item 2.2 * [I] 7-10,12,13
SEARCH- CHADERJIAN WENDY B ET AL, "Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, (20050301), vol. 21, no. 2, doi:10.1021/BP0497029, ISSN 8756-7938, pages 550 - 553, XP009107034 [YD] 1-3,5,13-20 * the whole document *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents