Use Of Landiolol Hydrochloride In The Long-Term Treatment Of Tachyarrhythmias - EP2988750

The patent EP2988750 was granted to AOP Orphan Pharmaceuticals on Sep 17, 2025. The application was originally filed on Apr 25, 2014 under application number EP14720107A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP2988750

AOP ORPHAN PHARMACEUTICALS
Application Number
EP14720107A
Filing Date
Apr 25, 2014
Status
Patent Maintained As Amended
Apr 25, 2025
Grant Date
Sep 17, 2025
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

BECKEROct 18, 2022BECKER KURIG & PARTNER PATENTANWALTE MBBADMISSIBLE

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONCN1827109
OPPOSITIONEP1652533
OPPOSITIONEP2234614
OPPOSITIONEP2796139
OPPOSITIONWO2014174076

Non-Patent Literature (NPL) Citations (54) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ALHASHEMI J.A. ET AL., BRIT.J.ANAESTHES., (2005), vol. 95, no. 5, pages 648 - 650-
DESCRIPTION- ANDERSON A.C., CLIN.PED.EMERGENCY MED., (2008), pages 4 - 16-
DESCRIPTION- HARRISON DC; ALDERMAN EL, CHEST, (1976), vol. 69, no. 1, pages 1 - 2-
DESCRIPTION- HAUSEN T., MMW MUNCH MED WOCHENSCHR., (1981), vol. 123, no. 42, pages 1583 - 4-
DESCRIPTION- HELLBRUNN S. ET AL., CIRCULATION, (1989), vol. 79, pages 483 - 490-
DESCRIPTION- KUBO K. ET AL., J.ANESTH., (2005), vol. 19, pages 174 - 176-
DESCRIPTION- MIWA Y. ET AL., CIRCULATION JOURNAL, (2010), vol. 74, pages 856 - 863-
DESCRIPTION- MIZUNO J. ET AL., EUR.J.CLIN.PHARMACOL., (2007), vol. 63, pages 243 - 252-
DESCRIPTION- MORISAKI A. ET AL., GEN.THORAC.CARDIOVASC.SURG., (2012), vol. 60, pages 386 - 390-
DESCRIPTION- MURAKAMI M. ET AL., DRUG METAB. PHARMACOKINET., (2005), vol. 20, no. 5, pages 337 - 344-
DESCRIPTION- NAGAI R. ET AL., CIRCULATION J., (2013), vol. 77, pages 908 - 916-
DESCRIPTION- NANOFFC. ET AL., BASIC RES. CARDIOL., (1990), vol. 85, pages 88 - 95-
DESCRIPTION- TAKAHASHI S. ET AL., CAN.J.ANESTH., (2000), vol. 47, pages 265 - 272-
DESCRIPTION- WARIISHI S. ET AL., "Interactive Cardiovasc", THORACIC SURGERY, (2009), vol. 9, pages 811 - 813-
EXAMINATION- G�NTHER KRUMPL ET AL, "Pharmacodynamic and -kinetic Behavior of Low-, Intermediate-, and High-Dose Landiolol During Long-Term Infusion in Whites :", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, NEW YORK, NY, (20170701), vol. 70, no. 1, doi:10.1097/FJC.0000000000000495, ISSN 0160-2446, pages 42 - 51, XP055686060
INTERNATIONAL-SEARCH-REPORT- TAKAHASHI S ET AL, "Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia.", CANADIAN JOURNAL OF ANAESTHESIA = JOURNAL CANADIEN D'ANESTHÉSIE JUN 1999, (199906), vol. 46, no. 6, ISSN 0832-610X, pages 599 - 604, XP002728764 [X] 1-17 * the whole document *
INTERNATIONAL-SEARCH-REPORT- SHINJI TAKAHASHI ET AL, "Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs", CANADIAN JOURNAL OF ANESTHESIA, (20000301), vol. 47, no. 3, doi:10.1007/BF03018925, ISSN 0832-610X, pages 265 - 272, XP055078074 [X] 1-17 * the whole document *
INTERNATIONAL-SEARCH-REPORT- JU MIZUNO ET AL, "Age and sex-related differences in dose-dependent hemodynamic response to landiolol hydrochloride during general anesthesia", EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, SPRINGER, BERLIN, DE, (20070109), vol. 63, no. 3, doi:10.1007/S00228-006-0249-1, ISSN 1432-1041, pages 243 - 252, XP019489181 [X] 1-15 * the whole document *
INTERNATIONAL-SEARCH-REPORT- KOZUE KUBO ET AL, "Successful management of cesarean section in a patient with Romano-Ward syndrome using landiolol, a selective and short-acting [beta]1 receptor antagonist", JOURNAL OF ANESTHESIA, SPRINGER-VERLAG, TO, (20050501), vol. 19, no. 2, doi:10.1007/S00540-005-0302-8, ISSN 1438-8359, pages 174 - 176, XP019373359 [X] 1-14 * the whole document *
INTERNATIONAL-SEARCH-REPORT- MORISAKI AKIMASA ET AL, "Very-low-dose continuous drip infusion of landiolol hydrochloride for postoperative atrial tachyarrhythmia in patients with poor left ventricular function.", GENERAL THORACIC AND CARDIOVASCULAR SURGERY JUN 2012, (201206), vol. 60, no. 6, ISSN 1863-6713, pages 386 - 390, XP002712698 [X] 1-15 * the whole document *
INTERNATIONAL-SEARCH-REPORT- T. NAKANO ET AL, "Effect of landiolol hydrochloride, an ultra-short-acting beta 1-selective blocker, on supraventricular tachycardia, atrial fibrillation and flutter after pulmonary resection", JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, (20120807), vol. 37, no. 4, doi:10.1111/j.1365-2710.2011.01315.x, ISSN 0269-4727, pages 431 - 435, XP055135833 [X] 1-14 * the whole document *
INTERNATIONAL-SEARCH-REPORT- MIWA YOSUKE ET AL, "Effects of landiolol, an ultra-short-acting beta1-selective blocker, on electrical storm refractory to class III antiarrhythmic drugs.", CIRCULATION JOURNAL : OFFICIAL JOURNAL OF THE JAPANESE CIRCULATION SOCIETY MAY 2010, (20100501), vol. 74, no. 5, ISSN 1347-4820, pages 856 - 863, XP002712727 [X] 1-17 * the whole document *
INTERNATIONAL-SEARCH-REPORT- NAGAI RYOZO ET AL, "Urgent management of rapid heart rate in patients with atrial fibrillation/flutter and left ventricular dysfunction: comparison of the ultra-short-acting [beta]1-selective blocker landiolol with digoxin (J-Land Study).", CIRCULATION JOURNAL : OFFICIAL JOURNAL OF THE JAPANESE CIRCULATION SOCIETY 2013, (2013), vol. 77, no. 4, ISSN 1347-4820, pages 908 - 916, XP002712699 [XP] 1-14 * the whole document *
INTERNATIONAL-SEARCH-REPORT- WARIISHI SEIICHIRO ET AL, "Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose", INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, OXFORD UNIVERSITY PRESS, UK, (20091101), vol. 9, no. 5, doi:10.1510/ICVTS.2009.212837, ISSN 1569-9293, pages 811 - 813, XP008164714 [X] 1-15 * the whole document *
OPPOSITION- Amomed Pharma Gmbh, "Rapibloc 300 mg powder for solution for infusionSUMMARY OF PRODUCT CHARACTERISTICS ", SUMMARY OF PRODUCT CHARACTERISTICS, (20200901), pages 1 - 14, SUMMARY OF PRODUCT CHARACTERISTICS , XP093221101-
OPPOSITION- Anonymous, "Approval for Additional Indication of Onoact ® 50 for injection, Short-Acting Selective β1 Blocker in Japan", (20131122), URL: https://www.ono-pharma.com/sites/default/files/en/news/press/sm_cn131122.pdf, XP055976811-
OPPOSITION- ATSUSHI S. et al., "Electrophysiologic, Cardiohemodynamic and β-Blocking Actions of a New Ultra-Short-Acting β-Blocker, ONO-1101, Assessed by the In Vivo Canine Model in Comparison with Esmolol", Journal of Cardiovascular Pharmacology, (19990700), vol. 34, no. 1, pages 70 - 77-
OPPOSITION- Hoffman Amnon, Stepensky David , "Pharmacodynamic Aspects of Modes of Drug Administration for Optimization of Drug Therapy", Critical Reviews™ in Therapeutic Drug Carrier Systems, (19990101), vol. 16, no. 6, pages 571 - 639, XP055976927-
OPPOSITION- Kono Tetsuya, Yanagiya Nobuyuki, Nishimura Kazunori, "Successful treatment of supraventricular tachyarrhythmias with landiolol during hemodialysis in a patient after receiving cardiac surgery", J Jpn Soc Intensive Care Med., (20100101), vol. 17, pages 77 - 78, XP055976934-
OPPOSITION- Krumpl G. et al., J. Cardiovascular Pharmacology, 70( 1 ):42-51 (2017);-
OPPOSITION- Morishima Atsutomo, Hirao Shingo, Nagasaka Shigeo, Yokoyama Shinya, Kaneda Kouzou, Nishiwaki Noboru, "Suppressive Effect of Landiolol Hydrochloride on Atrial Fibrillation Follwing Surgical Repair of Acute Type A Aortic Dissection (English translation enclosed)", Jpn J Vasc Surg, (20090101), vol. 18, no. 4, pages 481 - 485, XP055976802-
OPPOSITION- Murakami et al., 0-052, Journal of Cardiac Failure, 2012, 18, 10S,S157-S158-
OPPOSITION- Murakami Wakako, Shigeki Kobayashi, Takamasa Oda, Hiroki Tateishi, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki, "O-052 - Low-dose of Landiolol Effectively Slows Heart Rate of Rapid Atrial Fibrillation in Patient with Acute Decompensated Heart Failure", Journal of Cardiac Failure, (20121001), vol. 18, no. 10S, pages S157 - S158, XP055976929-
OPPOSITION- "Onoact 50 for injection (ONOACT®)", Information Leaflet (English translation enclosed), (20120401), pages 1 - 6, XP055976916-
OPPOSITION- "Onoact® 50 for injection <ONOACT®>", Information Leaflet (in Japanese, English translation enclosed), (20061001), pages 28 - 33, XP055976923-
OPPOSITION- Seo Hiroyuki, Miyamoto Satoshi, Yao Hideki, Minamura Hiroyoshi, Hosono Koji, Aoyama Takanobu, "Clinical Experience of Landiolol Hydrochloride, a Short-acting beta1-Blocker, for Atrial Fibrillation after Open Heart Surgery; Report of a Case (English translation enclosed)", Jpn J Med Pharm Sci, (20080101), vol. 59, no. 1, pages 115 - 118, XP055976781-
OPPOSITION- Tachikawa Mayumi, Shimazaki Mutsuhisa, Arai Takero, Saima Shunsuke, Adachi Eriko, Okuda Yasuhisa, "Effect of Landiolol and Combined Use of Landiolol and Olprinone on Hemodynamics in Patients Undergoing Off-pump Coronary Artery Bypass Grafting (English translation enclosed)", Masui (Jpn. J. Anesthesiol.), (20120101), vol. 61, no. 6, pages 566 - 573, XP055976935-
OPPOSITION- Yuko Yoshida ; Katsuyuki Terajima ; Chiyo Sato ; Shinji Akada ; Yasuo Miyagi ; Takashi Hongo ; Shinhiro Takeda ; Keiji Tanaka ; Atsuhiro Sakamoto, "Clinical role and efficacy of landiolol in the intensive care unit", Journal of Anesthesia, To , (20080227), vol. 22, no. 1, ISSN 1438-8359, pages 64 - 69, XP019591685-
OPPOSITION- Paul Abialbon, "Drug Absorption and Bioavailability", Introduction to Basics of Pharmacology and Toxicology : Volume 1: General and Molecular Pharmacology: Principles of Drug Action, Singapore, Springer Singapore, (20190101), pages 81 - 88, doi:10.1007/978-981-32-9779-1_5, ISBN 978-981-3297-79-1, XP055976938
OPPOSITION- Benet Leslie Z., "Effect of route of administration and distribution on drug action", Journal of Pharmacokinetics and Biopharmaceutics, (19781201), vol. 6, no. 6, doi:10.1007/BF01062110, pages 559 - 585, XP055976937
OPPOSITION- Shinji Takahashi, Fujii Yoshitaka, Inomata Shin-Ichi, Miyabe Masayuki, Toyooka Hidenori, "Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia", Canadian Journal of Anesthesia, (19990101), doi:10.1007/BF03013554, pages 599 - 604, XP055135914
OPPOSITION- Shinji Takahashi, Yoshitaka Fujii, Takuo Hoshi, Shin-Ichi Inomata, Masayuki Miyabe, Hidenori Toyooka, "Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs", Canadian journal of anesthesia, (20000301), vol. 47, no. 3, doi:10.1007/BF03018925, ISSN 0832610X, pages 265 - 272, XP055078074
OPPOSITION- Hiroaki Ito ; Kazuya Sobue ; MinHye So ; Hiroyuki Hirate ; Takeshi Sugiura ; Takafumi Azami ; Hiroshi Sasano ; Hirotada Katsuya, "Use of landiolol in the perioperative management of supraventricular tachycardia", Journal of Anesthesia, To , (20060801), vol. 20, no. 3, doi:10.1007/s00540-006-0398-5, ISSN 1438-8359, pages 253 - 254, XP019429576
OPPOSITION- Taenaka Nobuyuki, Kikawa Shinichi, "Dose-Dependent Effect of Landiolol, a New Ultra-Short-Acting β1-Blocker, on Supraventricular Tachyarrhythmias in Postoperative Patients", Clinical Drug Investigation, NZ , (20130701), vol. 33, no. 7, doi:10.1007/s40261-013-0093-x, ISSN 1173-2563, pages 505 - 514, XP055976921
OPPOSITION- Leier, C.V. ; Binkley, P.F., "Acute positive inotropic intervention: The catecholamines", American Heart Journal, AMSTERDAM, NL , (19910601), vol. 121, no. 6, doi:10.1016/0002-8703(91)90077-U, ISSN 0002-8703, pages 1866 - 1870, XP022928440
OPPOSITION- Park Haengnam; Otani Hajime; Noda Teppei; Sato Daisuke; Okazaki Toru; Ueyama Takanao; Iwasaka Junji; Yamamoto Yoshihiro; Iwasaka Toshiji, "Intracoronary followed by intravenous administration of the short-acting B-blocker landiolol prevents myocardial injury in the face of elective percutaneous coronary intervention", International Journal of Cardiology, AMSTERDAM, NL , (20120518), vol. 167, no. 4, doi:10.1016/j.ijcard.2012.04.096, ISSN 0167-5273, pages 1547 - 1551, XP028691251
OPPOSITION- Akira Sezai; Kazutomo Minami; Toshiko Nakai; Mitsumasa Hata; Isamu Yoshitake; Shinji Wakui; Motomi Shiono; Atsushi Hirayama;, "Landiolol hydrochloride for prevention of atrial fibrillation after coronary artery bypass grafting: New evidence from the PASCAL trial", The Journal of Thoracic and Cardiovascular Surgery, US , (20101023), vol. 141, no. 6, doi:10.1016/j.jtcvs.2010.10.045, ISSN 0022-5223, pages 1478 - 1487, XP028210732
OPPOSITION- Gelbenegger Georg; Jilma Bernd; Horvath Lisa Christina; Schoergenhofer Christian; Siller-Matula Jolanta M.; Sulzgruber Patrick; Grassmann Daniel; Hamp Thomas; Grafeneder Juergen; Schnaubelt Sebastian; Holzer Michael; Krammel Mario, "Landiolol for refractory ventricular fibrillation in out-of-hospital cardiac arrest: A randomized, double-blind, placebo-controlled, pilot trial", RESUSCITATION., ELSEVIER., IE, IE , (20240610), vol. 201, doi:10.1016/j.resuscitation.2024.110273, ISSN 0300-9572, XP087579284
OPPOSITION- Ogawa Shinji, Okawa Yasuhide, Goto Yoshihiro, Aoki Masakazu, Baba Hiroshi, "Perioperative use of a beta blocker in coronary artery bypass grafting", Asia Cardiovascular & Thoracic Annals, GB , (20130601), vol. 21, no. 3, doi:10.1177/0218492312451166, ISSN 0218-4923, pages 265 - 269, XP055976930
OPPOSITION- Sakamoto Atsuhiro, Kitakaze Masafumi, Takamoto Shinichi, Namiki Akiyoshi, Kasanuki Hiroshi, Hosoda Saichi, "Landiolol, an Ultra-Short-Acting β<sub>1</sub>-Blocker, More Effectively Terminates Atrial Fibrillation Than Diltiazem After Open Heart Surgery : - Prospective, Multicenter, Randomized, Open-Label Study (JL-KNIGHT Study) -", CIRCULATION JOURNAL, JP , (20120101), vol. 76, no. 5, doi:10.1253/circj.CJ-11-1332, ISSN 1346-9843, pages 1097 - 1101, XP055976767
OPPOSITION- Kobayashi Shigeki, Susa Takehisa, Tanaka Takeo, Murakami Wakako, Fukuta Seiko, Okuda Shinichi, Doi Masahiro, Wada Yasuaki, Nao Tomoko, Yamada Jutaro, Okamura Takayuki, Yano Masafumi, Matsuzaki Masunori, "Low-Dose β-Blocker in Combination With Milrinone Safely Improves Cardiac Function and Eliminates Pulsus Alternans in Patients With Acute Decompensated Heart Failure", CIRCULATION JOURNAL, JP , (20120101), vol. 76, no. 7, doi:10.1253/circj.CJ-12-0033, ISSN 1346-9843, pages 1646 - 1653, XP055976933
OPPOSITION- Stix Guenter, Wolzt Michael, Domanovits Hans, Kadlecová Pavla, Husch Bernhard, Trebs Michaela, Hodisch Juri, Unger Martin, Krumpl Guenther, "Open-Label Two-Dose Pilot Study of Landiolol for the Treatment of Atrial Fibrillation/Atrial Flutter in Caucasian Patients", CIRCULATION JOURNAL, JP , (20191225), vol. 84, no. 1, doi:10.1253/circj.CJ-19-0661, ISSN 1346-9843, pages 33 - 42, XP055976771
OPPOSITION- Wariishi Seiichiro; Yamashita Koichi; Nishimori Hideaki; Fukutomi Takashi; Yamamoto Masaki; Radhakrishnan Geethalakshmi; Sasaguri Shiro, "Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose.", Interactive Cardiovascular and Thoracic Surgery, UK , (20091101), vol. 9, no. 5, doi:10.1510/icvts.2009.212837, ISSN 1569-9293, pages 811 - 813, XP008164714
OPPOSITION- Jeong Seung-Hyun, Jang Ji-Hun, Lee Yong-Bok, "Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats", Pharmaceuticals, vol. 13, no. 9, doi:10.3390/ph13090231, page 231, XP055976939

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents