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Use Of Fertile Transgenic Animals For Producing Antibodies Bearing Human Variable Regions - EP2989894

The patent EP2989894 was granted to Kymab on Dec 14, 2022. The application was originally filed on Nov 30, 2012 under application number EP15188522A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP2989894

KYMAB
Application Number
EP15188522A
Filing Date
Nov 30, 2012
Status
Granted And Under Opposition
Jul 10, 2020
Grant Date
Dec 14, 2022
External Links
Slate, Register, Google Patents

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REGENERON PHARMACEUTICALSMay 11, 2021J A KEMPWITHDRAWN

Patent Citations (10) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
EXAMINATIONWO2013096142
OPPOSITIONWO02066630
OPPOSITIONWO2012141798
OPPOSITIONWO2013022782
OPPOSITIONWO2013096142
OTHERWO2013096142
SEARCHWO02066630
SEARCHWO2011004192
SEARCHWO2012141798
SEARCHWO2013022782

Non-Patent Literature (NPL) Citations (11) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- Priority document WO2013/096142-
EXAMINATION- STEVEN S, "Human antibody discovery VelocImmune- a novel platform", ASIA FOCUS, CHRISTIAN CONFERENCE OF ASIA, THAILAND, (20080101), no. 8, ISSN 0044-9164, pages 72 - 74, XP003035153-
EXAMINATION- ANDREW MURPHY, "VelocImmune: Immunoglobulin Variable Region Humanized Mice", RECOMBINANT ANTIBODIES FOR IMMUNOTHE, CAMBRIDGE UNIVERSITY PRESS, GB, (20090101), ISBN 978-0-521-88732-8, pages 100 - 107, XP008160379
OPPOSITION- Drew Murphy, "BAC-based Modifications of the Mouse Genome: The Big and the Backward", Slide Presentation, Wellcome Trust Advanced Course: Genetic Manipulation of ES Cells; October 26 - November 3, 2009; Hinxton, UK,, (20091103), pages 1 - 58, XP002752689-
OPPOSITION- Ebersbach Hilmar, Gabriele Proetzel, "Antibody Methods and Protocols", Springer, (20120500), pages 1 - 2, XP055837880-
OPPOSITION- Katherine E Kilpatrick; Wring Stephen A; Walker Duncan H; Macklin Michael D; Payne J Alan; Su Jui-Lan; Champion Brian R; Caterson Bruce; Mcintyre Gordon D, "Rapid Development of Affinity Matured Monoclonal Antibodies Using RIMMS", Hybridoma, (19970000), vol. 16, no. 4, pages 381 - 389, XP055010201
SEARCH- A.J. Murphy, "BAC-based modifications of the mouse genome: the big and the backward.", Presentation done at Wellcome Trust advance course: Genetic manipulation of ES cells., (20091103), European Patent Register, URL: https://register.epo.org/application?documentId=EX86YVZG2561DSU&appnumber=EP14176593&showPdfPage=all, XP002752689 [X] 4-6 * Document available after entering Application N° EP 14176593 (Patent:EP2813573) in "All Documents", date 22-11-2015. * * pages 9,23,26 * [I] 1-3-
SEARCH- A.J. Murphy, "Declaration (Affidavit-traversing rejectns or objectns rule 132)", (20140610), Uspto.gov, URL: http://portal.uspto.gov/pair/view/BrowsePdfServlet?objectId=IFFSQTDXPXXIFW3&lang=DINO, XP002752690 [T] * Document available after entering Application N° 14/192051 (Publication:US 20140213773 A1) in "Image File Wrapper", date 10-06-2015. Declaration has been dated on 10-06-2014 (see page 4). *-
SEARCH- LONBERG ET AL, "Fully human antibodies from transgenic mouse and phage display platforms", CURRENT OPINION IN IMMUNOLOGY, ELSEVIER, OXFORD, GB, vol. 20, no. 4, doi:10.1016/J.COI.2008.06.004, ISSN 0952-7915, (20080801), pages 450 - 459, (20080721), XP025771204 [X] 13-15 * page 451 * * figure 1 *
SEARCH- M. R. MARCELLO ET AL, "Lack of Tyrosylprotein Sulfotransferase-2 Activity Results in Altered Sperm-Egg Interactions and Loss of ADAM3 and ADAM6 in Epididymal Sperm", JOURNAL OF BIOLOGICAL CHEMISTRY, (20110221), vol. 286, no. 15, doi:10.1074/jbc.M110.175463, ISSN 0021-9258, pages 13060 - 13070, XP055053699 [A] 1-15 * figure 7 * * page 13069, column r, paragraph 2 *
SEARCH- CECIL HAN ET AL, "Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice", BIOLOGY OF REPRODUCTION,, NEW YORK, NY [U.A.] : ACADEM. PRESS, US, vol. 80, no. 5, doi:10.1095/BIOLREPROD.108.073700, ISSN 0006-3363, (20090501), pages 1001 - 1008, (20090107), XP002677427 [A] 1-15 * page 1005, column r, paragraph 1 * * page 1008, paragraph 2 *

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