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Human Application Of Engineered Chimeric Antigen Receptor (Car) T-Cells - EP2997134

The patent EP2997134 was granted to Board OF Regents on Jun 24, 2020. The application was originally filed on May 14, 2014 under application number EP14798046A. The patent is currently recorded with a legal status of "Revoked".

EP2997134

BOARD OF REGENTS
Application Number
EP14798046A
Filing Date
May 14, 2014
Status
Revoked
Dec 3, 2021
Publication Date
Jun 24, 2020
External Links
Slate, Register, Google Patents

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MAIWALDMar 24, 2021LASAR -

Patent Citations (4) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
INTERNATIONAL-SEARCH-REPORTWO2011059836
OPPOSITIONUS2007041941
OPPOSITIONWO2014186469
SEARCHEP2173378

Non-Patent Literature (NPL) Citations (17) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
EXAMINATION- LENKA V. HURTON ET AL, "Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, US, (20161114), vol. 113, no. 48, doi:10.1073/pnas.1610544113, ISSN 0027-8424, pages E7788 - E7797, XP055436232
INTERNATIONAL-SEARCH-REPORT- "ANTI-MUC1 T CELL CHIMERIC RECEPTOR [SYNTHETIC CONSTRUCT]", GENBANK, (20080429), Database accession no. ACC78293, URL: NCBI, XP055295496
INTERNATIONAL-SEARCH-REPORT- "INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA ISOFORM 1 PRECURSOR [HOMO SAPIENS]", PROTEIN, (20130421), Database accession no. NP_002180, URL: NCBI, XP055295498
INTERNATIONAL-SEARCH-REPORT- KRISHNAMURTHY, J. ET AL., "Targeting an ancient retrovirus expressed in melanoma using adoptive T- cell therapy", 2012 IMMUNOLOGY GRADUATE PROGRAM, (20120224), XP008182481
INTERNATIONAL-SEARCH-REPORT- "UNNAMED PROTEIN PRODUCT [SYNTHETIC CONSTRUCT]", PROTEIN, (20030124), Database accession no. CAD61786, URL: NCBI, XP055295470
INTERNATIONAL-SEARCH-REPORT- ROWLEY, JESSE ET AL., "Expression of IL -15RA or an IL -15/ IL -15RA fusion on CD 8+ T cells modifies adoptively transferred T- cell function in cis", EUROPEAN JOURNAL OF IMMUNOLOGY, (2009), vol. 39, no. 2, pages 491 - 506, XP002679900
INTERNATIONAL-SEARCH-REPORT- SINGH, HARJEET ET AL., "Redirecting specificity of T- cell populations for CD 19 using the Sleeping Beauty system", CANCER RESEARCH, (2008), vol. 68, no. 8, pages 2961 - 2971, XP055217568
INTERNATIONAL-SEARCH-REPORT- SINGH, HARJEET ET AL., "Reprogramming CD 19-specific T cells with IL -21 signaling can improve adoptive immunotherapy of B-lineage malignancies", CANCER RESEARCH, (2011), vol. 71, no. 10, pages 3516 - 3527, XP055295461
INTERNATIONAL-SEARCH-REPORT- HULS, M. HELEN ET AL., "Clinical application of sleeping beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood", JOURNAL OF VISUALIZED EXPERIMENTS, (201302), pages 1 - 8, XP055295436
OPPOSITION- CHUBET et al., "Vectors for Expression and Secretion of FLAG Epitope-Tagged Proteins in Mammalian Cells", BioTechniques, (19960100), vol. 20, pages 136 - 141, XP002155659
OPPOSITION- HURTON et al., "Improved Costimulation of CD 19-Specific T Cells Transpresenting a Membrane-Bound IL -15", Molecular Therapy, (20110500), vol. 9, no. Supplement 1, XP055795381
OPPOSITION- ROWLEY et al., "Expression of IL -15RA or an IL -15/ IL -15RA fusion on CD 8+ T cells modifies adoptively transferred T- cell function in cis", Eur. J. Immunol., (20090000), vol. 39, doi:10.1002/EJI.200838594, pages 491 - 506, XP002679900
OPPOSITION- IVICS et al., "Molecular Reconstruction of Sleeping Beauty, a Tc1- like Transposon from Fish, and Its Transposition in Human Cells", Cell, (19971114), vol. 91, doi:10.1016/S0092-8674(00)80436-5, pages 501 - 510, XP002072766
OPPOSITION- KENTEN et al., "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line", PNAS, (19821100), vol. 79, doi:10.1073/pnas.79.21.6661, pages 6661 - 6665, XP000942568
OPPOSITION- MORTIER Erwan et al., "Soluble Interleukin-15 Receptor alpha( IL -15Ralpha)-sushi as a Selective and Potent Agonist of IL -15 Action through IL - 15Rbeta/gamma", The Journal of Biological Chemistry, (20060120), vol. 281, no. 3, doi:10.1074/jbc.M508624200, pages 1612 - 1619, XP002394330
OPPOSITION- MEAZZA Raffaella, Azzarone Bruno, Orengo Anna Maria, Ferrini Silvano, "Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy", Journal of Biomedicine and Biotechnology, (20110000), vol. 2011, doi:10.1155/2011/861920, pages 1 - 16, XP055795380
SEARCH- KAI-PING HAN ET AL, "IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 56, no. 3, doi:10.1016/J.CYTO.2011.09.028, ISSN 1043-4666, (20110928), pages 804 - 810, (20111003), XP028115119 [Y] 1-15 * page 809, column 1, paragraph 2; figures 1, 7 *

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