Delivery, Use And Therapeutic Applications Of The Crispr-Cas Systems And Compositions For Targeting Disorders And Diseases Using Viral Components - EP3011034

The patent EP3011034 was granted to Massachusetts Institute OF Technology on Aug 7, 2019. The application was originally filed on Jun 11, 2014 under application number EP14736206A. The patent is currently recorded with a legal status of "Revoked".

EP3011034

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Application Number
EP14736206A
Filing Date
Jun 11, 2014
Status
Revoked
Jul 30, 2021
Grant Date
Aug 7, 2019
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MATHYS & SQUIREMay 7, 2020WILDINGADMISSIBLE

Patent Citations (124) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS20040491026-
DESCRIPTIONUS20070953797-
DESCRIPTIONUS20080064798-
DESCRIPTIONUS20090511940-
DESCRIPTIONWO1994US05700-
DESCRIPTIONWO2007US84654-
DESCRIPTIONEP0264166
DESCRIPTIONEP1519714
DESCRIPTIONEP1664316
DESCRIPTIONEP1766035
DESCRIPTIONEP1781593
DESCRIPTIONUS2003087817
DESCRIPTIONUS2004013648
DESCRIPTIONUS2004171156
DESCRIPTIONUS2005019923
DESCRIPTIONUS2005287127
DESCRIPTIONUS2006030837
DESCRIPTIONUS2006281180
DESCRIPTIONUS2007025970
DESCRIPTIONUS2007054961
DESCRIPTIONUS2007093878
DESCRIPTIONUS2008267903
DESCRIPTIONUS2009007284
DESCRIPTIONUS2009017543
DESCRIPTIONUS2009100536
DESCRIPTIONUS2009111106
DESCRIPTIONUS2009222937
DESCRIPTIONUS2009271881
DESCRIPTIONUS2010146651
DESCRIPTIONUS2010229252
DESCRIPTIONUS2010291048
DESCRIPTIONUS2010311124
DESCRIPTIONUS2010317109
DESCRIPTIONUS2011016540
DESCRIPTIONUS2011023139
DESCRIPTIONUS2011023144
DESCRIPTIONUS2011023145
DESCRIPTIONUS2011023146
DESCRIPTIONUS2011023153
DESCRIPTIONUS2011059502
DESCRIPTIONUS2011091441
DESCRIPTIONUS2011117189
DESCRIPTIONUS2011142917
DESCRIPTIONUS2011158957
DESCRIPTIONUS2011182867
DESCRIPTIONUS2011195123
DESCRIPTIONUS2011225664
DESCRIPTIONUS2011230839
DESCRIPTIONUS2011265198
DESCRIPTIONUS2011293571
DESCRIPTIONUS2011293703
DESCRIPTIONUS2012017290
DESCRIPTIONUS2012159653
DESCRIPTIONUS2012164118
DESCRIPTIONUS2012204282
DESCRIPTIONUS2012251618
DESCRIPTIONUS2012295960
DESCRIPTIONUS2012328580
DESCRIPTIONUS2013122591
DESCRIPTIONUS2013137104
DESCRIPTIONUS2013145487
DESCRIPTIONUS2013171732
DESCRIPTIONUS2013183282
DESCRIPTIONUS2013202678
DESCRIPTIONUS2013236946
DESCRIPTIONUS2013244279
DESCRIPTIONUS2013245107
DESCRIPTIONUS2013252281
DESCRIPTIONUS2013253040
DESCRIPTIONUS2013302401
DESCRIPTIONUS4186183
DESCRIPTIONUS4217344
DESCRIPTIONUS4235871
DESCRIPTIONUS4261975
DESCRIPTIONUS4485054
DESCRIPTIONUS4501728
DESCRIPTIONUS4774085
DESCRIPTIONUS4797368
DESCRIPTIONUS4837028
DESCRIPTIONUS4873316
DESCRIPTIONUS4897355
DESCRIPTIONUS4946787
DESCRIPTIONUS5049386
DESCRIPTIONUS5173414
DESCRIPTIONUS5210015
DESCRIPTIONUS5445934
DESCRIPTIONUS5580859
DESCRIPTIONUS5589466
DESCRIPTIONUS5593972
DESCRIPTIONUS5846946
DESCRIPTIONUS6603061
DESCRIPTIONUS6750059
DESCRIPTIONUS7206639
DESCRIPTIONUS7259015
DESCRIPTIONUS7303910
DESCRIPTIONUS7351585
DESCRIPTIONUS7745651
DESCRIPTIONUS7776321
DESCRIPTIONUS7799565
DESCRIPTIONUS7803397
DESCRIPTIONUS7838658
DESCRIPTIONUS7868149
DESCRIPTIONUS7901708
DESCRIPTIONUS7915399
DESCRIPTIONUS7982027
DESCRIPTIONUS8058069
DESCRIPTIONUS8101741
DESCRIPTIONUS8188263
DESCRIPTIONUS8236943
DESCRIPTIONUS8283333
DESCRIPTIONUS8372951
DESCRIPTIONUS8404658
DESCRIPTIONUS8454972
DESCRIPTIONUS8575305
DESCRIPTIONWO2011028929
DESCRIPTIONWO2013126794
DESCRIPTIONWO2013163628
DESCRIPTIONWO9116024
DESCRIPTIONWO9117424
DESCRIPTIONWO9324641
DESCRIPTIONWO9639154
DESCRIPTIONWO9703211
EXAMINATIONFR2872170
OPPOSITIONWO2013176772

Non-Patent Literature (NPL) Citations (305) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ADVANCED DRUG DELIVERY REVIEWS, (2012), vol. 64, pages 1730 - 1737-
DESCRIPTION- AHMAD ET AL., CANCER RES., (1992), vol. 52, pages 4817 - 4820-
DESCRIPTION- AHMAD, S. ET AL., J ROYAL SOC INTERFACE, (2010), vol. 7, pages 5423 - 33-
DESCRIPTION- AIUTI ET AL., NAT. MED., (2002), vol. 8, pages 423 - 425-
DESCRIPTION- AKINC ET AL., NAT. BIOTECH, (2010), vol. 26, pages 561 - 569-
DESCRIPTION- ALABI ET AL., PROC NATL ACAD SCI U S A., (20130806), vol. 110, no. 32, pages 12881 - 6-
DESCRIPTION- ALTSCHUL ET AL., J. MOL. BIOL., (1990), pages 403 - 410-
DESCRIPTION- ALVAREZ-ERVITI ET AL., NAT BIOTECHNOL, (2011), vol. 29, page 341-
DESCRIPTION- AMRANN ET AL., GENE, (1988), vol. 69, pages 301 - 315-
DESCRIPTION- ANDERSON, SCIENCE, (1992), vol. 256, pages 808 - 813-
DESCRIPTION- A.R. GRUBER ET AL., CELL, (2008), vol. 106, no. 1, pages 23 - 24-
DESCRIPTION- ATSCHUL ET AL., J. MOL. BIOL., (1990), pages 403 - 410-
DESCRIPTION- AUSUBEL ET AL., SHORT PROTOCOLS IN MOLECULAR BIOLOGY, (1999), pages 7 - 58,7-60-
DESCRIPTION- BAILEY ET AL., J MOL MED (BERL)., (199901), vol. 77, no. 1, pages 244 - 9-
DESCRIPTION- BALAGAAN, J GENE MED, (20051121), vol. 8, pages 275 - 285-
DESCRIPTION- BALAGAAN, J Gene Med, WILEY INTERSCIENCE, (20051121), vol. 8, pages 275 - 285-
DESCRIPTION- BALDARI ET AL., EMBO J., (1987), vol. 6, pages 229 - 234-
DESCRIPTION- BANEIJI ET AL., CELL, (1983), vol. 33, pages 729 - 740-
DESCRIPTION- BARTLETT ET AL., PNAS, (20070925), vol. 104, no. 39-
DESCRIPTION- BAUER ET AL., SCIENCE, (20131011), vol. 342, no. 6155, pages 253 - 257-
DESCRIPTION- BEHR ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 382 - 389-
DESCRIPTION- BINLEY ET AL., HUMAN GENE THERAPY, (201209), vol. 23, pages 980 - 991-
DESCRIPTION- BLAESE ET AL., CANCER GENE THER, (1995), vol. 2, pages 291 - 297-
DESCRIPTION- BORTOLANZA ET AL., MOLECULAR THERAPY, (201111), vol. 19, no. 11, pages 2055 - 2064-
DESCRIPTION- BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530-
DESCRIPTION- BOUDREAU ET AL., MOLECULAR THERAPY, (200906), vol. 17, no. 6-
DESCRIPTION- BOUSSO ET AL., PROC. NATL., ACAD. SCI. USA, (2000), vol. 97, pages 274 - 278-
DESCRIPTION- BUCAN ET AL., PLOS GENETICS, (2009), vol. 5, page EL000536-
DESCRIPTION- BUCHSCHER ET AL., J. VIROL., (1992), vol. 66, pages 2731 - 2739-
DESCRIPTION- BUNTING ET AL., HUM. GENE THER., (2000), vol. 11, pages 2353 - 2364-
DESCRIPTION- BUNTING ET AL., NAT. MED., (1998), vol. 4, pages 58 - 64-
DESCRIPTION- BYRNE; RUDDLE, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 5473 - 5477-
DESCRIPTION- CALAME; EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275-
DESCRIPTION- CAMPES; TILGHMAN, GENES DEV., (1989), vol. 3, pages 537 - 546-
DESCRIPTION- CAMPOCHIARO ET AL., HUMAN GENE THERAPY, (200602), vol. 17, pages 167 - 176-
DESCRIPTION- CANDOTTI ET AL., BLOOD, (1996), vol. 87, pages 3097 - 3102-
DESCRIPTION- CAVAZZANA-CALVO ET AL., ANNU. REV. MED., (2005), vol. 56, pages 585 - 602-
DESCRIPTION- CAVAZZANA-CALVO ET AL., BLOOD, (1996), vol. 88, pages 3901 - 3909-
DESCRIPTION- CAVAZZANA-CALVO ET AL., SCIENCE, (2000), vol. 288, pages 669 - 672-
DESCRIPTION- CHAN-HUI ET AL., CLINICAL IMMUNOLOGY, (2003), vol. 111, pages 162 - 174-
DESCRIPTION- CHEN ET AL., GENE THERAPY, (2007), vol. 14, pages 11 - 19-
DESCRIPTION- CHOI ET AL., PROC. NATL. ACAD. SCI. USA., (2013), vol. 110, no. 19, pages 7625 - 7630-
DESCRIPTION- COELHO ET AL., N ENGL J MED, (2013), vol. 369, pages 819 - 29-
DESCRIPTION- CRONICAN ET AL., ACS CHEMICAL BIOLOGY, (2010), vol. 5, pages 747 - 752-
DESCRIPTION- CRONICAN ET AL., CHEMISTRY & BIOLOGY, (2011), vol. 18, pages 833 - 838-
DESCRIPTION- CRYSTAL, SCIENCE, (1995), vol. 270, pages 404 - 410-
DESCRIPTION- CUTLER ET AL., J. AM. CHEM. SOC., (2011), vol. 133, pages 9254 - 9257-
DESCRIPTION- CUTLER ET AL., J. AM. CHEM. SOC., (2012), vol. 134, pages 1376 - 1391-
DESCRIPTION- DAVIS ET AL., NATURE, (20100415), vol. 464-
DESCRIPTION- DEVEREUX ET AL., NUC. ACIDS RESEARCH, (1984), vol. 12, page 387-
DESCRIPTION- DIFIGLIA ET AL., PNAS, (20071023), vol. 104, no. 43, pages 17204 - 17209-
DESCRIPTION- DUMITRACHE ET AL., GENETICS, (201108), vol. 188, no. 4, pages 787 - 797-
DESCRIPTION- DUMONCEAUX ET AL., MOLECULAR THERAPY, (201005), vol. 18, no. 5, pages 881 - 887-
DESCRIPTION- EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916-
DESCRIPTION- EL-ANDALOUSSI ET AL., NATURE PROTOCOLS, (2012), vol. 7, pages 2112 - 2126-
DESCRIPTION- EMBDEN ET AL., J. BACTERIOL., (2000), vol. 182, pages 2393 - 2401-
DESCRIPTION- EULALIO ET AL., NATURE, (2012), vol. 492, page 376-
DESCRIPTION- FEMS MICROBIOL LETT., (1999), vol. 174, no. 2, pages 247 - 50-
DESCRIPTION- FEMS MICROBIOL LETT., (1999), vol. 177, no. 1, pages 187 - 8-
DESCRIPTION- FISCHER ET AL., IMMUNOL. REV., (2005), vol. 203, pages 98 - 109-
DESCRIPTION- FREITAG ET AL., EUR. CHILD. ADOLESC. PSYCHIATRY, (2010), vol. 19, pages 169 - 178-
DESCRIPTION- GAO ET AL., GENE THERAPY, (1995), vol. 2, pages 710 - 722-
DESCRIPTION- GARRETT, N.L. ET AL., J BIOPHOTONICS, (2012), vol. 5, no. 5-6, pages 458 - 68-
DESCRIPTION- GARRETT, N.L. ET AL., J RAMAN SPECT, (2012), vol. 43, no. 5, pages 681 - 688-
DESCRIPTION- GASIUNAS ET AL., PROC. NATL. ACAD. SCI. USA, (2012), vol. 109, page E2579-
DESCRIPTION- GASPAR ET AL., LANCET, (2004), vol. 364, pages 2181 - 2187-
DESCRIPTION- GEISBERT ET AL., LANCET, (2010), vol. 375, pages 1896 - 905-
DESCRIPTION- GIBLETT ET AL., LANCET, (1972), vol. 2, pages 1067 - 1069-
DESCRIPTION- GIULIANO AVANZINI, JEFFREY L. NOEBELS,, Genetics of Epilepsy and Genetic Epilepsies, MARIANI FOUNDATION PAEDIATRIC NEUROLOGY, (2009), vol. 20-
DESCRIPTION- GOEDDEL, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185-
DESCRIPTION- GRIMM, D. ET AL., J. VIROL., (2008), vol. 82, pages 5887 - 5911-
DESCRIPTION- GRIMM ET AL., NATURE, (20060526), vol. 441-
DESCRIPTION- GROENEN ET AL., MOL. MICROBIOL., (1993), vol. 10, pages 1057 - 1065-
DESCRIPTION- GUSCHIN ET AL., METHODS MOL BIOL, (2010), vol. 649, page 247-
DESCRIPTION- HACEIN-BEY ET AL., BLOOD, (1998), vol. 92, pages 4090 - 4097-
DESCRIPTION- HAGSTROM ET AL., MOLECULAR THERAPY, (200408), vol. 10, no. 2-
DESCRIPTION- HAO ET AL., SMALL, (2011), vol. 7, pages 3158 - 3162-
DESCRIPTION- HERMONAT; MUZYCZKA, PNAS, (1984), vol. 81, pages 6466 - 6470-
DESCRIPTION- HICKERSON ET AL., MOLECULAR THERAPY-NUCLEIC ACIDS, (2013), vol. 2, page E129-
DESCRIPTION- HIGGINS DG; SHARP PM, GENE, (1988), vol. 73, no. 1, pages 237 - 244-
DESCRIPTION- HIRSCHHORN ET AL., NAT. GENET., (1996), vol. 13, pages 290 - 295-
DESCRIPTION- HOE ET AL., EMERG. INFECT. DIS., (1999), vol. 5, pages 254 - 263-
DESCRIPTION- HORWELL DC, TRENDS BIOTECHNOL., (1995), vol. 13, no. 4, pages 132 - 134-
DESCRIPTION- HSU, P.; SCOTT, D.; WEINSTEIN, J.; RAN, FA.; KONERMANN, S.; AGARWALA, V.; LI, Y.; FINE, E.; WU, X.; SHALEM, 0., "DNA targeting specificity of RNA-guided Cas9 nucleases", NAT BIOTECHNOL-
DESCRIPTION- ISHINO ET AL., J. BACTERIOL., (1987), vol. 169, pages 5429 - 5433-
DESCRIPTION- JANSEN ET AL., MOL. MICROBIOL., (2002), vol. 43, pages 1565 - 1575-
DESCRIPTION- JANSSEN ET AL., OMICS J. INTEG. BIOL., (2002), vol. 6, pages 23 - 33-
DESCRIPTION- JAYARAMAN, ANGEW. CHEM. INT. ED., (2012), vol. 51, pages 8529 - 8533-
DESCRIPTION- JENSEN ET AL., SCI. TRANSL. MED, (2013), vol. 5, page 209RA152-
DESCRIPTION- JIANG ET AL., NANO LETT., (20130313), vol. 13, no. 3, pages 1059 - 64-
DESCRIPTION- JIANG W.; BIKARD D.; COX D.; ZHANG F; MARRAFFINI LA., "Y RNA-gu ded editing of bacterial genomes using CRISPR-Cas systems", NAT BIOTECHNOL, (2013), vol. 31, no. 3, pages 233 - 9-
DESCRIPTION- J IMMUNOL., (20050315), vol. 174, no. 6, pages 3187 - 96-
DESCRIPTION- JINEK ET AL., SCIENCE, (2012), vol. 337, page 816-
DESCRIPTION- JOHANN ET AL., J. VIROL., (1992), vol. 66, pages 1635 - 1640-
DESCRIPTION- JONKERS ET AL., AM. J. VET. RES., (1964), vol. 25, pages 236 - 242-
DESCRIPTION- JUDGE, J. CLIN. INVEST., (2009), vol. 119, pages 661 - 673-
DESCRIPTION- JUNG ET AL., MOLECULAR THERAPY, (201304), vol. 21, no. 4, pages 834 - 841-
DESCRIPTION- KANASTY; ANDERSON, NATURE MATERIALS, (201311), vol. 12-
DESCRIPTION- KARAGIANNIS ET AL., ACS NANO, (20121023), vol. 6, no. 10, pages 8484 - 7-
DESCRIPTION- KARRA; DAHM, THE JOURNAL OF NEUROSCIENCE, (20100505), vol. 30, no. 18, pages 6171 - 6177-
DESCRIPTION- KAUFMAN ET AL., EMBO J., (1987), vol. 6, pages 187 - 195-
DESCRIPTION- KAUFMANN ET AL., EMBO MOL MED, (2013), vol. 5, pages 1642 - 1661-
DESCRIPTION- KESSEL; GRUSS, SCIENCE, (1990), vol. 249, pages 374 - 379-
DESCRIPTION- KINOUCHI ET AL., GENE THERAPY, (2008), vol. 15, pages 1126 - 1130-
DESCRIPTION- KONERMANN S; BRIGHAM MD; TREVINO AE; HSU PD; HEIDENREICH M; CONG L; PLATT RJ; SCOTT DA; CHURCH GM; ZHANG F, "Y Optical control of mammalian endogenous transcription and epigenetic states", NATURE, (20130822), vol. 500, no. 7463, pages 472 - 6-
DESCRIPTION- KOTIN, HUMAN GENE THERAPY, (1994), vol. 5, pages 793 - 801-
DESCRIPTION- KREMER; PERRICAUDET, BRITISH MEDICAL BULLETIN, (1995), vol. 51, no. 1, pages 31 - 44-
DESCRIPTION- KUIJAN; HERSKOWITZ, CELL, (1982), vol. 30, pages 933 - 943-
DESCRIPTION- LALATSA, A. ET AL., J CONTR REL, (2012), vol. 161, no. 2, pages 523 - 36-
DESCRIPTION- LALATSA, A. ET AL., MOL PHARM, (2012), vol. 9, no. 6, pages 1665 - 80-
DESCRIPTION- LALATSA, A. ET AL., MOL PHARM, (2012), vol. 9, no. 6, pages 1764 - 74-
DESCRIPTION- LALATSA ET AL., J CONTROL RELEASE., (20120720), vol. 161, no. 2, pages 523 - 36-
DESCRIPTION- LAWRENCE ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2007), vol. 129, pages 10110 - 10112-
DESCRIPTION- LEACHMAN ET AL., MOLECULAR THERAPY, (201002), vol. 18, no. 2, pages 442 - 446-
DESCRIPTION- LEE ET AL., NAT NANOTECHNOL, (20120603), vol. 7, no. 6, pages 389 - 93-
DESCRIPTION- LEWIS ET AL., NAT. GEN., (2002), vol. 32, pages 107 - 108-
DESCRIPTION- LI ET AL., MOLECULAR THERAPY, (200912), vol. 17, no. 12, pages 2067 - 2077-
DESCRIPTION- LI, GENE THERAPY, (2012), vol. 19, pages 775 - 780-
DESCRIPTION- LIN-YANGA ET AL., PNAS, (20090310), vol. 106, no. 10-
DESCRIPTION- LIVINGSTONE C.D.; BARTON G.J., "Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation", COMPUT. APPL. BIOSCI., (1993), vol. 9, pages 745 - 756-
DESCRIPTION- LUCKLOW; SUMMERS, VIROLOGY, (1989), vol. 170, pages 31 - 39-
DESCRIPTION- MACCHI ET AL., NATURE, (1995), vol. 377, pages 65 - 68-
DESCRIPTION- MAKAROVA ET AL., NAT REV MICROBIOL, (2011), vol. 9, page 467-
DESCRIPTION- MASEPOHL ET AL., BIOCHIM. BIOPHYS. ACTA, (1996), vol. 1307, pages 26 - 30-
DESCRIPTION- MAZZA ET AL., ACS NANO, (20130226), vol. 7, no. 2, pages 1016 - 26-
DESCRIPTION- MAZZA, M. ET AL., ACSNANO, (2013), vol. 7, no. 2, pages 1016 - 1026-
DESCRIPTION- MCBRIDE ET AL., MOLECULAR THERAPY, (20111212), vol. 19, pages 2152 - 2162-
DESCRIPTION- MCIVOR EI; POLAK U; NAPIERALA M, "New insights into repeat instability: role of RNA DNA hybrids", RNA BIOL., (201009), vol. 7, no. 5, pages 551 - 8-
DESCRIPTION- MCNAUGHTON ET AL., PROC. NATL. ACAD. SCI. USA, (2009), vol. 106, pages 6111 - 6116-
DESCRIPTION- METHODS IN ENZYMOLOGY, ACADEMIC PRESS, INC.-
DESCRIPTION- MICHAEL S D KORMANN ET AL., "Expression of therapeutic proteins after delivery of chemically modified mRNA in mice", NATURE BIOTECHNOLOGY, (20110109), pages 154 - 157-
DESCRIPTION- MILLER ET AL., J. VIROL., (1991), vol. 65, pages 2220 - 2224-
DESCRIPTION- MILLER, NATURE, (1992), vol. 357, pages 455 - 460-
DESCRIPTION- MILLINGTON-WARD ET AL., MOLECULAR THERAPY, (201104), vol. 19, no. 4, pages 642 - 649-
DESCRIPTION- MIRKIN ET AL., SMALL-
DESCRIPTION- MIRKIN, NANOMEDICINE, (2012), vol. 7, pages 635 - 638-
DESCRIPTION- MITANI; CASKEY, TIBTECH, (1993), vol. 11, pages 162 - 166-
DESCRIPTION- MOJICA ET AL., MOL. MICROBIOL., (1995), vol. 17, pages 85 - 93-
DESCRIPTION- MOJICA ET AL., MOL. MICROBIOL., (2000), vol. 36, pages 244 - 246-
DESCRIPTION- MOL. CELL. BIOL., (1988), vol. 8, no. 1, pages 466 - 472-
DESCRIPTION- MOLITORIS ET AL., J AM SOC NEPHROL, (2009), vol. 20, pages 1754 - 1764-
DESCRIPTION- MORRELL ET AL., "Crop genomics:advances and applications", NAT REV GENET., (20111229), vol. 13, no. 2, pages 85 - 96-
DESCRIPTION- MORRISSEY ET AL., NATURE BIOTECHNOLOGY, (200508), vol. 23, no. 8-
DESCRIPTION- MUKHE JEA ET AL., ANTIOXIDANTS & REDOX SIGNALING, (2010), vol. 13, no. 5-
DESCRIPTION- MUZYCZKA, J. CLIN. INVEST, (1994), vol. 94, page 1351-
DESCRIPTION- NABEL; FELGNER, TIBTECH, (1993), vol. 11, pages 211 - 217-
DESCRIPTION- NAKAGAWA ET AL., NAT. BIOTECHNOL., (2008), vol. 26, pages 101 - 106-
DESCRIPTION- NAKATA ET AL., J. BACTERIOL., (1989), vol. 171, pages 3553 - 3556-
DESCRIPTION- NISHIKOMORI ET AL., BLOOD, (2004), vol. 103, pages 4565 - 4572-
DESCRIPTION- NOGUCHI ET AL., CELL, (1993), vol. 73, pages 147 - 157-
DESCRIPTION- NOVOBRANTSEVA, MOLECULAR THERAPY-NUCLEIC ACIDS, (2012), vol. 1, page E4-
DESCRIPTION- OAKES; LIEBERMAN, CLIN ORTHOP RELAT RES., (200010), pages S101 - 12-
DESCRIPTION- OKITA ET AL., NATURE, (2007), vol. 448, pages 260 - 262-
DESCRIPTION- PA CARR; GM CHURCH, NATURE BIOTECHNOLOGY, (2009), vol. 27, no. 12, pages 1151 - 62-
DESCRIPTION- PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277-
DESCRIPTION- PROC. NATL. ACAD. SCI. USA., (1981), vol. 78, no. 3, pages 1527 - 31-
DESCRIPTION- QI ET AL., GENE THERAPY, (2013), pages 1 - 9-
DESCRIPTION- QUEEN; BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748-
DESCRIPTION- QU, X., BIOMACROMOLECULES, (2006), vol. 7, no. 12, pages 3452 - 9-
DESCRIPTION- RAN ET AL., CELL, (20130912), vol. 154, no. 6, pages 1380 - 9-
DESCRIPTION- RAN, FA.; HSU, PD.; LIN, CY.; GOOTENBERG, JS.; KONERMANN, S.; TREVINO, AE.; SCOTT, DA.; INOUE, A.; MATOBA, S.; ZHANG, Y., "Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity", CELL, (20130828), pages 0092 - 8674-
DESCRIPTION- REICH ET AL., MOL. VISION., (2003), vol. 9, pages 210 - 216-
DESCRIPTION- REMY ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 647 - 654-
DESCRIPTION- ROELVINKI ET AL., MOLECULAR THERAPY, (201209), vol. 20, no. 9, pages 1737 - 1749-
DESCRIPTION- ROSIN ET AL., MOLECULAR THERAPY, (201112), vol. 19, no. 12, pages 1286 - 2200-
DESCRIPTION- ROZEMA ET AL., PNAS, (20070807), vol. 104, no. 32-
DESCRIPTION- SALT; PLONTKE, DRUG DISCOVERY TODAY, (2005), vol. 10, pages 1299 - 1306-
DESCRIPTION- SAMULSKI ET AL., J. VIROL., (1989), vol. 63, pages 03822 - 3828-
DESCRIPTION- SAPRANAUSAKS ET AL., NUCLEIC ACIDS RESCH, (2011), vol. 39, page 9275-
DESCRIPTION- SAPRANAUSKAS ET AL., NUCLEIC ACIS RESEARCH, (2011), vol. 39, page 9275-
DESCRIPTION- SATO ET AL., NATURE BIOTECHNOLOGY, (200804), vol. 26, no. 4, pages 431 - 442-
DESCRIPTION- SCHIFFELERS ET AL., NUCLEIC ACIDS RESEARCH, (2004), vol. 32, no. 19-
DESCRIPTION- SCHROEDER, A.; LEVINS, C.; CORTEZ, C.; LANGER, R.; ANDERSON, D., "Lipid-based nanotherapeutics for siRNA delivery", JOURNAL OF INTERNAL MEDICINE, (2010), vol. 267, pages 9 - 21-
DESCRIPTION- SCHULTZ ET AL., GENE, (1987), vol. 54, pages 113 - 123-
DESCRIPTION- SCHWANK ET AL., CELL STEM CELL, (20131205), vol. 13, pages 653 - 658-
DESCRIPTION- SCHWANK ET AL., CELL STEM CELL, (2013), vol. 13, pages 653 - 58-
DESCRIPTION- SCIENCE, (2007), vol. 318, no. 5858, pages 1917 - 1920-
DESCRIPTION- SEED, NATURE, (1987), vol. 329, page 840-
DESCRIPTION- SEMPLE ET AL., NATURE NIOTECHNOLOGY, (201002), vol. 28, no. 2, pages 172 - 177-
DESCRIPTION- SHALEM, 0.; SANJANA, NE.; HARTENIAN, E.; SHI, X.; SCOTT, DA.; MIKKELSON, T.; HECKL, D.; EBERT, BL.; ROOT, DE; DOENCH, JG., "Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells", SCIENCE-
DESCRIPTION- SHEN ET AL., FEBS LET., (2003), vol. 539, pages 111 - 114-
DESCRIPTION- SHIMIZU ET AL., J AM SOC NEPHROL, (2010), vol. 21, pages 622 - 633-
DESCRIPTION- SIEW, A. ET AL., MOL PHARM, (2012), vol. 9, no. 1, pages 14 - 28-
DESCRIPTION- SIMEONI ET AL., NAR, (2003), vol. 31, no. 11, pages 2717 - 2724-
DESCRIPTION- SIMON RJ ET AL., PNAS, (1992), vol. 89, no. 20, pages 9367 - 9371-
DESCRIPTION- SMITH ET AL., MOL. CELL. BIOL., (1983), vol. 3, pages 2156 - 2165-
DESCRIPTION- SMITH; JOHNSON, GENE, (1988), vol. 67, pages 31 - 40-
DESCRIPTION- SOMASUNTHARAM ET AL., BIOMATERIALS, (2013), vol. 34, page 7790-
DESCRIPTION- SOMMNERFELT ET AL., VIROL., (1990), vol. 176, pages 58 - 59-
DESCRIPTION- SORENSEN ET AL., J. MOL. BIOL., (2003), vol. 327, pages 761 - 766-
DESCRIPTION- SOUDAIS ET AL., BLOOD, (2000), vol. 95, pages 3071 - 3077-
DESCRIPTION- SPUCH; NAVARRO, JOURNAL OF DRUG DELIVERY, (2011), vol. 2011, no. 12-
DESCRIPTION- SPUCH; NAVARRO, JOURNAL OF DRUG DELIVERY, (2011), vol. 2011, page 12-
DESCRIPTION- SPUCH; NAVARRO, JOURNAL OF DRUG DELIVERY, vol. 2011, page 12-
DESCRIPTION- STEPHAN ET AL., N. ENGL. J. MED., (1996), vol. 335, pages 1563 - 1567-
DESCRIPTION- STILES ET AL., EXPERIMENTAL NEUROLOGY, (2012), vol. 233, pages 463 - 471-
DESCRIPTION- STUDIER ET AL., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185, pages 60 - 89-
DESCRIPTION- TABERNERO ET AL., CANCER DISCOVERY, (201304), vol. 3, no. 4, pages 363 - 470-
DESCRIPTION- TAKAHASHI ET AL., CELL, (2007), vol. 131, no. 5, pages 861 - 872-
DESCRIPTION- TAKAHASHI; YAMANAKA, CELL, (2006), vol. 126, pages 663 - 76-
DESCRIPTION- TAYLOR ET AL., BLOOD, (1996), vol. 87, pages 3103 - 3107-
DESCRIPTION- THOMPSON, D.B. ET AL., CHEMISTRY & BIOLOGY, (2012), vol. 19, no. 7, pages 831 - 843-
DESCRIPTION- THOMPSON ET AL., METHODS IN ENZYMOLOGY, (2012), vol. 503, pages 293 - 319-
DESCRIPTION- THOMPSON ET AL., NUCLEIC ACID THERAPEUTICS, (2012), vol. 22, no. 4-
DESCRIPTION- TIBTECH, (1993), vol. 11, pages 167 - 175-
DESCRIPTION- TOLENTINO ET AL., RETINA, vol. 24, no. 4, page 660-
DESCRIPTION- TRATSCHIN ET AL., MOL. CELL. BIOL., (1984), vol. 4, pages 2072 - 2081-
DESCRIPTION- TRATSCHIN ET AL., MOL. CELL. BIOL., (1985), vol. 5, pages 3251 - 3260-
DESCRIPTION- TRAVASSOS DA ROSA ET AL., AM. J. TROPICAL MED. & HYGIENE, (1984), vol. 33, pages 999 - 1006-
DESCRIPTION- TSAI ET AL., BLOOD, (2002), vol. 100, pages 72 - 79-
DESCRIPTION- UCHEGBU, I.F. ET AL., INT J PHARM, (2001), vol. 224, pages 185 - 199-
DESCRIPTION- UCHEGBU, I.F., EXPERT OPIN DRUG DELIV, (2006), vol. 3, no. 5, pages 629 - 40-
DESCRIPTION- UCHEGBU; SIEW, J PHARM SCI., (2013), vol. 102, no. 2, pages 305 - 10-
DESCRIPTION- UNO ET AL., HUMAN GENE THERAPY, (201106), vol. 22, pages 711 - 719-
DESCRIPTION- VAN BRUNT, BIOTECHNOLOGY, (1988), vol. 6, no. 10, pages 1149 - 1154-
DESCRIPTION- VIGNE, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, (1995), vol. 8, pages 35 - 36-
DESCRIPTION- WADA ET AL., PROC. NATL. ACAD. SCI. USA, (2001), vol. 98, pages 8697 - 8702-
DESCRIPTION- WAHLGREN ET AL., NUCLEIC ACIDS RESEARCH, (2012), vol. 40, no. 17, page E130-
DESCRIPTION- WARING ET AL., ARCH. NEUROL., (2008), vol. 65, pages 329 - 334-
DESCRIPTION- WEINTRAUB, NATURE, (2013), vol. 495, pages S14 - S16-
DESCRIPTION- WEST ET AL., VIROLOGY, (1987), vol. 160, pages 38 - 47-
DESCRIPTION- WHITEHEAD ET AL., ACS NANO, (20120828), vol. 6, no. 8, pages 6922 - 9-
DESCRIPTION- WILSON ET AL., J. VIROL., (1989), vol. 63, pages 2374 - 2378-
DESCRIPTION- WINOTO; BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733-
DESCRIPTION- WOODDELL ET AL., MOLECULAR THERAPY, (201305), vol. 21, no. 5, pages 973 - 985-
DESCRIPTION- WU, CELL STEM CELL, (2013), vol. 13, pages 659 - 62-
DESCRIPTION- XIA ET AL., NAT. BIOTECH., (2002), vol. 20, pages 1006 - 1010-
DESCRIPTION- XIA ET AL., NATURE MEDICINE, (200408), vol. 10, no. 8-
DESCRIPTION- XU ET AL., SCIENCE, (20111118), vol. 334, no. 6058, pages 993 - 996-
DESCRIPTION- YATES ET AL., BLOOD, (2002), vol. 100, pages 3942 - 3949-
DESCRIPTION- YOUNG ET AL., NANO LETT., (2012), vol. 12, pages 3867 - 71-
DESCRIPTION- YUAN ET AL., AM J PHYSIOL RENAL PHYSIOL, (2008), vol. 295, pages F605 - F617-
DESCRIPTION- YU ET AL., CELL, (20120831), vol. 150, pages 895 - 908-
DESCRIPTION- YU ET AL., GENE THERAPY, (1994), vol. 1, pages 13 - 26-
DESCRIPTION- ZAEHRES; SCHOLER, CELL, (2007), vol. 131, no. 5, pages 834 - 835-
DESCRIPTION- ZAMORA ET AL., AM J RESPIR CRIT CARE MED, (2011), vol. 183, pages 531 - 538-
DESCRIPTION- ZHANG ET AL., ACS NANO., (2011), vol. 5, pages 6962 - 6970-
DESCRIPTION- ZHANG ET AL., ADV MATER., (20130906), vol. 25, no. 33, pages 4641 - 5-
DESCRIPTION- ZHANG ET AL., J. AM. CHEM. SOC., (2012), vol. 134, pages 16488 - 1691-
DESCRIPTION- ZHANG ET AL., MOL THER., (200301), vol. 7, no. 1, pages 11 - 8-
DESCRIPTION- ZHENG ET AL., PNAS, (20120724), vol. 109, no. 30, pages 11975 - 11980-
DESCRIPTION- ZHENG ET AL., PROC. NATL. ACAD. SCI. USA., (2012), vol. 109, pages 11975 - 80-
DESCRIPTION- ZIMMERMAN ET AL., NATURE LETTERS, (20060504), vol. 441-
DESCRIPTION- ZOU ET AL., HUMAN GENE THERAPY, (201104), vol. 22, pages 465 - 475-
DESCRIPTION- ZUKER; STIEGLER, NUCLEIC ACIDS RES., (1981), vol. 9, pages 133 - 148-
DESCRIPTION- CHO, S.; GOLDBERG, M.; SON, S.; XU, Q.; YANG, F.; MEI, Y.; BOGATYREV, S.; LANGER, R.; ANDERSON, D., "Lipid-like nanoparticles for small interfering RNA delivery to endothelial cells", ADVANCED FUNCTIONAL MATERIALS, (2010), vol. 19, doi:doi:10.1002/adfm.200900519, pages 3112 - 3118, XP001548633
DESCRIPTION- WANG H.; YANG H.; SHIVALILA CS.; DAWLATY MM.; CHENG AW.; ZHANG F.; JAENISCH R., "Y One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering.", CELL, (20130509), vol. 153, no. 4, doi:doi:10.1016/j.cell.2013.04.025, pages 910 - 8, XP028538358
DESCRIPTION- NISHIMASU, H.; RAN, FA.; HSU, PD.; KONERMANN, S.; SHEHATA, SI.; DOHMAE, N.; ISHITANI, R.; ZHANG, F.; NUREKI, O, "Crystal structure of cas9 in complex with guide RNA and target DNA", CELL, (20140227), vol. 156, no. 5, doi:doi:10.1016/j.cell.2014.02.001, pages 935 - 49, XP028667665
DESCRIPTION- HSU ET AL., "Development and Applications of CRISPR-Cas9 for Genome Engineering", CELL, (20140605), vol. 157, doi:doi:10.1016/j.cell.2014.05.010, pages 1262 - 1278, XP055529223
DESCRIPTION- KARGINOV; HANNON, "The CRISPR system: small RNA-guided defence in bacteria and archaea", MOLE CELL, (20100115), vol. 37, no. 1, doi:doi:10.1016/j.molcel.2009.12.033, page 7, XP055016972
DESCRIPTION- OMAR AKIL; REBECCA P. SEAL; KEVIN BURKE; CHUANSONG WANG; AURASH ALEMI; MATTHEW DURING; ROBERT H. EDWARDS; LAWRENCE R, "Lustig. Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy", NEURON, (2012), vol. 75, no. 2, doi:doi:10.1016/j.neuron.2012.05.019, XP028932447
DESCRIPTION- TAYLOR W.R., "The classification of amino acid conservation", J. THEOR. BIOL., (1986), vol. 119, doi:doi:10.1016/S0022-5193(86)80075-3, pages 205 - 218, XP055050432
DESCRIPTION- SU X; FRICKE J; KAVANAGH DG; IRVINE DJ, "In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles", MOL PHARM., (20110401), vol. 8, no. 3, doi:doi:10.1021/mp100390w, pages 774 - 87, XP055127583
DESCRIPTION- XIA CF; BOADO RJ; PARDRIDGE WM, "Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology", MOL PHARM., (200905), vol. 6, no. 3, doi:doi:10.1021/mp800194y, pages 747 - 51, XP055088899
DESCRIPTION- EL-ANDALOUSSI S ET AL., "Exosome-mediated delivery of siRNA in vitro and in vivo", NAT PROTOC., (20121115), vol. 7, no. 12, doi:doi:10.1038/nprot.2012.131, pages 2112 - 26, XP055129954
DESCRIPTION- RAN, FA.; HSU, PD.; WRIGHT, J.; AGARWALA, V.; SCOTT, DA.; ZHANG, F., "Genome engineering using the CRISPR-Cas9 system", NATURE PROTOCOLS, (201311), vol. 8, no. 11, doi:doi:10.1038/nprot.2013.143, pages 2281 - 308, XP009174668
DESCRIPTION- NAKAMURA, Y. ET AL., "Codon usage tabulated from the international DNA sequence databases: status for the year 2000", NUCL. ACIDS RES., (2000), vol. 28, doi:doi:10.1093/nar/28.1.292, page 292, XP002941557
DESCRIPTION- CONG, L.; RAN, F.A.; COX, D.; LIN, S.; BARRETTO, R.; HABIB, N.; HSU, P.D.; WU, X.; JIANG, W.; MARRAFFINI, L.A., "Multiplex genome engineering using CRISPR/Cas systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:doi:10.1126/science.1231143, pages 819 - 23, XP055400719
INTERNATIONAL-SEARCH-REPORT- WANG HAOYI ET AL, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", CELL, CELL PRESS, US, (20130502), vol. 153, no. 4, doi:10.1016/J.CELL.2013.04.025, ISSN 0092-8674, pages 910 - 918, XP028538358 [Y] 1-37 * figure 4 *
INTERNATIONAL-SEARCH-REPORT- LUKE A. GILBERT ET AL, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", CELL, (20130701), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843 [YP] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- HSU PATRICK D ET AL, "Development and Applications of CRISPR-Cas9 for Genome Engineering", CELL, (20140605), vol. 157, no. 6, doi:10.1016/J.CELL.2014.05.010, ISSN 0092-8674, pages 1262 - 1278, XP028849523 [XP] 1-38 * the whole document *
INTERNATIONAL-SEARCH-REPORT- GAJ THOMAS ET AL, "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, (20130509), vol. 31, no. 7, doi:10.1016/J.TIBTECH.2013.04.004, ISSN 0167-7799, pages 397 - 405, XP028571313 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- ELLIS B L ET AL, "Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs", GENE THERAPY, (201301), vol. 20, no. 1, pages 35 - 42, XP002730955 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- ASURI PRASHANTH ET AL, "Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.", MOLECULAR THERAPY:THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, (201202), vol. 20, no. 2, pages 329 - 338, XP002730957 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- LOMBARDO ANGELO ET AL, "Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20071101), vol. 25, no. 11, doi:10.1038/NBT1353, ISSN 1087-0156, pages 1298 - 1306, XP002465562 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- RICHARD GABRIEL ET AL, "An unbiased genome-wide analysis of zinc-finger nuclease specificity", NATURE BIOTECHNOLOGY, (20110807), vol. 29, no. 9, doi:10.1038/nbt.1948, ISSN 1087-0156, pages 816 - 823, XP055073828 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- G. GASIUNAS ET AL, "PNAS Plus: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 [A] 1-38 * page e2584, column 2, paragraph l; figures 2,5 *
INTERNATIONAL-SEARCH-REPORT- HÄNDEL EVA-MARIA ET AL, "Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.", HUMAN GENE THERAPY, (201203), vol. 23, no. 3, ISSN 1557-7422, pages 321 - 329, XP002730956 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055102030 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 1 - 25, XP002730884 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- P. MALI ET AL, "RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055111247 [Y] 1-37 * the whole document *
INTERNATIONAL-SEARCH-REPORT- SHALEM OPHIR ET AL, "Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells", SCIENCE, (201401), vol. 343, no. 6166, ISSN 0036-8075, pages 84 - 87, XP002723432 [IP] 1-38 * the whole document *
OPPOSITION- anonymous, "CRISPR Reagent Information", Genome Engineering, (20130121), URL: www.genome-engineering.org, XP055379723-
OPPOSITION- CRISPR-associated protein Cas9/Csn1 [Staphylococcus aureus subsp. aureus], Protein, (20130103), Database accession no. CCK74173.1, URL: ncbi, XP055337941-
OPPOSITION- SOFRONIEW et al., "Astrocytes: biology and pathology", Acta Neuropathol, (20091210), vol. 119, no. 1, pages 7 - 35, XP019780694-
OPPOSITION- Staphylococcus aureus subsp. aureus ORFX gene and pseudo SCCmec-SCC-SCCCRISPR element, strain M06/0171, Nucleotide, (20130103), Database accession no. HE980450.1, URL: ncbi, XP055338801-
OPPOSITION- WU et al., "Adeno-associated virus serotypes: vector toolkit for human gene therapy", Molecular Therapy, (20060901), vol. 14, no. 3, pages 316 - 327, XP002596754-
OPPOSITION- SKOFF et al., "Postmitotic oligodendrocytes generated during postnatal cerebral development are derived from proliferation of immature oligodendrocytes", Glia, (19940900), vol. 12, no. 1, pages 12 - 23, XP055699103
OPPOSITION- QI et al., "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", Cell, (20130201), vol. 152, pages 1173 - 1183, XP055068548
OPPOSITION- WANG et al., "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", Cell, (20130509), vol. 153, no. 4, pages 910 - 918, XP028538358
OPPOSITION- GILBERT et al., "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", Cell, (20130711), vol. 154, no. 2, pages 442 - 451, XP055115843
OPPOSITION- FURNESS et al., "Intrinsic primary afferent neurons and nerve circuits within the intestine", Progress in Neurobiology, (20040000), vol. 72, no. 2, pages 143 - 164, XP001193829
OPPOSITION- YAMASHITA et al., "Retroviral infection of non-dividing cells: Old and new perspectives", Virology, (20060105), vol. 344, no. 1, pages 88 - 93, XP005207408
OPPOSITION- CHARPENTIER et al., "Biotechnology: Rewriting a genome", Nature, (20130306), vol. 495, no. 7439, pages 50 - 51, XP055338357
OPPOSITION- HORVATH et al., "RNA-guided genome editing à la carte", Cell Research, (20130312), vol. 23, pages 733 - 734, XP055184973
OPPOSITION- CARROLL D., "A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120901), vol. 20, no. 9, pages 1658 - 1660, XP055106489
OPPOSITION- OUSTEROUT et al., "Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients", Molecular Therapy, (20130604), vol. 21, no. 9, pages 1718 - 1726, XP055184655
OPPOSITION- HWANG et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (20130129), vol. 31, no. 3, pages 227 - 229, XP055086625
OPPOSITION- MALI et al., "Cas9 as a versatile tool for engineering biology", Nature Methods, (20130927), vol. 10, no. 10, pages 957 - 963, XP002718606
OPPOSITION- JOUNG et al., "TALENs: a widely applicable technology for targeted genome editing", Nature Reviews Molecular Cell Biology, (20121121), vol. 14, no. 1, pages 49 - 55, XP055282847
OPPOSITION- MITROPHANOUS et al., "Stable gene transfer to the nervous system using a non-primate lentiviral vector", Gene Therapy, (19990000), vol. 6, no. 11, pages 1808 - 1818, XP000914884
OPPOSITION- GARRIGA-CANUT et al., "Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice", PNAS, (20121010), vol. 109, no. 45, pages E3136 - E3145, XP055161220
OPPOSITION- KOTIN, "Large-scale recombinant adeno-associated virus production", Human Molecular Genetics, (20110415), vol. 20, no. R1, pages R2 - R6, XP055016870
OPPOSITION- CHAN et al., "Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice", Nucleic Acids Research, (20110801), vol. 39, no. 14, pages 5955 - 5966, XP055699090
OPPOSITION- CERMAK et al., Nucleic Acids Research, (20110701), vol. 39, no. 12, pages 1 - 11, XP002659530
OPPOSITION- KIM et al., "Precision genome engineering with programmable DNA-nicking enzymes", Genome Research, (20120420), vol. 22, no. 7, pages 1327 - 1333, XP055106309
OPPOSITION- MCFARLAND et al., "Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system", J Neurochem, (20090500), vol. 109, no. 3, pages 838 - 845, XP055699094
OPPOSITION- BROUNS S. J. J., "A Swiss Army Knife of Immunity", Science, (20120000), vol. 337, no. 6096, pages 808 - 809, XP055113718
OPPOSITION- CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130103), vol. 339, no. 6, pages 819 - 823, XP055102030
OPPOSITION- PODSAKOFF et al., "Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors", J Virol, (19940900), vol. 68, no. 9, pages 5656 - 5666, XP055699091
OPPOSITION- RAMALINGAM et al., "A CRISPR way to engineer the human genome", Genome Biology, (20130000), vol. 14, no. 2, pages 1 - 4, XP055323697
OPPOSITION- KAUFMAN R. J., Molecular Biotechnology, (20000101), vol. 16, pages 151 - 160, XP001052951
OPPOSITION- HU et al., "Comparison of Various Nuclear Localization Signal-Fused Cas9 Proteins and Cas9 mRNA for Genome Editing in Zebrafish", G3, (20180301), vol. 8, pages 823 - 831, XP055513510
OPPOSITION- CHYLINSKI et al., "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA Biology, (20130501), vol. 10, no. 5, pages 726 - 737, XP055116068
OPPOSITION- YAN et al., "The CRISP-Cas9 system: A powerful tool for Genome Engineering and regulation", Adv Genet Eng, (20130000), vol. 2, no. 3, page 1000e103, XP055699093

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents