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High-Stability T-Cell Receptor And Preparation Method And Application Thereof - EP3015477

The patent EP3015477 was granted to Guangdong Xiangxue Life Sciences on Aug 18, 2021. The application was originally filed on Jun 25, 2014 under application number EP14817065A. The patent is currently recorded with a legal status of "Revoked".

EP3015477

GUANGDONG XIANGXUE LIFE SCIENCES
Application Number
EP14817065A
Filing Date
Jun 25, 2014
Status
Revoked
Mar 14, 2025
Grant Date
Aug 18, 2021
External Links
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MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBBMay 18, 2022-ADMISSIBLE

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS6080840
DESCRIPTIONWO2012013913
INTERNATIONAL-SEARCH-REPORTCN102574906
INTERNATIONAL-SEARCH-REPORTCN103097407
OPPOSITIONWO2005116075
OPPOSITIONWO2007106894
OPPOSITIONWO2011001152
OPPOSITIONWO2012013913
OPPOSITIONWO2013004186
SEARCHWO2005116075
SEARCHWO2007106894
SEARCHWO2011001152
SEARCHWO2012013913
SEARCHWO2013041865

Non-Patent Literature (NPL) Citations (13) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- V Beta ET AL, "Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain V[alpha]V[beta] fragments - Supplementary Figure 1", (20081029), URL: https://ars.els-cdn.com/content/image/1-s2.0-S0161589008006652-mmc1.pdf, (20180511), XP055474234-
EXAMINATION- Marie-Paule Lefranc ET AL, "IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY., US, (20030101), vol. 27, no. 1, doi:10.1016/S0145-305X(02)00039-3, ISSN 0145-305X, pages 55 - 77, XP055585227
OPPOSITION- ROBBINS PAUL F, ET AL, "Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions", The Journal of Immunology, Williams & Wilkins Co., US, US , (20080501), vol. 180, no. 9, ISSN 0022-1767, pages 6116 - 6131, XP002571412-
OPPOSITION- KYTE et al., "A simple method for displaying the hydropathic character of a protein", Journal of Molecular Biology, (19820000), vol. 157, no. 1, doi:10.1016/0022-2836(82)90515-0, pages 105 - 132, XP024014365
OPPOSITION- Richman, S.A. ; Aggen, D.H. ; Dossett, M.L. ; Donermeyer, D.L. ; Allen, P.M. ; Greenberg, P.D. ; Kranz, D.M., "Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain V@aV@b fragments", MOLECULAR IMMUNOLOGY, PERGAMON, GB, GB , (20090201), vol. 46, no. 5, doi:10.1016/j.molimm.2008.09.021, ISSN 0161-5890, pages 902 - 916, XP025912818
OPPOSITION- LEFRANC, MP et al., "IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains", Developmental & Comparative Immunology, (20030000), vol. 27, no. 1, doi:10.1016/S0145-305X(02)00039-3, pages 55 - 77, XP055585227
OPPOSITION- Kjer-Nielsen Lars, Clements Craig S., Purcell Anthony W., Brooks Andrew G., Whisstock James C., Burrows Scott R., Mccluskey James, Rossjohn Jamie, "A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity", Immunity, Cell Press, AMSTERDAM, NL, AMSTERDAM, NL , (20030101), vol. 18, no. 1, doi:10.1016/S1074-7613(02)00513-7, ISSN 1074-7613, pages 53 - 64, XP055925660
OPPOSITION- Yang Xinbo, Chen Guobing, Weng Nan-Ping, Mariuzza Roy A., "Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20171101), vol. 292, no. 45, doi:10.1074/jbc.M117.810382, ISSN 0021-9258, pages 18618 - 18627, XP055925661
OPPOSITION- D. H. Aggen, A. S. Chervin, F. K. Insaidoo, K. H. Piepenbrink, B. M. Baker, D. M. Kranz, "Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors", Protein Engineering Design and Selection, IRL Press, (20110401), vol. 24, no. 4, doi:10.1093/protein/gzq113, ISSN 17410126, pages 361 - 372, XP055190772
OPPOSITION- Marie-Paule Lefranc, "Immunoglobulin and T Cell Receptor Genes: IMGT® and the Birth and Rise of Immunoinformatics", Frontiers in Immunology, (20140101), vol. 5, doi:10.3389/fimmu.2014.00022, XP055324810
SEARCH- RICHMAN S A ET AL, "Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 46, no. 5, doi:10.1016/J.MOLIMM.2008.09.021, ISSN 0161-5890, (20090201), pages 902 - 916, (20081029), XP025912818 [X] 1-5,8-10,15-24,27 * page 906, column 1, paragraph l * * page 907, column 1, paragraph 1 * * figures 5,6A * * page 912, paragraph 4.1 * * page 913, paragraph 4.2 *
SEARCH- BOULTER JONATHAN M ET AL, "Stable, soluble T-cell receptor molecules for crystallization and therapeutics", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, (20030901), vol. 16, no. 9, doi:10.1093/PROTEIN/GZG087, ISSN 0269-2139, pages 707 - 711, XP002275339 [A] 1-28 * the whole document *
SEARCH- MARIE-PAULE LEFRANC, "Immunoglobulin and T Cell Receptor Genes: IMGT and the Birth and Rise of Immunoinformatics", FRONTIERS IN IMMUNOLOGY, (20140101), vol. 5, doi:10.3389/fimmu.2014.00022, XP055324810 [PA] 1-28 * the whole document *

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