| EXAMINATION | - Rodrigo José Alencar De Castro ET AL, "Pain Management in Burn Patients", Revista Brasileira de Anestesiologia, (201301), pages 149 - 153, URL: https://ac.els-cdn.com/S0104001413000298/1-s2.0-S0104001413000298-main.pdf?_tid=7bcf18f1-d741-4c69-a9a8-1c817a20d19d&acdnat=1538999444_18705e5d70593ef81b4de0bb1f1df86f, (20181008), XP055513291 | - |
| INTERNATIONAL-SEARCH-REPORT | - Mundipharma Pharmaceuticals Limited, "Targin 5/2.5mg, 10mg/5mg, 20mg/10mg and 40/20mg prolonged release tablets", (20130607), Internet, URL: http://www.medicines.ie/printfriendlydocument.aspx?documentid=14383&companyid=103, (20140820), XP002728808 [Y] 1-25 * Patients with impaired hepatic function; Patients with impaired renal function; page 3 * * Patients with impaired hepatic function; Patients with impaired renal function; page 11 - page 12 * * page 13 * | - |
| INTERNATIONAL-SEARCH-REPORT | - MEISSNER W ET AL, "A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation", EUROPEAN JOURNAL OF PAIN, SAUNDERS, LONDON, GB, vol. 13, no. 1, doi:10.1016/J.EJPAIN.2008.06.012, ISSN 1090-3801, (200901), pages 56 - 64, (20080831), XP025865529 [X] 1-9,11,14-18,20,21,25 * abstract * * page 56, column 1, paragraph 1 - column 2, paragraph 1 * * page 57, column 1, paragraph 2 * * table 2 * * figures 4-5 * [Y] 1-25 | |
| INTERNATIONAL-SEARCH-REPORT | - HOLZER ET AL, "Opioid receptors in the gastrointestinal tract", REGULATORY PEPTIDES, ELSEVIER SCIENCE BV, NL, vol. 155, no. 1-3, doi:10.1016/J.REGPEP.2009.03.012, ISSN 0167-0115, (20090605), pages 11 - 17, (20090402), XP026158567 [Y] 1-25 * abstract * * page 12, column 1, paragraph 3 * * page 13, column 1, paragraphs 2-4 * * page 14, column 1 * * figure 2 * | |
| INTERNATIONAL-SEARCH-REPORT | - KAASA T ET AL, "New therapeutic principles for adverse effects on upper and lower gastrointestinal tract in patients treated with opioid analgesics", SCANDINAVIAN JOURNAL OF PAIN, ELSEVIER, AMSTERDAM, NL, vol. 1, doi:10.1016/S1877-8860(09)70004-7, ISSN 1877-8860, (200905), pages S12 - S17, (20090501), XP026668925 [Y] 1-25 * abstract * * page S12, column 1, paragraph 1 * * page S13, column 1, paragraph 2 * * page S14, column 2, paragraph 4 * * page S15, column 1, paragraph 3 * * page S16, column 1, paragraph 2 * * tables 1, 2, 4 * | |
| INTERNATIONAL-SEARCH-REPORT | - NIEUWENHUIJS V B ET AL, "The role of interdigestive small bowel motility in the regulation of gut microflora, bacterial overgrowth, and bacterial translocation in rats", ANNALS OF SURGERY, J.B. LIPPINCOTT COMPANY, PHILADELPHIA, US, (199808), vol. 228, no. 2, ISSN 0003-4932, pages 188 - 193, XP009162973 [YD] 1-25 * abstract * * page 188, column 1, paragraph 1 - column 2, paragraph 1 * * page 190, column 2, paragraphs 1-2 * * table 3 * | |
| INTERNATIONAL-SEARCH-REPORT | - KUUSNIEMI K. ET AL, "Prolonged-Release Oxycodone/Naloxone in Postoperative Pain Management: From a Randomized Clinical Trial to Usual Clinical Practice", JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, (20121001), vol. 40, no. 5, doi:10.1177/030006051204000516, ISSN 0300-0605, pages 1775 - 1793, XP055134196 [X] 1-6,11,14-23,25 * abstract * * page 1776, column 1, paragraph 1 * * page 1779, column 1, paragraph 2 * * figures 2-3 * * tables 2-6 * [Y] 1-25 | |
| INTERNATIONAL-SEARCH-REPORT | - SIMPSON K ET AL, "Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain.", CURRENT MEDICAL RESEARCH AND OPINION DEC 2008, (200812), vol. 24, no. 12, ISSN 1473-4877, pages 3503 - 3512, XP009179717 [X] 1-9,11,14-18,20,21,25 * abstract * * page 3504, column 1, paragraph 1 - column 2, paragraph 1 * * page 3505, column 1, paragraph 2 * * table 3 * * figure 3 * [Y] 1-25 | |
| INTERNATIONAL-SEARCH-REPORT | - MENG JINGJING ET AL, "Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner", PLOS ONE, (20130118), vol. 8, no. 1, doi:10.1371/journal.pone.0054040, page e54040, XP055133905 [YD] 1-25 * abstract * * figure 8 * * page 4, column 2, paragraph 5 - page 8, column 1, paragraph 1 * * page 9, column 1, paragraph 2 * * figures 1A, 1B, 8 * | |
| INTERNATIONAL-SEARCH-REPORT | - HERMANNS K ET AL, "Prolonged-release oxycodone/naloxone in the treatment of neuropathic pain results from a large observational study", EXPERT OPINION ON PHARMACOTHERAPY 2012 INFORMA HEALTHCARE GBR, (201202), vol. 13, no. 3, ISSN 1465-6566, pages 299 - 311, XP009179722 [X] 1-9,11,14-19,25 * abstract * * page 299, column 2, paragraph 2 - page 300, column 1, paragraph 1 * * page 300, column 1, paragraph 2 - column 2, paragraph 1 * * page 301, column 1, paragraph 5 * * page 303, column 1, paragraph 2 - column 2, paragraph 2 * * table 1 * * figures 2-4 * [Y] 1-25 | |
| INTERNATIONAL-SEARCH-REPORT | - JAN BURES ET AL, "Small intestinal bacterial overgrowth syndrome", WORLD JOURNAL OF GASTROENTEROLOGY, (20100628), vol. 16, no. 24, doi:10.3748/wjg.v16.i24.2978, ISSN 1007-9327, pages 2978 - 2990, XP055135799 [AD] 1-25 * abstract * * page 2979, column 1, paragraph 1 - page 2981, column 2, paragraph 6 * | |
| OPPOSITION | - Anonymous, "Colorectal Cancer in Europe: A Framework for Improving Outcomes for Patients", White Paper, EuropaColon, (20121001), pages 1 - 22, XP093010456 | - |
| OPPOSITION | - Anonymous, "Gebrauchsinformation: Information fur den Anwender Targin 5 mg/2,5 mg Retardtabletten", Targin® label, (20150101), pages 1 - 17, XP055463577 | - |
| OPPOSITION | - "Diabetes-Atlas: Im Osten leben mehr Diabetiker ", DER SPIEGEL, (20131113), URL: https://www.spiegel.de/gesundheit/diagnose/diabetes-atlas-im-osten-leben-mehr-diabetiker-a-933367.html, XP093009909 | - |
| OPPOSITION | - Flint James A., Yvonne T Van Duynhoven, Fredrick J Angulo, Stephanie M Delong, Peggy Braun, Martyn Kirk, Elaine Scallan, Margaret Fitzgerald, Goutam K Adak, Paul Sockett, Andrea Ellis, Gillian Hall, Neyla Gargouri, Henry Walke, Peter Braam, "Estimating the burden of acute gastroenteritis, foodborne disease, and pathogens commonly transmitted by food: an international review", Clinical Infectious Diseases, (20050101), vol. 41, no. 5, pages 698 - 704, XP093010586 | - |
| OPPOSITION | - "Introduction and Executive Summary", Pawankar Ruby, Canonica Giorgio Walter, Holgate Stephen T., Lockney Richard F., World Allergy Organization (WAO) - White Book on Allergy, (20110101), pages 11 - 15, ISBN 978-0-615-46182-3, XP093009914 | - |
| OPPOSITION | - Kolovou Genovefa D., Katherine K.Anagnostopoulou, Klelia D.Salpea, Dimitri P. Mikhailidis, "The Prevalence of Metabolic Syndrome in Various Populations", The American Journal of the Medical Sciences, (20070101), vol. 333, no. 6, pages 362 - 371, XP093010463 | - |
| OPPOSITION | - "OBESITY UPDATE ", (20120101), URL: https://www.oecd.org/health/49716427.pdf, XP093009921 | - |
| OPPOSITION | - "OXECTA™", HIGHLIGHTS OF PRESCRIBING INFORMATION, (20130601), pages 1 - 15, XP093010603 | - |
| OPPOSITION | - Sandzen Birger; Rosenmuller Mats; Haapamaki Markku M; Nilsson Erik; Stenlund Hans C; Oman Mikael, "First attack of acute pancreatitis in Sweden 1988 - 2003: incidence, aetiological classification, procedures and mortality - a register study", BMC GASTROENTEROLOGY, GB , (20090305), vol. 9, no. 1, ISSN 1471-230X, page 18, XP021048563 | - |
| OPPOSITION | - Schwabe U, Paffrath D., Arzneiverordnungsreport, (20130101), page 261, XP093009898 | - |
| OPPOSITION | - "Targin ", Australian Public Assessment Report for Oxycodone hydrochloride/Naloxone hydrochloride, (20100501), pages 1 - 96, XP093009883 | - |
| OPPOSITION | - Bernatsky S., Joseph L., Pineau C. A., Belisle P., Hudson M., Clarke A. E., "Scleroderma prevalence: Demographic variations in a population-based sample", Arthritis & Rheumatism, US , (20090315), vol. 61, no. 3, doi:10.1002/art.24339, ISSN 0004-3591, pages 400 - 404, XP093010472 | |
| OPPOSITION | - Elsabbagh Mayada, Divan Gauri, Koh Yun-Joo, Kim Young Shin, Kauchali Shuaib, Marcín Carlos, Montiel-Nava Cecilia, Patel Vikram, Paula Cristiane S., Wang Chongying, Yasamy Mohammad Taghi, Fombonne Eric, "Global Prevalence of Autism and Other Pervasive Developmental Disorders : Global epidemiology of autism", Autism Research, (20120601), vol. 5, no. 3, doi:10.1002/aur.239, ISSN 1939-3792, pages 160 - 179, XP093010512 | |
| OPPOSITION | - Lindkvist Björn, Benito De Valle Maria, Gullberg Bo, Björnsson Einar, "Incidence and prevalence of primary sclerosing cholangitis in a defined adult population in sweden", Hepatology, US , (20100801), vol. 52, no. 2, doi:10.1002/hep.23678, ISSN 0270-9139, pages 571 - 577, XP093010487 | |
| OPPOSITION | - Runkel Norbert S. F., Moody Frank G., Smith Gregory S., Rodriguez Liliana F., Chen Ying, Larocco Mark T., Miller Thomas A., "Alterations in rat intestinal transit by morphine promote bacterial translocation", DIGESTIVE DISEASES AND SCIENCES, US , (19930801), vol. 38, no. 8, doi:10.1007/BF01308616, ISSN 0163-2116, pages 1530 - 1536, XP093010599 | |
| OPPOSITION | - Stefan Mueller-Lissner, "Fixed combination of oxycodone with naloxone: a new way to prevent and treat opioid-induced constipation", ADVANCES IN THERAPY, US , (20100901), vol. 27, no. 9, doi:10.1007/s12325-010-0057-y, ISSN 0741-238X, pages 581 - 590, XP055462846 | |
| OPPOSITION | - Mombaerts, P. ; Iacomini, J. ; Johnson, R.S. ; Herrup, K. ; Tonegawa, S. ; Papaioannou, V.E., "RAG-1-deficient mice have no mature B and T lymphocytes", Cell, Amsterdam NL , (19920306), vol. 68, no. 5, doi:10.1016/0092-8674(92)90030-G, ISSN 0092-8674, pages 869 - 877, XP024244600 | |
| OPPOSITION | - Bäckhed Fredrik, Fraser Claire m., Ringel Yehuda, Sanders Mary ellen, Sartor R. balfour, Sherman Philip m., Versalovic James, Young Vincent, Finlay B. brett, "Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications", Cell Host & Microbe, NL , (20121101), vol. 12, no. 5, doi:10.1016/j.chom.2012.10.012, ISSN 1931-3128, pages 611 - 622, XP093009888 | |
| OPPOSITION | - Meissner, W. ; Leyendecker, P. ; Mueller-Lissner, S. ; Nadstawek, J. ; Hopp, M. ; Ruckes, C. ; Wirz, S. ; Fleischer, W. ; Reimer, K., "A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation", EUROPEAN JOURNAL OF PAIN, GB , (20090101), vol. 13, no. 1, doi:10.1016/j.ejpain.2008.06.012, ISSN 1090-3801, pages 56 - 64, XP025865529 | |
| OPPOSITION | - Alamanos, Y. Voulgari, P.V. Drosos, A.A., "Incidence and Prevalence of Rheumatoid Arthritis, Based on the 1987 American College of Rheumatology Criteria: A Systematic Review", SEMINARS IN ARTHRITIS AND RHEUMATISM, AMSTERDAM, NL , (20061102), vol. 36, no. 3, doi:10.1016/j.semarthrit.2006.08.006, ISSN 0049-0172, pages 182 - 188, XP005843462 | |
| OPPOSITION | - Ordás Ingrid, Eckmann Lars, Talamini Mark, Baumgart Daniel C., Sandborn William J., "Ulcerative colitis", The Lancet, AMSTERDAM, NL , (20120101), vol. 380, no. 9853, doi:10.1016/S0140-6736(12)60150-0, ISSN 0140-6736, pages 1606 - 1619, XP093010482 | |
| OPPOSITION | - Matrana Marc R., David A. Margolin, "Epidemiology and Pathophysiology of Diverticular Disease", Clinics in Colon & Rectal Surgery, US , (20090101), vol. 22, doi:10.1055/s-0029-1236157, ISSN 1531-0043, pages 141 - 146, XP093010459 | |
| OPPOSITION | - Rothenbacher Dietrich, Michael Löw, Philip D. Hardt, Hans-Ulrich Klör, Hartwig Ziegler & Hermann Brenner, "Prevalence and determinants of exocrine pancreatic insufficiency among older adults: Results of a population-based study", Scandinavian Journal of Gastroenterology, (20050101), vol. 40, no. 6, doi:10.1080/00365520510023116, pages 697 - 704, XP093010467 | |
| OPPOSITION | - Nieuwenhuijs V B; Verheem A; van Duijvenbode-Beumer H; Visser M R; Verhoef J; Gooszen H G; Akkermans L M, "The role of interdigestive small bowel motility in the regulation of gut microflora, bacterial overgrowth, and bacterial translocation in rats.", ANNALS OF SURGERY, US , (19980801), vol. 228, no. 2, doi:10.1097/00000658-199808000-00007, ISSN 0003-4932, pages 188 - 193, XP009162973 | |
| OPPOSITION | - Husebye Einar, "Gastrointestinal motility disorders and bacterial overgrowth", JOURNAL OF INTERNAL MEDICINE, GB , (19950401), vol. 237, no. 4, doi:10.1111/j.1365-2796.1995.tb01196.x, ISSN 0954-6820, pages 419 - 427, XP093010601 | |
| OPPOSITION | - Prescott R J, Harris M, Banerjee S S, "Fungal infections of the small and large intestine", Journal of Clinical Pathology, GB , (19920901), vol. 45, no. 9, doi:10.1136/jcp.45.9.806, ISSN 0021-9746, pages 806 - 811, XP093010514 | |
| OPPOSITION | - Schutter U; Grunert S; Meyer C; Schmidt T; Nolte T, "Innovative pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: A large observational study under conditions of daily practice", Current Medical Research and Opinion, GB , (20100601), vol. 26, no. 6, doi:10.1185/03007991003787318, ISSN 0300-7995, pages 1377 - 1387, XP009179721 | |
| OPPOSITION | - Jingjing Meng, Haidong Yu, Jing Ma, Jinghua Wang, Santanu Banerjee, Rick Charboneau, Roderick A. Barke, Sabita Roy, "Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner", PLoS ONE, vol. 8, no. 1, doi:10.1371/journal.pone.0054040, page e54040, XP055133905 | |
| OPPOSITION | - Mercadante Sebastiano, Giarratano Antonello, "Combined oral prolonged-release oxycodone and naloxone in chronic pain management", Expert Opinion on Investigational Drugs, UK , (20130101), vol. 22, no. 1, doi:10.1517/13543784.2013.752460, ISSN 1354-3784, pages 161 - 166, XP093009901 | |
| OPPOSITION | - Health at a Glance: Europe, OECD, (20120101), pages 42 - 43, doi:10.1787/9789264183896-en, XP093009906 | |
| OPPOSITION | - Hardt Philip D., Brendel Mathias D., Kloer Hans U., Bretzel Reinhard G., "Is Pancreatic Diabetes (Type 3c Diabetes) Underdiagnosed and Misdiagnosed?", DIABETES CARE, US , (20080201), vol. 31, no. Supplement_2, doi:10.2337/dc08-s244, ISSN 0149-5992, pages S165 - S169, XP093010470 | |
| OPPOSITION | - Christiansen P. M., "The Incidence of Achlorhydria and Hypochlorhydria in Healthy Subjects and Patients with Gastrointestinal Diseases", Scandinavian Journal of Gastroenterology, Informa Healthcare, UK, UK , (19681001), vol. 3, no. 5, doi:10.3109/00365526809179909, ISSN 0036-5521, pages 497 - 508, XP093009926 | |
| OPPOSITION | - Christiansen P. M., "The Incidence of Achlorhydria and Hypochlorhydria in Healthy Subjects and Patients with Gastrointestinal Diseases", Scandinavian Journal of Gastroenterology, UK , (19681001), vol. 3, no. 5, doi:10.3109/00365526809179909, ISSN 0036-5521, pages 497 - 508, XP093009926 | |
| OPPOSITION | - Emanuele Rinninella, Pauline Raoul, Marco Cintoni, Francesco Franceschi, Giacinto Miggiano, Antonio Gasbarrini, Maria Mele, "What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases", Microorganisms, vol. 7, no. 1, doi:10.3390/microorganisms7010014, page 14, XP055743911 | |
| OPPOSITION | - Jan Bures, Cyrany J; Kohoutova D; Forstl M; Rejchrt S; Kvetina J; Vorisek V; Kopacova M, "Small intestinal bacterial overgrowth syndrome", World Journal of Gastroenterology, (20100628), vol. 16, no. 24, doi:10.3748/wjg.v16.i24.2978, ISSN 10079327, pages 2978 - 2990, XP055135799 | |
| OPPOSITION | - Jawad Issrah, Lukšić Ivana, Rafnsson Snorri Bjorn, "Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality", Journal of Global Health, (20120601), vol. 2, no. 1, doi:10.7189/jogh.02.010404, ISSN 2047-2978, pages 010404-1 - 010404-9, XP093010473 | |
