IP Verse

Animal Models And Therapeutic Molecules - EP3028564

The patent EP3028564 was granted to Kymab on Jan 24, 2024. The application was originally filed on Jul 7, 2010 under application number EP16151214A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3028564

KYMAB
Application Number
EP16151214A
Filing Date
Jul 7, 2010
Status
Patent Maintained As Amended
Dec 22, 2023
Grant Date
Jan 24, 2024
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

REGENERON PHARMACEUTICALSJun 26, 2018J A KEMPWITHDRAWN

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
OPPOSITIONEP3028565
OPPOSITIONUS2012204278
OPPOSITIONUS7205148
OPPOSITIONWO02066630
OPPOSITIONWO2007117410
OPPOSITIONWO2009013620
OPPOSITIONWO2009076464
SEARCHUS2006015957
SEARCHUS2009083870
SEARCHWO02066630
SEARCHWO2006122442
SEARCHWO2007117410
SEARCHWO2009013620
SEARCHWO2009076464

Non-Patent Literature (NPL) Citations (55) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- BRUGGEMANN, "58.The Preparation of Human Antibodies from Mice Harbouring Human Immunoglobulin Loci", Transgenic animals: generation and use, Amsterdam, pages 397 - 402, XP055303684-
OPPOSITION- BRUGGEMANN, "Human antibody expression in transgenic mice", Arch Immunol Ther Exp, (20010000), vol. 49, no. 3, pages 203 - 208, XP009039754-
OPPOSITION- HASTY et al., "Gene targeting, principles, and practice in mammalian cells", Gene Targeting, A Practical Approach, Oxford, pages 1 - 175, XP055500641-
OPPOSITION- KOTZAMANIS et al., "Construction of human artificial chromosome vectors by recombineering", Gene, (20050000), vol. 351, pages 29 - 38, XP027872271-
OPPOSITION- LONBERG, "Human antibodies from transgenic animals", Nature Biotechnology, (20050000), vol. 23, no. 9, pages 1117 - 1125, XP003025935-
OPPOSITION- NAGLE, "Regeneron helps make Sanofi Velocimmune to its 'weak' pipeline", Outsourcing-Pharma.Com, (20070000), URL: http://www.outsourcing-pharma.com/Preclinical-Research/Regeneron-helps-make-Sanofi-VelocImmune-to-its-weak-pipeline, (20131110), XP055304507-
OPPOSITION- SOSIO et al., "Assembly of large genomic segments in artificial chromosomes by homologous recombination in Escherichia coli", Nucleic Acids Res., (20010000), vol. 29, no. 7, pages 1 - 8, XP002630416-
OPPOSITION- STEVENS, "Human Antibody Discovery", Pharma Focus Asia, (20080000), vol. 8, pages 72 - 74, XP003035947-
OPPOSITION- TORRES et al., "Flox-and-invert", Laboratory Protocols for Conditional Gene targeting, Oxford, pages 37 - 41, XP055500666-
OPPOSITION- QU et al., "Gene targeting of ErbB using a Cre-mediated unidirectional DNA inversion strategy", Genesis, (20060000), vol. 44, pages 477 - 486, XP055500670
OPPOSITION- GUAN et al., "A Review of Current Large-Scale Mouse Knockout Efforts", Genesis, (20100000), vol. 48, no. 2, pages 73 - 85, XP055046410
OPPOSITION- LARGAESPADA, "Transposon mutagenesis in mice", NIH Public Access Author Manuscript, (20090000), vol. 530, pages 1 - 10, XP055304524
OPPOSITION- BIRLING et al., "Site-Specific Recombinases for Manipulation of the Mouse Genome", Transgenesis Techniques, Principles and Protocols, Dordrecht, (20090000), pages 245 - 263, XP055415138
OPPOSITION- ARTHUR et al., "Gene -Targeting Vectors", ARTHUR et al., Cartwright, Transgenesis Techniques, Principles and Protocols, Dordrecht, pages 127 - 144, XP055304425
OPPOSITION- OUMARD et al., "Recommended Method for Chromosome Exploitation: RMCE-based Cassette-exchange Systems in Animal Cell Biotechnology", Cytotechnology, (20060000), vol. 50, no. 1-3, pages 93 - 108, XP019393904
OPPOSITION- SORRELL et al., "Targeted modification of mammalian genomes", Biotechnology Advances, (20050000), vol. 23, pages 431 - 469, XP005076498
OPPOSITION- WALLACE et al., "Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence", Cell, (20070000), vol. 128, no. 1, pages 197 - 209, XP002481713
OPPOSITION- BAER et al., "Coping with kinetic and thermodynamic barriers: RMCE, an efficient strategy for the targeted integration of transgenes", Curr Opin Biotechnol., vol. 12, no. 5, pages 473 - 480, XP002209666
OPPOSITION- MUYRERS et al., "Techniques: Recombinogenic engineering - new options for cloning and manipulating DNA", TRENDS in Biochemical Sciences, (20010000), vol. 26, no. 5, pages 325 - 331, XP004241877
OPPOSITION- MANIS et al., "Mechanism and control of class-switch recombination", TRENDS Immunol, (20020000), vol. 23, no. 1, pages 31 - 39, XP004332191
OPPOSITION- MURPHY, "Veloclmmune: Immunoglobulin Variable Region Humanised Mice", Recombinant Antibodies for Immunotherapy, New York, pages 100 - 107, XP055304492
OPPOSITION- GIRALDO et al., "Size matters: use of YACs, BACs and PACs in transgenic animals", Transgenic Research, (20010000), vol. 10, pages 83 - 103, XP055022741
OPPOSITION- YANCOPOULOS et al., "Preferential utilisation of the most JH-proximal VH gene segments in pre-B- cell lines", Nature, (19840000), vol. 311, no. 5988, pages 727 - 733, XP055304516
OPPOSITION- COPELAND et al., "Recombineering: a powerful new tool for mouse functional genomics", Nature Reviews Genetics, (20010000), vol. 2, pages 769 - 779, XP001097509
OPPOSITION- RAMIREZ-SOLIS et al., "Chromosome engineering in mice", Nature, (19951214), vol. 378, pages 720 - 724, XP001026456
OPPOSITION- MITRA et al., "Piggybac can bypass DNA synthesis during cut and paste transposition", EMBO J, (20080000), vol. 27, pages 1097 - 1109, XP055500675
OPPOSITION- KLING, "Big Pharma vies for mice", Nature Biotechnology, (20070000), vol. 25, no. 6, pages 613 - 614, XP055304499
OPPOSITION- SCOTT, "Mice with a human touch", Nature Biotechnology, (20070000), vol. 25, no. 10, pages 1075 - 1077, XP003035613
OPPOSITION- SCHNUTGEN et al., "A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse", Nature Biotechnology, (20030000), vol. 21, pages 562 - 565, XP055108504
OPPOSITION- ADAMS et al., "Mutagenic insertion and chromosome engineering resource (MICER", Nature Genetics, (20040000), vol. 36, pages 867 - 871, XP055304429
OPPOSITION- GLASER et al., "Current issues in mouse genome engineering", Nature Genetics, (20050000), vol. 37, no. 11, pages 1187 - 1193, XP055277100
OPPOSITION- SHARAN et al., "Recombineering: a homologous recombination-based method of genetic engineering", Nature Protocols, (20090000), vol. 4, no. 2, pages 206 - 223, XP001525689
OPPOSITION- WANG et al., "Chromosomal transposition of PiggyBac in mouse embryonic stem cells", PNAS, (20080000), vol. 105, no. 27, pages 9290 - 9295, XP055026857
OPPOSITION- WU et al., "Double replacement: strategy for efficient introduction of subtle mutations into the murine Colla-1 gene by homologous recombination in embryonic stem cells", Proc Natl Acad Sci USA, (19940000), vol. 91, no. 7, pages 2819 - 2823, XP002074111
OPPOSITION- SAKAI et al., "Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions", PNAS, (19990000), vol. 96, pages 1526 - 1531, XP055356358
OPPOSITION- LUBY et al., "The µ switch region tandem repeats are important, but not required, for antibody class switch recombination", J Exp Med, (20010000), vol. 193, no. 2, pages 159 - 168, XP055054230
OPPOSITION- BATES et al., "Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination", JEM, (20070000), vol. 204, no. 13, pages 3247 - 3256, XP055304520
OPPOSITION- CALL et al., "A Cre-lox recombination system for the targeted integration of circular yeast artificial chromosomes into embryonic stem cells", Human Molecular Genetics, (20000000), vol. 9, pages 1745 - 1751, XP002956896
OPPOSITION- XU et al., "Site-specific recombination in Schizosaccharomyces pombe and systematic assembly of a 400kb transgene array in mammalian cells using the integrase of Streptomyces phage phiBT1", Nucleic Acids Res., (20070000), vol. 36, no. 1, pages 1 - 9, XP055500662
OPPOSITION- OBERDOERFFER et al., "Unidirectional cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71", Nucleic Acids Research, (20030000), vol. 31, no. 22, pages 1 - 7, XP002992914
OPPOSITION- DAFHNIS-CALAS et al., "Iterative in vivo assembly of large and complex transgenes by combining the activities of phiC31 integrase and Cre recombinase", Nucleic Acids Res, (20050000), vol. 33, no. 22, pages 1 - 14, XP002561513
OPPOSITION- GIBSON et al., "Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome", Science, (20080000), vol. 319, no. 5867, pages 1215 - 1220, XP009101716
OPPOSITION- HASTY et al., "Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells", Molecular and Cellular Biology, (19910000), vol. 11, no. 9, pages 4509 - 4517, XP055304430
OPPOSITION- ASKEW et al., "Site-Directed Point Mutations in Embryonic Stem Cells: a Gene -Targeting Tag-and-Exchange Strategy", Mol. Cell . Biol., (19930000), vol. 13, no. 7, pages 4115 - 4124, XP000568152
OPPOSITION- STACEY et al., "Use of double-replacement gene targeting to replace the murine a-lactalbumin gene with its human counterpart in embryonic stem cells and mice", Mol Cell Biol, (19940000), vol. 14, pages 1009 - 1016, XP000562809
OPPOSITION- ZHENG et al., "Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications", Mol Cell Biol, (20000000), vol. 20, no. 2, pages 648 - 655, XP001004605
OPPOSITION- STORB et al., "Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favours proximate target sequences", Mol. Cell . Biol., (19890000), vol. 9, no. 2, pages 711 - 718, XP055304521
OPPOSITION- ADAMS et al., "Contemporary approaches for modifying the mouse genome", Physiol. Genomics, (20080000), vol. 34, pages 225 - 238, XP055054853
OPPOSITION- MORTUZA et al., "Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukaemia reveals preferential usage of JH-proximal variable gene segments", Blood, (20010000), vol. 97, pages 2716 - 2726, XP055304512
OPPOSITION- UNGRIN et al., "Strict control of telomerase activation using Cre- mediated inversion", BMC Biotechnology, (20060000), vol. 6, no. 10, pages 1 - 9, XP021017036
OPPOSITION- BRAULT et al., "Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organization", PLoS Genetics, (20060700), vol. 2, no. 7, pages 0911 - 0919, XP055255516
OPPOSITION- BODE et al., "The transgeneticist's toolbox: Novel methods for the targeted modification of eukaryotic genomes", Biological Chemistry, (20000000), vol. 381, no. 9-10, pages 801 - 813, XP001021315
OPPOSITION- WILLIAMS et al., "Unequal VH gene rearrangement frequency within the large VH 7183 gene family is not due to recombination signal sequence variation...", J Immunol., (20010000), vol. 167, pages 257 - 263, XP055304513
OPPOSITION- GONDO et al., "Next-generation gene targeting in the mouse for functional genomics", BMB Reports, (20090600), vol. 42, no. 6, pages 315 - 323, XP055500658
SEARCH- BODE J ET AL, "THE TRANSGENETICIST'S TOOLBOX: NOVEL METHODS FOR THE TARGETED MODIFICATION OF EUKARYTOTIC GENOMES", BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER GMBH & CO, BERLIN, DE, (200009), vol. 381, no. 9/10, doi:10.1515/BC.2000.103, ISSN 1431-6730, pages 801 - 813, XP001021315 [A] 1-19 * page 805; figure 3 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents