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Delivery, Engineering And Optimization Of Systems, Methods And Compositions For Sequence Manipulation And Therapeutic Applications - EP3031921

The patent EP3031921 was granted to Massachusetts Institute OF Technology on Mar 12, 2025. The application was originally filed on Dec 12, 2013 under application number EP15179123A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3031921

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Application Number
EP15179123A
Filing Date
Dec 12, 2013
Status
Granted And Under Opposition
Feb 7, 2025
Grant Date
Mar 12, 2025
External Links
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VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBMar 12, 2025VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBB -

Patent Citations (2) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
EXAMINATIONWO2013176772
SEARCHUS2010076057

Non-Patent Literature (NPL) Citations (18) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
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EXAMINATION- ANGELO LOMBARDO ET AL, "Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery", NATURE BIOTECHNOLOGY, GALE GROUP INC., NEW YORK, US, vol. 25, no. 11, doi:10.1038/NBT1353, ISSN 1087-0156, (20071101), pages 1298 - 1306, (20071028), XP002633002
EXAMINATION- DABOUSSI FAYZA ET AL, "Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (20120701), Database accession no. PREV201200642504, XP055047022
EXAMINATION- Prashant Mali ET AL, "RNA-Guided Human Genome Engineering via Cas9", NIH Public Access Author Manuscript, (20130215), vol. 339, doi:10.1126/science.1232033, pages 1 - 8, XP055636507
EXAMINATION- Martin Jinek ET AL, "RNA-programmed genome editing in human cells (includes supplementary information)", eLIFE, (20130129), vol. 2, doi:10.7554/eLife.00471, pages 1 - 9+3pp, XP055285239
SEARCH- WANG HAOYI ET AL, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", CELL, (20130509), vol. 153, no. 4, doi:10.1016/J.CELL.2013.04.025, ISSN 0092-8674, pages 910 - 918, XP028538358 [IP] 1-15 * abstract *
SEARCH- LUKE A. GILBERT ET AL, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", CELL, (20130701), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843 [IP] 1-15 * abstract *
SEARCH- MICHAEL P TERNS ET AL, "CRISPR-based adaptive immune systems", CURRENT OPINION IN MICROBIOLOGY, (20110601), vol. 14, no. 3, doi:10.1016/j.mib.2011.03.005, ISSN 1369-5274, pages 321 - 327, XP055097823 [A] 1-15 * the whole document *
SEARCH- GAJ THOMAS ET AL, "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering", TRENDS IN BIOTECHNOLOGY, (20130701), vol. 31, no. 7, doi:10.1016/J.TIBTECH.2013.04.004, ISSN 0167-7799, pages 397 - 405, XP028571313 [IP] 1-15 * the whole document *
SEARCH- ELITZA DELTCHEVA ET AL, "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", NATURE, (20110331), vol. 471, no. 7340, doi:10.1038/nature09886, ISSN 0028-0836, pages 602 - 607, XP055068535 [A] 1-15 * abstract; figures 1-6 *
SEARCH- BLAKE WIEDENHEFT ET AL, "RNA-guided genetic silencing systems in bacteria and archaea", NATURE, (20120215), vol. 482, no. 7385, doi:10.1038/nature10886, ISSN 0028-0836, pages 331 - 338, XP055116249 [A] 1-15 * the whole document *
SEARCH- JIANG WENYAN ET AL, "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NATURE BIOTECHNOLOGY,, (20130129), vol. 31, no. 3, pages 233 - 239, XP002699849 [AP] 1-15 * abstract; figures 1-5 *
SEARCH- G. GASIUNAS ET AL, "PNAS Plus: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 [A] 1-15 * abstract; figures 4, S9 * * page E2579 * * page E2583 *
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067740 [A] 1-15 * the whole document *
SEARCH[ ] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067747 [ ] * figures S7, S8, S11; table S1 *
SEARCH- L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055102030 [XP] 1-15 * abstract; figures 1-4 * * page 820, column l *
SEARCH- L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067744 [P] * figures S1, S8 *
SEARCH- KRZYSZTOF CHYLINSKI ET AL, "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA BIOLOGY, (20130501), vol. 10, no. 5, doi:10.4161/rna.24321, ISSN 1547-6286, pages 726 - 737, XP055116068 [IP] 1-15 * the whole document *

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