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Porcine Circovirus Type 2 (Pcv2) Subunit Vaccine - EP3035958

The patent EP3035958 was granted to Boehringer Ingelheim Animal Health USA on Oct 26, 2022. The application was originally filed on Aug 20, 2014 under application number EP14761742A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3035958

BOEHRINGER INGELHEIM ANIMAL HEALTH USA
Application Number
EP14761742A
Filing Date
Aug 20, 2014
Status
Granted And Under Opposition
Sep 23, 2022
Grant Date
Oct 26, 2022
External Links
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CEVA SANTE ANIMALEJul 26, 2023CABINET BECKER ET ASSOCIESADMISSIBLE
VIRBACJul 25, 2023GEVERS & ORESADMISSIBLE

Patent Citations (14) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS2011305725
DESCRIPTIONUS2909462
DESCRIPTIONWO2006072065
DESCRIPTIONWO2008076915
INTERNATIONAL-SEARCH-REPORTCN103122352
INTERNATIONAL-SEARCH-REPORTWO2011116094
OPPOSITIONCN103122352
OPPOSITIONEP2657333
OPPOSITIONWO2006072065
OPPOSITIONWO2011116094
OPPOSITIONWO2012083837
OTHEREP2657333
OTHEREP3035958
OTHERWO2012083837

Non-Patent Literature (NPL) Citations (61) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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INTERNATIONAL-SEARCH-REPORT- TANJA OPRIESSNIG ET AL, "A PCV2 vaccine based on genotype 2b is more effective than a 2a-based vaccine to protect against PCV2b or combined PCV2a/2b viremia in pigs with concurrent PCV2, PRRSV and PPV infection", VACCINE, (20130101), vol. 31, no. 3, doi:10.1016/j.vaccine.2012.11.030, ISSN 0264-410X, pages 487 - 494, XP055151226 [Y] 1-20 * abstract *
INTERNATIONAL-SEARCH-REPORT- PAOLO MARTELLI ET AL, "One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 149, no. 3, doi:10.1016/J.VETMIC.2010.12.008, ISSN 0378-1135, (20101207), pages 339 - 351, (20101214), XP028159504 [Y] 1-20 * abstract * * page 341, column r, paragraph 3 - page 342, column l, paragraph 1 * * page 343, column r, paragraph 3 - paragraph 4 *
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OPPOSITION- Anonymous , "Porcine circovirus 2 isolate 22625-33, complete genome", Nucleotide , (20121023), Database accession no. JX535296, URL: Genbank, XP093094458-
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OPPOSITION- Beach, N.M. ; Ramamoorthy, S. ; Opriessnig, T. ; Wu, S.Q. ; Meng, X.J., "Novel chimeric porcine circovirus (PCV) with the capsid gene of the emerging PCV2b subtype cloned in the genomic backbone of the non-pathogenic PCV1 is attenuated in vivo and induces protective and cross-protective immunity against PCV2b and PCV2a subtypes in pigs", Vaccine, AMSTERDAM, NL , (20101216), vol. 29, no. 2, ISSN 0264-410X, pages 221 - 232, XP027539082-
OPPOSITION- Bégué Pierre, Girard Marc, Bazin Hervé, Bach Jean-François, "Commission VII (maladies infectieuses et médecine tropicale) Groupe de travail* sur Les adjuvants vaccinaux: quelle actualité en 2012 ?", Academie Nationale de Medecine, (20120626), pages 1 - 32, XP093090697-
OPPOSITION- Fachinger, V. Bischoff, R. Jedidia, S.B. Saalmuller, A. Elbers, K., "The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex", Vaccine, AMSTERDAM, NL , (20080301), vol. 26, no. 11, ISSN 0264-410X, pages 1488 - 1499, XP022505432-
OPPOSITION- Michael Haake, Andreas Palzer, Beate Rist, Christiane Weissenbacher-Lang, Vicky Fachinger, Alex Eggen, Mathias Ritzmann, Matthias Eddicks, "Influence of age on the effectiveness of PCV2 vaccination in piglets with high levels of maternally derived antibodies", Vet. Microbiol., (20130101), vol. 168, pages 1 - 9, XP055502963-
OPPOSITION- Shen, H.G. ; Beach, N.M. ; Huang, Y.W. ; Halbur, P.G. ; Meng, X.J. ; Opriessnig, T., "Comparison of commercial and experimental porcine circovirus type 2 (PCV2) vaccines using a triple challenge with PCV2, porcine reproductive and respiratory syndrome virus (PRRSV), and porcine parvovirus (PPV)", Vaccine, AMSTERDAM, NL , (20100823), vol. 28, no. 37, ISSN 0264-410X, pages 5960 - 5966, XP027204822-
OPPOSITION- Yan Weidong, "Identification of circovirus type 2 (PCV2) and research and development of live vaccines", Thesis, (20090601), pages 1 - 68, XP093094754-
OPPOSITION- Li Dongge; Wang Jing; Xu Shangen; Cai Shanxia; Ao Chaojie; Fang Liurong; Xiao Shaobo; Chen Huanchun; Jiang Yunbo, "Identification and functional analysis of the novel ORF6 protein of porcine circovirus type 2in vitro", Veterinary Research Communications, NL , (20171125), vol. 42, no. 1, doi:10.1007/s11259-017-9702-0, ISSN 0165-7380, pages 1 - 10, XP036421968
OPPOSITION- Chae Chanhee, "Commercial porcine circovirus type 2 vaccines: Efficacy and clinical application", Veterinary Journal, GB , (20121101), vol. 194, no. 2, doi:10.1016/j.tvjl.2012.06.031, ISSN 1090-0233, pages 151 - 157, XP093090693
OPPOSITION- Kixmoller, M. ; Ritzmann, M. ; Eddicks, M. ; Saalmuller, A. ; Elbers, K. ; Fachinger, V., "Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2", Vaccine, AMSTERDAM, NL , (20080625), vol. 26, no. 27-28, doi:10.1016/j.vaccine.2008.04.032, ISSN 0264-410X, pages 3443 - 3451, XP022710551
OPPOSITION- Fort, M. ; Sibila, M. ; Perez-Martin, E. ; Nofrarias, M. ; Mateu, E. ; Segales, J., "One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model", Vaccine, AMSTERDAM, NL , (20090619), vol. 27, no. 30, doi:10.1016/j.vaccine.2009.04.028, ISSN 0264-410X, pages 4031 - 4037, XP026153154
OPPOSITION- Tanja Opriessnig; Kevin O’neill; Priscilla F Gerber; Alessandra M M G De Castro; Luis G Gimenéz-Lirola; Nathan M Beach; Lei Zhou; Xiang-Jin Meng; Chong Wang; Patrick G Halbur, "A PCV2 vaccine based on genotype 2b is more effective than a 2a-based vaccine to protect against PCV2b or combined PCV2a/2b viremia in pigs with concurrent PCV2, PRRSV and PPV infection", Vaccine, (20130101), vol. 31, no. 3, doi:10.1016/j.vaccine.2012.11.030, ISSN 0264410X, pages 487 - 494, XP055151226
OPPOSITION- Tanja Opriessnig, Kevin O’neill, Priscilla F. Gerber, Alessandra M.M.G. De Castro, Luis G. Gimenéz-Lirola, Nathan M. Beach, Lei Zhou, Xiang-Jin Meng, Chong Wang, Patrick G. Halbur, "A PCV2 vaccine based on genotype 2b is more effective than a 2a-based vaccine to protect against PCV2b or combined PCV2a/2b viremia in pigs with concurrent PCV2, PRRSV and PPV infection", Vaccine, Elsevier, (20130101), vol. 31, no. 3, doi:10.1016/j.vaccine.2012.11.030, ISSN 0264410X, pages 487 - 494, XP055151226
OPPOSITION- Fort Maria, Sibila Marina, Nofrarías Miquel, Pérez-Martín Eva, Olvera Alex, Mateu Enric, Segalés Joaquim, "Evaluation of cell-mediated immune responses against porcine circovirus type 2 (PCV2) Cap and Rep proteins after vaccination with a commercial PCV2 sub-unit vaccine", Veterinary Immunology and Immunopathology, AMSTERDAM, NL, (20121101), vol. 150, no. 1-2, doi:10.1016/j.vetimm.2012.09.001, ISSN 0165-2427, pages 128 - 132, XP093094462
OPPOSITION- F. McNeilly , J. Ellis , S. Krakowka , A. Botner , K. McCullough , H. Nauwynck , S. Kennedy , B. Meehan , C. Charreyre, "PMWS: experimental model and co-infections", Veterinary microbiology, NL , (20040204), vol. 98, no. 2, doi:10.1016/j.vetmic.2003.10.009, ISSN 0378-1135, pages 165 - 168, XP093165762
OPPOSITION- Paolo Martelli; Luca Ferrari; Marina Morganti; Elena De Angelis; Paolo Bonilauri; Stefano Guazzetti; Antonio Caleffi; Paolo Borghetti;, "One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions", Veterinary Microbiology, NL , (20101207), vol. 149, no. 3, doi:10.1016/j.vetmic.2010.12.008, ISSN 0378-1135, pages 339 - 351, XP028159504
OPPOSITION- Tanja Opriessnig, Chao-Ting Xiao, Priscilla F. Gerber, Patrick G. Halbur, "Emergence of a novel mutant PCV2b variant associated with clinical PCVAD in two vaccinated pig farms in the U.S. concurrently infected with PPV2", Veterinary microbiology, (20130401), vol. 163, no. 1-2, doi:10.1016/j.vetmic.2012.12.019, ISSN 03781135, pages 177 - 183, XP055159909
OPPOSITION- Fang Wang, Xin Guo, Xinna Ge, Zhongtian Wang, Yanhong Chen, Zhenlin Cha, Hanchun Yang, "Genetic variation analysis of Chinese strains of porcine circovirus type 2", Virus Research, (20091001), vol. 145, no. 1, doi:10.1016/j.virusres.2009.05.015, ISSN 0168-1702, pages 151 - 156, XP055215765
OPPOSITION- Beach Nathan M.; Meng Xiang-Jin, "Efficacy and future prospects of commercially available and experimental vaccines against porcine circovirus type 2 (PCV2)", Virus research, NL , (19000101), vol. 164, no. 1, doi:10.1016/j.virusres.2011.09.041, ISSN 0168-1702, pages 33 - 42, XP028897951
OPPOSITION- Beach Nathan M.; Meng Xiang-Jin, "Efficacy and future prospects of commercially available and experimental vaccines against porcine circovirus type 2 (PCV2)", Virus research, NL , (20120301), vol. 164, no. 1, doi:10.1016/j.virusres.2011.09.041, ISSN 0168-1702, pages 33 - 42, XP028897951
OPPOSITION- Tanja Opriessnig, John R. Prickett, Darin M. Madson, Hui-Gang Shen, Nicole M. Juhan, Roman M. Pogranichniy, Xiang-Jin Meng, Patrick G. Halbur, "Porcine circovirus type 2 (PCV2)-infection and re-inoculation with homologous or heterologous strains: virological, serological, pathological and clinical effects in growing pigs", Veterinary Research, NL , (20100501), vol. 41, no. 3, doi:10.1051/vetres/2010003, ISSN 0928-4249, page 31, XP055769027
OPPOSITION- Chao-Ting Xiao, Patrick G. Halbur, Tanja Opriessnig, "Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms the presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d", Journal of General Virology, (20150701), vol. 96, no. 7, doi:10.1099/vir.0.000100, ISSN 0022-1317, pages 1830 - 1841, XP055415245
OPPOSITION- Chao-Ting Xiao, Halbur Patrick G., Opriessnig Tanja, "Complete Genome Sequence of a Novel Porcine Circovirus Type 2b Variant Present in Cases of Vaccine Failures in the United States", Journal of Virology, (20120101), vol. 86, no. 22, doi:10.1128/JVI.02345-12, page 12469, XP055705989
OPPOSITION- Segalés J; Olvera A; Grau-Roma L; Charreyre C; Nauwynck H; Larsen L; Dupont K; McCullough K; Ellis J; Krakowka S; Mankertz A; Fredholm M; Fossum C; Timmusk S; Stockhofe-Zurwieden N; Beattie V; Armstrong D; Grassland B; Baekbo P; Allan G, "PCV-2 genotype definition and nomenclature.", Veterinary Record, GB , (20080628), vol. 162, no. 26, doi:10.1136/vr.162.26.867, ISSN 0042-4900, pages 867 - 868, XP009179386
OPPOSITION- Wentao Li;Shuqing Liu;Yang Wang;Feng Deng;Weidong Yan;Kun Yang;Huanchun Chen;Qigai He;Catherine Charreyre;Jean-Christophe Audoneet, "Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type 2", BMC Genomics, London, UK , (20130527), vol. 14, no. 1, doi:10.1186/1471-2164-14-353, ISSN 1471-2164, pages 1 - 15, XP021151975
OPPOSITION- Guo Long J; Lu Yue H; Wei Yan W; Huang Li P; Liu Chang M, "Porcine circovirus type 2 (PCV2): genetic variation and newly emerging genotypes in China", Virology Journal, GB , (20101019), vol. 7, no. 1, doi:10.1186/1743-422X-7-273, ISSN 1743-422X, page 273, XP021080203
OPPOSITION- Yifei Yang;Ruihan Shi;Ruiping She;Jingjing Mao;Yue Zhao;Fang Du;Can Liu;Jianchai Liu;Minheng Cheng;Rining Zhu;Wei Li;Xiaoyang Wang;Majid Hussain Soomro, "Fatal disease associated with Swine Hepatitis E virus and Porcine circovirus 2 co-infection in four weaned pigs in China", BMC Veterinary Research, GB , (20150326), vol. 11, no. 1, doi:10.1186/s12917-015-0375-z, ISSN 1746-6148, pages 1 - 11, XP021220421
OPPOSITION- S. Krakowka, J. A. Ellis, F. Mcneilly, S. Ringler, D. M. Rings, G. Allan, "Activation of the Immune System is the Pivotal Event in the Production of Wasting Disease in Pigs Infected with Porcine Circovirus-2 (PCV-2)", Veterinary Patholgy, US , (20010101), vol. 38, no. 1, doi:10.1354/vp.38-1-31, ISSN 0300-9858, pages 31 - 42, XP055277395
OPPOSITION- Longjun Guo, Fu Yujie, Wang Yiping, Lu Yuehua, Wei Yanwu, Tang Qinghai, Fan Peihu, Liu Jianbo, Zhang Long, Zhang Feiyan, Huang Liping, Liu Dan, Li Shengbin, Wu Hongli, Liu Changming, Vartanian Jean-Pierre, "A Porcine Circovirus Type 2 (PCV2) Mutant with 234 Amino Acids in Capsid Protein Showed More Virulence In Vivo, Compared with Classical PCV2a/b Strain", PLoS ONE, (20120719), vol. 7, no. 7, doi:10.1371/journal.pone.0041463, pages 1 - 10, XP055458039
OTHER- "Porcine circovirus 2 strain HBwh-2a, complete genome", Nucleotide, (2090505), Database accession no. FJ870967, URL: ncbi, XP055799251-
OTHER- OPRIESSNIG T. et al., "Emergence of a novel mutant PCV2b variant associated with clinical PCVAD in two vaccinated pig farms in the U.S. concurrently infected with PPV2", Veterinary Microbiology, (20130401), vol. 163, no. 1-2, pages 177 - 183, XP055159909
OTHER- SEGALES J. et al, "PCV-2 genotype definition and nomenclature", VETERINARY RECORD, (20080628), vol. 162, no. 26, pages 867 - 868, XP009179386
OTHER- LI et al., "Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type", BMC genomics, (20130527), vol. 14, no. 1, page 353, XP021151975
OTHER- YANG Z. et al, "Fatal disease associated with Swine Hepatitis E virus and Porcine circovirus 2 co-infection in four weaned pigs in China", BMC Veterinary Research, (20150326), vol. 11, page 77, XP021220421

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