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The patent EP3056568 was granted to Chugai Seiyaku Kabushiki Kaisha on Sep 15, 2021. The application was filed on Mar 30, 2007 under application number EP15196240A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
Methods for controlling the blood half-life of antibodies by modifying surface-exposed amino acid residues in the variable regions, without affecting antibody structure or function. The modification involves amino acid substitutions that shift the isoelectric point (pI) of the antibody, enabling control of pharmacokinetics in blood. The methods are applicable to humanized, chimeric, and human antibodies, and can be used to prolong or reduce the half-life of antibodies in blood.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| NOVO NORDISK | Jun 15, 2022 | J A KEMP | ADMISSIBLE |
| STRAWMAN | Jun 14, 2022 | PLASSERAUD | WITHDRAWN |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | JP20050112514 |
| DESCRIPTION | EP0125023 |
| DESCRIPTION | EP0239400 |
| DESCRIPTION | JPH0159878B |
| DESCRIPTION | JPH10504970 |
| DESCRIPTION | WO2005035756 |
| DESCRIPTION | WO9201047 |
| DESCRIPTION | WO9203918 |
| DESCRIPTION | WO9219759 |
| DESCRIPTION | WO9220791 |
| DESCRIPTION | WO9306213 |
| DESCRIPTION | WO9311236 |
| DESCRIPTION | WO9319172 |
| DESCRIPTION | WO9402602 |
| DESCRIPTION | WO9501438 |
| DESCRIPTION | WO9515388 |
| DESCRIPTION | WO9515393 |
| DESCRIPTION | WO9602576 |
| DESCRIPTION | WO9633735 |
| DESCRIPTION | WO9634096 |
| DESCRIPTION | WO9813388 |
| DESCRIPTION | WO9846777 |
| DESCRIPTION | WO9951743 |
| EXAMINATION | US2006057149 |
| EXAMINATION | WO2005121180 |
| OPPOSITION | EP0329185 |
| OPPOSITION | EP2006381 |
| OPPOSITION | EP3056568 |
| OPPOSITION | US2005244403 |
| OPPOSITION | WO9803546 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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Decision to grant a European patent
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Letter accompanying subsequently filed items
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Letter accompanying subsequently filed items
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Annex to the communication
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Sep 18, 2017
Communication from the Examining Division
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Examination started
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Jun 21, 2017
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Payment of fees and costs
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Notification of forthcoming publication
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European search opinion
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European search report
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Information on Search Strategy
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Search started
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Claims
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Mar 30, 2016
Matter concerning the application
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Mar 29, 2016
Payment of fees and costs
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Communication to designated inventor
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Communication to designated inventor
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Communication to designated inventor
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Invitation to file claims
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Nov 25, 2015
Abstract
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Annex
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Annex
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Converted Sequence Listing
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Description
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Designation of inventor
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Drawings
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Sequence listing
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Oct 30, 2007